Dimitrios J Stravopodis

Summary

Affiliation: University of Athens
Country: Greece

Publications

  1. doi request reprint Data of sperm-entry inability in Drosophila melanogaster ovarian follicles that are depleted of s36 chorionic protein
    Athanassios D Velentzas
    Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens NKUA, Athens, Greece
    Data Brief 12:180-183. 2017
  2. pmc 17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
    Panagiotis K Karkoulis
    Laboratory of Environmental Mutagenesis and Carcinogenesis, Institute of Biology, National Center for Scientific Research NCSR Demokritos, 15310 Athens, Greece
    BMC Cancer 10:481. 2010
  3. ncbi request reprint Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex
    Dimitrios J Stravopodis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis 15784, Zografou, Athens, Greece
    Curr Med Chem 14:3122-38. 2007
  4. ncbi request reprint Mechanisms of programmed cell death during oogenesis in Drosophila virilis
    Athanassios D Velentzas
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Cell Tissue Res 327:399-414. 2007
  5. ncbi request reprint Chromatin condensation of ovarian nurse and follicle cells is regulated independently from DNA fragmentation during Drosophila late oogenesis
    Ioannis P Nezis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Differentiation 74:293-304. 2006
  6. ncbi request reprint Apoptosis and autophagy function cooperatively for the efficacious execution of programmed nurse cell death during Drosophila virilis oogenesis
    Athanassios D Velentzas
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Athens, Greece
    Autophagy 3:130-2. 2007
  7. doi request reprint Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis
    Panagiotis D Velentzas
    Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Zografou, Athens, Greece
    Cell Biol Toxicol 29:13-37. 2013
  8. ncbi request reprint The dual role of chorion peroxidase in Bactrocera oleae chorion assembly
    Ourania A Konstandi
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, 15784 Athens, Greece
    Int J Dev Biol 50:543-52. 2006
  9. ncbi request reprint Autophagy is required for the degeneration of the ovarian follicular epithelium in higher Diptera
    Ioannis P Nezis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
    Autophagy 2:297-8. 2006
  10. ncbi request reprint Programmed cell death of the ovarian nurse cells during oogenesis of the silkmoth Bombyx mori
    Vicky E Mpakou
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Dev Growth Differ 48:419-28. 2006

Collaborators

  • Ioannis P Nezis
  • Issidora S Papassideri
  • George Th Tsangaris
  • Christos Consoulas
  • Konstantinos N Syrigos
  • Juerg Schwaller
  • George Theodoropoulos
  • Christos G Zervas
  • Panagiotis K Karkoulis
  • Athanassios D Velentzas
  • Lukas H Margaritis
  • Panagiotis D Velentzas
  • Vassiliki E Mpakou
  • Eumorphia G Konstantakou
  • Areti K Manta
  • Marianna H Antonelou
  • Athanasios K Anagnostopoulos
  • Adamantia F Fragopoulou
  • Ema Anastasiadou
  • Vicky E Mpakou
  • Gerassimos E Voutsinas
  • Ourania A Konstandi
  • Stamatia Katarachia
  • Niki E Sagioglou
  • Maria M Tsioka
  • Vasiliki K Taraslia
  • Theodoros Karantanos
  • Angeliki Thanasopoulou
  • Antonis D Lampidonis
  • Christos A Kenoutis
  • Triantafyllia G Douroupi
  • Dimitris Thanos
  • Alkiviadis Constantinos Cefalas
  • Alexander P Polyzos
  • Zoe Kollia
  • Evangelia Sarantopoulou
  • Aikaterini S Skouroliakou
  • Deppie Papadopoulou
  • Nikolaos Kostomitsopoulos
  • Evangelos Balafas
  • Aggeliki Stefania Basogianni
  • Efthimios Paronis
  • Alexandros Kouskoukis
  • Asimina D Pantazi
  • Christina Karantanou
  • Dimitrios Pektasidis
  • Maria Gazouli
  • Anna Vaiopoulou
  • Konstantinos Bramis
  • Maria Lymperi
  • Aggeliki Papadopoulou
  • Konstantinos Vougas
  • Eugenia Koutsogiannopoulou
  • Athina Samara
  • Anta Xanthopoulou
  • Konstantinos S Dimas
  • Emmanuel Rogdakis
  • Gerasimos Aravantinos
  • Despina C Stefanidou
  • Zulfiqar Hasan
  • Theodoros Katsorchis
  • Ron Wever
  • Fotini J Karababa
  • Afroditi Loutradi

Detail Information

Publications38

  1. doi request reprint Data of sperm-entry inability in Drosophila melanogaster ovarian follicles that are depleted of s36 chorionic protein
    Athanassios D Velentzas
    Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens NKUA, Athens, Greece
    Data Brief 12:180-183. 2017
    ....
  2. pmc 17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
    Panagiotis K Karkoulis
    Laboratory of Environmental Mutagenesis and Carcinogenesis, Institute of Biology, National Center for Scientific Research NCSR Demokritos, 15310 Athens, Greece
    BMC Cancer 10:481. 2010
    ..In this study, we have investigated the effect of 17-AAG on the regulation of Hsp90-dependent signaling pathways directly implicated in cell cycle progression, survival and motility of human urinary bladder cancer cell lines...
  3. ncbi request reprint Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex
    Dimitrios J Stravopodis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis 15784, Zografou, Athens, Greece
    Curr Med Chem 14:3122-38. 2007
    ..This review includes information on the current model of ternary interactions between Hsp90, client proteins and a vast array of co-chaperones followed by a list of characteristic inhibitors and ongoing clinical trials reported thus far...
  4. ncbi request reprint Mechanisms of programmed cell death during oogenesis in Drosophila virilis
    Athanassios D Velentzas
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Cell Tissue Res 327:399-414. 2007
    ..We propose that apoptosis and autophagy function synergistically during oogenesis in D. virilis in order to achieve a more efficient elimination of the degenerated nurse cells and abnormal egg chambers...
  5. ncbi request reprint Chromatin condensation of ovarian nurse and follicle cells is regulated independently from DNA fragmentation during Drosophila late oogenesis
    Ioannis P Nezis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Differentiation 74:293-304. 2006
    ..The above results demonstrate, for the first time, that chromatin condensation in Drosophila ovarian nurse and follicle cells is a caspase-3-like independent process and is regulated independently from DNA fragmentation...
  6. ncbi request reprint Apoptosis and autophagy function cooperatively for the efficacious execution of programmed nurse cell death during Drosophila virilis oogenesis
    Athanassios D Velentzas
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Athens, Greece
    Autophagy 3:130-2. 2007
    ..We propose that apoptosis and autophagy operate synergistically during D. virilis oogenesis for a more efficient elimination of the degenerated nurse cells...
  7. doi request reprint Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis
    Panagiotis D Velentzas
    Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Zografou, Athens, Greece
    Cell Biol Toxicol 29:13-37. 2013
    ..Our data reveal the in vivo significance of proteasome functional integrity as a major defensive system against cellular toxicity likely occurring during critical biological processes and morphogenetic courses...
  8. ncbi request reprint The dual role of chorion peroxidase in Bactrocera oleae chorion assembly
    Ourania A Konstandi
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, 15784 Athens, Greece
    Int J Dev Biol 50:543-52. 2006
    ..Immunolocalization experiments revealed that bPxd peroxidase constitutes an essential structural chorionic component, being abundantly localized in all the successive chorionic layers and vitelline membrane as well...
  9. ncbi request reprint Autophagy is required for the degeneration of the ovarian follicular epithelium in higher Diptera
    Ioannis P Nezis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
    Autophagy 2:297-8. 2006
    ..The similarity of the cell death process among B. oleae, C. capitata and Drosophila melanogaster species strongly suggests that autophagy-mediated cell death is conserved in higher Diptera species...
  10. ncbi request reprint Programmed cell death of the ovarian nurse cells during oogenesis of the silkmoth Bombyx mori
    Vicky E Mpakou
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Dev Growth Differ 48:419-28. 2006
    ..We propose that apoptosis and autophagy operate synergistically during vitellogenesis of B. mori, in order to achieve an efficient and rapid clearance of the degenerated nurse cell cluster...
  11. pmc Targeted Downregulation of s36 Protein Unearths its Cardinal Role in Chorion Biogenesis and Architecture during Drosophila melanogaster Oogenesis
    Athanassios D Velentzas
    Section of Cell Biology and Biophysics, Department of Biology, School of Science, National and Kapodistrian University of Athens NKUA, Athens, Greece
    Sci Rep 6:35511. 2016
    ..Moreover, we herein unveil a novel function of s36 chorionic protein in the regulation of number and morphogenetic integrity of dorsal appendages in follicles sporadically undergoing aged fly-dependent stress...
  12. doi request reprint Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells
    Dimitrios J Stravopodis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece
    J Cancer Res Clin Oncol 137:359-74. 2011
    ..In the present study, we have investigated the effects of 5-FU treatment on apoptosis induction in wild-type and mutant p53 urinary bladder cancer cells...
  13. ncbi request reprint Stage-specific regulation of programmed cell death during oogenesis of the medfly Ceratitis capitata (Diptera, Tephritidae)
    Athanassios D Velentzas
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
    Int J Dev Biol 51:57-66. 2007
    ..We propose that apoptosis and autophagy operate synergistically during C. capitata oogenesis for a more efficient elimination of the degenerated nurse cells and abnormal egg chambers...
  14. ncbi request reprint Different modes of programmed cell death during oogenesis of the silkmoth Bombyx mori
    Vicky E Mpakou
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
    Autophagy 4:97-100. 2008
    ..In contrast, at the late stages of Bombyx mori oogenesis, paraptosis, autophagy and apoptosis operate synergistically, resulting in a more efficient elimination of the degenerated nurse cells...
  15. ncbi request reprint Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis
    Ioannis P Nezis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Athens, Greece
    Cell Motil Cytoskeleton 60:14-23. 2005
    ..Interestingly, the mutated egg chambers are protected by staurosporine-induced apoptosis in a percentage of 40%, strongly suggesting the essential role of dcp-1 and/or pita during mid-oogenesis...
  16. ncbi request reprint Programmed cell death of follicular epithelium during the late developmental stages of oogenesis in the fruit flies Bactrocera oleae and Ceratitis capitata (Diptera, Tephritidae) is mediated by autophagy
    Ioannis P Nezis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Dev Growth Differ 48:189-98. 2006
    ....
  17. ncbi request reprint Global Proteomic Profiling of Drosophila Ovary: A High-resolution, Unbiased, Accurate and Multifaceted Analysis
    Athanassios D Velentzas
    Department of Cell Biology and Biophysics, Faculty of Biology, School of Sciences, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, Athens, Greece
    Cancer Genomics Proteomics 12:369-84. 2015
    ..melanogaster ovary by applying high-resolution proteomic tools and bioinformatics programs...
  18. pmc Proteasome, but not autophagy, disruption results in severe eye and wing dysmorphia: a subunit- and regulator-dependent process in Drosophila
    Panagiotis D Velentzas
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece
    PLoS ONE 8:e80530. 2013
    ..In toto, our findings clearly demonstrate the gene-specific fundamental contribution of proteasome, but not autophagy, in invertebrate eye and wing organ development. ..
  19. doi request reprint Programmed cell death of the ovarian nurse cells during oogenesis of the ladybird beetle Adalia bipunctata (Coleoptera: Coccinellidae)
    Vassiliki E Mpakou
    Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Greece
    Dev Growth Differ 53:804-15. 2011
    ..bipunctata provide strong evidence for the structural and functional conserved nature of PCD during insect evolution among meroistic telotrophic and meroistic polytrophic ovary-type insects...
  20. ncbi request reprint Follicular atresia during Dacus oleae oogenesis
    Ioannis P Nezis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, 15784 Athens, Greece
    J Insect Physiol 52:282-90. 2006
    ..All these observations also support the notion that mid-oogenesis in D. oleae may be the critical regulation point at which superfluous and defective egg chambers are selectively eliminated before they reach maturity...
  21. ncbi request reprint Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines
    Dimitrios J Stravopodis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, 15784 Athens, Greece
    Int J Oncol 34:137-60. 2009
    ....
  22. pmc 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants
    Eumorphia G Konstantakou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou 15784, Athens, Greece
    Mol Cancer 14:135. 2015
    ....
  23. ncbi request reprint Molecular cloning and tissue-specific transcriptional regulation of the first peroxidase family member, Udp1, in stinging nettle (Urtica dioica)
    Triantafyllia G Douroupi
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, 15784, Athens, Greece
    Gene 362:57-69. 2005
    ....
  24. ncbi request reprint Proteomic analysis of normal murine brain parts
    Vasiliki K Taraslia
    Division of Biotechnology, Centre of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Cancer Genomics Proteomics 10:125-54. 2013
    ..These results will aid in addressing unmet scientific needs regarding physiological and pathological brain functions...
  25. pmc Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster
    Areti K Manta
    a Section of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece
    Fly (Austin) . 2016
    ..melanogaster...
  26. pmc Loss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint control
    Angeliki Thanasopoulou
    Department of Genetics and Gene Therapy, Biomedical Research Foundation of Academy of Athens, Athens, Greece
    PLoS ONE 7:e31007. 2012
    ..These observations suggest that CCDC6 plays a key role in cell cycle control, maintenance of genomic stability and cell survival and provide a rational of how disruption of CCDC6 normal function contributes to malignancy...
  27. ncbi request reprint Modes of programmed cell death during Ceratitis capitata oogenesis
    Ioannis P Nezis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Athens, Greece
    Tissue Cell 35:113-9. 2003
    ..They also suggest that, the sporadic apoptotic pattern consists of a possible protective mechanism throughout oogenesis when damaged or abnormal egg chambers, are eliminated before they reach maturity...
  28. pmc Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines
    Panagiotis K Karkoulis
    Laboratory of Environmental Mutagenesis and Carcinogenesis, Institute of Biosciences and Applications, National Center for Scientific Research NCSR Demokritos, Aghia Paraskevi, 15310, Athens, Greece
    Cancer Cell Int 13:11. 2013
    ..Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone...
  29. doi request reprint 17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy
    Panagiotis K Karkoulis
    Laboratory of Environmental Mutagenesis and Carcinogenesis, Institute of Biosciences and Applications, National Center for Scientific Research NCSR Demokritos, 15310, Athens, Greece
    Tumour Biol 37:6861-73. 2016
    ..In toto, we have clearly demonstrated the dose-dependent and cell type-specific effects of 17-DMAG on the hallmark traits of cancer, appointing Hsp90 as a key molecular component in bladder cancer targeted therapy. ..
  30. doi request reprint Proteasome inhibition induces developmentally deregulated programs of apoptotic and autophagic cell death during Drosophila melanogaster oogenesis
    Panagiotis D Velentzas
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 157 84, Athens, Greece
    Cell Biol Int 35:15-27. 2011
    ..melanogaster, since targeted and cell type-dependent proteasome inactivation initiates developmentally deregulated apoptotic and autophagic mechanisms...
  31. ncbi request reprint Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses
    Eumorphia G Konstantakou
    Department of Cell Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou 157 84, Greece
    Int J Oncol 35:401-16. 2009
    ....
  32. doi request reprint Reactive oxygen species elevation and recovery in Drosophila bodies and ovaries following short-term and long-term exposure to DECT base EMF
    Areti K Manta
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece
    Electromagn Biol Med 33:118-31. 2014
    ....
  33. ncbi request reprint The enzymatic component of Drosophila melanogaster chorion is the Pxd peroxidase
    Ourania A Konstandi
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, 15784 Athens, Greece
    Insect Biochem Mol Biol 35:1043-57. 2005
    ..The immunolocalization approach, using the anti-rAePO polyclonal antibody, has revealed that the Pxd peroxidase is selectively localized in the chorion structures and particularly in the endochorion and innermost chorionic layer (ICL)...
  34. doi request reprint A PCR-based integrated protocol for the structural analysis of the 13th exon of the human beta-myosin heavy chain gene (MYH7): development of a diagnostic tool for HCM disease
    Dimitrios J Stravopodis
    Faculty of Biology, Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis 15784, Zografou, Athens, Greece
    Exp Mol Pathol 84:245-50. 2008
    ..Interestingly, through a DNA sequencing approach, a single nucleotide substitution from "G" to "T" was detected in the adjacent 13th intron, thus divulging the versatile potential of the present molecular protocol to clinical practice...
  35. doi request reprint The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis
    Antonis D Lampidonis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, 157 84 Athens, Greece
    Gene 477:1-11. 2011
    ..We, herein, discuss the metabolic regulation and function of lipases mediating mammalian lipolysis with a focus on HSL, quoting newly identified members of the lipolytic proteome...
  36. doi request reprint Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation
    Adamantia F Fragopoulou
    Department of Cell Biology and Biophysics, Athens University, Athens, Greece
    Electromagn Biol Med 31:250-74. 2012
    ....
  37. doi request reprint Association of the clock genes polymorphisms with colorectal cancer susceptibility
    Theodoros Karantanos
    First Department of Propaedeutic Surgery, School of Medicine, University of Athens, Athens, Greece
    J Surg Oncol 108:563-7. 2013
    ..The aim of our study was to investigate the association between polymorphisms in the CLOCK1, PER2, and PER3 genes with the colorectal cancer (CRC) susceptibility and clinicopathological variables...
  38. ncbi request reprint Defective organization of the erythroid cell membrane in a novel case of congenital anemia
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Greece
    Blood Cells Mol Dis 30:43-54. 2003
    ..Our observations shed light into critical membrane alterations leading to hemolysis in the novel CDA-associated disease and probably into the CDA-I or CDA-I-like diseases...