Mustapha Umar Imam

Summary

Affiliation: Universiti Putra Malaysia
Location: Serdang, Malaysia
Summary:
Nutrigenomics, Preventive medicine, Diabetes, antioxidants, Oxidative stress
Grants:
Antidiabetic properties of germinated brown rice (GBR), 2009, BERNAS Sdn Bhd Malaysia

Publications

  1. pmc Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells
    Norsharina Ismail
    Nutricosmeceuticals and Nutrigenomics Programme, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia E Mails M I S F F S N A M M U I J B F S I
    Int J Mol Sci 13:9692-708. 2012
  2. pmc Effects of brown rice and white rice on expression of xenobiotic metabolism genes in type 2 diabetic rats
    Mustapha Umar Imam
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia e mail
    Int J Mol Sci 13:8597-608. 2012
  3. pmc Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies
    Xuexian Fang
    Department of Nutrition, Nutrition Discovery Innovation Center, Institute of Nutrition and Food Safety, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China
    BMC Med 14:210. 2016
  4. pmc Modulation of platelet functions by crude rice (Oryza sativa) bran policosanol extract
    Wai Teng Wong
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
    BMC Complement Altern Med 16:252. 2016
  5. pmc Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity
    Norsharina Ismail
    Nutricosmeceuticals and Nutrigenomics Programme, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia
    BMC Complement Altern Med 14:467. 2014
  6. pmc In vitro bioaccessibility and antioxidant properties of edible bird's nest following simulated human gastro-intestinal digestion
    Zhang Yida
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:468. 2014
  7. pmc A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
    Ramlah Mohamad Ibrahim
    Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
    J Transl Med 12:82. 2014
  8. pmc Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways
    Jhi Biau Foo
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:197. 2014
  9. pmc Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa
    Yin Sim Tor
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:55. 2014
  10. pmc Effects of white rice, brown rice and germinated brown rice on antioxidant status of type 2 diabetic rats
    Mustapha Umar Imam
    Laboratory of Molecular Biomedicine, Institute of Bioscience, University Putra Malaysia, UPM Serdang 43400 Serdang, Selangor, Malaysia
    Int J Mol Sci 13:12952-69. 2012

Collaborators

  • Maznah Ismail
  • Norsharina Ismail
  • Zhang Yida
  • Jhi Biau Foo
  • Yin Sim Tor
  • Nur Hanisah Azmi
  • Hadiza Altine Adamu
  • Nadarajan Sarega
  • Xuexian Fang
  • Wai Teng Wong
  • Maizaton Atmadini Abdullah
  • Aini Ideris
  • Nurdin Armania
  • Rasedee Abdullah
  • Ramlah Mohamad Ibrahim
  • Yoke Kqueen Cheah
  • Latifah Saiful Yazan
  • Siti Farhana Fathy
  • Der Jiun Ooi
  • Rozita Rosli
  • Norhaizan Mohd Esa
  • Norhasnida Zawawi
  • Zhiguang Ping
  • Kai Wang
  • Jiayu Wei
  • Yusheng Li
  • Junxia Min
  • Fudi Wang
  • Norhaizan Md Esa
  • Xuyan He
  • Lu Zhao
  • Yuming Xu
  • Yi Da Zhang
  • Dan Han
  • Norharina Ismail
  • Waiteng Wong
  • Zhiping Hou
  • Siti Aisyah Abd Ghafar
  • Saiful Nizam Abd Rashid
  • Muhammad Firdaus Abu Bakar
  • Swee Keong Yeap
  • Rozi Mahmud
  • Suraini Mohd Saini
  • Nurul Syima Hamdan
  • Latiffah Ab Latiff
  • Shahid Iqbal
  • Siti Nor Asma Musa

Detail Information

Publications18

  1. pmc Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells
    Norsharina Ismail
    Nutricosmeceuticals and Nutrigenomics Programme, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia E Mails M I S F F S N A M M U I J B F S I
    Int J Mol Sci 13:9692-708. 2012
    ..Therefore, GBR could be developed as a value added functional food to prevent neurodegenerative diseases caused by oxidative stress and apoptosis...
  2. pmc Effects of brown rice and white rice on expression of xenobiotic metabolism genes in type 2 diabetic rats
    Mustapha Umar Imam
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia e mail
    Int J Mol Sci 13:8597-608. 2012
    ..These results may have profound implications for rice eating populations, constituting half the world's population...
  3. pmc Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies
    Xuexian Fang
    Department of Nutrition, Nutrition Discovery Innovation Center, Institute of Nutrition and Food Safety, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Food Nutrition and Human Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, China
    BMC Med 14:210. 2016
    ..Here, we conducted a dose-response meta-analysis of prospective cohort studies in order to investigate the correlation between magnesium intake and the risk of cardiovascular disease (CVD), type 2 diabetes (T2D), and all-cause mortality...
  4. pmc Modulation of platelet functions by crude rice (Oryza sativa) bran policosanol extract
    Wai Teng Wong
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
    BMC Complement Altern Med 16:252. 2016
    ..Thus, in this study, platelet aggregation and adhesion of platelets to major components of basal lamina were examined in vitro. In addition, cellular protein secretion was quantified as a measurement of platelet activation...
  5. pmc Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity
    Norsharina Ismail
    Nutricosmeceuticals and Nutrigenomics Programme, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia
    BMC Complement Altern Med 14:467. 2014
    ..Rice bran is a bioactive-rich by-product of rice milling process. It possesses antioxidant properties, making it a promising source of antioxidants that could potentially prevent oxidative stress-induced neurodegenerative diseases...
  6. pmc In vitro bioaccessibility and antioxidant properties of edible bird's nest following simulated human gastro-intestinal digestion
    Zhang Yida
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:468. 2014
    ..However, the fate of its antioxidants after oral consumption is not yet reported. To explore this, we hypothesized that EBN antioxidants are released from their matrix when subjected to in vitro simulated gastrointestinal digestion...
  7. pmc A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
    Ramlah Mohamad Ibrahim
    Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
    J Transl Med 12:82. 2014
    ..The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to CVD development...
  8. pmc Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways
    Jhi Biau Foo
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:197. 2014
    ..The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient MCF-7 breast cancer cells...
  9. pmc Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa
    Yin Sim Tor
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:55. 2014
    ..In this study, the anticancer effect of ethyl acetate extract of D. suffruticosa (EADs) was examined on human breast adenocarcinoma cell line MCF-7 and the molecular pathway involved was elucidated...
  10. pmc Effects of white rice, brown rice and germinated brown rice on antioxidant status of type 2 diabetic rats
    Mustapha Umar Imam
    Laboratory of Molecular Biomedicine, Institute of Bioscience, University Putra Malaysia, UPM Serdang 43400 Serdang, Selangor, Malaysia
    Int J Mol Sci 13:12952-69. 2012
    ..From the data so far, the antioxidant effects of BR and GBR are worth studying further especially on a long term to determine their effects on development of oxidative stress-related problems, which WR consumption predisposes to...
  11. pmc Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes
    Nur Hanisah Azmi
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 13:177. 2013
    ..In view of the rich antioxidant content of GBR, we studied its potential to modulate processes leading up to AD...
  12. pmc Edible Bird's Nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes
    Zhang Yida
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
    BMC Complement Altern Med 15:310. 2015
    ..Its antioxidant and anti-inflammatory properties have been reported using in vitro system. This paper aimed to determine the antioxidant and anti-inflammatory effects of EBN in in high fat diet induced rats model...
  13. ncbi request reprint N-Acetylneuraminic acid attenuates hypercoagulation on high fat diet-induced hyperlipidemic rats.
    Zhang Yida
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia
    Food Nutr Res 59:29046. 2015
    ..The implications of the present findings are that Neu5Ac may be used to prevent coagulation-related cardiovascular events in hyperlipidemic conditions. These findings are worth studying further...
  14. pmc Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance
    Nadarajan Sarega
    Institute of Bioscience, Laboratory of Molecular Biomedicine, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia
    BMC Complement Altern Med 16:88. 2016
    ..We explored the potential use of C. nutans for prevention of high fat and high cholesterol diet-(HFHC-) induced insulin resistance in rats...
  15. pmc In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats
    Hadiza Altine Adamu
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
    BMC Complement Altern Med 17:67. 2017
    ..Thus, we investigated the effects of supplementation of HFD with germinated brown rice (GBR) and GBR-derived gamma oryzanol-rich extract (OE) on insulin resistance and its epigenetic implications in pregnant rats and their offsprings...
  16. doi request reprint Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress
    Mustapha Umar Imam
    Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
    Nutrients 9:. 2017
    ....
  17. pmc Antidiabetic properties of germinated brown rice: a systematic review
    Mustapha Umar Imam
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Evid Based Complement Alternat Med 2012:816501. 2012
    ....
  18. pmc Effects of germinated brown rice and its bioactive compounds on the expression of the peroxisome proliferator-activated receptor gamma gene
    Mustapha Umar Imam
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia
    Nutrients 5:468-77. 2013
    ..Upregulation of the gene may have therapeutic potential in diabetes mellitus and cardiovascular diseases, while its downregulation likely contributes to GBR's antiobesity effects. These potentials are worth studying further...