Deepa Bhartiya

Summary

Country: India

Publications

  1. pmc Ovarian stem cells are always accompanied by very small embryonic-like stem cells in adult mammalian ovary
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India
    J Ovarian Res 8:70. 2015
  2. pmc VSELs may obviate cryobanking of gonadal tissue in cancer patients for fertility preservation
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai, 400 012, India
    J Ovarian Res 8:75. 2015
  3. pmc Very small embryonic-like stem cells are involved in pancreatic regeneration and their dysfunction with age may lead to diabetes and cancer
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai, 400012, India
    Stem Cell Res Ther 6:96. 2015
  4. doi request reprint FSH-FSHR3-stem cells in ovary surface epithelium: basis for adult ovarian biology, failure, aging, and cancer
    Deepa Bhartiya
    Stem Cell Biology DepartmentNational Institute for Research in Reproductive Health ICMR, Mumbai 400 012, India
    Reproduction 149:R35-48. 2015
  5. pmc Making gametes from pluripotent stem cells--a promising role for very small embryonic-like stem cells
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health ICMR, Mumbai 400 012, India
    Reprod Biol Endocrinol 12:114. 2014
  6. pmc Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro
    Prasad Pethe
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, J, M, Street, Parel 12, Mumbai, India
    BMC Cell Biol 15:18. 2014
  7. pmc Very small embryonic-like stem cells: implications in reproductive biology
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health ICMR, Mumbai, Maharashtra 400 012, India
    Biomed Res Int 2013:682326. 2013
  8. pmc Gonadotropin treatment augments postnatal oogenesis and primordial follicle assembly in adult mouse ovaries?
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Mumbai, 400 012, India
    J Ovarian Res 5:32. 2012
  9. doi request reprint Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, India
    Stem Cells Dev 21:1-6. 2012
  10. pmc Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker
    Deepa Bhartiya
    Dept of Stem Cell Biology, National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai 400012, India
    J Histochem Cytochem 58:1093-106. 2010

Collaborators

  • Deepak Modi
  • Sujata Mohanty
  • Prasad Pethe
  • Seema Parte
  • Sandhya Anand
  • Harsha Pawani
  • Punam Nagvenkar
  • Neeraj Kumar
  • Kalpana Sriraman
  • Hiren Patel
  • Indira Hinduja
  • Kusum Zaveri
  • Jyoti Telang
  • Sreepoorna Unni
  • Sreepoorna K Unni
  • Smita Bhutda
  • Varsha Pursani
  • Purna Kurkure
  • Amita Joshi
  • Dhananjay D Manjramkar
  • Anahita Chauhan
  • Vandana Dhamankar
  • Dhananjay Manjramkar
  • Ganesh Bakshi
  • Sujata Patwardhan
  • Serena D'Souza
  • Srabani Mukherjee
  • Sandhya Kasiviswanathan
  • Sushma Khavale
  • Vinita Salvi
  • Vinita Daithankar
  • Lakshmi Pillai
  • Chander Puri
  • Sadhana Desai
  • Vijay Mangoli
  • Shilpa G Pathak
  • Ranjana Mangoli
  • Jayesh V Dhabalia
  • Leena Mukadam
  • Gurvinder Kaur
  • Shreyas Padgaonkar

Detail Information

Publications30

  1. pmc Ovarian stem cells are always accompanied by very small embryonic-like stem cells in adult mammalian ovary
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India
    J Ovarian Res 8:70. 2015
    ..Data has accumulated in support of ovarian stem cells (OSCs) proliferation, maintenance in culture, formation of germ cell nests and differentiation into oocytes and primordial follicle assembly using different strategies...
  2. pmc VSELs may obviate cryobanking of gonadal tissue in cancer patients for fertility preservation
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai, 400 012, India
    J Ovarian Res 8:75. 2015
    ..Thus the source of oocytes/sperm which result in spontaneous pregnancies still remains contentious...
  3. pmc Very small embryonic-like stem cells are involved in pancreatic regeneration and their dysfunction with age may lead to diabetes and cancer
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai, 400012, India
    Stem Cell Res Ther 6:96. 2015
    ..In the future, such understanding may allow manipulation of endogenous VSELs to our advantage in patients with diabetes and also to treat cancer. ..
  4. doi request reprint FSH-FSHR3-stem cells in ovary surface epithelium: basis for adult ovarian biology, failure, aging, and cancer
    Deepa Bhartiya
    Stem Cell Biology DepartmentNational Institute for Research in Reproductive Health ICMR, Mumbai 400 012, India
    Reproduction 149:R35-48. 2015
    ....
  5. pmc Making gametes from pluripotent stem cells--a promising role for very small embryonic-like stem cells
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health ICMR, Mumbai 400 012, India
    Reprod Biol Endocrinol 12:114. 2014
    ..However, first the scientific community needs to arrive at a consensus about VSELs in the gonads and then work towards exploiting their potential...
  6. pmc Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro
    Prasad Pethe
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, J, M, Street, Parel 12, Mumbai, India
    BMC Cell Biol 15:18. 2014
    ..In the present study, the expression of RING1A, RING1B, BMI1, CBX2, SUZ12, EZH2, EED and JARID2 during differentiation of hES cells towards pancreatic lineage was examined...
  7. pmc Very small embryonic-like stem cells: implications in reproductive biology
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health ICMR, Mumbai, Maharashtra 400 012, India
    Biomed Res Int 2013:682326. 2013
    ..It will also be relevant for future regenerative medicine, translational research, and clinical applications in human reproduction...
  8. pmc Gonadotropin treatment augments postnatal oogenesis and primordial follicle assembly in adult mouse ovaries?
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Mumbai, 400 012, India
    J Ovarian Res 5:32. 2012
    ..Present study was undertaken to investigate the effect of pregnant mare serum gonadotropin (PMSG) on adult mice ovaries with a focus on VSELs, OGSCs, postnatal oogenesis and primordial follicle assembly...
  9. doi request reprint Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, India
    Stem Cells Dev 21:1-6. 2012
    ....
  10. pmc Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker
    Deepa Bhartiya
    Dept of Stem Cell Biology, National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai 400012, India
    J Histochem Cytochem 58:1093-106. 2010
    ..spermatocytes, spermatids, and sperm. Besides maintaining normal testicular homeostasis, PSCs may also be implicated in germ cell tumors and ES-like colonies that have recently been derived from adult human testicular tissue...
  11. doi request reprint Evaluating differentiation propensity of in-house derived human embryonic stem cell lines KIND-1 and KIND-2
    Punam Nagvenkar
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, 400 012, India
    In Vitro Cell Dev Biol Anim 47:406-19. 2011
    ..Our data provide evidence for existence of distinct differentiation propensity among hES cell lines and emphasizes the need to derive more hES cell lines for future regenerative medicine...
  12. pmc Detection, characterization, and spontaneous differentiation in vitro of very small embryonic-like putative stem cells in adult mammalian ovary
    Seema Parte
    Department of Stem Cell Biology, National Institute for Research in Reproductive Health, Mumbai, India
    Stem Cells Dev 20:1451-64. 2011
    ..Research at the single-cell level, including complete gene expression profiling, is required to further confirm whether postnatal oogenesis is a conserved phenomenon in adult mammals...
  13. doi request reprint Role of TGFbeta and myofibroblasts in supporting the propagation of human embryonic stem cells in vitro
    Neeraj Kumar
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, India
    Int J Dev Biol 54:1329-36. 2010
    ....
  14. ncbi request reprint Endogenous, very small embryonic-like stem cells: critical review, therapeutic potential and a look ahead
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health Indian Council of Medical Research, Jehangir Merwanji Street, Parel, Mumbai 400 012, India
    Hum Reprod Update . 2016
    ..The VSELs maintain life-long tissue homeostasis, serve as a backup pool for adult stem cells and are mobilized under stress conditions. An imbalance in VSELs function (uncontrolled proliferation) may result in cancer...
  15. pmc Stage-specific localization and expression of c-kit in the adult human testis
    Sreepoorna K Unni
    Scientist D and Divisional Head, Stem Cell Biology Department, National Institute for Research in Reproductive Health ICMR, J M Street, Parel, Mumbai 400012, India
    J Histochem Cytochem 57:861-9. 2009
    ..The results of the present study may expand current knowledge about the c-kit/SCF system in human spermatogenesis...
  16. doi request reprint Differentiation of human ES cell line KIND-2 to yield tripotent cardiovascular progenitors
    Harsha Pawani
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, 400 012, India
    In Vitro Cell Dev Biol Anim 49:82-93. 2013
    ..We propose to use tripotent cardiovascular progenitors derived by directed differentiation for further preclinical studies...
  17. doi request reprint Efficient cryopreservation of testicular tissue: effect of age, sample state, and concentration of cryoprotectant
    Sreepoorna Unni
    Department of Stem Cell Biology, National Institute for Research in Reproductive Health, Mumbai, India
    Fertil Steril 97:200-8.e1. 2012
    ..To study the effect of age and sample state on cryopreservation of testicular tissue, evaluate toxicity of commonly used cryoprotectants (CPs), and determine their optimal concentration for use...
  18. doi request reprint Derivation and characterization of two genetically unique human embryonic stem cell lines on in-house-derived human feeders
    Neeraj Kumar
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Mumbai, India
    Stem Cells Dev 18:435-45. 2009
    ..The addition of our hES cell lines contributes usefully to the globally restricted repertoire of human ES cell lines...
  19. ncbi request reprint Quiescent Very Small Embryonic-like Stem Cells Resist Oncotherapy and can Restore Spermatogenesis in Germ Cell Depleted Mammalian Testis
    Sandhya Anand
    National Institute for Research in Reproductive Health, Stem Cell Biology, Mumbai, Maharashtra, India
    Stem Cells Dev . 2013
    ..Further studies are warranted to delineate the underlying mechanisms and to study quality and potential of sperm generated by this approach...
  20. doi request reprint Isolation and characterization of stem cells in the adult mammalian ovary
    Seema Parte
    Stem Cell Biology Department, National Institute for Research and Reproductive Health ICMR, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India
    Methods Mol Biol 1235:203-29. 2015
    ....
  21. pmc Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends
    Harsha Pawani
    Stem Cell Biology Department, National Institute for Research in Reproductive Health ICMR, Mumbai, India
    Indian J Med Res 137:270-82. 2013
    ..Generation of a 3-D pulsatile myocardial tissue has been achieved. However, these advances have to be looked at with cautious optimism as many challenges need to be overcome before using these in clinical practice...
  22. pmc Mouse Ovarian Very Small Embryonic-Like Stem Cells Resist Chemotherapy and Retain Ability to Initiate Oocyte-Specific Differentiation
    Kalpana Sriraman
    Stem Cell Biology Department, National Institute for Research in Reproductive Health NIRRH, Mumbai, Maharashtra, India
    Reprod Sci 22:884-903. 2015
    ..These results show relevance to women who undergo premature ovarian failure because of oncotherapy. ..
  23. pmc Chemoablated mouse seminiferous tubular cells enriched for very small embryonic-like stem cells undergo spontaneous spermatogenesis in vitro
    Sandhya Anand
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Mumbai, 400 012, India
    Reprod Biol Endocrinol 13:33. 2015
    ..We have earlier reported that busulphan (25 mg/Kg) treatment to 4 weeks old mice destroys actively dividing cells and sperm but VSELs survive and differentiate into sperm when a healthy niche is provided in vivo...
  24. ncbi request reprint Y chromosome mosaicism and occurrence of gonadoblastoma in cases of Turner syndrome and amenorrhoea
    Deepak Modi
    Cell Biology Department, Research Society, Bai Jerbai Wadia Hospital for Children, Parel, Mumbai, India
    Reprod Biomed Online 15:547-53. 2007
    ....
  25. pmc Stem cell interaction with somatic niche may hold the key to fertility restoration in cancer patients
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai 400 012, India
    Obstet Gynecol Int 2012:921082. 2012
    ..Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options...
  26. doi request reprint Lineage specific expression of Polycomb Group Proteins in human embryonic stem cells in vitro
    Prasad Pethe
    Stem Cell Biology Department, National Institute for Research in Reproductive Health NIRRH, Jehangir Merwanji Street, Parel, Mumbai, 400012, India
    Cell Biol Int 39:600-10. 2015
    ..Our study shows that hES cells differentiating into endoderm, mesoderm, and ectoderm lineages show distinct PcG expression profile at transcript and protein level. ..
  27. ncbi request reprint Developmental expression and cellular distribution of Mullerian inhibiting substance in the primate ovary
    Deepak Modi
    Cell Biology Department, Research Laboratory, BJ Wadia Hospital for Children, AD Marg, Parel, Mumbai 400 012, India
    Reproduction 132:443-53. 2006
    ..The presence of MIS in a small subset of oocytes in the fetal ovary further points towards its additional role during fetal oocyte development...
  28. pmc Stimulation of ovarian stem cells by follicle stimulating hormone and basic fibroblast growth factor during cortical tissue culture
    Seema Parte
    Stem Cell Biology Department, National Institute for Research in Reproductive Health NIRRH, JM Street, Parel, Mumbai, 400 012, India
    J Ovarian Res 6:20. 2013
    ..The present study was undertaken to decipher effect of follicle stimulating hormone (FSH) and basic fibroblast growth factor (bFGF) on the growth initiation of PF during organ culture with a focus on ovarian stem cells...
  29. ncbi request reprint Cellular origin of testis-derived pluripotent stem cells: a case for very small embryonic-like stem cells
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, India
    Stem Cells Dev 21:670-4. 2012
    ..We conclude that like Oct-4 biology, presence of VSELs in adult body tissues has somewhat surprised stem cell biologists...