Alexandra Margeli

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. pmc Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival
    Constantinos Giaginis
    First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 M, Asias str, Goudi, Athens GR11527, Greece
    BMC Clin Pathol 14:8. 2014
  2. doi Ephrin receptor (Eph) -A1, -A2, -A4 and -A7 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Institut Curie, Paris, France
    Pathol Oncol Res 20:277-84. 2014
  3. pmc Eph-A2 and Eph-A4 expression in human benign and malignant thyroid lesions: an immunohistochemical study
    Nikolaos P Karidis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Med Sci Monit 17:BR257-65. 2011
  4. pmc Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, University of Athens, Athens, Greece
    Med Sci Monit 18:BR123-9. 2012
  5. pmc Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, University of Athens, Athens, Greece
    Med Sci Monit 17:CR381-91. 2011
  6. pmc Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer
    Costas Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 11527 Athens, Greece
    PPAR Res 2008:431763. 2008
  7. pmc Hepatic encephalopathy: an updated approach from pathogenesis to treatment
    Giannakis T Toris
    Department of Forensic Medicine and Toxicology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Med Sci Monit 17:RA53-63. 2011
  8. pmc Expression of DNA repair proteins MSH2, MLH1 and MGMT in human benign and malignant thyroid lesions: an immunohistochemical study
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Med Sci Monit 17:BR81-90. 2011
  9. pmc Correlation of plasma osteoprotegerin (OPG) and receptor activator of the nuclear factor κB ligand (RANKL) levels with clinical risk factors in patients with advanced carotid atherosclerosis
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Med Sci Monit 18:CR597-604. 2012
  10. doi Pregnane X receptor polymorphisms associated with human diseases
    Ioly Kotta-Loizou
    Medical School, National and Kapodistrian University of Athens, First Department of Pathology, 75, Mikras Asias Street, Goudi, Athens, 11527, Greece
    Expert Opin Ther Targets 17:1167-77. 2013

Collaborators

Detail Information

Publications91

  1. pmc Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival
    Constantinos Giaginis
    First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 M, Asias str, Goudi, Athens GR11527, Greece
    BMC Clin Pathol 14:8. 2014
    ..The present study aimed to evaluate the clinical significance of EphA1, A4, A5 and A7 protein expression in non-small cell lung carcinoma (NSCLC)...
  2. doi Ephrin receptor (Eph) -A1, -A2, -A4 and -A7 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Institut Curie, Paris, France
    Pathol Oncol Res 20:277-84. 2014
    ....
  3. pmc Eph-A2 and Eph-A4 expression in human benign and malignant thyroid lesions: an immunohistochemical study
    Nikolaos P Karidis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Med Sci Monit 17:BR257-65. 2011
    ..The aim of the present study was to evaluate the clinical significance of Eph-A2 and Eph-A4 expression in human benign and malignant thyroid lesions...
  4. pmc Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, University of Athens, Athens, Greece
    Med Sci Monit 18:BR123-9. 2012
    ..The present study aimed to evaluate the clinical significance of RCAS1 expression in human benign and malignant thyroid lesions...
  5. pmc Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, University of Athens, Athens, Greece
    Med Sci Monit 17:CR381-91. 2011
    ..The present study aimed to assess the clinical significance of PPAR-gamma and RXR-alpha expression in different cellular populations localized within advanced carotid atherosclerosis lesions...
  6. pmc Peroxisome Proliferator-Activated Receptor-gamma Ligands: Potential Pharmacological Agents for Targeting the Angiogenesis Signaling Cascade in Cancer
    Costas Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 11527 Athens, Greece
    PPAR Res 2008:431763. 2008
    ....
  7. pmc Hepatic encephalopathy: an updated approach from pathogenesis to treatment
    Giannakis T Toris
    Department of Forensic Medicine and Toxicology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Med Sci Monit 17:RA53-63. 2011
    ..Eventually, liver transplantation is often the most successful long-term therapy for HE...
  8. pmc Expression of DNA repair proteins MSH2, MLH1 and MGMT in human benign and malignant thyroid lesions: an immunohistochemical study
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Med Sci Monit 17:BR81-90. 2011
    ..The present study aimed to evaluate the clinical significance of DNA repair proteins MSH2, MLH1 and MGMT in benign and malignant thyroid lesions...
  9. pmc Correlation of plasma osteoprotegerin (OPG) and receptor activator of the nuclear factor κB ligand (RANKL) levels with clinical risk factors in patients with advanced carotid atherosclerosis
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Med Sci Monit 18:CR597-604. 2012
    ..The present study aimed to assess the clinical implication of plasma OPG and RANKL levels in patients with advanced carotid atherosclerosis...
  10. doi Pregnane X receptor polymorphisms associated with human diseases
    Ioly Kotta-Loizou
    Medical School, National and Kapodistrian University of Athens, First Department of Pathology, 75, Mikras Asias Street, Goudi, Athens, 11527, Greece
    Expert Opin Ther Targets 17:1167-77. 2013
    ..In addition, PXR polymorphisms have been associated with both benign and malignant disease states, in terms of disease risk and severity, gene expression and drug clearance...
  11. doi Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    J Oral Pathol Med 40:706-14. 2011
    ..The aim of the present study was to evaluate the clinical significance of HDAC-1 and -2 protein expression in mobile tongue squamous cell carcinoma (SCC)...
  12. doi FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Institut Curie, Paris, France
    J Cancer Res Clin Oncol 138:1369-77. 2012
    ..The present study aimed to evaluate the clinical significance of FAK and Src protein expression in mobile tongue squamous cell carcinoma (SCC)...
  13. pmc Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications
    Costas T Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
    World J Surg Oncol 6:59. 2008
    ..As CAR appears to modulate the proliferation and characteristics of cancer cells, its expression could be considered of possible clinical importance for future (gene) therapy applications...
  14. pmc Heat Shock Protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    BMC Gastroenterol 9:14. 2009
    ..The aim of the present study was to evaluate the clinical significance of HSP -27, -60, and -90 expression in gastric carcinoma...
  15. doi Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    J Oral Pathol Med 40:218-26. 2011
    ..The present study aimed to evaluate the clinical significance of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma (SCC)...
  16. pmc RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institute Curie, Paris, France
    Med Sci Monit 17:BR228-234. 2011
    ..The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC)...
  17. ncbi Metallothionein and heat shock protein expression during acute liver injury and regeneration in rats
    S E Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
    Clin Chem Lab Med 38:1137-40. 2000
    ..Our findings indicate that the differential distribution of MT and HSPs in the liver after toxin-induced injury, in common with the observed pattern of staining, reflect liver proliferating capacity...
  18. doi Toll-like receptors: a novel target for therapeutic intervention in intestinal and hepatic ischemia-reperfusion injury?
    Ioanna Vasileiou
    University of Athens, Medical School, Department of Forensic Medicine and Toxicology, Athens, Greece
    Expert Opin Ther Targets 14:839-53. 2010
    ..Ischemia-reperfusion injury (IRI) represents one of these tissue damage states in which TLR-mediated mechanisms might be implicated...
  19. doi Peroxisome proliferator-activated receptor-γ in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    J Cancer Res Clin Oncol 137:251-9. 2011
    ..The present study aimed to evaluate the clinical significance of PPAR-γ in mobile tongue squamous cell carcinoma (SCC)...
  20. ncbi Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumor proliferative capacity
    Stamatios E Theocharis
    Department of Tumor Biology, Section of Cytopathology, Institut Curie, Paris, France
    Med Sci Monit 15:BR221-6. 2009
    ..Additionally, in vivo FAK has been implicated in malignant transformation and disease progression. The aim of the present study was to evaluate the clinical significance of FAK expression in breast ductal invasive carcinoma (DIC)...
  21. ncbi Liver metallothionein expression in thioacetamide-intoxicated rats
    S E Theocharis
    Department of Histology Embryology, Medical School, University of Athens, Greece
    Pathol Res Pract 196:313-9. 2000
    ..This study suggests that MT participates in hepatocyte replication after toxin-induced liver injury...
  22. ncbi Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats: an immunohistochemical study
    S E Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 11527 Goudi, Athens, Greece
    Toxicology 161:129-38. 2001
    ..Induction of MT expression was observed in the liver after a single administration of CCl(4), being more prominent at the time of maximum hepatocellular proliferation, participating actively in the replication of hepatocytes...
  23. doi Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    Histopathology 59:514-25. 2011
    ..The aim of the present study was to evaluate the clinical significance of MT expression in mobile tongue squamous cell carcinoma (SCC)...
  24. ncbi Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival
    Stamatios Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 M Asias str, Goudi, GR11527, Athens, Greece
    Dig Dis Sci 52:2305-11. 2007
    ....
  25. ncbi Peroxisome proliferator-activated receptor-gamma ligands as bone turnover modulators
    Costas Giaginis
    University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75 Mikras Asias Street, Athens 11527, Greece
    Expert Opin Investig Drugs 16:195-207. 2007
    ..Taking into account the data so far, PPAR-gamma ligands seem to be able to contribute to the treatment of various bone disorders including osteoporosis, as well as diabetic and age-related osteopoenia...
  26. ncbi Expression of metallothionein in lung carcinoma: correlation with histological type and grade
    S Theocharis
    Department of Histology and Embryology, University of Athens, Medical School, Athens, Greece
    Histopathology 40:143-51. 2002
    ..The aim of this study was to assess metallothionein expression in cases of lung carcinoma and to correlate it with histopathological parameters...
  27. ncbi Peroxisome proliferator-activated receptor-gamma ligands as cell-cycle modulators
    Stamos Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75, Mikras Asias Street, GR 11527 Athens, Greece
    Cancer Treat Rev 30:545-54. 2004
    ..In this review, the latest knowledge on the role of PPAR-gamma ligands as cell-cycle modulators is presented, discussing also their role in cell proliferation, apoptosis and cancer...
  28. ncbi Metallothionein expression in human neoplasia
    S E Theocharis
    Department of Tumour Biology, Institut Curie, Paris, France
    Histopathology 45:103-18. 2004
    ....
  29. ncbi Metallothionein: a multifunctional protein from toxicity to cancer
    S E Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
    Int J Biol Markers 18:162-9. 2003
    ..In the present review the involvement of MT in defense mechanisms to toxicity and in carcinogenicity is discussed...
  30. ncbi Peroxisome proliferator activated receptor-gamma ligands as potent antineoplastic agents
    S Theocharisa
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
    Curr Med Chem Anticancer Agents 3:239-51. 2003
    ..In vitro and in vivo studies concerning the use of PPAR-gamma ligands in different cancer types are also included...
  31. doi Effect of inflammation induced by prolonged exercise on circulating erythroid progenitors and markers of erythropoiesis
    Antonia Spiropoulos
    Stem Cell Transplant Unit, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Chem Lab Med 48:199-203. 2010
    ..We investigated the effect of inflammation on erythroid marrow activity by mobilization of erythroid progenitor cells (EPs) along with soluble markers of erythropoiesis...
  32. doi Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization
    Sophia D Sakka
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Aghia Sophia Children s Hospital, Athens University Medical School, Athens, Greece
    Fertil Steril 94:1693-9. 2010
    ..To investigate the metabolic profile, traditional adipokines, and indices of insulin resistance and low-grade inflammation in children born as a result of IVF compared with spontaneously conceived controls...
  33. ncbi Diagnostic and prognostic utility of serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) levels in colon cancer patients
    Costas Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Int J Biol Markers 24:70-6. 2009
    ..Assessment of serum RCAS1 levels could therefore be considered as a diagnostic and prognostic marker in colon neoplasia...
  34. doi Circulating visfatin levels in healthy preterm infants are independently associated with high-density lipoprotein cholesterol levels and dietary long-chain polyunsaturated fatty acids
    Tania Siahanidou
    Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, 11527 Athens, Greece
    Metabolism 60:389-93. 2011
    ..Whether the higher visfatin levels in the +LCPUFA preterm infant group are beneficial for the later health of these infants remains to be determined...
  35. doi Serial plasma concentrations of adiponectin, leptin, and resistin during therapy in children with acute lymphoblastic leukemia
    Maria Moschovi
    Pediatric Hematology Oncology double daggerEndocrinology, Metabolism and Diabetes Units, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    J Pediatr Hematol Oncol 32:e8-13. 2010
    ..To investigate adipocytokine secretion, at diagnosis and during chemotherapy in children with the acute lymphoblastic leukemia (ALL)...
  36. ncbi Effect of platelet-activating factor (PAF) receptor antagonist (BN52021) on acetaminophen-induced acute liver injury and regeneration in rats
    A D Grypioti
    Department of Experimental Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Liver Int 26:97-105. 2006
    ..In the present study, the possible influence of PAF-R antagonist (BN52021) on the protection of liver injury after 4-hydroxyacetanilide, N-acetyl-p-aminophenol, paracetamol (APAP) intoxication was investigated...
  37. doi Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: when children are not just "small adults"
    Christina Kanaka-Gantenbein
    First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes, Athens University Medical School, Athens, Greece
    Clin Chem 54:1176-82. 2008
    ....
  38. doi Gender dimorphic increase in RBP-4 and NGAL in children born after IVF: an epigenetic phenomenon?
    Sophia D Sakka
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Eur J Clin Invest 43:439-48. 2013
    ..We studied the lipocalins RBP-4 and NGAL as well as visfatin in children born after IVF...
  39. doi Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation
    Maria G Pavlatou
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Eur J Clin Invest 41:652-8. 2011
    ..In this study, we examined the effects of candesartan, an angiotensin receptror blocker, in the chronic low-grade inflammation observed in DM 2...
  40. doi Severe hyperinsulinemia, decreased GLUT3 and GLUT4 expression, and increased retinol binding protein 4 in a patient with chronic graft-versus-host disease post bone marrow transplantation
    Sarantis Livadas
    First Department of Pediatrics, Athens University Medical School, Athens, Greece
    Pediatr Transplant 16:E221-4. 2012
    ..It is not clear whether insulin resistance was caused by the drugs, the process itself, or the residual damage to the muscles and/or adipose tissue...
  41. ncbi Glucocorticoid receptor (GR) immunohistochemical expression is correlated with cell cycle-related molecules in human colon cancer
    Stamatios Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Dig Dis Sci 48:1745-50. 2003
    ....
  42. ncbi Using higher-order crossings to distinguish liver regeneration indices in hepatectomized diabetic and non-diabetic rats
    Christos Liatsos
    Department of Experimental Pharmacology, Medical School, University of Athens, Athens, Greece
    J Gastroenterol Hepatol 20:126-34. 2005
    ....
  43. pmc An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study
    Spilios Manolakopoulos
    Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece
    BMC Gastroenterol 7:17. 2007
    ....
  44. pmc Circulating levels of inflammatory markers in intrauterine growth restriction
    Theodora Boutsikou
    Neonatal Division, Second Department of Obstetrics and Gynecology, University of Athens, 11528 Athens, Greece
    Mediators Inflamm 2010:790605. 2010
    ..However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g. preeclampsia), cannot be excluded...
  45. doi Disparity in circulating adiponectin multimers between term and preterm infants
    Tania Siahanidou
    Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Athens, Greece
    J Perinat Med 37:683-8. 2009
    ..To study circulating levels and distribution of adiponectin multimers [low molecular weight (LMW)-, medium molecular weight (MMW)- and high molecular weight (HMW)-adiponectin] in preterm and full-term infants...
  46. ncbi Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients
    S E Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75, Mikras Asias Street, GR 11527, Athens, Greece
    Eur J Surg Oncol 29:571-4. 2003
    ..FAK expression in tumor cells in vitro may correlate with their ability for invasion and metastasis...
  47. ncbi Decreased circulating 25-(OH) Vitamin D concentrations in obese female children and adolescents: positive associations with Retinol Binding Protein-4 and Neutrophil Gelatinase-associated Lipocalin
    Dimitra Metheniti
    Childhood Obesity Clinic, First Department of Pediatrics, University of Athens Medical School, Athens, Greece
    Hormones (Athens) 12:397-404. 2013
    ..The aim of this study was to examine circulating 25-(OH) Vitamin D (25-(OH) D) concentrations according to BMI and its associations with RBP-4 and NGAL in female children and adolescents...
  48. doi The effect of diet on total antioxidant status, ceruloplasmin, transferrin and ferritin serum levels in phenylketonuric children
    Kleopatra H Schulpis
    Institute of Child Health Research Centre, Athens, Greece
    Acta Paediatr 99:1565-70. 2010
    ..To investigate the effect of diet on total antioxidative status (TAS), transferrin, ferritin and ceruloplasmin serum levels in phenylketonuric (PKU) children...
  49. ncbi Peroxisome proliferator-activated receptor-gamma ligands as investigational modulators of angiogenesis
    Costas Giaginis
    University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75 M Asias Street, Goudi, GR11527, Athens, Greece
    Expert Opin Investig Drugs 16:1561-72. 2007
    ..Taking into careful consideration the data so far, PPAR-gamma could be considered as a therapeutic target for diverse disease states in which excessive angiogenesis is implicated, including cancer and diabetes complications...
  50. ncbi Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration
    A D Grypioti
    Department of Experimental Pharmacology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, GR 11527 Athens, Greece
    Arch Toxicol 79:466-74. 2005
    ..However, the putative role of PAF during liver toxicity and regeneration remains to be established...
  51. doi Calprotectin: a protein related to cardiovascular risk in adult patients with obstructive sleep apnea
    Kyriaki G Cholidou
    First Respiratory Medicine Department, National and Kapodistrian University of Athens, Medical School, SOTIRIA Chest Diseases Hospital, Athens, Greece
    Cytokine 61:917-23. 2013
    ..As a secondary objective was the evaluation of the atherogenic markers post-CPAP treatment...
  52. ncbi Effect of acute ethanol exposure on hepatic stimulator substance (HSS) levels during liver regeneration: protective function of HSS
    George D Liatsos
    Department of Experimental Pharmacology, Medical School, University of Athens, Mikras Asias 75 GR 11527 Athens, Greece
    Dig Dis Sci 48:1929-38. 2003
    ..Exogenous administration of HSS to ethanol-treated partially hepatectomized rats restored DNA synthesis and ameliorated serum AST levels, indicating that HSS could be used in the treatment of ethanol-induced hepatic failures...
  53. ncbi Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade
    Stamatios Theocharis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 11527, Athens, Greece
    Lung Cancer 36:249-55. 2002
    ....
  54. doi The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change
    Georgios Valsamakis
    2nd Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens Medical School, Athens, Greece
    Eur J Endocrinol 162:897-903. 2010
    ..This study aimed at examining the associations of gut hormones during pregnancy with maternal glucose homeostasis, maternal weight, and fetal growth...
  55. doi Cystatin C levels in patients with beta-thalassemia during deferasirox treatment
    Ioannis Papassotiriou
    Department of Clinical Biochemistry, Aghia Sophia Children s Hospital, Athens, Greece
    Blood Cells Mol Dis 44:152-5. 2010
    ..However hemodynamic signals such as LVEF alterations and iron mobilization do appear to affect changes in cystatin C concentration...
  56. ncbi Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident
    Panagiota Pervanidou
    First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Psychoneuroendocrinology 32:991-9. 2007
    ....
  57. doi Neutrophil Gelatinase--Associated Lipocalin and Cystatin C Are Sensitive Markers of Renal Injury in Patients With Multiple Myeloma
    Gerasimos Petros Papassotiriou
    Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Alexandra General Hospital, Athens, Greece
    Clin Lymphoma Myeloma Leuk 16:29-35. 2016
    ....
  58. pmc Plasma metabolomic profiling suggests early indications for predisposition to latent insulin resistance in children conceived by ICSI
    Alexandra Gkourogianni
    Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, University of Athens Medical School, Athens, Greece
    PLoS ONE 9:e94001. 2014
    ..We assessed differences in their metabolic profile based on biochemical measurements, while, for a subgroup, plasma metabolomic analysis was also performed, investigating any relevant insulin resistance indices...
  59. doi Non-traditional adipokines in pediatric HIV-related lipodystrophy: a-FABP as a biomarker of central fat accumulation
    Kalliopi Theodoridou
    First Department of Pediatrics, University of Athens, Aghia Sophia Children s Hospital, Athens
    Scand J Clin Lab Invest 74:67-73. 2014
    ..In a previous study of HIV-infected children, we did not detect insulin resistance, despite a high percentage of body fat redistribution abnormalities...
  60. doi Serial plasma concentrations of PYY and ghrelin during chemotherapy in children with acute lymphoblastic leukemia
    Maria Moschovi
    Pediatric Hematology Oncology Unit, First Department of Pediatrics, Athens University Medical School, Agia Sophia Children s Hospital, Athens, Greece
    J Pediatr Hematol Oncol 30:733-7. 2008
    ..To investigate peptide YY (PYY) and ghrelin secretion, at diagnosis and during chemotherapy in children with acute lymphoblastic leukemia (ALL)...
  61. doi Circulating adiponectin in preterm infants fed long-chain polyunsaturated fatty acids (LCPUFA)-supplemented formula--a randomized controlled study
    Tania Siahanidou
    Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children s Hospital, Athens, 11527, Greece
    Pediatr Res 63:428-32. 2008
    ..In conclusion, circulating adiponectin concentrations were higher in preterm infants fed a formula containing LCPUFA than infants fed an LCPUFA-free formula and they correlated with lipidemic profile...
  62. doi Spartathlon, a 246 kilometer foot race: effects of acute inflammation induced by prolonged exercise on circulating progenitor reparative cells
    Evgenios Goussetis
    Stem Cell Transplant Unit, Aghia Sophia Children s Hospital, Athens, Greece
    Blood Cells Mol Dis 42:294-9. 2009
    ..Given the ability of EPCs to promote angiogenesis and vascular regeneration, we may suggest that this kind of cell mobilization may serve as a physiologic repair mechanism in acute inflammatory tissue injury...
  63. doi Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, Medical School, Laiko General Hospital, University of Athens, 11527 Athens, Greece
    Eur J Endocrinol 158:525-31. 2008
    ..Since the instability of atherosclerotic plaque is a key factor in the clinical manifestations of cardiovascular disease, molecules challenging the plaque stability should be investigated...
  64. doi Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys
    George Paltoglou
    Endocrine Unit, Aretaieion Hospital, National and Kapodistrian University of Athens Faculty of Medicine, Athens, Greece
    Endocrine . 2017
    ..They were investigated in pre- and early pubertal normal-weight and obese boys before and after an exercise bout employed as an energy demanding stimulator...
  65. doi Plasma neutrophil gelatinase-associated lipocalin levels are markedly increased in patients with non-transfusion-dependent thalassemia: Lack of association with markers of erythropoiesis, iron metabolism and renal function
    Aikaterini Patsaoura
    Department of Clinical Biochemistry, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Biochem 47:1060-4. 2014
    ..In this study we investigated the possible association of NGAL with parameters of erythropoiesis, iron metabolism and renal injury in patients with non-transfusion-dependent thalassemia (thalassemia intermedia or TI)...
  66. doi Effect of atorvastatin on baroreflex sensitivity in subjects with type 2 diabetes and dyslipidaemia
    Pinelopi Grigoropoulou
    First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
    Diab Vasc Dis Res 11:26-33. 2014
    ..This finding emphasizes the beneficial effect of atorvastatin on cardiovascular system, beyond the lipid-lowering effects. ..
  67. ncbi Serum tissue inhibitor of metalloproteinase 1 and 2 (TIMP-1 and TIMP-2) levels in colorectal cancer patients: associations with clinicopathological variables and patient survival
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Int J Biol Markers 24:245-52. 2009
    ..0379 and p=0.0451, respectively). In conclusion, assessment of serum TIMP-1 can be considered a useful biomarker in colon cancer, whereas TIMP-2 appears to be of limited value...
  68. ncbi The role of adipocytokines in insulin resistance in normal pregnancy: visfatin concentrations in early pregnancy predict insulin sensitivity
    George Mastorakos
    Endocrine Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens Medical School, Athens, Greece
    Clin Chem 53:1477-83. 2007
    ..We explored the role of serum adipocytokines, including the newly identified adipocytokine visfatin, in the process of insulin resistance in normal pregnancy...
  69. doi Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration
    N Tsantila
    Faculty of Chemistry, National and Kapodistrian University of Athens, Athens, Greece
    Nutr Metab Cardiovasc Dis 20:740-7. 2010
    ..Our aim was to compare the effect of PPL with that of simvastatin on the progression of atherogenesis...
  70. ncbi Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury
    Costas Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens 11527, Greece
    Curr Mol Med 8:562-79. 2008
    ..Taking into consideration the data so far, PPAR-gamma ligands seem to represent potential therapeutic agents in the aim to reduce or even prevent injury associated with ischemia-reperfusion...
  71. doi Does the expression of cyclin E, pRb, and p21 correlate with prognosis in gastric adenocarcinoma?
    Gregory Kouraklis
    2nd Department of Propedeutic Surgery, Medical School University of Athens, Athens, Greece
    Dig Dis Sci 54:1015-20. 2009
    ..The expression of these proteins, among many others, is being deregulated in tumorogenesis. The aim of this study was to investigate whether cyclin E, pRb, and p21 can be used as prognostic indicators in gastric cancer...
  72. ncbi Toll-like receptors in liver ischemia reperfusion injury: a novel target for therapeutic modulation?
    Athanasios Katsargyris
    University of Athens, Athens, Greece
    Expert Opin Ther Targets 13:427-42. 2009
    ..TLRs are considered to be involved in many primarily non-immune-related diseases. Hepatic ischemia reperfusion injury (IRI) represents one of these disorders...
  73. doi Assessment of serum bioactive hepcidin-25, soluble transferrin receptor and their ratio in predialysis patients: Correlation with the response to intravenous ferric carboxymaltose
    Athina Drakou
    Renal Unit, Attikon General University Hospital, University of Athens, School of Medicine, Athens, Greece
    Blood Cells Mol Dis 59:100-5. 2016
    ..We aimed to investigate the clinical value of bioactive Hepcidin-25 and soluble Transferrin Receptor (sTfR) levels in predialysis patients...
  74. doi Direct injection liquid chromatography/positive ion electrospray ionization mass spectrometric quantification of methotrexate, folinic acid, folic acid and ondansetron in human serum
    Panagiotis Koufopantelis
    University of Athens, School of Pharmacy, Division of Pharmaceutical Chemistry, Panepistimiopolis, Zografou 157 71, Athens, Greece
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3850-6. 2009
    ....
  75. ncbi Valproic acid monotherapy induces DNA oxidative damage
    Kleopatra H Schulpis
    Institute of Child Health, Research Center Athens, Athens, Greece
    Toxicology 217:228-32. 2006
    ..8-OHdG evaluation may be a useful biomarker to follow up the increased risk of degeneration process in VPA patients...
  76. doi Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 M Asias str, Goudi, Athens, 11527, Greece
    Dig Dis Sci 54:282-91. 2009
    ..The current data suggest that MCM-2 protein expression is significantly associated with important clinicopathological characteristics for patients' management, being correlated with the cell proliferation state in colon cancer...
  77. pmc Circadian variation in expression of G1 phase cyclins D1 and E and cyclin-dependent kinase inhibitors p16 and p21 in human bowel mucosa
    John Griniatsos
    1st Department of Surgery, Medical School, University of Athens, Greece
    World J Gastroenterol 12:2109-14. 2006
    ..To evaluate whether the cellular proliferation rate in the large bowel epithelial cells is characterized by circadian rhythm...
  78. ncbi A consideration of PPAR-gamma ligands with respect to lipophilicity: current trends and perspectives
    Costas Giaginis
    University of Athens, Department of Pharmaceutical Chemistry, School of Pharmacy, Panepistimiopolis, Zografou, Athens 157 71, Greece
    Expert Opin Investig Drugs 16:413-7. 2007
    ..A survey on the lipophilic behavior of thiazolidinediones and tyrosine-based derivatives with well-established PPAR-gamma affinity and functional activity suggests that excessive lipophilicity may not be favorable for their action...
  79. doi Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands as potential therapeutic agents to treat arthritis
    Costas Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens 11527, Greece
    Pharmacol Res 60:160-9. 2009
    ..However, the precise molecular mechanisms through which PPAR-gamma ligands exert their actions are strongly recommended to be clarified, as both receptor-dependent and -independent actions were shown to be elicited...
  80. ncbi Structural basis for the design of PPAR-gamma ligands: a survey on quantitative structure- activity relationships
    Costas Giaginis
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece
    Mini Rev Med Chem 9:1075-83. 2009
    ..The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined...
  81. ncbi Clinical significance of tumor-associated antigen RCAS1 expression in human pancreatic ductal adenocarcinoma
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 Mikras Asias St, 11527 Athens, Greece
    Dig Dis Sci 53:1728-34. 2008
    ..Our data provide evidence for the implication of RCAS1 in pancreatic neoplasia. However, the prediction of survival using RCAS1 expression as a marker seems uncertain for this type of cancer...
  82. ncbi Zinc and the liver: an active interaction
    Ioannis Stamoulis
    Department of Forensic Medicine and Toxicology, University of Athens, Medical School, Goudi, Athens, Greece
    Dig Dis Sci 52:1595-612. 2007
    ..It is concluded that zinc could protect against liver diseases, although up to now the underlying pathophysiology of zinc and liver interactions have not been defined...
  83. ncbi Peroxisome proliferator-activated receptors (PPARs) in the control of bone metabolism
    Costas Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 Mikras Asias Street, Athens 11527, Greece
    Fundam Clin Pharmacol 21:231-44. 2007
    ..PPARs, especially of the gamma isotype, could be targets for the treatment of diverse bone diseases such as osteoporosis and osteopenia related to either diabetes or aging...
  84. ncbi Investigation of the lipophilic behaviour of some thiazolidinediones. Relationships with PPAR-gamma activity
    Costas Giaginis
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece
    J Chromatogr B Analyt Technol Biomed Life Sci 857:181-7. 2007
    ..An equation relating pEC(50) data to experimental logD(7.4) or reversed-phase logk(w) values could be established, while pK(i) data did not lead to satisfactory correlation...
  85. ncbi Peroxisome proliferator-activated receptor-gamma and retinoid X receptor-alpha expression in pancreatic ductal adenocarcinoma: association with clinicopathological parameters, tumor proliferative capacity, and patients' survival
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, University of Athens, Athens, Greece
    Med Sci Monit 15:BR148-56. 2009
    ..The aim of the present study was to evaluate the clinical significance of PPAR-gamma and RXR-alpha expression in pancreatic adenocarcinoma...
  86. ncbi PPAR-gamma signaling pathway in placental development and function: a potential therapeutic target in the treatment of gestational diseases
    Costas Giaginis
    University of Athens, Department of Forensic Medicine and Toxicology, Medical School, 75, M Asias Street, Goudi, Athens, GR11527, Greece
    Expert Opin Ther Targets 12:1049-63. 2008
    ..Pleiotropic functions, such as antiproliferative and anti-inflammatory effects against several pathological states, including cardiovascular disease and cancer, are currently being explored in clinical studies...
  87. doi Quantitative structure-activity relationships for PPAR-gamma binding and gene transactivation of tyrosine-based agonists using multivariate statistics
    Costas Giaginis
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, Athens 15771, Greece
    Chem Biol Drug Des 72:257-64. 2008
    ..The higher complexity incorporated in gene transactivation data was further investigated by establishing a PLS model, which improved the inter-relationship between pEC(50) and pKi...
  88. doi Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response
    Maria Konstandi
    Department of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece
    J Appl Toxicol 29:101-9. 2009
    ..Thus, CD may modify drug effectiveness and toxicity, as well as drug-drug interactions, particularly those related to ACET and PB...
  89. ncbi MCM proteins as diagnostic and prognostic tumor markers in the clinical setting
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Histol Histopathol 25:351-70. 2010
    ....
  90. doi Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum
    Athina Zira
    Department of Forensic Medicine and Toxicology, University of Athens, Greece
    J Appl Toxicol 29:395-402. 2009
    ....
  91. doi Primary liver tumors: origin and target therapy
    Michail Papoulas
    University of Athens, Medical School, Department of Forensic Medicine and Toxicology, Goudi, Athens, GR11527, Greece
    Expert Opin Ther Targets 13:957-65. 2009
    ..Recent studies have focused on the ancestors of mature hepatocytes, which are capable of proliferating, differentiating and self-renewing...