C Morsczeck

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. doi request reprint Comparison of human dental follicle cells (DFCs) and stem cells from human exfoliated deciduous teeth (SHED) after neural differentiation in vitro
    Christian Morsczeck
    Department of Conservative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Oral Investig 14:433-40. 2010
  2. pmc Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes.
    Arnab Nayak
    Epigenetics Chromatin 10:15. 2017
  3. doi request reprint Lipopolysaccharide from Escherichia coli but not from Porphyromonas gingivalis induce pro-inflammatory cytokines and alkaline phosphatase in dental follicle cells
    Christian O Morsczeck
    Department of Cranio and Maxillofacial Surgery, University Hospital Regensburg, Germany
    Arch Oral Biol 57:1595-601. 2012
  4. doi request reprint Transcriptomes and proteomes of dental follicle cells
    C Morsczeck
    Department of Operative Dentistry and Periodontology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Dent Res 89:445-56. 2010
  5. doi request reprint Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro
    Christian Morsczeck
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Oral Investig 13:383-91. 2009
  6. ncbi request reprint Dental stem cell patents
    Christian Morsczeck
    University of Regensburg, Germany
    Recent Pat DNA Gene Seq 3:39-43. 2009
  7. doi request reprint Gene expression of nestin, collagen type I and type III in human dental follicle cells after cultivation in serum-free medium
    Christian Morsczeck
    Institut fur Humangenetik, Universitat Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Oral Maxillofac Surg 12:89-92. 2008
  8. doi request reprint Somatic stem cells for regenerative dentistry
    Christian Morsczeck
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Clin Oral Investig 12:113-8. 2008
  9. ncbi request reprint Total RNA-isolation of abdominal hernia of rats for quantitative real-time reverse transcription (RT) PCR assays
    Christian Morsczeck
    Stiftung Caesar, Bonn, Germany
    Prep Biochem Biotechnol 38:87-93. 2008
  10. ncbi request reprint [The state of the art in human dental stem cell research]
    Christian Morsczeck
    Institut fur Humangenetik, Universitat Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Mund Kiefer Gesichtschir 11:259-66. 2007

Collaborators

Detail Information

Publications38

  1. doi request reprint Comparison of human dental follicle cells (DFCs) and stem cells from human exfoliated deciduous teeth (SHED) after neural differentiation in vitro
    Christian Morsczeck
    Department of Conservative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Oral Investig 14:433-40. 2010
    ..In conclusion, SHED and DFCs have different neural differentiation potentials under the same cell culture conditions...
  2. pmc Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes.
    Arnab Nayak
    Epigenetics Chromatin 10:15. 2017
    ..Altogether, these data reveal a crucial functional interconnection of FLII with the sumoylation machinery that converges on epigenetic regulation and cell fate determination...
  3. doi request reprint Lipopolysaccharide from Escherichia coli but not from Porphyromonas gingivalis induce pro-inflammatory cytokines and alkaline phosphatase in dental follicle cells
    Christian O Morsczeck
    Department of Cranio and Maxillofacial Surgery, University Hospital Regensburg, Germany
    Arch Oral Biol 57:1595-601. 2012
    ..gingivalis LPS induces the expression of pro-inflammatory cytokines in PDL cells and disturbs the differentiation of dental stem cells. Our study investigated the administration of LPS to DFCs for the first time...
  4. doi request reprint Transcriptomes and proteomes of dental follicle cells
    C Morsczeck
    Department of Operative Dentistry and Periodontology, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Dent Res 89:445-56. 2010
    ..This review describes the transcriptomes and proteomes of dental follicle cells before and after differentiation, and compares them with differentially expressed populations from dental tissue or bone marrow...
  5. doi request reprint Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro
    Christian Morsczeck
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Oral Investig 13:383-91. 2009
    ..In conclusion, we present the first transcriptome of human DFCs before and after osteogenic differentiation. This study sheds new light on the complex mechanism of osteogenic differentiation in DFCs...
  6. ncbi request reprint Dental stem cell patents
    Christian Morsczeck
    University of Regensburg, Germany
    Recent Pat DNA Gene Seq 3:39-43. 2009
    ..This following review summarizes patents about dental stem cells for dental tissue engineering and considers their value for regenerative dentistry...
  7. doi request reprint Gene expression of nestin, collagen type I and type III in human dental follicle cells after cultivation in serum-free medium
    Christian Morsczeck
    Institut fur Humangenetik, Universitat Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Oral Maxillofac Surg 12:89-92. 2008
    ..In the age of bovine spongiform encephalopathy (BSE), a serum-free cell culture system for dental follicle cells are recommended, if these cells will be applied in dentistry...
  8. doi request reprint Somatic stem cells for regenerative dentistry
    Christian Morsczeck
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Clin Oral Investig 12:113-8. 2008
    ..These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This review gives a short overview of stem cells of dental origin...
  9. ncbi request reprint Total RNA-isolation of abdominal hernia of rats for quantitative real-time reverse transcription (RT) PCR assays
    Christian Morsczeck
    Stiftung Caesar, Bonn, Germany
    Prep Biochem Biotechnol 38:87-93. 2008
    ..Moreover, real-time RT PCR assays for collagen type I and III and TGF-beta1 are demonstrated for relative gene expression analyses. Both methods enable relative gene expression analyses of hernia tissues for the first time...
  10. ncbi request reprint [The state of the art in human dental stem cell research]
    Christian Morsczeck
    Institut fur Humangenetik, Universitat Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Mund Kiefer Gesichtschir 11:259-66. 2007
    ..Nonetheless dental stem cells are CD45 negative and they express rarely hematopoietic stem cell markers. These research results plead for the participation of dental stem cells in dental practice in future...
  11. ncbi request reprint Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro
    C Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn 53175, Germany
    Calcif Tissue Int 78:98-102. 2006
    ..These real-time PCR results display molecular mechanisms in dental follicle precursor cells during osteogenic differentiation that are different from those in bone marrow-derived mesenchymal stem cells...
  12. ncbi request reprint In vitro differentiation of human dental follicle cells with dexamethasone and insulin
    C Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Cell Biol Int 29:567-75. 2005
    ..Our work demonstrates differentiation of dental follicle cells with an insulin-based protocol for the first time...
  13. ncbi request reprint Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth
    C Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Matrix Biol 24:155-65. 2005
    ..Therefore, our results demonstrate that cultured PCs are unique undifferentiated lineage committed cells residing in the periodontium prior or during tooth eruption...
  14. doi request reprint β-Tricalcium phosphate induces apoptosis on dental follicle cells
    S Viale-Bouroncle
    Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Calcif Tissue Int 92:412-7. 2013
    ..In conclusion, TCP supports osteogenic differentiation in DFCs but also induces programmed cell death. Our data suggest that surviving DFCs avoid programmed cell death by inducing antiapoptotic genes...
  15. doi request reprint A two-step strategy for neuronal differentiation in vitro of human dental follicle cells
    Florian Völlner
    Institute of Human Genetics, Franz Josef Strauss Allee 11, University of Regensburg, 93053 Regensburg, Germany
    Differentiation 77:433-41. 2009
    ..In conclusion, we demonstrated the differentiation of human DFCs into neuron-like cells after a two-step strategy for neuronal differentiation...
  16. doi request reprint Spontaneous immortalization of neural crest-derived corneal progenitor cells after chromosomal aberration
    C Brandl
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Cell Prolif 43:372-7. 2010
    ....
  17. doi request reprint The parathyroid hormone-related protein is secreted during the osteogenic differentiation of human dental follicle cells and inhibits the alkaline phosphatase activity and the expression of DLX3
    C Klingelhöffer
    Department of Cranio and Maxillofacial Surgery, Hospital of the University of Regensburg, Regensburg, Germany
    Tissue Cell 48:334-9. 2016
    ..In conclusion, our results suggest that PTHrP regulates independently of the hedgehog signaling pathway the osteogenic differentiated in DFCs. ..
  18. doi request reprint A protein kinase A (PKA)/β-catenin pathway sustains the BMP2/DLX3-induced osteogenic differentiation in dental follicle cells (DFCs)
    S Viale-Bouroncle
    Department of Cranio and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany
    Cell Signal 27:598-605. 2015
    ..In conclusion, while the activation of the canonical WNT pathway inhibits the osteogenic differentiation of DFCs, β-catenin sustains the BMP2/DLX3-mediated osteogenic differentiation via the activation of PKA. ..
  19. doi request reprint The differentiation and gene expression profile of human dental follicle cells
    Michael Saugspier
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Stem Cells Dev 19:707-17. 2010
    ..To evaluate this mechanism, the transcription factor ZBTB16 is a target for further investigations...
  20. doi request reprint TGF-beta stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs)
    Oliver Felthaus
    Department of Operative Dentistry and Periodontology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Neurosci Lett 471:179-84. 2010
    ..In contrast gene expression of neural cell markers was not regulated. In conclusion, TGF-beta improved glial-like, but not neural-like, differentiation of mDFPCs...
  21. doi request reprint Comparison of murine dental follicle precursor and retinal progenitor cells after neural differentiation in vitro
    Wolfgang Ernst
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Cell Biol Int 33:758-64. 2009
    ..The data presents new evidence of neural differentiation of mDFPCs, but only a small percentage of mDFPCs differentiated into glia cells, unlike mRPCs...
  22. doi request reprint Proteomic analysis of osteogenic differentiation of dental follicle precursor cells
    Christian Morsczeck
    Institute of Human Genetics, University of Regensburg, Regensburg, Germany
    Electrophoresis 30:1175-84. 2009
    ..Further studies will investigate the impact of identified regulatory proteins for cell proliferation and osteogenic differentiation in DFPCs...
  23. ncbi request reprint [Comparison of clinical immunohistochemical findings in keratocystic odontogenic tumours and ameloblastomas considering their risk of recurrence]
    Oliver Driemel
    Universitat Regensburg, Klinik und Poliklinik fur Mund, Kiefer und Gesichtschirurgie, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Mund Kiefer Gesichtschir 11:221-31. 2007
    ..With the new term "keratocystic odontogenic tumour" (KCOT) keratocyts are even in the nomenclature a close differential diagnosis to ameloblastomas (A)...
  24. doi request reprint Characterization of progenitor cells and stem cells from the periodontal ligament tissue derived from a single person
    E Prateeptongkum
    Department of Cranio and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany
    J Periodontal Res 51:265-72. 2016
    ..However, these cells were obtained from different patients. This study was the first report to compare the characterization of PDLPs and PDLSCs from the same person...
  25. doi request reprint The AKT signaling pathway sustains the osteogenic differentiation in human dental follicle cells
    S Viale-Bouroncle
    Department of Cranio and Maxillofacial Surgery, Hospital of the University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Mol Cell Biochem 406:199-204. 2015
    ..Our results suggest that the AKT signaling pathway submits the BMP2-dependent osteogenic differentiation in DFCs via the expression of the transcription factor EGR1. ..
  26. doi request reprint EGR1 supports the osteogenic differentiation of dental stem cells
    T Press
    Department of Cranio and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany
    Int Endod J 48:185-92. 2015
    ..To evaluate whether and how the transcription factor early growth response gene 1 (EGR1) affects the osteogenic differentiation of dental stem cells...
  27. doi request reprint Migration of human dental follicle cells in vitro
    O Felthaus
    Department of Cranio and Maxillofacial Surgery, University of Regensburg, Regensburg, Germany
    J Periodontal Res 49:205-12. 2014
    ..Growth factors such as epidermal growth factor (EGF), bone morphogenetic protein-2 (BMP2) or transforming growth factor β1 (TGF-β1) can be used to modify the behavior of cells...
  28. doi request reprint Identification of neural crest-derived stem cell-like cells from the corneal limbus of juvenile mice
    Caroline Brandl
    Department of Operative Dentistry and Periodontology, Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Exp Eye Res 89:209-17. 2009
    ..We conclude that MCCs are stem cell-like cells of an early postnatal period of murine eye growth, probably involved in the early development of the postnatal cornea...
  29. pmc The extracellular concentration of osteocalcin decreased in dental follicle cell cultures during biomineralization
    C Klingelhöffer
    Department of Cranio and Maxillofacial Surgery, University Hospital Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Cytotechnology 68:2171-6. 2016
    ..Hence, extracellular OCN in the cell culture medium is not a marker for the osteogenic differentiation of DFCs. ..
  30. doi request reprint The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells
    S Viale-Bouroncle
    Department of Cranio and Maxillofacial Surgery, Hospital of the University of Regensburg, Regensburg, Germany
    Biochem Biophys Res Commun 457:314-7. 2015
    ..In conclusion, our data disclosed an unusual role of APCDD1 in DFCs during the osteogenic differentiation. APCDD1 sustains the expression and activation of β-Catenin. ..
  31. doi request reprint Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells
    Christian Florian
    Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Biochem Biophys Res Commun 374:187-91. 2008
    ..Here, we report for the first time that murine Müller cells can be progenitors for both, fibrous tissue cells and neuronal cells, depending on the age of the cell culture...
  32. doi request reprint The hedgehog-signaling pathway is repressed during the osteogenic differentiation of dental follicle cells
    C Morsczeck
    Department of Cranio and Maxillofacial Surgery, Hospital of the University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Mol Cell Biochem . 2017
    ..In conclusion, our results suggest that BMP2 inhibits the hedgehog signaling after the induction of the osteogenic differentiation in DFCs...
  33. doi request reprint The influence of the donor on dental apical papilla stem cell properties
    E Prateeptongkum
    Department of Cranio and Maxillofacial Surgery, Hospital of the University of Regensburg, Regensburg, Germany
    Tissue Cell 47:382-8. 2015
    ..These differences were regardless of the donor of the cell lines. In conclusion, we suppose that stem cell characteristics of SCAP cell cultures are independent from the donor. ..
  34. doi request reprint Cancer stem cell-like cells from a single cell of oral squamous carcinoma cell lines
    O Felthaus
    Department of Operative Dentistry and Periodontology, University of Regensburg, Germany
    Biochem Biophys Res Commun 407:28-33. 2011
    ..Our study shows a method for the isolation of CSC-like cell lines from OSCC cell lines. These CSC-like cell lines could be new targets for the development of anticancer drugs under in vitro conditions...
  35. ncbi request reprint [Immunohistochemical study on collagen I content in the gingiva in cleidocranial dysplasia]
    Tobias Ach
    Klinik und Poliklinik fur Mund, Kiefer und Gesichtschirurgie, Klinikum der Universitat Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Mund Kiefer Gesichtschir 11:349-54. 2007
    ..Patients with cleidocranial dysplasia (CCD) present a thickend and fibrotic gingiva...
  36. ncbi request reprint Strategies for mycobacterial genetics
    Christian Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Bonn, Germany
    Int J Med Microbiol 293:251-9. 2003
    ..Inactivation of putative virulence genes is a powerful tool not only for characterization of pathogenic bacteria. This review summarizes recently described strategies for DNA transfer and gene inactivation in mycobacteria...
  37. ncbi request reprint A quantitative real-time PCR assay for the detection of tetR of Tn10 in Escherichia coli using SYBR Green and the Opticon
    Christian Morsczeck
    Stiftung Caesar, Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn 53175, Germany
    J Biochem Biophys Methods 59:217-27. 2004
    ..In conclusion, the tetR real-time PCR offers new methods for detection and quantification of tetracycline-resistant bacteria and tTA in transfected cell-lines or transgenic animals...