Horst H Simon

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta
    Sandrine Thuret
    Department of Anatomy and Cell Biology III, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Cell Neurosci 25:394-405. 2004
  2. ncbi The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta
    Sandrine Thuret
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1302-11. 2004
  3. pmc Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat, Heidelberg, Germany
    Neural Dev 4:11. 2009
  4. pmc Merging mouse transcriptome analyses with Parkinson's disease linkage studies
    Daniel Gherbassi
    Department of Neuroanatomy, Interdisciplinary Center for Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    DNA Res 14:79-89. 2007
  5. ncbi Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors
    Horst H Simon
    Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, 69120 Heidelberg, Germany
    Ann N Y Acad Sci 991:36-47. 2003
  6. pmc Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience IZN Ruprecht Karls Universität 69120 Heidelberg, Germany
    Mol Neurodegener 4:6. 2009
  7. ncbi Midbrain dopaminergic neurons: control of their cell fate by the engrailed transcription factors
    Horst H Simon
    Department of Neuroanatomy, Interdisciplinary Center of Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 318:53-61. 2004
  8. ncbi Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner
    Horst H Simon
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Cell Neurosci 28:96-105. 2005
  9. pmc Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
    Paola Sgadò
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:15242-7. 2006
  10. ncbi Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons
    Lavinia Alberi
    Department of Neuroanatomy, Interdisciplinary Center of Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Development 131:3229-36. 2004

Detail Information

Publications12

  1. ncbi Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta
    Sandrine Thuret
    Department of Anatomy and Cell Biology III, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Cell Neurosci 25:394-405. 2004
    ..Synaptotagmin I is expressed from E14 into adulthood. Ebf3, in contrast, is transiently expressed during early postmitotic differentiation...
  2. ncbi The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta
    Sandrine Thuret
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1302-11. 2004
    ..Finally, an assessment of their motor function revealed no behavioral deficits. The apparent lack of any mutant phenotype suggests the presence of a strong compensatory mechanism...
  3. pmc Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat, Heidelberg, Germany
    Neural Dev 4:11. 2009
    ....
  4. pmc Merging mouse transcriptome analyses with Parkinson's disease linkage studies
    Daniel Gherbassi
    Department of Neuroanatomy, Interdisciplinary Center for Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    DNA Res 14:79-89. 2007
    ..Furthermore, our transcriptome analysis identified several classes of candidate genes for PD mutations and may also provide insight into the molecular pathways active in nigral dopaminergic neurons...
  5. ncbi Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors
    Horst H Simon
    Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, 69120 Heidelberg, Germany
    Ann N Y Acad Sci 991:36-47. 2003
    ..Interestingly, alpha-synuclein, a gene recently linked to familial forms of Parkinson's disease, is regulated by engrailed-1 and -2...
  6. pmc Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience IZN Ruprecht Karls Universität 69120 Heidelberg, Germany
    Mol Neurodegener 4:6. 2009
    ....
  7. ncbi Midbrain dopaminergic neurons: control of their cell fate by the engrailed transcription factors
    Horst H Simon
    Department of Neuroanatomy, Interdisciplinary Center of Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 318:53-61. 2004
    ..The inactivation of engrailed by RNA interference induces apoptosis in less than 24 h. These data suggest that the engrailed genes control an essential mechanism for the survival of mesDA neurons...
  8. ncbi Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner
    Horst H Simon
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Cell Neurosci 28:96-105. 2005
    ..An almost identical phenotype is found in mutant mice null for Wnt1, indicating that the engrailed genes provide essential positional information for the development of the two nuclei during early embryogenesis...
  9. pmc Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
    Paola Sgadò
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, Ruprecht Karls Universitat Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:15242-7. 2006
    ..This genetic model may provide access to the molecular etiology for Parkinson's disease and could assist in the development of novel treatments for this neurodegenerative disorder...
  10. ncbi Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons
    Lavinia Alberi
    Department of Neuroanatomy, Interdisciplinary Center of Neuroscience, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Development 131:3229-36. 2004
    ..This rapid induction of cell death in mDA neurons suggests that the engrailed genes participate directly in the regulation of apoptosis, a proposed mechanism for Parkinson's disease...
  11. ncbi One step cloning of defined DNA fragments from large genomic clones
    Christian Scholz
    Interdisciplinary Center for Neuroscience, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    J Biochem Mol Biol 39:464-7. 2006
    ..The only prerequisites are the sequences of ends of the insert and of the underlying genome...
  12. ncbi Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death
    Kambiz N Alavian
    Interdisciplinary Centre for Neuroscience, Department of Neuroanatomy Ruprecht Karls, Universitat Heidelberg, Heidelberg, Germany
    Mov Disord 23:319-28. 2008
    ..In this review, we will discuss the function of these transcription factors throughout the life of mesencephalic dopaminergic neurons and their value in the study of the disease mechanism...