Rory E Morty

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. doi request reprint Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells
    Bi Tang
    Department of Pulmonology, University Clinic of Internal Medicine, University Clinic Giessen, Giessen, Germany
    Am J Respir Cell Mol Biol 41:476-83. 2009
  2. ncbi request reprint Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species
    Rory E Morty
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 277:26057-65. 2002
  3. ncbi request reprint Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 292:L537-49. 2007
  4. pmc Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial
    Matthias Hecker
    University of Giessen and Marburg Lung Center UGMLC, Justus Liebig University of Giessen, Klinikstr 33, Giessen, D 35392, Germany
    Crit Care 19:226. 2015
  5. doi request reprint Accepting the challenge: maintaining AJP-Lung as the best place to publish basic and translational studies in lung biology and pathophysiology
    Rory E Morty
    University of Giessen and Marburg Lung Center UGMLC
    Am J Physiol Lung Cell Mol Physiol . 2017
  6. ncbi request reprint Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts
    Rory E Morty
    Department of Internal Medicine, University of Giessen Medical Centre, Aulweg 123 Raum 6 11, D 35392 Giessen, Germany
    J Biol Chem 280:10925-37. 2005
  7. ncbi request reprint Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?
    Rory E Morty
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, 35392, Giessen, Germany
    Intensive Care Med 33:1229-40. 2007
  8. pmc Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts
    Rory E Morty
    Department of Internal Medicine, University Hospital Giessen and Marburg, Aulweg 123, D 35392 Giessen, Germany
    Biochem J 394:635-45. 2006
  9. ncbi request reprint Tropolysin, a new oligopeptidase from African trypanosomes
    Rory E Morty
    Department of Internal Medicine, University Hospital Giessen, Aulweg 123, D 35392 Giessen, Germany
    Biochemistry 44:14658-69. 2005
  10. ncbi request reprint Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension
    Rory E Morty
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Aulweg 123 Raum 6 11, D 35392 Giessen, Germany
    Arterioscler Thromb Vasc Biol 27:1072-8. 2007

Collaborators

Detail Information

Publications48

  1. doi request reprint Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells
    Bi Tang
    Department of Pulmonology, University Clinic of Internal Medicine, University Clinic Giessen, Giessen, Germany
    Am J Respir Cell Mol Biol 41:476-83. 2009
    ..This is the first time that the background K(+) channel, TASK-1, has been identified in the ET-1-mediated depolarization in native hPASMC, and might represent a novel pathologic mechanism related to pulmonary arterial hypertension...
  2. ncbi request reprint Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species
    Rory E Morty
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 277:26057-65. 2002
    ..Lap was not secreted by Leishmania in vitro and was localized to the parasite cytosol...
  3. ncbi request reprint Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 292:L537-49. 2007
    ..The amenability of these pathways to genetic and pharmacological manipulation may provide alternative avenues for the management of BPD...
  4. pmc Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial
    Matthias Hecker
    University of Giessen and Marburg Lung Center UGMLC, Justus Liebig University of Giessen, Klinikstr 33, Giessen, D 35392, Germany
    Crit Care 19:226. 2015
    ....
  5. doi request reprint Accepting the challenge: maintaining AJP-Lung as the best place to publish basic and translational studies in lung biology and pathophysiology
    Rory E Morty
    University of Giessen and Marburg Lung Center UGMLC
    Am J Physiol Lung Cell Mol Physiol . 2017
    ....
  6. ncbi request reprint Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts
    Rory E Morty
    Department of Internal Medicine, University of Giessen Medical Centre, Aulweg 123 Raum 6 11, D 35392 Giessen, Germany
    J Biol Chem 280:10925-37. 2005
    ..evansi-infected rats. Thus, we propose a role for OpdB in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of ANF in mammals infected with T. evansi...
  7. ncbi request reprint Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?
    Rory E Morty
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, 35392, Giessen, Germany
    Intensive Care Med 33:1229-40. 2007
    ..The failure of patients to resolve the alveolar edema associated with these conditions is a major contributing factor to mortality; hence there is continued interest to understand the mechanisms of alveolar edema fluid clearance...
  8. pmc Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts
    Rory E Morty
    Department of Internal Medicine, University Hospital Giessen and Marburg, Aulweg 123, D 35392 Giessen, Germany
    Biochem J 394:635-45. 2006
    ..The abnormal degradation of TRH and GnRH, and perhaps other neuropeptides N-terminally blocked with a pyroglutamyl moiety, by trypanosome PGP, may contribute to some of the endocrine lesions observed in African trypanosomiasis...
  9. ncbi request reprint Tropolysin, a new oligopeptidase from African trypanosomes
    Rory E Morty
    Department of Internal Medicine, University Hospital Giessen, Aulweg 123, D 35392 Giessen, Germany
    Biochemistry 44:14658-69. 2005
    ....
  10. ncbi request reprint Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension
    Rory E Morty
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Aulweg 123 Raum 6 11, D 35392 Giessen, Germany
    Arterioscler Thromb Vasc Biol 27:1072-8. 2007
    ..The aim of this study was to assess BMP signaling and its physiological effects in a monocrotaline (MCT) model of PAH...
  11. pmc TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury
    Dorothea M Peters
    Department of Internal Medicine, Department of Biochemistry, Justus Liebig University, Universities of Giessen and Marburg Lung Center, German Center for Lung Research, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 111:E374-83. 2014
    ....
  12. doi request reprint Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels
    Mike Althaus
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Aulweg 123 Room 6 11, D 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 41:639-50. 2009
    ....
  13. ncbi request reprint TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Dev Dyn 237:259-69. 2008
    ..These data suggest that active TGF-beta signaling is required for normal late lung development...
  14. ncbi request reprint Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Dev Dyn 236:2825-35. 2007
    ....
  15. ncbi request reprint Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase
    István Vadász
    University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Cell Mol Biol 33:343-54. 2005
    ....
  16. doi request reprint Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells
    Mike Althaus
    Department of Internal Medicine Pulmonology, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Cell Mol Biol 44:53-65. 2011
    ..These data demonstrate that, in the H441 cell model, NO impairs Na(+) reabsorption by interfering with the activity of highly selective Na(+) channels and the Na(+)/K(+)-ATPase...
  17. pmc Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs
    Arun Kumarasamy
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 180:1239-52. 2009
    ..Disordered extracellular matrix production is a feature of bronchopulmonary dysplasia (BPD). The basis of this phenomenon is not understood...
  18. pmc Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury
    Christine U Vohwinkel
    1 Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany
    Am J Respir Cell Mol Biol 57:589-602. 2017
    ..Together, we discovered that the TGF-β-GSK3β-megalin axis is centrally involved in disturbances of alveolar protein clearance in acute lung injury and provide preclinical evidence for therapeutic efficacy of GSK3β inhibition...
  19. doi request reprint Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension
    Matthias Hecker
    Department of Internal Medicine Pulmonology, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 182:805-18. 2010
    ..Inflammation is proposed to play a role in vessel remodeling associated with IPAH. IL-13 is emerging as a regulator of tissue remodeling; however, the contribution of the IL-13 system to IPAH has not been assessed...
  20. ncbi request reprint Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension
    Anna Zakrzewicz
    University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, D 35392 Giessen, Germany
    Circulation 115:2957-68. 2007
    ..Heterozygous mutations in BMPR2, encoding the type II bone morphogenetic protein receptor (BMPRII), were identified in PAH, suggesting that alterations to BMPRII function are involved in disease onset and/or progression...
  21. doi request reprint HbA1c in pulmonary arterial hypertension: a marker of prognostic relevance?
    Michael J Belly
    Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
    J Heart Lung Transplant 31:1109-14. 2012
    ..Patients with pulmonary arterial hypertension (PAH) exhibit impaired glucose metabolism and increased insulin resistance. The clinical consequences of these metabolic changes are not known...
  22. doi request reprint The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs
    István Vadász
    University of Giessen Lung Center, Giessen, Germany
    Crit Care Med 36:1543-50. 2008
    ..This study was performed to determine whether the lectin-like domain of tumor necrosis factor-alpha (designated TIP) can improve fluid balance in experimental lung injury by affecting alveolocapillary permeability and/or fluid clearance...
  23. pmc Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs
    Yasmin Buchäckert
    Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Klinikstrasse 33, 35392 Giessen, Germany
    J Physiol 590:5167-81. 2012
    ..Further understanding of this mechanism is of clinical importance, since an inability to clear excess protein from the alveolar space is associated with poor outcome in patients with acute lung injury/acute respiratory distress syndrome...
  24. doi request reprint Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis
    Sibel Avcuoglu
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, D 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 45:768-80. 2011
    ....
  25. doi request reprint Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1...
  26. doi request reprint TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin
    Luciana C Mazzocchi
    Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 313:L807-L824. 2017
    ..Further understanding of these mechanisms may lead to novel therapeutic approaches for the treatment of ARDS...
  27. doi request reprint Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension
    Alexander H Nave
    From the Division of Pulmonology, Department of Internal Medicine, University of Giessen and Marburg Lung Center UGMLC, Giessen, Germany A H N, I M, G N, F R, M L T, F V, S H, K M, I V, N W, W S, R E M Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany A H N, I M, G N, W S, R E M and the Department of Dermatology J B and Institute of Virology and Cell Biology J B, H S, University of Lubeck, Lubeck, Germany
    Arterioscler Thromb Vasc Biol 34:1446-58. 2014
    ..A role of dysregulated matrix cross-linking and stability as a pathogenic mechanism has received little attention. We aimed to assess whether matrix cross-linking enzymes played a causal role in experimental pulmonary hypertension (PH)...
  28. ncbi request reprint Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?
    István Vadász
    University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, D 35392 Giessen, Germany
    Am J Respir Crit Care Med 171:469-79. 2005
    ..Therefore, OA impaired the two essential transepithelial active sodium transport mechanisms of the lung, and could thus promote alveolar edema formation and prevent edema resolution, thereby contributing to the development of ARDS...
  29. doi request reprint Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension
    Manuel J Richter
    Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
    Respir Med 106:308-13. 2012
    ..Patients with pulmonary arterial hypertension often present with a mild obstructive lung pattern, however, the functional consequences are not known...
  30. ncbi request reprint Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited
    Oliver Eickelberg
    Department of Medicine II, University of Giessen Lung Center, University of Giessen School of Medicine, 35392 Giessen, Germany
    Trends Cardiovasc Med 17:263-9. 2007
    ....
  31. ncbi request reprint Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Biol Chem 282:21671-82. 2007
    ....
  32. pmc Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line
    Paulina Gwozdzinska
    Department of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, German Center for Lung Research, Giessen, Germany
    Front Immunol 8:591. 2017
    ..The hypercapnia-induced ENaC dysfunction may contribute to impaired alveolar edema clearance and thus, interfering with these molecular mechanisms may improve alveolar fluid balance and lead to better outcomes in patients with ARDS...
  33. pmc Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair
    Jennifer Quantius
    Department of Internal Medicine II, Universities Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research DZL, Giessen, Germany
    PLoS Pathog 12:e1005544. 2016
    ..Furthermore, increase of alveolar Fgf10 levels may represent a putative therapy to overcome regeneration failure after IV-induced lung injury. ..
  34. doi request reprint The H2S-generating enzymes cystathionine β-synthase and cystathionine γ-lyase play a role in vascular development during normal lung alveolarization
    Alicia Madurga
    Department of Internal Medicine Pulmonology, University of Giessen and Marburg Lung Center, German Center for Lung Research, Giessen, Germany Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Am J Physiol Lung Cell Mol Physiol 309:L710-24. 2015
    ..These data confirm a key role for the H2S-generating enzymes Cbs and Cth in pulmonary vascular development and homeostasis and in lung alveolarization. ..
  35. doi request reprint Impact of short- and medium-chain fatty acids on mitochondrial function in severe inflammation
    Matthias Hecker
    University of Giessen Lung Center UGLC, Justus Liebig University of Giessen, Giessen, Germany
    JPEN J Parenter Enteral Nutr 38:587-94. 2014
    ....
  36. doi request reprint Epithelial Na+ channels derived from human lung are activated by shear force
    Martin Fronius
    Institute of Animal Physiology, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Respir Physiol Neurobiol 170:113-9. 2010
    ..From our observations we conclude that lung-derived hENaCs are directly activated by SF and this may represent an important feature for the regulation of pulmonary Na(+) reabsorption and pulmonary fluid homeostasis...
  37. ncbi request reprint Impact of TASK-1 in human pulmonary artery smooth muscle cells
    Andrea Olschewski
    Department of Anaesthesiology, Intensive Care Medicine, Medical University Graz, A 8029 Graz, Austria
    Circ Res 98:1072-80. 2006
    ....
  38. doi request reprint FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells
    Łukasz A Wujak
    Department of Internal Medicine Pulmonology, University of Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research DZL, Giessen, Germany Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany Department of Biochemistry, University of Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research DZL, Giessen, Germany
    Respir Physiol Neurobiol 220:54-61. 2016
    ..Thus, we speculate that FXYD1 overexpression in ARDS patient lungs may limit Na(+)/K(+)-ATPase activity, and contribute to edema persistence. ..
  39. ncbi request reprint Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases
    Ali O Yildirim
    Department of Medicine II, University of Giessen Lung Center, Justus Liebig University Giessen, Aulweg 123, Room 6 11, D 35392 Giessen, Germany
    Am J Respir Cell Mol Biol 35:436-43. 2006
    ..These data suggest that structural and functional changes caused by hypoxia may be linked to ADMA metabolism...
  40. ncbi request reprint Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei
    Rory E Morty
    Department of Internal Medicine, University of Giessen School of Medicine, Aulweg 123 Room 6 11, D 35392 Giessen, Germany
    FEBS Lett 579:2191-6. 2005
    ..These studies may facilitate the development of specific OpdB inhibitors with therapeutic potential, by exploiting these unique properties of this enzyme...
  41. ncbi request reprint Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor
    Manda S Krishnaveni
    Department of Medicine II, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Biochem Biophys Res Commun 351:651-7. 2006
    ..Our study thus demonstrates previously unappreciated complex formation of TGF-beta type II receptors, and suggests that mTbetaRII-B can direct TGF-beta-induced signalling in vitro and in vivo...
  42. ncbi request reprint N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts
    Martina Barbara Schaefer
    University of Giessen Lung Center UGLC, University Hospital of Giessen and Marburg, Klinikstr 33, 35392, Giessen, Germany
    Inflamm Res 65:881-894. 2016
    ..In inflammation, monocyte adhesion to endothelial cells is a crucial step mediated by intracellular calcium changes. We investigated whether lipid rafts mediate FA-induced modulation of adhesion and intracellular calcium...
  43. doi request reprint Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia
    Diogo M G Silva
    Department of Internal Medicine Pulmonology, University of Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research DZL, Giessen, Germany Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Am J Physiol Lung Cell Mol Physiol 309:L1239-72. 2015
    ..It is the objective of this Perspectives article to update the reader about recent developments in our understanding of the molecular mechanisms of alveolarization and the pathogenesis of BPD. ..
  44. doi request reprint Activation of the WNT/β-catenin pathway attenuates experimental emphysema
    Nikolaus Kneidinger
    Department of Medicine, University of Giessen Lung Center, University of Giessen, Giessen, Germany
    Am J Respir Crit Care Med 183:723-33. 2011
    ..Chronic obstructive pulmonary disease (COPD) is a devastating disease, for which no causal therapy is available...
  45. pmc Substrate recognition properties of oligopeptidase B from Salmonella enterica serovar Typhimurium
    Rory E Morty
    Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Bacteriol 184:3329-37. 2002
    ..We have also identified a second pair of residues, Asp(460) and Asp(462), that may be involved in defining P(2) specificity and thus direct preferential cleavage by OpdB after pairs of basic residues...
  46. pmc Expression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei
    Dean Rea
    Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:808-10. 2006
    ..The crystals belong to space group P3(1)21 or P3(2)21, with unit-cell parameters a = b = 124.5, c = 249.9 angstroms. A complete data set to 2.7 angstroms was collected using synchrotron radiation...
  47. pmc Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity
    Jefferson P Hemerly
    Department of Biophysics, Escola Paulista de Medicina, Rua Tres de Maio 100, São Paulo SP 04044 020, Brazil
    Biochem J 373:933-9. 2003
    ..Excellent substrates were obtained for Tb-OP and Tc-OP (Abz-AMRRTISQ-EDDnp and Abz-AHKRYSHQ-EDDnp respectively), which were hydrolysed with remarkably high k (cat) and low K (m) values...
  48. ncbi request reprint CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium
    Dagmar Sommer
    Institute of Animal Physiology, Justus Liebig University of Giessen, Wartweg 95, 35392 Giessen, Germany
    Respir Physiol Neurobiol 158:97-106. 2007
    ..We conclude that Xenopus lung epithelium exhibits functional CFTR channels and that this tissue represents a valuable model for the investigation of ion transport properties in pulmonary epithelia...