Ingo Roeder

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi request reprint Stem cell biology meets systems biology
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiologie, University of Leipzig, D 04107 Leipzig, Germany
    Development 136:3525-30. 2009
  2. doi request reprint An "age"-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Bull Math Biol 71:602-26. 2009
  3. ncbi request reprint Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstr 16 18, D 04107 Leipzig, Germany
    J Theor Biol 241:852-65. 2006
  4. ncbi request reprint Quantitative stem cell biology: computational studies in the hematopoietic system
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Curr Opin Hematol 13:222-8. 2006
  5. ncbi request reprint Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, D 04107 Leipzig, Haertelstrasse 16 18, Germany
    Nat Med 12:1181-4. 2006
  6. pmc Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood 112:4874-83. 2008
  7. ncbi request reprint Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia--insights from mathematical model analyses
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Leipzig, Germany
    J Mol Med (Berl) 86:17-27. 2008
  8. ncbi request reprint Asymmetry of stem cell fate and the potential impact of the niche: observations, simulations, and interpretations
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
    Stem Cell Rev 2:171-80. 2006
  9. doi request reprint Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia
    Matthias Horn
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, Leipzig, Germany
    Blood 121:378-84. 2013
  10. ncbi request reprint A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Germany
    Exp Hematol 30:853-61. 2002

Collaborators

Detail Information

Publications27

  1. doi request reprint Stem cell biology meets systems biology
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiologie, University of Leipzig, D 04107 Leipzig, Germany
    Development 136:3525-30. 2009
    ....
  2. doi request reprint An "age"-structured model of hematopoietic stem cell organization with application to chronic myeloid leukemia
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Bull Math Biol 71:602-26. 2009
    ..We show that the PDE model qualitatively and quantitatively reproduces the results of the agent-based approach...
  3. ncbi request reprint Towards an understanding of lineage specification in hematopoietic stem cells: a mathematical model for the interaction of transcription factors GATA-1 and PU.1
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstr 16 18, D 04107 Leipzig, Germany
    J Theor Biol 241:852-65. 2006
    ....
  4. ncbi request reprint Quantitative stem cell biology: computational studies in the hematopoietic system
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Curr Opin Hematol 13:222-8. 2006
    ....
  5. ncbi request reprint Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, D 04107 Leipzig, Haertelstrasse 16 18, Germany
    Nat Med 12:1181-4. 2006
    ..Moreover, we predict that the therapeutic benefit of imatinib can, under certain circumstances, be accelerated by combination with proliferation-stimulating treatment strategies...
  6. pmc Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood 112:4874-83. 2008
    ..The model provides comprehensive systemic and quantitative insights into the clonal heterogeneity among HSCs with potential applications in predicting the behavior of malignant and/or genetically modified cells...
  7. ncbi request reprint Pathogenesis, treatment effects, and resistance dynamics in chronic myeloid leukemia--insights from mathematical model analyses
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Leipzig, Germany
    J Mol Med (Berl) 86:17-27. 2008
    ..The theoretical results clearly indicate that further experimental effort with the particular focus on the quantitative monitoring of resistant clones will be required to definitely distinguish between these hypotheses...
  8. ncbi request reprint Asymmetry of stem cell fate and the potential impact of the niche: observations, simulations, and interpretations
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
    Stem Cell Rev 2:171-80. 2006
    ..The concept implies that stem cell fate is only predictable in a probabilistic sense and that retrospective categorization of stem cell potential, based on individual cellular fates, provides an incomplete picture...
  9. doi request reprint Model-based decision rules reduce the risk of molecular relapse after cessation of tyrosine kinase inhibitor therapy in chronic myeloid leukemia
    Matthias Horn
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, Leipzig, Germany
    Blood 121:378-84. 2013
    ..Application of the suggested rule for deciding about the time point of treatment cessation is predicted to result in a significant reduction in rate of molecular relapse...
  10. ncbi request reprint A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology IMISE, University of Leipzig, Germany
    Exp Hematol 30:853-61. 2002
    ..To solve this problem, we propose a new, comprehensive model concept...
  11. pmc Stem cell proliferation and quiescence--two sides of the same coin
    Ingmar Glauche
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    PLoS Comput Biol 5:e1000447. 2009
    ..Furthermore, we suggest an experimental strategy which is suited to demonstrate that the repopulation ability among the population of label retaining cells changes during the course of dilution...
  12. ncbi request reprint Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications
    Ingmar Glauche
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Stem Cells 25:1791-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  13. ncbi request reprint Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood 105:609-16. 2005
    ..We conclude that hematopoietic stem cell organization should be understood as a flexible, self-organized rather than a fixed, preprogrammed process...
  14. doi request reprint Mathematical modeling of genesis and treatment of chronic myeloid leukemia
    Matthias Horn
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Cells Tissues Organs 188:236-47. 2008
    ....
  15. pmc Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics
    Maria Herberg
    Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany Interdisciplinary Center for Bioinformatics, Faculty of Medicine, Universitat Leipzig, Leipzig, Germany
    J R Soc Interface 13:. 2016
    ..Moreover, we studied the impact of TF-related proliferation capacities on the frequency of state transitions and demonstrate that cellular genealogies can provide insights into the heredity structures of mESCs. ..
  16. ncbi request reprint Conceptual models to understand tissue stem cell organization
    Markus Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany
    Curr Opin Hematol 11:81-7. 2004
    ..Specifically, they contribute to an understanding of latent mechanisms and crucial parameters of biologic processes. The following review gives an overview of recent developments in the field of hematopoietic tissue stem cell modeling...
  17. pmc Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis
    Ingmar Glauche
    Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e11238. 2010
    ..Furthermore, we provide a conceptual framework that consistently explains Nanog variability and a potential "gate-keeper" function of Nanog expression with respect to the control of ES cell differentiation...
  18. pmc New experimental and theoretical investigations of hematopoietic stem cells and chronic myeloid leukemia
    Ingo Roeder
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Blood Cells Mol Dis 43:88-97. 2009
    ..It is our strong belief that a more integrated and coherent interdisciplinary approach will further advance the treatment of CML in future years...
  19. doi request reprint Factor graph analysis of live cell-imaging data reveals mechanisms of cell fate decisions
    Theresa Niederberger
    Gene Center, Department of Chemistry and Biochemistry, Ludwig Maximilians University Munchen, Germany, Max Planck Institute for Plant Breeding Research, Cologne, Germany Department of Biology, Albertus Magnus University, Cologne, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany and Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
    Bioinformatics 31:1816-23. 2015
    ..Cell fate decisions have a strong stochastic component. The identification of the underlying mechanisms therefore requires a rigorous statistical analysis of large ensembles of single cells that were tracked and phenotyped over time...
  20. doi request reprint Elucidating functional heterogeneity in hematopoietic progenitor cells: a combined experimental and modeling approach
    Enrica Bach
    Department of Hematology, Oncology and Hemostasiology, Universitat Leipzig, Leipzig, Germany
    Exp Hematol 42:826-37.e1-17. 2014
    ..Our results demonstrate the power of a combined experimental/modeling approach in which single cell fate analysis is the key to revealing regulatory principles at the cellular level. ..
  21. pmc Multiplexing clonality: combining RGB marking and genetic barcoding
    Kerstin Cornils
    Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany, Institute for Medical Informatics and Biometry, Faculty of Medicine, Technische Universitat Dresden, Dresden 01307, Germany, ALS Automated Lab Solutions GmbH, Jena 07747, Germany, Department of Neuropathology, Hannover Medical School, Institute of Pathology, Hannover 30625, Germany, Department of Internal Medicine I, University Medical Center Hamburg Eppendorf, Hamburg 20246, Germany, Deep Sequencing Group SFB 655, Biotechnology Center, Technische Universitat Dresden, Dresden 01307, Germany
    Nucleic Acids Res 42:e56. 2014
    ..Moreover, the introduction of color-specific signatures in barcodes will facilitate studies on the impact of different variables (e.g. vector type, transgenes, culture conditions) in the context of competitive repopulation studies. ..
  22. ncbi request reprint Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models--a conceptual approach
    Markus Loeffler
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Cells Tissues Organs 171:8-26. 2002
    ..We provide some general ideas on how to proceed with such theories and illustrate this with worked models for tissue stem cells of the hematopoietic system and the intestinal epithelium...
  23. doi request reprint On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup
    Nico Scherf
    Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Exp Hematol 40:119-30.e9. 2012
    ....
  24. ncbi request reprint No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells
    Farastuk Bozorgmehr
    Research Group Pharmacology of Cancer Treatment, German Cancer Research Center, Heidelberg, Germany
    Stem Cells 25:2610-8. 2007
    ..0008% +/- 0.0003% to 0.0041% +/- 0.00032% of primate peripheral blood cells. No clonal dominance was observed. Disclosure of potential conflicts of interest is found at the end of this article...
  25. ncbi request reprint Discrete stem cells: subsets or a continuum?
    Mark A Kirkland
    Blood 108:3949; author reply 3950. 2006
  26. ncbi request reprint Quantitative tissue stem cell modeling
    Ingo Roeder
    Blood 102:1143-4; author reply 1144-5. 2003