Otto Haller

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint Protective role of interferon-induced Mx GTPases against influenza viruses
    O Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79008 Freiburg, Germany
    Rev Sci Tech 28:219-31. 2009
  2. doi request reprint A tribute to Jean Lindenmann, co-discoverer of interferon (1924-2015)
    Otto Haller
    Institute of Virology, University Medical Center Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany Electronic address
    Cytokine 76:113-5. 2015
  3. doi request reprint Mx GTPases: dynamin-like antiviral machines of innate immunity
    Otto Haller
    Institute of Virology, University Medical Center Freiburg, Freiburg, Germany Electronic address
    Trends Microbiol 23:154-63. 2015
  4. doi request reprint Dynamins are forever: MxB inhibits HIV-1
    Otto Haller
    Institute of Virology, Department of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany Electronic address
    Cell Host Microbe 14:371-3. 2013
  5. pmc Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity
    Otto Haller
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Biol Chem 285:28419-24. 2010
  6. doi request reprint Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity
    Otto Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Interferon Cytokine Res 31:79-87. 2011
  7. ncbi request reprint The Mx GTPase family of interferon-induced antiviral proteins
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Hermann Herderstrasse 11, D 79008 Freiburg, Germany
    Microbes Infect 9:1636-43. 2007
  8. ncbi request reprint Interferon-induced Mx proteins in antiviral host defense
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:812-8. 2007
  9. ncbi request reprint Pathogenic viruses: smart manipulators of the interferon system
    O Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, 79008 Freiburg, Germany
    Curr Top Microbiol Immunol 316:315-34. 2007
  10. ncbi request reprint Interferon, Mx, and viral countermeasures
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Cytokine Growth Factor Rev 18:425-33. 2007

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Protective role of interferon-induced Mx GTPases against influenza viruses
    O Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, D 79008 Freiburg, Germany
    Rev Sci Tech 28:219-31. 2009
    ....
  2. doi request reprint A tribute to Jean Lindenmann, co-discoverer of interferon (1924-2015)
    Otto Haller
    Institute of Virology, University Medical Center Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany Electronic address
    Cytokine 76:113-5. 2015
    ..Jean Lindenmann died in Zürich on January 15, 2015, at the age of 90, after having survived Alick Isaacs (1921-1967) for almost five decades. ..
  3. doi request reprint Mx GTPases: dynamin-like antiviral machines of innate immunity
    Otto Haller
    Institute of Virology, University Medical Center Freiburg, Freiburg, Germany Electronic address
    Trends Microbiol 23:154-63. 2015
    ..The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses. ..
  4. doi request reprint Dynamins are forever: MxB inhibits HIV-1
    Otto Haller
    Institute of Virology, Department of Medical Microbiology and Hygiene, University of Freiburg, D 79104 Freiburg, Germany Electronic address
    Cell Host Microbe 14:371-3. 2013
    ..Three recent papers, including one in this issue of Cell Host & Microbe, show that MxB inhibits human immunodeficiency virus type 1 (HIV-1) infection. ..
  5. pmc Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity
    Otto Haller
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Biol Chem 285:28419-24. 2010
    ..Moreover, the structural knowledge paves the way for the development of novel antiviral drugs against influenza and other highly pathogenic viruses...
  6. doi request reprint Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity
    Otto Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Interferon Cytokine Res 31:79-87. 2011
    ..Thus, MxA may form oligomeric rings around tubular nucleocapsid structures, thereby inhibiting their transcriptional and replicative function. Here we briefly review the most salient features of MxA expression and antiviral function...
  7. ncbi request reprint The Mx GTPase family of interferon-induced antiviral proteins
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Hermann Herderstrasse 11, D 79008 Freiburg, Germany
    Microbes Infect 9:1636-43. 2007
    ..They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence...
  8. ncbi request reprint Interferon-induced Mx proteins in antiviral host defense
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:812-8. 2007
    ..As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles...
  9. ncbi request reprint Pathogenic viruses: smart manipulators of the interferon system
    O Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, 79008 Freiburg, Germany
    Curr Top Microbiol Immunol 316:315-34. 2007
    ..Here, we summarize current knowledge in light of most recent findings on the intricate interactions of viruses with the IFN system...
  10. ncbi request reprint Interferon, Mx, and viral countermeasures
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Cytokine Growth Factor Rev 18:425-33. 2007
    ..Here, we summarize recent findings about the astonishing interplay of viruses with the IFN response pathway...
  11. ncbi request reprint The interferon response circuit: induction and suppression by pathogenic viruses
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Virology 344:119-30. 2006
    ..Here we discuss the current view on the balancing act between virus-induced IFN responses and the viral counterplayers...
  12. ncbi request reprint Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum
    Silke Stertz
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Interferon Cytokine Res 26:650-60. 2006
    ..The present results demonstrate that MxA is an IFN-induced antiviral effector protein that resembles the constitutively expressed large GTPase family members in its capacity to localize to and reorganize intracellular membranes...
  13. ncbi request reprint The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus
    Silke Stertz
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Interferon Cytokine Res 27:847-55. 2007
    ..Therefore, cotton rats are a suitable animal model to study experimental infections with FLUAV and other RNA viruses...
  14. pmc Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling
    Dirk Holzinger
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 81:7776-85. 2007
    ..In summary, our study reveals that MxA is a unique marker for the detection of type I and type III IFN activity during virus infections and IFN therapy...
  15. ncbi request reprint Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes
    Mike Reichelt
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Traffic 5:772-84. 2004
    ..Our results suggest that this membrane compartment is the preferred place where MxA and N interact, leading to efficient sequestration and missorting of an essential viral component...
  16. pmc Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase
    Jan Dittmann
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, 79107 Freiburg, Germany
    J Virol 82:3624-31. 2008
    ....
  17. pmc Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene
    Daniel Grimm
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 104:6806-11. 2007
    ..These results reveal a surprisingly simple concept of how influenza viruses may gain virulence and illustrate that high speed of virus growth can outcompete the antiviral response of the infected host...
  18. pmc Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice
    Thierry Rolling
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, 79104 Freiburg, Germany
    J Virol 83:6673-80. 2009
    ..Interestingly, all virulence-enhancing mutations that we identified in this study resulted in substantially increased viral polymerase activity...
  19. ncbi request reprint Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies
    Othmar G Engelhardt
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Gen Virol 85:2315-26. 2004
    ..Taken together, these findings suggest that Mx1 dots represent distinct nuclear domains ('Mx nuclear domains') that are frequently associated with, but functionally independent of, PML NBs...
  20. pmc Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3
    Martin Spiegel
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Virol 79:2079-86. 2005
    ..In order to escape activation of the IFN system, SARS-CoV appears to block a step after the early nuclear transport of IRF-3...
  21. ncbi request reprint Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist
    Daniel Thomas
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Biol Chem 279:31471-7. 2004
    ..Moreover, by inducing a general transcriptional block, NSs may contribute to the lytic infection observed in mammalian cells as opposed to persistent infection in the insect host...
  22. pmc The viral nucleoprotein determines Mx sensitivity of influenza A viruses
    Petra Zimmermann
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Virol 85:8133-40. 2011
    ..This also explains our previous observations that human and avian influenza A viruses differ in their sensitivities to Mx...
  23. ncbi request reprint Assay and functional analysis of dynamin-like Mx proteins
    Georg Kochs
    Department of Virology, University of Freiburg, Germany
    Methods Enzymol 404:632-43. 2005
    ....
  24. doi request reprint Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus
    Iris Koerner
    Department of Virology, University of Freiburg, 79008 Freiburg, Germany
    J Gen Virol 93:970-9. 2012
    ..Our data suggest that the HA of hvPR8 enhances virulence by mediating optimal receptor binding and membrane fusion thereby promoting rapid and efficient viral entry into host cells...
  25. pmc Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop
    Alexander von der Malsburg
    Department of Virology, Institute of Microbiology, University of Freiburg, 79104 Freiburg, Germany
    J Biol Chem 286:37858-65. 2011
    ..Thus, the present results indicate that the oligomeric structures formed by MxA critically differ from those of dynamin...
  26. ncbi request reprint Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids
    Gjon Blakqori
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Gen Virol 84:1207-14. 2003
    ..In passaging experiments using parental helper virions, it was demonstrated that the recombinant nucleocapsids are a useful model for transcription, replication and packaging of LACV...
  27. ncbi request reprint Inverse interference: how viruses fight the interferon system
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, Germany
    Viral Immunol 17:498-515. 2004
    ..A better understanding of virus-host interactions is now emerging with great implications for vaccine development and drug design...
  28. ncbi request reprint Induction of interferon synthesis by the PKR-inhibitory VA RNAs of adenoviruses
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Interferon Cytokine Res 26:1-7. 2006
    ..These data may be considered when using genetically modified adenoviruses as therapeutic agents and suggest caution in choosing VA RNA constructs as a means to increase expression of a gene of interest...
  29. pmc Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein
    Benjamin Mänz
    Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    PLoS Pathog 9:e1003279. 2013
    ..We conclude that human MxA represents a barrier against zoonotic introduction of avian influenza viruses and that adaptive mutations in the viral NP should be carefully monitored...
  30. pmc Emergence of a C-terminal seven-amino-acid elongation of NS1 in around 1950 conferred a minor growth advantage to former seasonal influenza A viruses
    Florens Lohrmann
    Institute for Virology, University Medical Center Freiburg, Freiburg, Germany
    J Virol 87:11300-3. 2013
    ..However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages. ..
  31. pmc Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes
    Georg Kochs
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Proc Natl Acad Sci U S A 99:3153-8. 2002
    ..These results illustrate an efficient mechanism of IFN action whereby an essential virus component is trapped in cytoplasmic inclusions and becomes unavailable for the generation of new virus particles...
  32. ncbi request reprint The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
    Martin Spiegel
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Clin Virol 30:211-3. 2004
    ..Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV...
  33. ncbi request reprint Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Traffic 3:710-7. 2002
    ..As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles...
  34. ncbi request reprint Viral suppression of the interferon system
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:836-42. 2007
    ..Here, we will describe a few well-characterized examples to illustrate the sophisticated and often multi-layered anti-IFN mechanisms employed by viruses...
  35. ncbi request reprint Viral evasion of the interferon system: old viruses, new tricks
    Friedemann Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Interferon Cytokine Res 23:209-13. 2003
    ..The emerging understanding of how viral proteins intercept the IFN response was the focus of a workshop held at the University of Freiburg, Germany, on September 27-28, 2002...
  36. pmc Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets
    Daniela Kugel
    Department of Virology, University of Freiburg, Freiburg, Germany
    J Virol 83:3843-51. 2009
    ..Based on these results, a more intensive evaluation of IFN-alpha as an emergency drug against pandemic influenza A is warranted...
  37. pmc Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice
    Andreas Pichlmair
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    J Virol 78:11422-4. 2004
    ..Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models...
  38. pmc Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus
    Corinna Patzina
    From the Institute of Virology, University of Freiburg, 79008 Freiburg, Germany
    J Biol Chem 289:6020-7. 2014
    ....
  39. ncbi request reprint Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers
    Georg Kochs
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Biol Chem 277:14172-6. 2002
    ..Our data indicate that binding and hydrolysis of GTP induce conformational changes in MxA that may be essential for viral target recognition and antiviral activity...
  40. pmc The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA
    David Riegger
    Institute of Virology, University Medical Center, Freiburg, Germany
    J Virol 89:2241-52. 2015
    ..This might contribute to zoonotic transmission of H7N9 and to the severe to fatal outcome of H7N9 infections in humans...
  41. ncbi request reprint Rapid and simple detection of IFN-neutralizing antibodies in chronic hepatitis C non-responsive to IFN-alpha
    Carl Jorns
    Department of Virology, Institute of Medical Microbiology and Hygiene, Freiburg, Germany
    J Med Virol 78:74-82. 2006
    ....
  42. pmc Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import
    Veronika Götz
    Institute of Virology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    Sci Rep 6:23138. 2016
    ..This inherent difficulty may partially explain the frequent failure of AIV to become pandemic. ..
  43. ncbi request reprint Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs
    Michael Frese
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Hepatology 35:694-703. 2002
    ....
  44. ncbi request reprint The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML
    Othmar G Engelhardt
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Exp Cell Res 283:36-50. 2003
    ..We propose that PKM is able to modify ND10 structure by inducing changes in the posttranslational modification of PML and by interacting with SUMO-1 modification pathways...
  45. ncbi request reprint The interferon response circuit in antiviral host defense
    O Haller
    Department of Virology, University of Freiburg, D 79008 Freiburg
    Verh K Acad Geneeskd Belg 71:73-86. 2009
    ..Virus mutants lacking IFN antagonistic properties represent safe yet highly immunogenic candidate vaccines. Furthermore, novel drugs intercepting viral IFN-antagonists could be used to disarm the viral intruders...
  46. ncbi request reprint Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies
    O G Engelhardt
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Freiburg, D 79008, Germany
    Exp Cell Res 271:286-95. 2001
    ..This suggests a role of PML NBs and SUMO-1 in the antiviral action of Mx1 and may allow us to discover novel functions of this large GTPase...
  47. pmc Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids
    G Kochs
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Proc Natl Acad Sci U S A 96:2082-6. 1999
    ..Our results reveal an antiviral mechanism whereby an interferon-induced protein traps the incoming virus and interferes with proper transport of the viral genome to its ultimate target compartment within the infected cell...
  48. ncbi request reprint Interferon-induced rat Mx proteins confer resistance to Rift Valley fever virus and other arthropod-borne viruses
    M Sandrock
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79104 Freiburg, Germany
    J Interferon Cytokine Res 21:663-8. 2001
    ..The results indicate that rats have evolved two Mx proteins to efficiently control viruses with different replication strategies...
  49. ncbi request reprint Constitutive expression of interferon-induced human MxA protein in transgenic tobacco plants does not confer resistance to a variety of RNA viruses
    M Frese
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Transgenic Res 9:429-38. 2000
    ..Neither was the multiplication of tobacco mosaic virus, cucumber mosaic virus and potato virus Y inhibited in MxA-transgenic plants. The results indicate that the expression of human MxA alone does not enhance virus resistance in planta...
  50. pmc MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes
    F Weber
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Virol 74:560-3. 2000
    ..The present findings are consistent with previous data which indicated that cytoplasmic MxA prevents transport of vRNPs into the nucleus, whereas nuclear MxA directly inhibits the viral polymerase activity in the nucleus...
  51. ncbi request reprint GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae)
    G Kochs
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Biol Chem 274:4370-6. 1999
    ..We propose that GTP-bound MxA adopts an antivirally active conformation that allows interaction with viral nucleocapsids, thereby impairing their normal function...
  52. ncbi request reprint A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins
    F Weber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Freiburg, D 79008, Germany
    Virology 250:9-18. 1998
    ..These findings suggest that NP of orthomyxoviruses have two independent NLSs, namely cNLS and nNLS. They further suggest that NAS and NLSs may assume opposing roles in nucleocytoplasmic transport of NP...
  53. ncbi request reprint MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures
    G Kochs
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Hermann Herder Strasse 11, Freiburg, D 79008, Germany
    Methods 15:255-63. 1998
    ..It not only will be useful for studying physical interactions of MxA with partner molecules, but may also be applicable to other studies on protein-protein interactions in living cells...
  54. ncbi request reprint Thogoto and Dhori virus replication is blocked by inhibitors of cellular polymerase II activity but does not cause shutoff of host cell protein synthesis
    J Siebler
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Federal Republic of Germany
    Arch Virol 141:1587-94. 1996
    ..In contrast to influenza viruses, Thogoto and Dhori virus infection did not lead to down-regulation of cellular protein synthesis indicating marked differences regarding the fate of infected cells...
  55. ncbi request reprint Intragenic variability of human cytomegalovirus glycoprotein B in clinical strains
    U Meyer-König
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    J Infect Dis 177:1162-9. 1998
    ..In 22 of 44 strains, the gB type determined at the cleavage site was different from the gBn or gBc type (or either), indicating that intragenic variability within the gB gene occurs frequently...
  56. pmc Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity
    A Ponten
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    J Virol 71:2591-9. 1997
    ..We propose that dominant-negative mutants directly influence wild-type activity within hetero-oligomers or else compete with wild-type MxA for a cellular or viral target...
  57. pmc A monomeric GTPase-negative MxA mutant with antiviral activity
    C Janzen
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Virol 74:8202-6. 2000
    ..MxA(L612K) is rapidly degraded in cells, whereas wild-type MxA is stable. We propose that high-molecular-weight MxA oligomers represent a stable intracellular pool from which active MxA monomers are recruited...
  58. ncbi request reprint Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infection
    Lioubov M Pletneva
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 26:914-21. 2006
    ....
  59. ncbi request reprint Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Am J Clin Pathol 124:37-48. 2005
    ..We believe this cytotoxic immune response represents an evolutionarily conserved pathway against intracellular pathogens...
  60. pmc Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus
    Ida Andersson
    Center for Microbiological Preparedness Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
    J Virol 78:4323-9. 2004
    ..These results suggest that MxA, by interacting with a component of the nucleocapsid, prevents replication of CCHFV viral RNA and thereby inhibits the production of new infectious virus particles...
  61. pmc Induction of type I interferons and interferon-inducible Mx genes during respiratory syncytial virus infection and reinfection in cotton rats
    Lioubov M Pletneva
    Virion Systems Inc, 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, USA
    J Gen Virol 89:261-70. 2008
    ..Virus replication and Mx gene expression became more prominent with increasing intervals between primary infection and reinfection. These results highlight the role of type I IFN in modulation of the immune response to RSV...
  62. ncbi request reprint Type I interferon inhibits Crimean-Congo hemorrhagic fever virus in human target cells
    Ida Andersson
    Center for Microbiological Preparedness Swedish Institute for Infectious Disease Control, Karolinska Intitutet, Stockholm, Sweden
    J Med Virol 78:216-22. 2006
    ..The identification of intrinsic cellular resistance factors that block CCHFV replication may help in designing novel antiviral agents...
  63. ncbi request reprint Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimod
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Cutan Pathol 32:257-62. 2005
    ..We hypothesize that TLR7-signaling strongly induces the production of interferon (IFN) alpha, which is able to enhance Th1-mediated cellular antiviral and antitumor immunity...
  64. ncbi request reprint Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    J Pathol 205:435-42. 2005
    ..It is proposed that type I IFNs induce a Th1-biased inflammatory immune response, with recruitment of CXCR3-expressing T-lymphocytes into the skin...
  65. pmc Hantaan virus infection causes an acute neurological disease that is fatal in adult laboratory mice
    Dominic Wichmann
    Institut fur Virologie, Philipps Universitat, Marburg, Germany
    J Virol 76:8890-9. 2002
    ..The present model may help to overcome shortcomings in the development of therapeutic and prophylactic measurements against hantavirus infections...
  66. pmc NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription
    Agnès Billecocq
    Unité de Génétique Moléculaire des Bunyaviridés, Institut Pasteur, Paris, France
    J Virol 78:9798-806. 2004
    ..The present results suggest that NSs, unlike other viral IFN antagonists, does not inhibit IFN-specific transcription factors but blocks IFN gene expression at a subsequent step...
  67. pmc The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses
    Terrence M Tumpey
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:10818-21. 2007
    ..Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses...