Genomes and Genes
Affiliation: University of Heidelberg
Location: Heidelberg, Germany
Bacterial protein toxins and immune evasion.
Rho GTPase, JAK-STAT and cytokine receptor signalling
- Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependentDagmar Hildebrand
Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
Infect Immun 79:220-8. 2011..These results suggest that the osteoclastic properties characteristic for PMT may result from a cross talk between bone cells and lymphoid cells and that B cells might be an important target of Pasteurella multocida...
- Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptorK F Kubatzky
Max-Planck-Institute of Immunobiology, Freiburg 79108, Germany
Curr Biol 11:110-5. 2001..Thus, efficient signal transduction through EpoR and possibly other preformed receptor oligomers may be determined by the dynamics of TM self assembly...
- The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteinsStefan N Constantinescu
Ludwig Institute for Cancer Research and University of Louvain, Brussels B 1200, Belgium
J Biol Chem 278:43755-63. 2003..As unliganded EpoR forms TM-dependent but inactive homodimers, we propose that the EpoR can be activated to different extents by homodimeric gp55 proteins, depending on the conformation of the gp55 protein dimer in the TM region...
- Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimerNadine Seubert
Ludwig Institute for Cancer Research, Brussels B 1200, Belgium
Mol Cell 12:1239-50. 2003..The active and inactive conformations were independently identified by computational searches for low-energy TM dimeric structures. We propose a specific EpoR-activated interface and suggest its use for structural and signaling studies...
- Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor functionKatharina F Kubatzky
Ludwig Institute for Cancer Research, Bruxelles 1200, Belgium
J Biol Chem 280:14844-54. 2005..This structure is important for EpoR function because replacement of this motif by consecutive leucines rendered the receptor constitutively active...
- Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxinJoachim H C Orth
Institut fur Experimentelle and Klinische Pharmakologie and Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg, Germany
J Biol Chem 282:3050-7. 2007..Because constitutive activation of STATs has been found in a number of cancers, our findings offer a new mechanism for a carcinogenic role of PMT...
- The small GTPase RhoH is an atypical regulator of haematopoietic cellsFlorian Fueller
Ruprecht Karls Universitat Heidelberg, Hygiene Institut, Abteilung für Hygiene und Medizinische Mikrobiologie, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Cell Commun Signal 6:6. 2008..The recent generation of RhoH knockout mice showed a defect in thymocyte selection and TCR signalling of thymic and peripheral T-cells. However, RhoH-deficient mice did not develop lymphomas or showed obvious defects in haematopoiesis...
- Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunologyFrank Entschladen
Institute of Immunology, Witten Herdecke University, Germany
Cell Commun Signal 8:2. 2010..This report gives an overview of the presentations of the conference...
- Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathwaysInga Preuss
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
Cell Microbiol 12:1174-85. 2010..Our data indicate that PMT is a highly potent anti-apoptotic agent, which supports the view of a carcinogenic potential of the toxin...
- Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activityDagmar Hildebrand
Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
Cell Microbiol 12:1732-45. 2010..Thus we hypothesize that P. multocida Toxin alters host cell signalling using mechanisms that have so far only been known to be employed by oncogenic viral kinases to avoid host immune defence mechanisms...
- The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expressionMehtap S Gündogdu
Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Ruprecht Karls Universitat, Im Neuenheimer Feld 324, Heidelberg, Germany
Mol Cancer 9:225. 2010..Here, we examined the activation of signal transducer and activator of transcription (STAT) proteins in response to stimulation with interleukin 3 (IL3)...
- Meeting report: Signal transduction meets systems biologyChristine Louis-Dit-Sully
Max Planck Institute of Immunobiology and Epigenetics and Biology III, Faculty of Biology, University of Freiburg, 79108, Freiburg, Germany
Cell Commun Signal 10:11. 2012..Here we report on a selection of ongoing projects of SYBILLA and how they were discussed at this interdisciplinary conference...
- Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signallingDagmar Hildebrand
Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Im Neuenheimer, Feld 324, D 69120, Heidelberg, Germany
Cell Commun Signal 10:22. 2012..PMT is known to induce signalling events involved in cell proliferation, cell survival and cytoskeleton rearrangement...
- Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activationBianca Kloos
Zentrum für Infektiologie, Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
Cell Commun Signal 13:40. 2015..However, on the molecular level the process of bone loss remains largely uncharacterised...
- Signaling cascades of Pasteurella multocida toxin in immune evasionKatharina F Kubatzky
Medical Microbiology and Hygiene, Department of Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, Heidelberg 69120, Germany
Toxins (Basel) 5:1664-81. 2013..Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host's immune system are just beginning to unravel. ..
- Pasteurella multocida and immune cellsKatharina F Kubatzky
Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany
Curr Top Microbiol Immunol 361:53-72. 2012..Recently, more attention was drawn to the osteoimmunological effects of PMT and the interplay between bone and immune cells. This review summarises the knowledge of effects of P. multocida virulence factors on the host's immune system...