Magdalena Sastre

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    Magdalena Sastre
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 23:9796-804. 2003
  2. ncbi request reprint Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
    Magdalena Sastre
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Dev Neurosci 24:167-76. 2006
  3. pmc Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
    Magdalena Sastre
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Proc Natl Acad Sci U S A 103:443-8. 2006
  4. ncbi request reprint Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, Bonn, Germany
    Brain 128:1442-53. 2005
  5. ncbi request reprint Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 26:1343-54. 2006
  6. ncbi request reprint Systemic inflammation induces apoptosis with variable vulnerability of different brain regions
    Alexander Semmler
    Department of Neurology, University of Bonn, Germany
    J Chem Neuroanat 30:144-57. 2005
  7. ncbi request reprint Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    J Immunol 175:4948-55. 2005
  8. pmc Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
    Michael T Heneka
    Department of Neurology, University of Munster, 48149 Munster, Germany
    J Neuroinflammation 2:22. 2005
  9. ncbi request reprint Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons
    Luisa Klotz
    Department of Neurology, University of Bonn, Bonn, Germany
    J Neurochem 86:907-16. 2003
  10. ncbi request reprint Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients
    Stephan Schmidt
    Department of Neurology, University of Bonn, Germany
    J Leukoc Biol 75:478-85. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    Magdalena Sastre
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 23:9796-804. 2003
    ..In conclusion, proinflammatory cytokines activate beta-secretase, and NSAIDs inhibit this effect through PPARgamma...
  2. ncbi request reprint Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
    Magdalena Sastre
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Dev Neurosci 24:167-76. 2006
    ..The implication of PPAR-gamma in the control of Abeta-induced inflammation suggests a new target for AD therapy and emphasize the contribution of neuroinflammatory mechanisms to the pathogenesis of AD...
  3. pmc Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
    Magdalena Sastre
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Proc Natl Acad Sci U S A 103:443-8. 2006
    ....
  4. ncbi request reprint Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, Bonn, Germany
    Brain 128:1442-53. 2005
    ..These findings demonstrate that anti-inflammatory drugs can act rapidly to inhibit inflammatory responses in the brain and negatively modulate amyloidogenesis...
  5. ncbi request reprint Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 26:1343-54. 2006
    ..Our data demonstrate that the degeneration of LC affects morphology, metabolism, and function of amyloid plaque-containing higher brain regions in APP23 mice. We postulate that LC degeneration substantially contributes to AD development...
  6. ncbi request reprint Systemic inflammation induces apoptosis with variable vulnerability of different brain regions
    Alexander Semmler
    Department of Neurology, University of Bonn, Germany
    J Chem Neuroanat 30:144-57. 2005
    ..We therefore conclude, that peripheral inflammation leads to a profound glial activation, the generation of nitric oxide and changes of Bax and Bcl-2 protein regulation critical for apoptosis...
  7. ncbi request reprint Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    J Immunol 175:4948-55. 2005
    ....
  8. pmc Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
    Michael T Heneka
    Department of Neurology, University of Munster, 48149 Munster, Germany
    J Neuroinflammation 2:22. 2005
    ..Transgenic mice overexpressing the london mutant of amyloid precursor protein, APP [V717I], robustly recapitulate the amyloid pathology of AD...
  9. ncbi request reprint Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons
    Luisa Klotz
    Department of Neurology, University of Bonn, Bonn, Germany
    J Neurochem 86:907-16. 2003
    ..Conversely, decreased NA due to LC cell death in AD may reduce endogenous PPARgamma expression and therefore potentiate neuroinflammatory processes...
  10. ncbi request reprint Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients
    Stephan Schmidt
    Department of Neurology, University of Bonn, Germany
    J Leukoc Biol 75:478-85. 2004
    ..In summary, the data support the potential use of PPAR-gamma agonists as immunomodulatory, therapeutic agents for autoimmune diseases...
  11. ncbi request reprint GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide
    Tina Wahle
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 26:12838-46. 2006
    ..Thus, GGA proteins might be involved in the pathogenesis of AD...
  12. ncbi request reprint Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation
    Magdalena Sastre
    Departments of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA
    Neurobiol Aging 25:1033-43. 2004
    ..Notably, cystatin C association with Abeta results in a concentration-dependent inhibition of Abeta fibril formation...
  13. ncbi request reprint Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
    Steffen Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Prog Neurobiol 79:95-111. 2006
    ....
  14. ncbi request reprint Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide
    Monika Pawlik
    Department of Pharmacology, New York University School of Medicine, New York, NY, 10016, USA
    J Mol Neurosci 22:13-8. 2004
    ..Thus, in vivo overexpression of human cystatin C does not affect Abeta levels in mice that do not deposit Abeta...
  15. pmc Interactions between APP secretases and inflammatory mediators
    Magdalena Sastre
    Division of Neuroscience and Mental Health, Imperial College London, The Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Neuroinflammation 5:25. 2008
    ..In this review we will discuss some of these issues and the role of the secretases in inflammation, independent of their effect on Abeta formation...
  16. ncbi request reprint Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment
    Christian Grommes
    Department of Neurosciences, Alzheimer Research Laboratory, Case Western Reserve University, Cleveland, Ohio, USA
    Mol Pharmacol 70:1524-33. 2006
    ..Together, these data indicate that pioglitazone may be of potential use in treatment of malignant gliomas...
  17. ncbi request reprint Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation
    Thomas Dehmer
    Neurodegeneration Laboratory, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    J Neurochem 88:494-501. 2004
    ..In conclusion, treatment with pioglitazone may offer a treatment opportunity in PD to slow the progression of disease that is mediated by inflammation...
  18. ncbi request reprint Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Acta Neuropathol 114:231-41. 2007
    ..g., Abeta protein or neurofibrillary changes of the Alzheimer type, do not appear to influence the development of the alpha-synuclein immunoreactive astrocytes...
  19. ncbi request reprint Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models
    Weiqian Mi
    Nathan S Kline Institute, Orangeburg, New York 10962, USA
    Nat Genet 39:1440-2. 2007
    ..Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease...