Panagiotis Vlachostergios

Summary

Affiliation: University of Thessaly, School of Health Sciences, Faculty of Medicine
Location: Larissa, Greece
Summary:
DECEMBER 2009-PRESENT
1st Department of Internal Medicine, General Hospital of Larissa, Greece
National Health System/Teaching Hospital
Resident in Internal Medicine
 Clinical work in the full spectrum of Internal Medicine
 In-patient management
 Emergency cover & management
 Participation in Departmental meetings
 Assistance in the teaching & training of interns and junior residents
AUGUST 2007-PRESENT
Medical Oncology Clinic, University Hospital of Larissa, Greece;
Department of Medical Oncology, School of Medicine, Faculty of Health Sciences University of Thessaly, Greece
National Health System/UniversityTeaching Hospital
Honorary Clinical & Research Associate (Part-time)
• Implementation of clinical and basic research projects; involvement in clinical trials as Co-investigator, attending & participating in daily and on-call activities of the Clinic
OCTOBER 2008-SEPTEMBER 2009
Hellenic Cooperative Oncology Group (HeCOG)
Non-governmental medical organisation (NGO)
Medical Oncology Clinical Study Assistant & Data Manager (Full-time)
• Involvement in HeCOG clinical trials as Sub-investigator, Study Assistant, Data Manager & Translational Research Co-ordinator

Publications

  1. pmc AFP-producing hepatoid adenocarcinoma of the stomach: a case report
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, University of Thessaly, School of Medicine, Larissa, Greece
    Cases J 2:9296. 2009
  2. pmc Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells
    Anna Patrikidou
    Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    Cancer Cell Int 11:13. 2011
  3. pmc The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    J Cell Mol Med 13:3006-18. 2009
  4. doi Nonbacterial thrombotic (marantic) endocarditis in a patient with colorectal cancer
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University Hospital of Larissa, Mezourlo 41110, Larissa, Greece
    Onkologie 33:456-9. 2010
  5. pmc Orbital metastasis of breast carcinoma
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    Breast Cancer (Auckl) 3:91-7. 2009
  6. doi Mini Nutritional Assessment (MNA) and biochemical markers of cachexia in metastatic lung cancer patients: interrelations and associations with prognosis
    Ioannis Gioulbasanis
    Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece
    Lung Cancer 74:516-20. 2011
  7. pmc The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    J Cell Mol Med 13:3019-31. 2009
  8. pmc The ubiquitin-proteasome system in glioma cell cycle control
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, 41110, Greece
    Cell Div 7:18. 2012
  9. pmc Neuropeptide-inducible upregulation of proteasome activity precedes nuclear factor kappa B activation in androgen-independent prostate cancer cells
    Anna Patrikidou
    Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    Cancer Cell Int 12:31. 2012
  10. pmc The Bmi-1/NF-κB/VEGF story: another hint for proteasome involvement in glioma angiogenesis?
    Panagiotis J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, 41110, Larissa, Greece
    J Cell Commun Signal 7:235-7. 2013

Collaborators

Detail Information

Publications19

  1. pmc AFP-producing hepatoid adenocarcinoma of the stomach: a case report
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, University of Thessaly, School of Medicine, Larissa, Greece
    Cases J 2:9296. 2009
    ..Poor outcome in most of the cases is due to the fact that, as in our patient, metastatic disease is already present at diagnosis...
  2. pmc Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells
    Anna Patrikidou
    Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    Cancer Cell Int 11:13. 2011
    ..Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process...
  3. pmc The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    J Cell Mol Med 13:3006-18. 2009
    ....
  4. doi Nonbacterial thrombotic (marantic) endocarditis in a patient with colorectal cancer
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University Hospital of Larissa, Mezourlo 41110, Larissa, Greece
    Onkologie 33:456-9. 2010
    ..Marantic endocarditis, presently termed nonbacterial thrombotic endocarditis (NBTE), is an infrequent post-mortem diagnosis in the adult population but a not so rare event in the course of neoplastic conditions...
  5. pmc Orbital metastasis of breast carcinoma
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    Breast Cancer (Auckl) 3:91-7. 2009
    ..Breast cancer accounts for the majority of these cases. The appearance of eye symptoms in patients with a history of cancer should always be investigated with a consideration of ocular metastatic disease...
  6. doi Mini Nutritional Assessment (MNA) and biochemical markers of cachexia in metastatic lung cancer patients: interrelations and associations with prognosis
    Ioannis Gioulbasanis
    Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece
    Lung Cancer 74:516-20. 2011
    ..The aim of this study was to evaluate the correlation of MNA with laboratory markers of inflammation/cachexia in patients with metastatic lung cancer. The prognostic value of the measured parameters was also examined...
  7. pmc The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation
    Panagiotis J Vlachostergios
    Division of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    J Cell Mol Med 13:3019-31. 2009
    ..Furthermore, the contribution of UPS to the regulation of localization and accessibility of DNA repair proteins to chromatin, in response to cellular stress is discussed...
  8. pmc The ubiquitin-proteasome system in glioma cell cycle control
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, 41110, Greece
    Cell Div 7:18. 2012
    ....
  9. pmc Neuropeptide-inducible upregulation of proteasome activity precedes nuclear factor kappa B activation in androgen-independent prostate cancer cells
    Anna Patrikidou
    Department of Medical Oncology, University Hospital of Larissa, Larissa, Greece
    Cancer Cell Int 12:31. 2012
    ....
  10. pmc The Bmi-1/NF-κB/VEGF story: another hint for proteasome involvement in glioma angiogenesis?
    Panagiotis J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, 41110, Larissa, Greece
    J Cell Commun Signal 7:235-7. 2013
    ....
  11. pmc The Role of the Small Ubiquitin-Related Modifier (SUMO) Pathway in Prostate Cancer
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University of Thessaly School of Medicine, University Hospital of Larissa, Biopolis 41110, Larissa, Greece
    Biomolecules 2:240-55. 2012
    ..Thus, an important role has been revealed for members of the SUMO pathway in prostate cancer (PCa) development and progression, offering new therapeutic targets. ..
  12. pmc Hashimoto's Thyroiditis and Kikuchi's Disease: Presentation of a Case and Review of the Literature
    Athanasios Saratziotis
    Department of Otorhinolaryngology, General Hospital of Larissa, 41221 Larissa, Greece
    Case Report Otolaryngol 2012:267595. 2012
    ....
  13. doi Predictive and prognostic value of LPS-stimulated cytokine secretion in metastatic non-small cell lung cancer
    P J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Larissa, 41110, Greece
    Clin Transl Oncol 15:903-9. 2013
    ..The aim of this study was to investigate the clinical relevance of chemokine response after lipopolysaccharide (LPS)-stimulation in metastatic non-small cell lung cancer (NSCLC)...
  14. doi Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner
    Panagiotis J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41110, Larissa, Greece
    Invest New Drugs 31:1169-81. 2013
    ..Collectively, these results suggest that proteasome inhibition by BZ overcomes MGMT-mediated GBM chemoresistance, with scheduling of administration being critical for obtaining the maximal tumoricidal effect of combination with TMZ...
  15. doi Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma
    Panagiotis J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Larissa, 41110, Greece
    Cell Biol Toxicol 29:199-211. 2013
    ....
  16. doi The role of ubiquitin-proteasome system in glioma survival and growth
    Panagiotis J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larissa, Larissa, Greece
    Growth Factors 31:106-13. 2013
    ..In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas...
  17. doi Bortezomib downregulates MGMT expression in T98G glioblastoma cells
    Panagiotis J Vlachostergios
    Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41110, Larissa, Greece
    Cell Mol Neurobiol 33:313-8. 2013
    ..Taken together, these results suggest a novel role for bortezomib as a potent MGMT inhibitor and support its ongoing testing as a chemosensitizer in glioblastoma...
  18. pmc Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece
    J Negat Results Biomed 11:2. 2012
    ..Available clinical data of time to PSA recurrence were correlated with the examined parameters and combined with pre-operative PSA level, Gleason score and pathological TNM (pT) stage assessment...
  19. doi p53 and cyclooxygenase-2 expression are directly associated with cyclin D1 expression in radical prostatectomy specimens of patients with hormone-naïve prostate cancer
    Panagiotis J Vlachostergios
    Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Biopolis, 41110, Larissa, Greece
    Pathol Oncol Res 18:245-52. 2012
    ..With respect to COX-2 and cyclin D1, further studies are required to elucidate their role in early prediction of PCa relapse after RP...