Marcela Hern

Summary

Affiliation: Faculty of Dentistry Universidad de Chile
Location: Santiago, Chile
Summary:
Dentistry, Oral Pathologist, PhD Candidate in dental sciences University of Helsinki
Grants:
Proteolytic patterns associated with chronic periodontitis progression and their relationship with MMP-13 activity DI MULT 06/05-2. 2006-2007; Funding: Universidad de Chile

Gingival crevicular fluid characterization in teeth with apical periodontitis and its aplplication to clinical monitoring DI 07/02-2, 2008-2009; Funding: Universidad de Chile

Characterization of oxidant status and MMP-mediated proteolysis during progression of apical periodontitis in gingival crevicular fluid: A new tool in the search of early prognostic markers?
Publications:
Pther ISI publications

Levels of interleukin 21 in untreated chronic periodontitis patients. 2011. Accepted in press in J Periodontol.

Host-pathogen interactions in progressive chronic Periodontitis; 2011 J Dent Res. Oct;90(10):1164-70.

Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines. 2010. Pharmacol Res. Oct 16. [Epub ahead of print].

MCP-3/CCL-7: Possible involvement in Apical Periodontitis Chemotaxis. 2010. Int Endod J. Oct;43(10):902-8. doi: 10.1111/j.1365-2591.2010.01764.x. Epub 2010 Jul 15.

Mouthrinse MMP-8 point-of-care test identifies patients with severe periodontitis. 2010. Oral Dis. Jul 23. [Epub ahead of print].

Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods

Publications

  1. doi Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods
    T Sorsa
    Institute of Dentistry, University of Helsinki, 00014 Helsinki, Finland
    Oral Dis 16:39-45. 2010
  2. ncbi Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity
    Marcela Hernandez
    Periodontal Biology Laboratory, Dentistry School, University of Chile, Santiago, Chile
    J Periodontol 77:1863-70. 2006
  3. ncbi High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes
    Rolando Vernal
    Periodontal Biology Laboratory, Conservative Department, Dentistry Faculty, University of Chile, Santiago, Chile
    J Periodontol 77:1772-80. 2006
  4. doi Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
    Nora Silva
    Area de Microbiologia, Dentistry School, University of Chile, Santiago, Chile
    J Clin Periodontol 35:206-14. 2008
  5. doi Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis
    Andrea Dezerega
    Periodontal Biology Laboratory, Conservative Dentistry Department, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Periodontol 81:267-76. 2010
  6. ncbi Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis
    Nicolas Dutzan
    Periodontal Biology Laboratory, Department of Conservative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile
    J Periodontol 80:290-6. 2009
  7. doi Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin.
    M Salinas Mu oz
    Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile
    Clin Oral Investig 21:2613-2618. 2017
  8. pmc Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response
    Andrea Dezerega
    Laboratorio de Biología Periodontal, Facultad de Odontologia, Avenida Sergio Livingstone 943, Comuna de Independencia, Santiago, Chile
    J Inflamm (Lond) 9:8. 2012
  9. ncbi MMP-13 and TIMP-1 determinations in progressive chronic periodontitis
    Marcela Hernandez
    Periodontal Biology Laboratory, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Clin Periodontol 34:729-35. 2007
  10. doi Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade
    Marcela Hernández Ríos
    Periodontal Biology Laboratory, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Clin Periodontol 36:1011-7. 2009

Collaborators

  • R Vernal
  • Carlos Lopez-Otin
  • C M Overall
  • Marcela Hernandez
  • Jorge Gamonal
  • Andrea Dezerega
  • M Hernandez
  • Nicolas Dutzan
  • T Sorsa
  • Patricia Pozo
  • Oriana Rivera
  • Nora Silva
  • M Salinas Mu oz
  • Maria Antonieta Valenzuela
  • Mauricio Garrido
  • T Tervahartiala
  • J Gamonal
  • P Mäntylä
  • Marcela Hernández Ríos
  • Juan Carlos Aguillon
  • María José Belmar
  • Benjamin Martinez
  • M Garrido Flores
  • J Garc a Sesnich
  • R Bologna
  • M Baeza
  • P Huam n Chipana
  • M Hern ndez
  • Verónica Mundi
  • Ana V Ortega
  • Rodolfo Paredes
  • Sonia Madrid
  • Jocelyn Garcia-Sesnich
  • Maria A Valenzuela
  • T Salo
  • M Hukkanen
  • L Tjäderhane
  • Alejandro Oyarzún
  • Emilio Ortiz
  • S Munjal
  • Ana Gutierrez-Fernandez
  • O Rivera
  • Marcela Alcota
  • N Dutzan
  • L Netuschil
  • J Leppilahti
  • A Dezerega
  • Marek Molas
  • Taina Tervahartiala
  • Javier Puente
  • Emmanuel Lesaffre
  • Timo Sorsa
  • Fabián Obregón
  • Octavio Aravena
  • Pedro Lastres
  • Carolina Pabst
  • José María Tejerina
  • Jose Manuel Lopez
  • Jesus Alvarez

Detail Information

Publications13

  1. doi Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods
    T Sorsa
    Institute of Dentistry, University of Helsinki, 00014 Helsinki, Finland
    Oral Dis 16:39-45. 2010
    ..The aim of the study was to compare four methods for gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-8 detection...
  2. ncbi Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity
    Marcela Hernandez
    Periodontal Biology Laboratory, Dentistry School, University of Chile, Santiago, Chile
    J Periodontol 77:1863-70. 2006
    ..We also determined the activity of MMP-13 present in lesions undergoing episodic attachment loss in gingival crevicular fluid (GCF) samples...
  3. ncbi High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes
    Rolando Vernal
    Periodontal Biology Laboratory, Conservative Department, Dentistry Faculty, University of Chile, Santiago, Chile
    J Periodontol 77:1772-80. 2006
    ..Our study was aimed at associating the levels of RANKL with the CD4(+) T-cell activity present in gingival tissues of chronic periodontitis patients...
  4. doi Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
    Nora Silva
    Area de Microbiologia, Dentistry School, University of Chile, Santiago, Chile
    J Clin Periodontol 35:206-14. 2008
    ..The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells in periodontal sites characterized by active periodontal connective tissue destruction...
  5. doi Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis
    Andrea Dezerega
    Periodontal Biology Laboratory, Conservative Dentistry Department, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Periodontol 81:267-76. 2010
    ..The aim of this study is to determine the levels and expression of MCP-3 in periodontal sites characterized by active periodontal connective tissue destruction...
  6. ncbi Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis
    Nicolas Dutzan
    Periodontal Biology Laboratory, Department of Conservative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile
    J Periodontol 80:290-6. 2009
    ....
  7. doi Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin.
    M Salinas Mu oz
    Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile
    Clin Oral Investig 21:2613-2618. 2017
    ..Clinically symptomatic apical periodontitis might represent biologically progressive apical lesions based on TRAP5 levels. TRAP5 has diagnostic potential to identify these lesions, representing a candidate prognostic biomarker...
  8. pmc Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response
    Andrea Dezerega
    Laboratorio de Biología Periodontal, Facultad de Odontologia, Avenida Sergio Livingstone 943, Comuna de Independencia, Santiago, Chile
    J Inflamm (Lond) 9:8. 2012
    ....
  9. ncbi MMP-13 and TIMP-1 determinations in progressive chronic periodontitis
    Marcela Hernandez
    Periodontal Biology Laboratory, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Clin Periodontol 34:729-35. 2007
    ....
  10. doi Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade
    Marcela Hernández Ríos
    Periodontal Biology Laboratory, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Clin Periodontol 36:1011-7. 2009
    ..We additionally addressed whether MMP-13 could potentiate gelatinase activation in diseased gingival tissue...
  11. doi Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study
    M Hernandez
    Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Periodontol 81:1644-52. 2010
    ....
  12. doi Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice
    M Hernandez
    Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago, Chile
    J Periodontal Res 46:58-66. 2011
    ..Therefore, the aim of this study was to characterize the expression of LIX/CXCL5, SDF1/CXCL12 and RANKL in Porphyromonas gingivalis-induced experimental periodontitis in MMP-8⁻/⁻ (knockout) and wild-type mice...
  13. doi Gelatinolytic activity in gingival crevicular fluid from teeth with periapical lesions
    María José Belmar
    Department of Oral Pathology, Faculty of Dentistry, Universidad Mayor, Santiago, Chile
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:801-6. 2008
    ..The aim of this study was to determine gelatinolytic activity in gingival crevicular fluid (GCF) from teeth with apical lesions and healthy controls...