A Hrabak

Summary

Affiliation: Semmelweis University
Country: Hungary

Publications

  1. doi request reprint The effect of various inflammatory agents on the phagocytosis and cytokine profile of mouse and rat macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Inflamm Res 57:75-83. 2008
  2. ncbi request reprint The inhibitory effect of various indolyl amino acid derivatives on arginase activity in macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Medical School, Budapest, Hungary
    Amino Acids 34:293-300. 2008
  3. ncbi request reprint The inhibitory effect of nitrite, a stable product of nitric oxide (NO) formation, on arginase
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Medical School, Budapest, Hungary
    FEBS Lett 390:203-6. 1996
  4. ncbi request reprint Action of chloroquine on nitric oxide production and parasite killing by macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Eur J Pharmacol 354:83-90. 1998
  5. ncbi request reprint Indomethacin prevents the induction of inducible nitric oxide synthase in murine peritoneal macrophages and decreases their nitric oxide production
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Life Sci 68:1923-30. 2001
  6. pmc Common ligands of G-protein-coupled receptors and arginine-utilizing enzymes
    András Hrabák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, VIII Puskin u 9, H 1444 POB 260, Hungary
    Br J Pharmacol 147:835-7. 2006
  7. ncbi request reprint The effect of various inflammatory agents on the alternative metabolic pathways of arginine in mouse and rat macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Inflamm Res 55:23-31. 2006
  8. ncbi request reprint The cytotoxic anti-tumor effect of MTH-68/H, a live attenuated Newcastle disease virus is mediated by the induction of nitric oxide synthesis in rat peritoneal macrophages in vitro
    András Hrabák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, VIII, Puskin u 9, P O Box 260, H 1444 Budapest, Hungary
    Cancer Lett 231:279-89. 2006
  9. ncbi request reprint Differences in the nitric oxide metabolism in streptozotocin-treated rats and children suffering from Type 1 diabetes
    András Hrabák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, VIII Puskin u 9, postal address H 1444, POB 260, Hungary
    Life Sci 78:1362-70. 2006
  10. ncbi request reprint The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats
    A Szabo
    2nd Department of Ophthalmology, Semmelweis University, Budapest, Hungary
    Inflamm Res 53:262-7. 2004

Collaborators

Detail Information

Publications14

  1. doi request reprint The effect of various inflammatory agents on the phagocytosis and cytokine profile of mouse and rat macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Inflamm Res 57:75-83. 2008
    ..The correlations between cytokine concentrations and the expressions of NOS II and arginase were also studied...
  2. ncbi request reprint The inhibitory effect of various indolyl amino acid derivatives on arginase activity in macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Medical School, Budapest, Hungary
    Amino Acids 34:293-300. 2008
    ..Computer studies that were performed did not provide additional structural information...
  3. ncbi request reprint The inhibitory effect of nitrite, a stable product of nitric oxide (NO) formation, on arginase
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University Medical School, Budapest, Hungary
    FEBS Lett 390:203-6. 1996
    ..This inhibition was non-competitive, and could not be explained by the reaction of nitrite with arginine, or by the irreversible covalent modification of arginase, or by the removal of Mn2+, a cofactor of arginase...
  4. ncbi request reprint Action of chloroquine on nitric oxide production and parasite killing by macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Eur J Pharmacol 354:83-90. 1998
    ..cruzi). This suggests that chloroquine decreases NO formation by macrophages by inhibiting the induction of NO synthase. The findings are further evidence that NO is involved in the anti-parasitic response of macrophages...
  5. ncbi request reprint Indomethacin prevents the induction of inducible nitric oxide synthase in murine peritoneal macrophages and decreases their nitric oxide production
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Life Sci 68:1923-30. 2001
    ..Indomethacin also decreased uridine incorporation in macrophages. The effect of indomethacin on the induction of other enzymes (i.e. arginase) was weaker...
  6. pmc Common ligands of G-protein-coupled receptors and arginine-utilizing enzymes
    András Hrabák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, VIII Puskin u 9, H 1444 POB 260, Hungary
    Br J Pharmacol 147:835-7. 2006
    ..In order to define the most potent agonists, and elucidate further the biological significance of the receptor family, a detailed ligand-based quantitative structure-activity relationship study may be helpful...
  7. ncbi request reprint The effect of various inflammatory agents on the alternative metabolic pathways of arginine in mouse and rat macrophages
    A Hrabak
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Inflamm Res 55:23-31. 2006
    ..The effects of various inflammatory stimuli on the alternative arginine metabolic pathways in mouse and rat peritoneal macrophages were investigated in vitro and compared...
  8. ncbi request reprint The cytotoxic anti-tumor effect of MTH-68/H, a live attenuated Newcastle disease virus is mediated by the induction of nitric oxide synthesis in rat peritoneal macrophages in vitro
    András Hrabák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, VIII, Puskin u 9, P O Box 260, H 1444 Budapest, Hungary
    Cancer Lett 231:279-89. 2006
    ..These results strongly suggested the participation of induced NO synthesis of macrophages in the anti-tumor effect of MTH-68/H vaccine treatment...
  9. ncbi request reprint Differences in the nitric oxide metabolism in streptozotocin-treated rats and children suffering from Type 1 diabetes
    András Hrabák
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, VIII Puskin u 9, postal address H 1444, POB 260, Hungary
    Life Sci 78:1362-70. 2006
    ....
  10. ncbi request reprint The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats
    A Szabo
    2nd Department of Ophthalmology, Semmelweis University, Budapest, Hungary
    Inflamm Res 53:262-7. 2004
    ..The effect of a steroid and a non-steroid anti-inflammatory drug on the inducible nitric oxide synthase (NOS II) in rats suffering from lipopolysaccharide (LPS)-induced uveoretinitis was studied...
  11. ncbi request reprint Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages
    A Hrabak
    Department of Biochemistry I, Semmelweis University Medical School, Budapest, Hungary
    Biochem Biophys Res Commun 198:206-12. 1994
    ..The comparison of these effects of arginine analogues and derivatives made possible a computer-aided approximation for the fitting of active centers of these enzymes to their substrates...
  12. ncbi request reprint The salvage of deoxycytidine into dCDP-diacylglycerol by macrophages and lymphocytes
    A Hrabak
    Department of Biochemistry I, Semmelweis University Medical School, Budapest, Hungary
    Biochem Biophys Res Commun 193:212-9. 1993
    ..No interconversion between deoxy- and and ribocytidine could be observed neither in lymphocytes nor in macrophages...
  13. ncbi request reprint Systematic investigation of different steroid precursors with respect to their effect on superoxide anion production by human neutrophil granulocytes
    G Bekesi
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Horm Metab Res 36:155-63. 2004
    ..This may lead to new opportunities for finding really efficient antioxidants, which might perhaps be used in a combined manner with other agents in the fight against certain life-threatening diseases...
  14. ncbi request reprint Plasma concentration of myeloperoxidase enzyme in pre- and post-climacterial people: related superoxide anion generation
    G Bekesi
    2nd Department of Medicine, Semmelweis University, Szentkirályi utca 46, 1088, Budapest, Hungary
    Exp Gerontol 37:137-48. 2001
    ..Thus, after further studies MPO might become one of the indicators of cardiovascular risk and the scavenger capacity in general...