Bela Gyurcsik

Summary

Affiliation: University of Szeged
Location: Szeged, Hungary
URL: http://www.staff.u-szeged.hu/~gyurcsik/
Summary:
Bioinorganic chemistry, artificial metallonucleases.

Publications

  1. doi request reprint Towards artificial metallonucleases for gene therapy: recent advances and new perspectives
    Bela Gyurcsik
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6720 Szeged, Hungary
    Future Med Chem 3:1935-66. 2011
  2. doi request reprint Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease
    Andrea Lakatos
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6720, Szeged, Hungary
    Dalton Trans 41:1713-26. 2012
  3. doi request reprint Towards the role of metal ions in the structural variability of proteins: CdII speciation of a metal ion binding loop motif
    Attila Jancsó
    Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary
    Metallomics 3:1331-9. 2011
  4. doi request reprint Theoretical design of a specific DNA-Zinc-finger protein interaction with semi-empirical quantum chemical methods
    Gabor Nagy
    Department of Physical Chemistry and Material Sciences, University of Szeged, Aradi Vertanuk tere 1, H 6720 Szeged, Hungary
    J Mol Graph Model 29:928-34. 2011
  5. doi request reprint Effect of fluorine position on the coordinating ability of fluorosalicylic acids--an experimental study complemented with computations
    Terézia Szabó-Plánka
    Department of Physical Chemistry and Material Sciences, University of Szeged, Aradi Vertanuk tere 1, H 6720 Szeged, Hungary
    J Inorg Biochem 105:75-83. 2011
  6. doi request reprint Probing the Cu(2+) and Zn(2+) binding affinity of histidine-rich glycoprotein
    Attila Jancsó
    Department of Inorganic and Analytical Chemistry, University of Szeged, P O Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 103:1634-43. 2009
  7. doi request reprint A pH-metric, UV, NMR, and X-ray crystallographic study on arsenous acid reacting with dithioerythritol
    András Kolozsi
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6701 Szeged, Hungary
    Inorg Chem 47:3832-40. 2008
  8. doi request reprint Copper(II), nickel(II) and zinc(II) complexes of N-acetyl-His-Pro-His-His-NH2: equilibria, solution structure and enzyme mimicking
    Noémi I Jakab
    Department of Inorganic and Analytical Chemistry, University of Szeged, P O Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 102:1438-48. 2008
  9. ncbi request reprint Complexation of 5-fluorosalicylic acid with copper(II): a pH-potentiometric, UV-vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra
    Terézia Szabó-Plánka
    Department of Physical Chemistry, University of Szeged, P O Box 105, H 6701 Szeged, Hungary
    J Inorg Biochem 102:101-9. 2008
  10. ncbi request reprint Design of histidine containing peptides for better understanding of their coordination mode toward copper(II) by CD spectroscopy
    Noémi I Jakab
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, PO Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 101:1376-85. 2007

Collaborators

Detail Information

Publications24

  1. doi request reprint Towards artificial metallonucleases for gene therapy: recent advances and new perspectives
    Bela Gyurcsik
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6720 Szeged, Hungary
    Future Med Chem 3:1935-66. 2011
    ..The results collected provide useful guidance for engineering highly controlled enzymes for use in gene therapy...
  2. doi request reprint Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease
    Andrea Lakatos
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6720, Szeged, Hungary
    Dalton Trans 41:1713-26. 2012
    ..Our results suggest that branched peptides containing potential metal-binding sites may be suitable metal chelators for reducing the risk of amyloid plaque formation in Alzheimer's disease...
  3. doi request reprint Towards the role of metal ions in the structural variability of proteins: CdII speciation of a metal ion binding loop motif
    Attila Jancsó
    Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary
    Metallomics 3:1331-9. 2011
    ..In an equilibrium of several co-existing species the peptide is exchanging between a number of structures also in its metal ion bound state(s), as indicated by NMR and PAC data...
  4. doi request reprint Theoretical design of a specific DNA-Zinc-finger protein interaction with semi-empirical quantum chemical methods
    Gabor Nagy
    Department of Physical Chemistry and Material Sciences, University of Szeged, Aradi Vertanuk tere 1, H 6720 Szeged, Hungary
    J Mol Graph Model 29:928-34. 2011
    ..The stacking interactions between the nucleic bases were also characterized in the DNA duplexes...
  5. doi request reprint Effect of fluorine position on the coordinating ability of fluorosalicylic acids--an experimental study complemented with computations
    Terézia Szabó-Plánka
    Department of Physical Chemistry and Material Sciences, University of Szeged, Aradi Vertanuk tere 1, H 6720 Szeged, Hungary
    J Inorg Biochem 105:75-83. 2011
    ..For the interpretation of these findings, ab initio and semi-empirical quantum chemical calculations were carried out for the ligand molecules, isolated and surrounded by water molecules, respectively...
  6. doi request reprint Probing the Cu(2+) and Zn(2+) binding affinity of histidine-rich glycoprotein
    Attila Jancsó
    Department of Inorganic and Analytical Chemistry, University of Szeged, P O Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 103:1634-43. 2009
    ..Whether the observed cooperativity has similarities to the cooperative metal binding feature of HRG or the two phenomena have different sources is a question yet to be clarified...
  7. doi request reprint A pH-metric, UV, NMR, and X-ray crystallographic study on arsenous acid reacting with dithioerythritol
    András Kolozsi
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6701 Szeged, Hungary
    Inorg Chem 47:3832-40. 2008
    ..In such alkaline solutions, most probably, rearrangement of the bonding scheme occurs, resulting in ligands being bound to the arsenic(III) through the oxygen donor atoms...
  8. doi request reprint Copper(II), nickel(II) and zinc(II) complexes of N-acetyl-His-Pro-His-His-NH2: equilibria, solution structure and enzyme mimicking
    Noémi I Jakab
    Department of Inorganic and Analytical Chemistry, University of Szeged, P O Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 102:1438-48. 2008
    ..At pH 10 an octahedral NiH(-2)L species is present at first, which transforms slowly to a yellow square planar complex...
  9. ncbi request reprint Complexation of 5-fluorosalicylic acid with copper(II): a pH-potentiometric, UV-vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra
    Terézia Szabó-Plánka
    Department of Physical Chemistry, University of Szeged, P O Box 105, H 6701 Szeged, Hungary
    J Inorg Biochem 102:101-9. 2008
    ..In frozen solutions, the ESR analysis revealed a slight rhombic distortion of coordination polyhedra for the latter three species...
  10. ncbi request reprint Design of histidine containing peptides for better understanding of their coordination mode toward copper(II) by CD spectroscopy
    Noémi I Jakab
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, PO Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 101:1376-85. 2007
    ..CD spectra strongly suggest the participation of the imidazole nitrogen both in the Cu(2)H(-2)L(2) and CuH(-2)L complexes...
  11. ncbi request reprint Interpretation of synchrotron radiation circular dichroism spectra of anionic, cationic, and zwitterionic dialanine forms
    Jirí Sebek
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
    J Phys Chem A 111:2750-60. 2007
    ..Future peptide and protein conformational studies based on circular dichroic spectroscopy can be reliable only if such effects of molecular dynamics, solvent structure, and polar solvent-solute interactions are taken into account...
  12. ncbi request reprint Binding modes of the precursor of adenovirus major core protein VII to DNA and template activating factor I: implication for the mechanism of remodeling of the adenovirus chromatin
    Bela Gyurcsik
    Department of Infection Biology, Graduate School of Comprehensive Human Sciences, and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Biochemistry 45:303-13. 2006
    ..This binding mode suggests the formation of the ternary complexes among DNA, protein VII, and TAF-I. On the basis of the binding modes in binary systems, we discussed the remodeling mechanism of the Ad core in early phases of infection...
  13. ncbi request reprint Ternary complex formation between DNA-adenovirus core protein VII and TAF-Ibeta/SET, an acidic molecular chaperone
    Hirohito Haruki
    Department of Infection Biology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    FEBS Lett 555:521-7. 2003
    ..In vitro binding assays using recombinant proteins showed that TAF-I forms ternary complexes with DNA-protein VII complexes...
  14. ncbi request reprint The effects of Al(III) speciation on the activity of trypsin
    Ágnes Dörnyei
    Biocoordination Chemistry Research Group of Hungarian Academy of Sciences, Department of Inorganic and Analytical Chemistry, University of Szeged, P O Box 440, H 6701 Szeged, Hungary
    J Inorg Biochem 97:118-23. 2003
    ..These results strongly suggest that there is no direct involvement of Al(III) in the enzymatic reactions of trypsin...
  15. ncbi request reprint Metal ion coordination of macromolecular bioligands: formation of zinc(II) complex of hyaluronic acid
    K Burger
    Department of Inorganic and Analytical Chemistry, Szeged University, Hungary
    Carbohydr Res 332:197-207. 2001
    ....
  16. ncbi request reprint CD spectroscopic study on the speciation and solution structure of copper(II) complexes of some tripeptides in combination with potentiometric and spectrophotometric results
    B Gyurcsik
    Department of Inorganic and Analytical Chemistry, Szeged University, P.O. Box 440. H-6701, Szeged, Hungary
    J Inorg Biochem 85:89-98. 2001
    ..The CD spectra strongly support the coordination also of the C-terminal part of the peptide in the CuLH(-1) complex of GGA, and even the deprotonation of the Ala peptide group instead of that belonging to Gly cannot be excluded...
  17. pmc Design of a colicin E7 based chimeric zinc-finger nuclease
    Eszter Nemeth
    Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, Szeged, 6720, Hungary
    J Comput Aided Mol Des 28:841-50. 2014
    ..This study was complemented by random mutagenesis experiments identifying potentially important residues for NColE7 function outside the catalytic region. ..
  18. ncbi request reprint Rescue of the activity of HNH nuclease mutants - towards controlled enzymes for gene therapy
    Bela Gyurcsik
    Department of Inorganic and Analytical Chemistry, Faculty of Science and Informatics, University of Szeged, 6720 Szeged, Dom Ter 7, Hungary
    Curr Protein Pept Sci 17:191-7. 2016
    ..Here we collect the results on the properties of the HNH nucleases that allow for their redesign into enzymes with possible therapeutic applications. ..
  19. doi request reprint Cloning, purification and metal binding of the HNH motif from colicin E7
    Bela Gyurcsik
    MTA SZTE Bioinorganic Chemistry Research Group of Hungarian Academy of Sciences, Department of Inorganic and Analytical Chemistry, University of Szeged, Dom Ter 7, H 6720 Szeged, Hungary
    Protein Expr Purif 89:210-8. 2013
    ..Comparison of the glutathion-S-transferase-fused N-terminal deletion mutants of the colicin E7 nuclease domain suggested that the presence of the DNA-binding site is still not sufficient for the catalytic activity...