R Wagener

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. doi request reprint The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene
    Raimund Wagener
    Center for Biochemistry, Medical Faculty, University of Cologne, D 50931 Cologne, Germany
    Matrix Biol 28:307-10. 2009
  2. pmc Characterization of recombinantly expressed matrilin VWA domains
    Ann Kathrin A Becker
    Center for Biochemistry, Medical Faculty, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, D 50931, Germany
    Protein Expr Purif 107:20-8. 2015
  3. pmc A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein
    Ann Kathrin A Becker
    Center for Biochemistry, Medical Faculty, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne 50931, Germany
    Structure 22:199-208. 2014
  4. ncbi request reprint Matrilin-4, a new member of the matrilin family of extracellular matrix proteins
    R Wagener
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Germany
    FEBS Lett 436:123-7. 1998
  5. ncbi request reprint Genomic organisation, alternative splicing and primary structure of human matrilin-4
    R Wagener
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Germany
    FEBS Lett 438:165-70. 1998
  6. ncbi request reprint Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l
    R Wagener
    Institute for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, Cologne, D 50931, Germany
    Genomics 76:89-98. 2001
  7. ncbi request reprint Molecular structure, processing, and tissue distribution of matrilin-4
    A R Klatt
    Institute for Biochemistry and the Center for Molecular Medicine Cologne Service Laboratory, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    J Biol Chem 276:17267-75. 2001
  8. ncbi request reprint Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart
    D Segat
    Institute for Biochemistry, Medical Faculty, University of Cologne, D 50931, Cologne, Germany
    Matrix Biol 19:649-55. 2000
  9. ncbi request reprint Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron
    R Wagener
    Institute for Biochemistry, Medical Faculty, University of Cologne, Germany
    Mamm Genome 11:85-90. 2000
  10. doi request reprint The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes
    A R Klatt
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Osteoarthritis Cartilage 21:869-73. 2013

Collaborators

  • A Aszodi
  • Z Liu
  • F Zaucke
  • D R Beier
  • O Pullig
  • Wilhelm Stoffel
  • A R Klatt
  • Ann Kathrin A Becker
  • M Paulsson
  • Halina Mikolajek
  • Mats Paulsson
  • Jörn M Werner
  • B Kobbe
  • C Otten
  • D Segat
  • W Johannis
  • G Klinger
  • U Hillebrand
  • B Paul-Klausch
  • G Kuhn
  • J H Renno
  • D P Nitsche
  • D Piecha
  • N Smyth
  • M Macht
  • C Frie
  • M Morgelin
  • F Deak
  • P D Nitsche
  • E Korpos
  • R Pfitzner

Detail Information

Publications16

  1. doi request reprint The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene
    Raimund Wagener
    Center for Biochemistry, Medical Faculty, University of Cologne, D 50931 Cologne, Germany
    Matrix Biol 28:307-10. 2009
    ..Here we present information that the newly identified DVWA represents the human gene coding for the collagen VI alpha 4 chain, which could point to a more complex disease mechanism...
  2. pmc Characterization of recombinantly expressed matrilin VWA domains
    Ann Kathrin A Becker
    Center for Biochemistry, Medical Faculty, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, D 50931, Germany
    Protein Expr Purif 107:20-8. 2015
    ..Structural studies of matrilin VWA domains will depend on the use of eukaryotic expression systems. ..
  3. pmc A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein
    Ann Kathrin A Becker
    Center for Biochemistry, Medical Faculty, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Cologne 50931, Germany
    Structure 22:199-208. 2014
    ..Homology modeling is used to locate a number of disease-associated mutations and analyze their structural impact, which will allow mechanistic analysis of collagen-VI-associated muscular dystrophy phenotypes. ..
  4. ncbi request reprint Matrilin-4, a new member of the matrilin family of extracellular matrix proteins
    R Wagener
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Germany
    FEBS Lett 436:123-7. 1998
    ..Additionally an alternatively spliced mRNA lacking the sequence coding for the first vWFA domain was found in 7 weeks old mice leading to a protein precursor of 434 amino acids and a predicted Mr of the mature protein of 45468...
  5. ncbi request reprint Genomic organisation, alternative splicing and primary structure of human matrilin-4
    R Wagener
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Germany
    FEBS Lett 438:165-70. 1998
    ..Due to a G to A mutation at the splice donor site of intron C, the third exon encodes an untranslated pseudo-exon specifying the first EGF-like domain when compared to mouse matrilin-4...
  6. ncbi request reprint Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l
    R Wagener
    Institute for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, Cologne, D 50931, Germany
    Genomics 76:89-98. 2001
    ..In situ hybridization of brain sections showed a partially overlapping expression pattern for the two genes...
  7. ncbi request reprint Molecular structure, processing, and tissue distribution of matrilin-4
    A R Klatt
    Institute for Biochemistry and the Center for Molecular Medicine Cologne Service Laboratory, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    J Biol Chem 276:17267-75. 2001
    ..In the matrix formed by cultured primary embryonic fibroblasts, matrilin-4 is found in a filamentous network connecting individual cells...
  8. ncbi request reprint Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart
    D Segat
    Institute for Biochemistry, Medical Faculty, University of Cologne, D 50931, Cologne, Germany
    Matrix Biol 19:649-55. 2000
    ..The complementary, but in part overlapping, expression of matrilins indicates the possibility for both redundant and unique functions among the members of this novel family of extracellular matrix proteins...
  9. ncbi request reprint Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron
    R Wagener
    Institute for Biochemistry, Medical Faculty, University of Cologne, Germany
    Mamm Genome 11:85-90. 2000
    ..Single-strand conformation polymorphism analysis was used to map the Matn3 gene to the proximal end of Chr 12, linked to the genes Synd1, Apob, Dntb, and Kif3c...
  10. doi request reprint The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes
    A R Klatt
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Osteoarthritis Cartilage 21:869-73. 2013
    ..Here, we investigated the potential of matrilin-3 (MATN3) and truncated matrilin-3 proteins, in both monomeric and oligomeric form, to stimulate interleukin (IL)-6 release in PHCs...
  11. ncbi request reprint The matrilins: a growing family of A-domain-containing proteins
    M Paulsson
    Institute for Biochemistry, Medical Faculty, University of Cologne, Germany
    Biochem Soc Trans 27:824-6. 1999
  12. pmc Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation associated with hand osteoarthritis does not
    C Otten
    Center for Biochemistry, Medical Faculty, University of Cologne, Germany
    J Med Genet 42:774-9. 2005
    ....
  13. ncbi request reprint Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor
    R Wagener
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Germany
    FEBS Lett 413:129-34. 1997
    ..8%. Northern blot hybridization of mouse matrilin-3 mRNA showed a 2.9 kb mRNA expressed in sternum, femur and trachea and indicates a cartilage-specific expression...
  14. ncbi request reprint Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development
    A R Klatt
    Institute for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    J Biol Chem 275:3999-4006. 2000
    ..In trachea and in costal cartilage of adult mice, an expression was seen in the perichondrium. Furthermore, matrilin-3 is found in bone, and its expression is, therefore, not restricted to chondroblasts and chondrocytes...
  15. ncbi request reprint Matrilin-3 in human articular cartilage: increased expression in osteoarthritis
    O Pullig
    Division of Orthopaedic Rheumatology, Department of Orthopaedics, University of Erlangen Nuremberg, Rathsberger Str 57, D 91054 Erlangen, Germany
    Osteoarthritis Cartilage 10:253-63. 2002
    ..Detailed information on expression and distribution of extracellular matrix proteins is important to understand cartilage function in health and in disease like osteoarthritis (OA)...
  16. ncbi request reprint Isolation, expression and characterization of a human apolipoprotein B 100-specific cDNA clone
    R Pfitzner
    Biol Chem Hoppe Seyler 367:1077-83. 1986
    ..In Northern blot hybridization analysis the insert of the apo B 100-cDNA clone hybridized to a 20 to 22 kb mRNA from adult human liver...