A Salameh

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Protective effects of pulsatile flow during cardiopulmonary bypass
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Leipzig, Germany Electronic address
    Ann Thorac Surg 99:192-9. 2015
  2. pmc On the role of the gap junction protein Cx43 (GJA1) in human cardiac malformations with fallot-pathology. a study on paediatric cardiac specimen
    Aida Salameh
    Clinic for Paediatric Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    PLoS ONE 9:e95344. 2014
  3. pmc Role of connexins in human congenital heart disease: the chicken and egg problem
    Aida Salameh
    Clinic for Pediatric Cardiology, Heart Centre, University of Leipzig Leipzig, Germany
    Front Pharmacol 4:70. 2013
  4. ncbi request reprint Cardiac fibroblasts inhibit β-adrenoceptor-dependent connexin43 expression in neonatal rat cardiomyocytes
    A Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:421-33. 2013
  5. ncbi request reprint On the different roles of AT1 and AT2 receptors in stretch-induced changes of connexin43 expression and localisation
    Aida Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Leipzig, Germany
    Pflugers Arch 464:535-47. 2012
  6. ncbi request reprint Right or left ventricular pacing in young minipigs with chronic atrioventricular block: long-term in vivo cardiac performance, morphology, electrophysiology, and cellular biology
    Aida Salameh
    Department of Paediatric Cardiology, University of Leipzig, Heart Centre, Germany
    Circulation 125:2578-87. 2012
  7. ncbi request reprint Adrenergic control of cardiac gap junction function and expression
    Aida Salameh
    Clinic for Paediatric Cardiology, Heart Centre, University of Leipzig, Strümpellstraße 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:331-46. 2011
  8. ncbi request reprint Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43
    Aida Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Germany
    Pharmacol Res 62:506-13. 2010
  9. ncbi request reprint The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts
    A Salameh
    Heart Centre, Department of Paediatric Cardiology, University of Leipzig, Leipzig, Germany
    J Physiol Pharmacol 61:141-51. 2010
  10. ncbi request reprint Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Circ Res 106:1592-602. 2010

Detail Information

Publications28

  1. ncbi request reprint Protective effects of pulsatile flow during cardiopulmonary bypass
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Leipzig, Germany Electronic address
    Ann Thorac Surg 99:192-9. 2015
    ..Therefore, we attempted to elucidate whether CPB with pulsatile flow preserves organ integrity compared with nonpulsatile flow...
  2. pmc On the role of the gap junction protein Cx43 (GJA1) in human cardiac malformations with fallot-pathology. a study on paediatric cardiac specimen
    Aida Salameh
    Clinic for Paediatric Cardiology, Heart Centre, University of Leipzig, Leipzig, Germany
    PLoS ONE 9:e95344. 2014
    ..Moreover, GJA1-gene analysis of 16 patients and 20 healthy subjects was performed...
  3. pmc Role of connexins in human congenital heart disease: the chicken and egg problem
    Aida Salameh
    Clinic for Pediatric Cardiology, Heart Centre, University of Leipzig Leipzig, Germany
    Front Pharmacol 4:70. 2013
    ..This review addresses the potentional role of gap junctions in the development of inborn heart anomalies like the conotruncal heart defects...
  4. ncbi request reprint Cardiac fibroblasts inhibit β-adrenoceptor-dependent connexin43 expression in neonatal rat cardiomyocytes
    A Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:421-33. 2013
    ..Thus, our study indicates that cardiac fibroblasts inhibit β-adrenoceptor-dependent Cx43 signalling in CM involving angiotensin II...
  5. ncbi request reprint On the different roles of AT1 and AT2 receptors in stretch-induced changes of connexin43 expression and localisation
    Aida Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Leipzig, Germany
    Pflugers Arch 464:535-47. 2012
    ....
  6. ncbi request reprint Right or left ventricular pacing in young minipigs with chronic atrioventricular block: long-term in vivo cardiac performance, morphology, electrophysiology, and cellular biology
    Aida Salameh
    Department of Paediatric Cardiology, University of Leipzig, Heart Centre, Germany
    Circulation 125:2578-87. 2012
    ..To determine the hemodynamic and ultrastructural remodeling after either RV free wall or LV apical pacing, we used a chronic minipig model...
  7. ncbi request reprint Adrenergic control of cardiac gap junction function and expression
    Aida Salameh
    Clinic for Paediatric Cardiology, Heart Centre, University of Leipzig, Strümpellstraße 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:331-46. 2011
    ..They probably are involved in the formation of an arrhythmogenic substrate in certain heart diseases...
  8. ncbi request reprint Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43
    Aida Salameh
    Clinic for Paediatric Cardiology, University of Leipzig, Germany
    Pharmacol Res 62:506-13. 2010
    ..However, CMS and adrenergic stimulation differentially affected Cx43-protein/mRNA ratio and Cx43-phosphorylation...
  9. ncbi request reprint The aging heart: changes in the pharmacodynamic electrophysiological response to verapamil in aged rabbit hearts
    A Salameh
    Heart Centre, Department of Paediatric Cardiology, University of Leipzig, Leipzig, Germany
    J Physiol Pharmacol 61:141-51. 2010
    ..L) (reduced maximum conductance, a shift of the steady state inactivation) in the aged heart which may influence the response to verapamil...
  10. ncbi request reprint Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Struempellstr 39, 04289 Leipzig, Germany
    Circ Res 106:1592-602. 2010
    ..Cyclic mechanical stretch (CMS) is an important physiological and pathological factor in the heart...
  11. ncbi request reprint Cardiac gap junction channels are upregulated by metoprolol: an unexpected effect of beta-blockers
    Aida Salameh
    Clinic for Pediatric Cardiology, University of Leipzig, Leipzig, Germany
    Pharmacology 85:203-10. 2010
    ....
  12. pmc The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors
    A Salameh
    Department of Paediatric Cardiology, University of Leipzig, Heart Centre, Leipzig, Germany
    Br J Pharmacol 158:198-208. 2009
    ..As the beta-adrenoceptor is involved in many cardiac diseases, we wanted to clarify the pathway by which beta-adrenoceptor stimulation may control Cx43 expression...
  13. ncbi request reprint Signal transduction and transcriptional control of cardiac connexin43 up-regulation after alpha 1-adrenoceptor stimulation
    Aida Salameh
    Department of Pediatric Cardiology, University of Leipzig, Heart Centre, 04289 Leipzig, Germany
    J Pharmacol Exp Ther 326:315-22. 2008
    ..Therefore, we conclude that alpha(1)-adrenoceptor stimulation up-regulates cardiac Cx43 expression via a PKC p38- and p42/44 MAPK-regulated pathway, possibly involving AP1...
  14. ncbi request reprint Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression
    A Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Leipzig, Germany
    FASEB J 20:365-7. 2006
    ..Adrenergic stimulation of cardiomyocytes can enhance Cx43 expression thereby increasing cellular coupling, indicating a possible role for catecholamines in the regulation of cardiac gap junction expression in cardiac disease...
  15. pmc Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation
    S Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Br J Pharmacol 164:607-16. 2011
    ..We investigated the influence of metoprolol on gap junction proteins connexin43 (Cx43) and connexin40 (Cx40) in atrial tissue from patients with/without atrial fibrillation (AF)...
  16. ncbi request reprint Chronic regulation of the expression of the gap junction protein connexin 43 in transfected HeLa cells
    A Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 368:33-40. 2003
    ..From these results we conclude that 1.Cx43 content can be regulated via AC/cAMP/PKA, PKC and TNF alpha-receptor-dependent pathways 2. Activation of p38 MAP kinase is a common pathway for regulation of Cx43 content in HeLa cells..
  17. ncbi request reprint Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40
    Stefan Dhein
    Clinic for Cardiac Surgery, Heart Center Leipzig, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Biol Cell 94:409-22. 2002
    ..Interestingly, it appears that the expression of Cx43 and Cx40 can be differentially regulated...
  18. ncbi request reprint Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin45 in neonatal rat cardiomyocytes
    Aida Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Eur J Pharmacol 503:9-16. 2004
    ..This may contribute to the changes observed in heart failure with regard to the formation of an arrhythmogenic substrate...
  19. ncbi request reprint Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?
    Aida Salameh
    Clinic I for Internal Medicine, Department of Cardiology, University of Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Biochim Biophys Acta 1719:36-58. 2005
    ..GJIC can be affected acutely by changing gap junction conductance or--more chronic--by altering connexin expression and membrane localisation. This review gives an overview on drugs affecting GJIC...
  20. ncbi request reprint Life cycle of connexins: regulation of connexin synthesis and degradation
    Aida Salameh
    Abteilung Kardiologie, Klinik fur Innere Medizin I, Universitat Leipzig, Leipzig, Germany
    Adv Cardiol 42:57-70. 2006
    ..In the present article, the various steps of the life cycle of cardiac connexins and its regulation are reviewed...
  21. ncbi request reprint Differential effects of the site of permanent epicardial pacing on left ventricular synchrony and function in the young: implications for lead placement
    Roman A Gebauer
    Department of Pediatric Cardiology, Heart Center, University of Leipzig, Strumpellstrasse 39, Leipzig, Germany
    Europace 11:1654-9. 2009
    ..To analyse left ventricular (LV) synchrony and function with respect to the epicardial pacing site in the young...
  22. ncbi request reprint Enhanced expression of VEGF following bFGF inhibition in non-small cell lung cancer cell lines
    Hartmut Kuhn
    Department of Respiratory Medicine, University of Leipzig, Germany
    Lung Cancer 54:149-53. 2006
    ..These results demonstrate that inhibition of bFGF appears to stimulate VEGF production in a p42/44 MAPK-dependent manner. These findings suggest that inhibition of bFGF alone is not a promising strategy to inhibit angiogenesis...
  23. ncbi request reprint Selective arterialization of a cardiac vein in a model of cardiac microangiopathy and macroangiopathy in sheep
    Michaela Elisabeth Resetar
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Thorac Cardiovasc Surg 133:1252-6. 2007
    ..We investigated the benefit of arterialization of a cardiac vein under these circumstances in an acute animal model...
  24. ncbi request reprint Role of the cardiac Na(+)/H(+)exchanger in [Ca(2+)](i)and [Na(+)](i)handling during intracellular acidosis. Effect of cariporide (Hoe 642)
    Aida Salameh
    Medizinische Klinik I, Abt Kardiologie, Universitat Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Pharmacol Res 45:35-41. 2002
    ..The effect of cariporide (Hoe 642) in intracellular acidosis seems to be based on antagonization of the rise in intracellular sodium rather than calcium in this model...
  25. ncbi request reprint Activation of cardiomyocytes depending on their proximity to human bone marrow stem cells
    F Roeske
    Clinic for Cardiac Surgery, University of Leipzig, Leipzig, Germany
    Thorac Cardiovasc Surg 59:78-84. 2011
    ..Thus, a small number of BMC can affect a larger number of cardiomyocytes by activating an intracellular signaling cascade and enhancing β-adrenoceptor density...
  26. ncbi request reprint [Modern pacing therapy]
    N Klein
    Zentrum fur Innere Medizin, Abteilung Kardiologie Angiologie, Universitatsklinikum Leipzig, Johannisallee 32, 04103, Leipzig, Germany
    Internist (Berl) 47:1024, 1026-30, 1032-3. 2006
    ..Indications for pacing therapy increases continuously. Not only bradycardia, but also heart failure, prophylactic pacing to prevent and to terminate tachyarrhythmias are modern fields of pacing therapy...
  27. ncbi request reprint Normal limits for heart rate as established using 24-hour ambulatory electrocardiography in children and adolescents
    Aida Salameh
    Department of Pediatric Cardiology, University of Leipzig, Heart Centre Leipzig, Germany
    Cardiol Young 18:467-72. 2008
    ..To the best of our knowledge, normal limits of heart rate with respect to gender, and as established using 24-hour ambulatory Holter electrocardiography, have yet to be published for the entire age range of children and adolescents...