Jayashree Shanker

Summary

Country: India

Publications

  1. pmc Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: the Indian Atherosclerosis Research Study
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bangalore, India
    Vasc Health Risk Manag 3:1063-8. 2007
  2. doi request reprint Role of vitamin D levels and vitamin D receptor polymorphisms in relation to coronary artery disease: the Indian atherosclerosis research study
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, London and Thrombosis Research Institute, India
    Coron Artery Dis 22:324-32. 2011
  3. doi request reprint Contribution of classical and emerging risk factors to coronary artery disease in Asian Indians
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, India Electronic address
    Int J Cardiol 214:97-106. 2016
  4. ncbi request reprint Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes
    Prathima Arvind
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bengaluru 560 099, India
    J Genet 94:601-10. 2015
  5. pmc Understanding the expression of Toll-like receptors in Asian Indians predisposed to coronary artery disease
    Arindam Maitra
    Thrombosis Research Institute, India
    Arch Med Sci 7:781-7. 2011
  6. doi request reprint Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians
    Jayashree Shanker
    Dr Jayashree Shanker, Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, India, Narayana Hrudayalaya 258 A, Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, Karnataka, India, Tel 91 80 27835303, Fax 91 80 27835302, E mail
    Thromb Haemost 111:960-9. 2014
  7. pmc Implications of genetic polymorphisms in inflammation-induced atherosclerosis
    Jayashree Shanker
    Thrombosis Research Institute, India
    Open Cardiovasc Med J 4:30-7. 2010
  8. pmc Prevalence and component analysis of metabolic syndrome: an Indian atherosclerosis research study perspective
    Saikat Kanjilal
    Division of Cardiology, St Johns Medical College and Hospital Bangalore, India
    Vasc Health Risk Manag 4:189-97. 2008
  9. doi request reprint Relationship between periodontal disease, Porphyromonas gingivalis, peripheral vascular resistance markers and coronary artery disease in Asian Indians
    Jayashree Shanker
    Clinical Research Unit, Thrombosis Research Institute, India
    Thromb Res 132:e8-14. 2013
  10. ncbi request reprint Relationship of adiponectin and leptin to coronary artery disease, classical cardiovascular risk factors and atherothrombotic biomarkers in the IARS cohort
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute India, Bangalore, India
    Thromb Haemost 108:769-80. 2012

Collaborators

  • Arindam Maitra
  • Armen Yuri Gasparyan
  • Veena S Rao
  • Jiny Nair
  • Prathima Arvind
  • Vijay V Kakkar
  • Srikarthika Jambunathan
  • Rajani Kanth Vangala
  • Lakshmi A Mundkur
  • Saikat Kanjilal
  • Shanker Jayashree
  • Madankumar Ghatge
  • Meghala Shekar
  • Vandana Ravindran
  • Madan Ghatge
  • Hima Bindu
  • Radhika K Nagaraj
  • Hemapriya Shivanandan
  • Sridhar Hebbagudi
  • Shamanna S Iyengar
  • Manjari Mukherjee
  • Natesha B Khadrinarasimhaih

Detail Information

Publications22

  1. pmc Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: the Indian Atherosclerosis Research Study
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bangalore, India
    Vasc Health Risk Manag 3:1063-8. 2007
    ..033) in our study. These findings suggest a probable dominant genetic component in the causation of DM and HTN and a predominantly nongenetic component for metabolic syndrome among Asian Indians...
  2. doi request reprint Role of vitamin D levels and vitamin D receptor polymorphisms in relation to coronary artery disease: the Indian atherosclerosis research study
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, London and Thrombosis Research Institute, India
    Coron Artery Dis 22:324-32. 2011
    ..Assessment of association between plasma vitamin D levels, vitamin D receptor (VDR) gene polymorphisms, and coronary artery disease (CAD) in a predisposed Asian Indian cohort...
  3. doi request reprint Contribution of classical and emerging risk factors to coronary artery disease in Asian Indians
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, India Electronic address
    Int J Cardiol 214:97-106. 2016
    ..We analyzed the role of conventional (age, gender, diabetes, hypertension, smoking) and non-conventional risk factors (anthropometrics, fasting blood sugar, atherogenic index of plasma - AIP, family history) in Asian Indians with CAD...
  4. ncbi request reprint Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes
    Prathima Arvind
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bengaluru 560 099, India
    J Genet 94:601-10. 2015
    ..In conclusion, global gene expression profiling combined with network analysis can help in identifying key genes and pathways for CAD. ..
  5. pmc Understanding the expression of Toll-like receptors in Asian Indians predisposed to coronary artery disease
    Arindam Maitra
    Thrombosis Research Institute, India
    Arch Med Sci 7:781-7. 2011
    ..Toll-like receptors (TLRs) are an important link between innate and adaptive immunity...
  6. doi request reprint Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians
    Jayashree Shanker
    Dr Jayashree Shanker, Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, India, Narayana Hrudayalaya 258 A, Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, Karnataka, India, Tel 91 80 27835303, Fax 91 80 27835302, E mail
    Thromb Haemost 111:960-9. 2014
    ..3 locus for CAD wherein the risk allele regulate the expression of ANRIL and adjacent tumour suppressor genes which in turn alter smooth muscle proliferation, a fundamental process in atherosclerosis. ..
  7. pmc Implications of genetic polymorphisms in inflammation-induced atherosclerosis
    Jayashree Shanker
    Thrombosis Research Institute, India
    Open Cardiovasc Med J 4:30-7. 2010
    ..Therefore, consideration of all these factors can build towards an 'atherosclerotic bionetwork' that can refine our quest for developing a robust risk stratification tool for cardiovascular disease...
  8. pmc Prevalence and component analysis of metabolic syndrome: an Indian atherosclerosis research study perspective
    Saikat Kanjilal
    Division of Cardiology, St Johns Medical College and Hospital Bangalore, India
    Vasc Health Risk Manag 4:189-97. 2008
    ..In conclusion, the revision of definition criteria for MS with lowered cut-offs for WC and BMI is critical for the accurate assessment of MS among Asian Indians...
  9. doi request reprint Relationship between periodontal disease, Porphyromonas gingivalis, peripheral vascular resistance markers and coronary artery disease in Asian Indians
    Jayashree Shanker
    Clinical Research Unit, Thrombosis Research Institute, India
    Thromb Res 132:e8-14. 2013
    ..We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinical markers and coronary artery disease (CAD) in a representative Asian Indian cohort...
  10. ncbi request reprint Relationship of adiponectin and leptin to coronary artery disease, classical cardiovascular risk factors and atherothrombotic biomarkers in the IARS cohort
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute India, Bangalore, India
    Thromb Haemost 108:769-80. 2012
    ..In conclusion, our findings strengthen the reported association between low adiponectin, high leptin, obesity-related metabolic disturbances and incident CAD in Asian Indians...
  11. pmc Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bangalore, India
    Lipids Health Dis 7:33. 2008
    ....
  12. ncbi request reprint Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms
    Jayashree Shanker
    Thrombosis Research Institute, Bommasandra Industrial Area, Anekal Taluk, Bangalore, India
    Curr Vasc Pharmacol 9:479-89. 2011
    ..Additional information is, however, needed to evaluate the cost-effectiveness of complex genetic and platelet function testing...
  13. ncbi request reprint Genotype-phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease
    Jayashree Shanker
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, 258 A, Bommasandra Industrial Area, Bangalore 560 099, India
    J Genet 88:291-7. 2009
    ..c activity with lipid markers, particularly among those with RR and RQ genotype after covariate adjustment. In conclusion, the F7 R353Q SNP appears to moderately influence plasma FVII.c activity and risk of CAD in Indians...
  14. doi request reprint Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study
    Arindam Maitra
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Narayana Hrudayalaya Hospital, 258 A Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, India
    Thromb Haemost 99:944-50. 2008
    ..001). In conclusion, IL6 gene polymorphisms appear to be important genetic factors in premature CAD, and in the regulation of key atherogenic markers in Asian Indian families...
  15. ncbi request reprint Polymorphisms in the pituitary growth hormone gene and its receptor associated with coronary artery disease in a predisposed cohort from India
    Arindam Maitra
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute India, 258 A, Bommasandra Industrial Area, Bangalore 560 099, India
    J Genet 89:437-47. 2010
    ..006). In conclusion, genetic polymorphisms in the GHR gene and its ligand, GH1, may modulate the risk of CAD in the Asian Indian population...
  16. ncbi request reprint Rationale, design & preliminary findings of the Indian Atherosclerosis Research Study
    Jayashree Shanker
    Thrombosis Research Institute, India
    Indian Heart J 62:286-95. 2010
    ..Cardiovascular disease is highly prevalent among Asian Indians. The objective of the Indian Atherosclerosis Research Study (IARS) is to understand the molecular basis of Coronary Artery Disease (CAD) in this population...
  17. doi request reprint CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort
    Prathima Arvind
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Unit, Bangalore 560099, India
    J Cardiol 64:339-46. 2014
    ....
  18. ncbi request reprint Expression analysis of leukotriene-inflammatory gene interaction network in patients with coronary artery disease
    Jiny Nair
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute
    J Atheroscler Thromb 21:329-45. 2014
    ....
  19. pmc Integrative bioinformatics analysis of genomic and proteomic approaches to understand the transcriptional regulatory program in coronary artery disease pathways
    Rajani Kanth Vangala
    Tata Proteomics and Coagulation Department, Thrombosis Research Institute, Bangalore, Karnataka, India
    PLoS ONE 8:e57193. 2013
    ..This kind of analysis can enhance the elucidation of mechanisms in the disease and give better strategies of developing multimarker module based risk predictions...
  20. pmc Usefulness of C-reactive protein as a marker for prediction of future coronary events in the asian Indian population: Indian atherosclerosis research study
    Veena S Rao
    Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, India, Narayana Hrudayalaya Hospital, 560099 Bangalore, India
    Int J Vasc Med 2010:389235. 2010
    ..58 mg/L) were found to have a fourfold higher risk. In conclusion, hsCRP appears to be an independent predictor of recurrent CAD events in Asian Indian population...
  21. pmc Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease
    Jiny Nair
    Mary and Garry Weston Functional Genomics Unit, Thrombosis Research Institute, Bengaluru, Karnataka, India
    PLoS ONE 9:e94328. 2014
    ..05). Thus, analysis of complex networks aid in the prioritization of genes and their transcriptional regulators in complex diseases. ..
  22. pmc Pathogen burden, cytomegalovirus infection and inflammatory markers in the risk of premature coronary artery disease in individuals of Indian origin
    Lakshmi A Mundkur
    Thrombosis Research Institute, Bangalore, India
    Exp Clin Cardiol 17:63-8. 2012
    ..Coronary artery disease (CAD) occurs at an earlier age in South Asians compared with other ethnic groups. Infection and inflammation show a positive association with the disease...