Luisa Klotz

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy
    Luisa Klotz
    Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, Germany
    J Immunol 178:2122-31. 2007
  2. doi request reprint Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Germany
    J Immunol 183:129-36. 2009
  3. doi request reprint Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    Neurosci Lett 449:81-3. 2009
  4. ncbi request reprint Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro
    Luisa Klotz
    Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Neuroimmunol 190:34-43. 2007
  5. pmc The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, Department of Neurology, University of Bonn, Bonn 53105, Germany
    J Exp Med 206:2079-89. 2009
  6. ncbi request reprint Higher sensitivity in the detection of inflammatory brain lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis using high field MRI: an intraindividual comparison of 1.5 T with 3.0 T
    Mike P Wattjes
    Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Radiol 16:2067-73. 2006
  7. ncbi request reprint Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    J Immunol 175:4948-55. 2005
  8. ncbi request reprint Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets
    Catharina C Gross
    Department of Neurology, University Hospital Munster, Munster, Germany
    Mult Scler . 2016
  9. pmc B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity
    Luisa Klotz
    Department of Neurology, University Hospital Munster, 48149 Muenster, Germany
    Proc Natl Acad Sci U S A 113:E6182-E6191. 2016
  10. doi request reprint The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion
    Stephanie Hucke
    Department of Neurology, University of Muenster, Albert Schweitzer Campus 1, Building A1, 48149, Muenster, Germany
    Acta Neuropathol 132:413-31. 2016

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy
    Luisa Klotz
    Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, Germany
    J Immunol 178:2122-31. 2007
    ..Collectively, our data support the notion that PPARgamma is an efficient regulator of DC immunogenicity that may be exploited to deliberately target CD4(+) T cell-mediated immune responses...
  2. doi request reprint Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Germany
    J Immunol 183:129-36. 2009
    ..g., in T cell-mediated autoimmunity...
  3. doi request reprint Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    Neurosci Lett 449:81-3. 2009
    ..Our population-based study demonstrates that the Pro12Ala polymorphism resulting in an amino acid exchange in the N-terminal sequence of PPARgamma may influence the onset of MS...
  4. ncbi request reprint Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro
    Luisa Klotz
    Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Neuroimmunol 190:34-43. 2007
    ..We therefore propose that PPARgamma in brain EC may be exploited to target detrimental EC-T cell interactions under inflammatory conditions...
  5. pmc The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, Department of Neurology, University of Bonn, Bonn 53105, Germany
    J Exp Med 206:2079-89. 2009
    ..We therefore propose that PPAR gamma represents a promising molecular target for specific immunointervention in Th17-mediated autoimmune diseases such as MS...
  6. ncbi request reprint Higher sensitivity in the detection of inflammatory brain lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis using high field MRI: an intraindividual comparison of 1.5 T with 3.0 T
    Mike P Wattjes
    Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Radiol 16:2067-73. 2006
    ..01; p=0.01). In conclusion, high-field MRI at 3.0 T provides a significantly higher detection rate of inflammatory brain lesions especially in the infratentorial, juxtacortical and periventricular anatomic region...
  7. ncbi request reprint Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    J Immunol 175:4948-55. 2005
    ....
  8. ncbi request reprint Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets
    Catharina C Gross
    Department of Neurology, University Hospital Munster, Munster, Germany
    Mult Scler . 2016
    ..Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS)...
  9. pmc B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity
    Luisa Klotz
    Department of Neurology, University Hospital Munster, 48149 Muenster, Germany
    Proc Natl Acad Sci U S A 113:E6182-E6191. 2016
    ..Our findings suggest that a single immune-regulatory molecule on T cells can be ultimately responsible for localized BBB breakdown, and thus substantial changes in lesion topography in the context of CNS autoimmunity...
  10. doi request reprint The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion
    Stephanie Hucke
    Department of Neurology, University of Muenster, Albert Schweitzer Campus 1, Building A1, 48149, Muenster, Germany
    Acta Neuropathol 132:413-31. 2016
    ..We therefore, propose an important role of FXR in control of T cell-mediated autoimmunity by promoting anti-inflammatory macrophage responses. ..
  11. pmc Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis
    Catharina C Gross
    Department of Neurology, University Hospital Munster, Munster, Germany
    Neurol Neuroimmunol Neuroinflamm 3:e183. 2016
    ..To evaluate the effect of dimethyl fumarate (DMF; Tecfidera, Biogen, Weston, MA) on CD4(+) and CD8(+) T cell subsets in patients with multiple sclerosis (MS)...
  12. doi request reprint B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway
    Martin Herold
    Department of Neurology, University of Muenster, 48149 Muenster, Germany
    J Immunol 195:3584-95. 2015
    ....
  13. ncbi request reprint Imaging of inflammatory lesions at 3.0 Tesla in patients with clinically isolated syndromes suggestive of multiple sclerosis: a comparison of fluid-attenuated inversion recovery with T2 turbo spin-echo
    Mike P Wattjes
    Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Radiol 16:1494-500. 2006
    ..In conclusion, FLAIR provides the highest sensitivity when compared with the T2 TSE, although T2 TSE still has a diagnostic relevance in terms of MRI criteria classification...
  14. doi request reprint Implications of dietary salt intake for multiple sclerosis pathogenesis
    Stephanie Hucke
    University of Muenster, Department of Neurology, Germany
    Mult Scler 22:133-9. 2016
    ..Here, we discuss the association of dietary salt levels and MS with a special focus on the mechanisms of salt-mediated modulation of the different cell types critically involved in the pathophysiology of MS. ..
  15. pmc Lack of PPARγ in myeloid cells confers resistance to Listeria monocytogenes infection
    Zeinab Abdullah
    Institutes of Molecular Medicine and Experimental Immunology, Universitat Bonn, Bonn, Germany
    PLoS ONE 7:e37349. 2012
    ..Pharmacological interference with PPARγ activity in myeloid cells might represent a novel strategy to overcome intracellular bacterial infection...
  16. pmc CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells
    Karola Poppensieker
    Institute of Molecular Psychiatry, University of Bonn, 53127 Bonn, Germany
    Proc Natl Acad Sci U S A 109:3897-902. 2012
    ..Our study identified a unique role for CCR4 in regulating DC function in EAE, harboring therapeutic potential for the treatment of CNS autoimmunity by targeting CCR4 on this specific cell type...
  17. ncbi request reprint Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons
    Luisa Klotz
    Department of Neurology, University of Bonn, Bonn, Germany
    J Neurochem 86:907-16. 2003
    ..Conversely, decreased NA due to LC cell death in AD may reduce endogenous PPARgamma expression and therefore potentiate neuroinflammatory processes...
  18. pmc Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation
    Catharina C Gross
    Department of Neurology, University Hospital Munster, Muenster D 48149, Germany
    Proc Natl Acad Sci U S A 113:E2973-82. 2016
    ..Therapeutic immune modulation of IL-2 receptor restores impaired immune regulation in MS by increasing the proportion of CD155-expressing CD4(+) T cells and the cytolytic activity of NK cells...
  19. pmc Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study
    Volker Limmroth
    Department of Neurology, Cologne General Hospitals, University of Cologne, Cologne, Germany
    BMC Neurol 17:11. 2017
    ..This study aims to assess cardiac safety of fingolimod first dose. Individual bradyarrhythmic episodes were evaluated to assess the relevance of continuous electrocardiogram (ECG) monitoring...
  20. pmc ALAIN01--Alemtuzumab in autoimmune inflammatory neurodegeneration: mechanisms of action and neuroprotective potential
    Tobias Ruck
    Department of Neurology, University of Munster, Albert Schweitzer Campus 1, 48149, Munster, Germany
    BMC Neurol 16:34. 2016
    ..Markers for risk stratification and treatment response improving patient selection and therapy guidance are a big unmet need for MS patients and health care providers...
  21. doi request reprint Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity
    Stephanie Hucke
    Department of Neurology, University of Muenster, Germany
    J Autoimmun 67:90-101. 2016
    ..Together with other studies, these results underline the need to further determine the relevance of increased dietary salt intake for MS disease severity. ..
  22. pmc Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
    Kerstin Göbel
    Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Munster, 48149 Munster, Germany
    Nat Commun 7:11626. 2016
    ..Our study demonstrates that a member of the plasmatic coagulation cascade is a key mediator of autoimmunity. FXII inhibition may provide a strategy to combat MS and other immune-related disorders. ..
  23. doi request reprint FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis
    Felix Luessi
    Department of Neurology, University Medical Center of the Johannes Gutenberg University of Mainz, Germany
    Mult Scler 21:1811-22. 2015
    ..We aimed to clarify whether fingolimod has direct effects on antigen-presenting cells in multiple sclerosis patients...
  24. doi request reprint Monoclonal antibodies in neuroinflammatory diseases
    Luisa Klotz
    Department of Neurology, Inflammatory Disorders of the Nervous System and Neurooncology, Clinic for Neurology, Albert Schweitzer Campus 1, Building A10, 48149 Munster, Germany
    Expert Opin Biol Ther 13:831-46. 2013
    ..However, some of these approaches are currently investigated or translated for use in other, rare neuroinflammatory diseases, such as neuromyelitis optica (NMO), inflammatory neuropathies and (neuro)-muscular disorders...
  25. ncbi request reprint Multiple system atrophy with macrosquare-wave jerks
    Luisa Klotz
    Department of Neurology, University of Bonn, Bonn, Germany
    Mov Disord 20:253-4. 2005
    ..g., multiple sclerosis or parkinsonian syndromes, but very rarely in patients with multiple system atrophy. We present here a patient with multiple system atrophy exhibiting the oculomotor feature of macrosquare-wave jerks...