Halise Inci Gul

Summary

Publications

  1. doi Synthesis of some Mannich bases with dimethylamine and their hydrazones and evaluation of their cytotoxicity against Jurkat cells
    Kaan Kucukoglu
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 61:366-71. 2011
  2. ncbi Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone
    H I Gul
    Department of Chemistry, University of Kuopio, Kuopio, Finland
    Arzneimittelforschung 51:72-5. 2001
  3. ncbi Syntheses and stability studies of some Mannich bases of acetophenones and evaluation of their cytotoxicity against Jurkat cells
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Arzneimittelforschung 52:628-35. 2002
  4. ncbi Antifungal evaluation of bis Mannich bases derived from acetophenones and their corresponding piperidinols and stability studies
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 25:1307-10. 2002
  5. ncbi Antimicrobial evaluation of some Mannich bases of acetophenones and representative quaternary derivatives
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Arzneimittelforschung 52:773-7. 2002
  6. ncbi Cytotoxic activities of some mono and bis Mannich bases derived from acetophenone in brine shrimp bioassay
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 52:840-3. 2002
  7. ncbi Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 52:863-9. 2002
  8. ncbi Cytotoxicity of some azines of acetophenone derived mono-Mannich bases against Jurkat cells
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 26:631-7. 2003
  9. ncbi Synthesis and cytotoxicity of novel 3-aryl-1-(3'-dibenzylaminomethyl-4'-hydroxyphenyl)-propenones and related compounds
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Chem Pharm Bull (Tokyo) 56:1675-81. 2008
  10. ncbi Evaluation of anticonvulsant activities of bis(3-aryl-3-oxo-propyl) ethylamine hydrochlorides and 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinol hydrochlorides
    Halise Inci Gul
    Ataturk University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Erzurum, Turkey
    Arzneimittelforschung 57:133-6. 2007

Collaborators

Detail Information

Publications39

  1. doi Synthesis of some Mannich bases with dimethylamine and their hydrazones and evaluation of their cytotoxicity against Jurkat cells
    Kaan Kucukoglu
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 61:366-71. 2011
    ....
  2. ncbi Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone
    H I Gul
    Department of Chemistry, University of Kuopio, Kuopio, Finland
    Arzneimittelforschung 51:72-5. 2001
    ..Our results suggest that acetophenone derived mono Mannich base 3 and quaternary derivatives 4 and 8 may serve as leading compounds for further studies to develop new antifungal agents with their highly potent antifungal activity...
  3. ncbi Syntheses and stability studies of some Mannich bases of acetophenones and evaluation of their cytotoxicity against Jurkat cells
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Arzneimittelforschung 52:628-35. 2002
    ..Quaternization procedure also increased the cytotoxicity in both series I and III. Quaternary derivatives seem to be promising compounds for further studies to develop new anticancer drugs...
  4. ncbi Antifungal evaluation of bis Mannich bases derived from acetophenones and their corresponding piperidinols and stability studies
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 25:1307-10. 2002
    ..Even though all compounds showed antifungal activity against dermatophytes, bis Mannich bases B1, B2, B4, and B5 appear to have potential for developing novel antifungal agents against dermatophytes...
  5. ncbi Antimicrobial evaluation of some Mannich bases of acetophenones and representative quaternary derivatives
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Arzneimittelforschung 52:773-7. 2002
    ..Especially compound IIIf may serve as a model compound to develop new agents against dermatophytes...
  6. ncbi Cytotoxic activities of some mono and bis Mannich bases derived from acetophenone in brine shrimp bioassay
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 52:840-3. 2002
    ....
  7. ncbi Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 52:863-9. 2002
    ..Since no neurotoxicity was detected for the compounds B4 and C4, they seem to be candidate compounds for further synthesis and in vivo studies for their potential anticonvulsant activity...
  8. ncbi Cytotoxicity of some azines of acetophenone derived mono-Mannich bases against Jurkat cells
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 26:631-7. 2003
    ..Azine derivatives with equal or less cytotoxic potency compared to the mono-Mannich bases they are derived from seemed to be less suitable derivatives for the development of new cytotoxic compounds...
  9. ncbi Synthesis and cytotoxicity of novel 3-aryl-1-(3'-dibenzylaminomethyl-4'-hydroxyphenyl)-propenones and related compounds
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Chem Pharm Bull (Tokyo) 56:1675-81. 2008
    ..The results suggested that it is not only the pK(a) but also the shape and size of the amine that is critical in governing the cytotoxic activity...
  10. ncbi Evaluation of anticonvulsant activities of bis(3-aryl-3-oxo-propyl) ethylamine hydrochlorides and 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinol hydrochlorides
    Halise Inci Gul
    Ataturk University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Erzurum, Turkey
    Arzneimittelforschung 57:133-6. 2007
    ....
  11. ncbi Biological activity of 1-aryl-3-phenethylamino-1-propanone hydrochlorides and 3-aroyl-4-aryl-1-phenethyl-4-piperidinols on PC-3 cells and DNA topoisomerase I enzyme
    Ebru Mete
    Department of Chemistry, Faculty of Sciences, Ataturk University, 25240, Erzurum, Turkey
    Z Naturforsch C 65:647-52. 2010
    ....
  12. doi Cytotoxicity of 1-aryl-3-buthylamino-1-propanone hydrochlorides against Jurkat and L6 cells
    Mustafa Gul
    Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 59:364-9. 2009
    ..These results suggest that the most potent compound 5 (a 4-bromo derivative) against both cell lines may serve as a model compound to develop new cytotoxic agents for further studies...
  13. ncbi Effect of some bis Mannich bases and corresponding piperidinols on DNA topoisomerase I
    Pakize Canturk
    Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Izmir, Turkey
    Arzneimittelforschung 58:686-91. 2008
    ..Among the compounds studied, the most potent topoisomerase I inhibiting compounds B1 (46%) and B3 (40%) may serve as model compounds to develop new more potent topoisomerase inhibitors in future studies...
  14. doi Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 24:804-7. 2009
    ..23 and 4.21, respectively) and exerted both highest cytotoxicity and strongest DNA topoisomerase I inhibition. Compounds I and II gave moderate interference with the DNA topoisomerase I while III & V did not interfere with the enzyme...
  15. ncbi Synthesis of some mono-Mannich bases and corresponding azine derivatives and evaluation of their anticonvulsant activity
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 54:359-64. 2004
    ....
  16. ncbi Evaluation of antimicrobial activities of several mannich bases and their derivatives
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arch Pharm (Weinheim) 338:335-8. 2005
    ..Especially quaternary derivatives Ig4, and to some extent C6, seem to be model compounds to develop new antimicrobial agents for further studies...
  17. doi 1-(3-aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: a novel group of tumour-selective cytotoxins
    Sinan Bilginer
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 28:974-80. 2013
    ..A representative compound 4c caused cleavage of PARP1 in HSC-2 cells but not in HGF cells, which may be a contributing factor to the tumour-selectivity. ..
  18. doi Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects
    Halise Inci Gul
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 31:568-73. 2016
    ..79 ± 0.22-2.73 ± 0.08 nM against hCA I and in the range of 1.72 ± 0.58-11.64 ± 5.21 nM against hCA II, respectively. ..
  19. ncbi Biological evaluation and structure-activity relationships of bis-(3-aryl-3-oxo-propyl)-methylamine hydrochlorides and 4-aryl-3-arylcarbonyl-1-methyl-4-piperidinol hydrochlorides as potential cytotoxic agents and their alkylating ability towards cellular
    Mustafa Gul
    Department of Physiology, Faculty of Medicine, University of Kuopio, Kuopio, Finland
    Arzneimittelforschung 55:332-7. 2005
    ..Bis-Mannich bases 1a, 1c and 1e may serve as candidate anticancer agents for future development...
  20. ncbi Evaluation of the cytotoxicity of some mono-mannich bases and their corresponding azine derivatives against androgen-independent prostate cancer cells
    Halise Inci Gul
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    Arzneimittelforschung 56:850-4. 2006
    ..The results emerged from this investigation guide the future expansion of these series of compounds...
  21. ncbi Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones
    Elif Unluer
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 31:105-109. 2016
    ..Chemical modifications of this lead are thus necessary to further investigate it as a drug candidate and to obtain compounds with a better activity profile...
  22. doi Synthesis and antifungal evaluation of 1-aryl-2-dimethyl- aminomethyl-2-propen-1-one hydrochlorides
    Ebru Mete
    Department of Chemistry, Faculty of Sciences, Ataturk University, 25240 Erzurum, Turkey
    Molecules 16:4660-71. 2011
    ..In addition, microwave irradiation can be considered to reduce reaction period, while the conventional method can still be considered to obtain compounds with higher reaction yields in the synthesis of new Mannich bases...
  23. ncbi Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines
    Kaan Kucukoglu
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem . 2016
    ..5-55.5 nM against hCA I and of 18.9-28.8 nM against hCA II, respectively...
  24. doi Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides
    Halise Inci Gul
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 31:1619-24. 2016
    ....
  25. ncbi Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides
    Halise Inci Gul
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem . 2016
    ..5-923 nM and 6.2-95 nM, respectively. These compounds were 2.5-13.4 times more selective for the inhibition of hCA XII versus hCA IX, except compound 2 which had similar inhibitory action towards both isoenzymes...
  26. doi Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
    Dilan Ozmen Ozgun
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ağrı İbrahim Çeçen University, Agri, Turkey
    J Enzyme Inhib Med Chem 31:1498-501. 2016
    ..This study suggests that isatin Mannich bases P1-P3 are good candidate compounds especially for the development of new cholinesterase inhibitors since they were 2.2-5.9 times better inhibitors than clinically used drug Tacrine. ..
  27. doi The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes
    Cem Yamali
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey and
    J Enzyme Inhib Med Chem 31:1678-81. 2016
    ..All compounds synthesized 1-15 were 1.3-1.9 times more effective on hCA II comparing with the effectivenes of the compounds on hCA I. ..
  28. ncbi Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines
    Halise Inci Gul
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem . 2016
    ....
  29. ncbi The effects of some Mannich bases on heat shock proteins HSC70 and GRP75, and thioredoxin and glutaredoxin levels in Jurkat cells
    Mustafa Gul
    Department of Physiology, Faculty of Medicine, University of Kuopio, 70211 Kuopio, Finland
    Toxicol In Vitro 19:573-80. 2005
    ....
  30. ncbi Synthesis of 1-Aryl-3-phenethylamino-1-propanone hydrochlorides as possible potent cytotoxic agents
    Ebru Mete
    Department of Chemistry, Faculty of Arts and Sciences, Ataturk University, 25240, Erzurum, Turkey
    Molecules 12:2579-88. 2007
    ..This study may serve as a guide for the conditions of the reactions to synthesizecompounds having similar chemical structures...
  31. ncbi Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases
    Cem Yamali
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem . 2016
    ..5-5.2 times) toward hCA I isoenzyme. It seems that the compounds need molecular modifications for the development of better CA inhibitors...
  32. doi Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities
    Mehtap Tugrak
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey and
    J Enzyme Inhib Med Chem 31:818-23. 2016
    ..According to data obtained, the compound MT8 with the highest PSE value bearing N-methylpiperazine moiety seems to be a good candidate to develop new cytotoxic compounds and is suited for further investigation. ..
  33. doi Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives
    Kadir Ozden Yerdelen
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey and
    J Enzyme Inhib Med Chem 30:383-8. 2015
    ..Using specific concentrations of compounds 4 and 6 caused cleavage of PARP1 in HSC-2 cells but not HGF cells, which may be a contributing factor to cytotoxicities and the tumour-selectivities. ..
  34. doi Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II
    Halise Inci Gul
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey and
    J Enzyme Inhib Med Chem 31:1540-4. 2016
    ..The CA inhibitory properties of these compounds were tested on the human carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I and hCA II. These new compounds, as many phenols show moderate CA inhibitory properties. ..
  35. doi Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
    Kaan Kucukoglu
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 30:564-8. 2015
    ..In the light of these results, compounds 2a, 2c, 2f, 2g and 3 may serve as model compounds for further studies. ..
  36. doi Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase
    Sinan Bilginer
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
    J Enzyme Inhib Med Chem 29:495-9. 2014
    ..8-52.4 µM (hCA II). The model organism S. cerevisiae and this particular enzyme may be useful for detecting antifungals with a novel mechanism of action compared to the classical azole drugs to which significant drug resistance emerged...
  37. ncbi Anti-inflammatory activity of bis(3-aryl-3-oxo-propyl)methylamine hydrochloride in rat
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 30:63-7. 2007
    ..Further detailed studies are needed to clarify the mechanism(s) of action responsible for the anti-inflammatory activity of B1...
  38. doi Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities
    Halise Inci Gul
    a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey and
    J Enzyme Inhib Med Chem 31:147-51. 2016
    ..PSE of the compound TA2, which has a methyl substituent on phenyl ring, pointed out the compound TA2 as a leader compound to be considered. ..
  39. ncbi Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride
    Halis Suleyman
    Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey
    Pharmacol Res 47:471-5. 2003
    ..1 and 43.1%, respectively, in cotton pellet test. C1 and indomethacin both significantly inhibited the hyaluronidase-induced increase in capillary permeability...