V Ivaskevicius

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint International registry on factor XIII deficiency: a basis formed mostly on European data
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University of Bonn, 53127 Bonn, German
    Thromb Haemost 97:914-21. 2007
  2. ncbi request reprint A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia. Predicted structure and function consequences
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 43 20, Email
    Hamostaseologie 36:S34-S38. 2016
  3. ncbi request reprint Combined coagulation factor VIII and factor IX deficiency (CDF8F9) in a patient from Lithuania
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany Tel 49 0 228 28 71 51 75, Fax 43 20, Email
    Hamostaseologie 36:S29-S33. 2016
  4. ncbi request reprint Neoplasm-induced bleeding in inherited, heterozygous FXIII-A deficiency
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 49 0 228 28 71 43 20
    Hamostaseologie 35:S32-5. 2015
  5. ncbi request reprint A novel fibrinogen γ chain frameshift deletion (c.637delT) in a patient with hypodysfibrinogenemia associated with thrombosis
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 49 0 228 28 71 43 20, E mail
    Hamostaseologie 35:S27-31. 2015
  6. doi request reprint Inhibitor development and management in three non-severe haemophilia A patients with T295A variant
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 49 228 28 71 43 20, E mail
    Hamostaseologie 34:S9-12. 2014
  7. doi request reprint A common F13A1 intron 1 variant IVS1+12(A) is associated with mild FXIII deficiency in Caucasian population
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127, Bonn, Germany
    Ann Hematol 92:975-9. 2013
  8. pmc Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, 53127 Bonn, Germany
    Haematologica 95:956-62. 2010
  9. doi request reprint Mutations affecting disulphide bonds contribute to a fairly common prevalence of F13B gene defects: results of a genetic study in 14 families with factor XIII B deficiency
    V Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    Haemophilia 16:675-82. 2010
  10. doi request reprint The first case of combined coagulation factor V and coagulation factor VIII deficiency in Poland due to a novel p.Tyr135Asn missense mutation in the MCFD2 gene
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    Blood Coagul Fibrinolysis 19:531-534. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint International registry on factor XIII deficiency: a basis formed mostly on European data
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University of Bonn, 53127 Bonn, German
    Thromb Haemost 97:914-21. 2007
    ..f13-database.de) will provide clinicians and scientists working on FXIII deficiency with a helpful tool to improve patient care and direct future studies towards better understanding and treatment of the disease...
  2. ncbi request reprint A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia. Predicted structure and function consequences
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 43 20, Email
    Hamostaseologie 36:S34-S38. 2016
    ..Afibrinogenemia represents the rarest form of fibrinogen deficiency. Causative missense mutations occur rarely and may improve the understanding of fibrinogen structure and function...
  3. ncbi request reprint Combined coagulation factor VIII and factor IX deficiency (CDF8F9) in a patient from Lithuania
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany Tel 49 0 228 28 71 51 75, Fax 43 20, Email
    Hamostaseologie 36:S29-S33. 2016
    ..It is a very rare event to identify both haemophilias in the same patient. So far, only two families with such combination are reported in the literature worldwide supported by genetic background...
  4. ncbi request reprint Neoplasm-induced bleeding in inherited, heterozygous FXIII-A deficiency
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 49 0 228 28 71 43 20
    Hamostaseologie 35:S32-5. 2015
    ..Blood coagulation status showed significantly elevated D-dimer and decreased FXIII levels (FXIII-activity 35%, FXIIIA-Ag 16-26%). Plasma mixing studies excluded neutralizing antibodies against FXIII...
  5. ncbi request reprint A novel fibrinogen γ chain frameshift deletion (c.637delT) in a patient with hypodysfibrinogenemia associated with thrombosis
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 49 0 228 28 71 43 20, E mail
    Hamostaseologie 35:S27-31. 2015
    ..While the majority of patients with clinically relevant FG deficiencies demonstrate a bleeding phenotype, a subset of patients are at increased risk of thrombosis...
  6. doi request reprint Inhibitor development and management in three non-severe haemophilia A patients with T295A variant
    V Ivaskevicius
    Vytautas Ivaskevicius, Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany, Tel 49 0 228 28 71 51 75, Fax 49 228 28 71 43 20, E mail
    Hamostaseologie 34:S9-12. 2014
    ..This resulted in his depletion of B cells, measurable endogenous FVIII levels and non measurable inhibitors. This study demonstrated T295A variant to be associated with significantly increased (3/16 patients, 17%) inhibitor development...
  7. doi request reprint A common F13A1 intron 1 variant IVS1+12(A) is associated with mild FXIII deficiency in Caucasian population
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, 53127, Bonn, Germany
    Ann Hematol 92:975-9. 2013
    ..001). The greater frequency of the IVS1+12(A) variant among C2 cohort patients suggests that this polymorphism is associated with mild FXIII deficiency...
  8. pmc Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, 53127 Bonn, Germany
    Haematologica 95:956-62. 2010
    ..In most cases, the disease is caused by F13A gene mutations. Causative mutations associated with the F13B gene are rarer...
  9. doi request reprint Mutations affecting disulphide bonds contribute to a fairly common prevalence of F13B gene defects: results of a genetic study in 14 families with factor XIII B deficiency
    V Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    Haemophilia 16:675-82. 2010
    ..The present study reports on a fairly common prevalence of F13B gene defects in the German population. The regions in and around the cysteine disulphide bonds in the FXIII-B protein may be regions prone to frequent mutations...
  10. doi request reprint The first case of combined coagulation factor V and coagulation factor VIII deficiency in Poland due to a novel p.Tyr135Asn missense mutation in the MCFD2 gene
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    Blood Coagul Fibrinolysis 19:531-534. 2008
    ..Tyr135Asn). This variant represents the third missense mutation found in the MCFD2 gene and most likely disrupts the MCFD2-LMAN1 interaction, thus leading to the disease phenotype...
  11. ncbi request reprint Phenotype-genotype correlation in eight Polish patients with inherited Factor XIII deficiency: identification of three novel mutations
    V Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, 53127 Bonn, Germany
    Haemophilia 13:649-57. 2007
    ..In conclusion, the severe phenotype with high incidence of intracranial bleeding and haemarthrosis was in accordance with laboratory findings on FXIII and with severe molecular defects of the F13A gene...
  12. ncbi request reprint Lithuanian haemophilia A and B registry comprising phenotypic and genotypic data
    V Ivaskevicius
    Klaipeda Seamen s Hospital, Haemophilia Centre, Klaipeda, Lithuania
    Br J Haematol 112:1062-70. 2001
    ..The information provided by this registry will be helpful for monitoring the treatment of Lithuanian haemophilia patients and also for reliable genetic counselling of the affected families in the future...
  13. ncbi request reprint Evaluation of DHPLC in the analysis of hemophilia A
    J Oldenburg
    Department of Human Genetics, University of Wurzburg, Biozentrum, Am Hubland, D 97074, Wurzburg, Germany
    J Biochem Biophys Methods 47:39-51. 2001
    ..4%), dHPLC facilitated the detection of the disease-associated nucleotide alterations. From these findings we conclude that the dHPLC technology is a highly sensitive method well suited to the molecular analysis of hemophilia A...
  14. doi request reprint Haemostasis management of massive bleeding
    B Pötzsch
    Institute of Experimental Heamatology and Transfusion Medicine, University Hospital, Germany
    Hamostaseologie 31:15-20. 2011
    ..In addition, plasma should be administered in a 1:1 ratio with red cells. The use of recombinant factor VIIa should be considered if major bleeding persists despite best-practive use of blood products...
  15. doi request reprint Coagulation factor XIII deficiency. Diagnosis, prevalence and management of inherited and acquired forms
    A Biswas
    Arijit Biswas Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25 53127 Bonn, Germany, Tel 49 0 228 28 71 94 28, Fax 49 0 228 28 71 43 20, E mail
    Hamostaseologie 34:160-6. 2014
    ..Here, we update the knowledge about the pathophysiology of factor XIII deficiency and its therapeutic options. ..
  16. ncbi request reprint Identification of 32 novel mutations in the factor VIII gene in Indian patients with hemophilia A
    Rafeeq P H Ahmed
    Haematologica 90:283-4. 2005
    ..These included 14 missense, 7 nonsense, 9 splice site, 8 deletional, 3 insertional mutations and one indel mutation. Of these, 32 were novel gene alterations. The hotspots included intron 22 inversion, CpG and adenine runs...
  17. ncbi request reprint Protection from type 1 diabetes by vitamin D receptor haplotypes
    Elizabeth Ramos-Lopez
    Department of Internal Medicine I, Division of Endocrinology, University Hospital Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Ann N Y Acad Sci 1079:327-34. 2006
    ..Furthermore, normal serum levels of 25(OH)D(3) appear to correlate with a VDR genotype. This supports a role of vitamin D in the immune pathogenesis of type 1 diabetes...
  18. ncbi request reprint Genetic background and inhibitors in previously untreated or minimally treated young patients with severe haemophilia A treated with sucrose-formulated recombinant factor VIII
    Johannes Oldenburg
    Thromb Haemost 95:903-5. 2006
  19. ncbi request reprint Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe
    Anne Hofer
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Germany
    Stroke 34:1207-11. 2003
    ..Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients...