Steven W Kerrigan

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. doi request reprint Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis.
    Carolina D Garciarena
    Cardiovascular Infection Research Group, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Crit Care 21:246. 2017
  2. doi request reprint Dysregulation of the endothelium following Staphylococcus aureus infection
    Steven W Kerrigan
    School of Pharmacy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Biochem Soc Trans 43:715-9. 2015
  3. pmc Multiple sites on Streptococcus gordonii surface protein PadA bind to platelet GPIIbIIIa
    Ciara Keane
    Dr Steve Kerrigan, Cardiovascular Infection Group, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland, E mail
    Thromb Haemost 110:1278-87. 2013
  4. pmc Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Infect Immun 75:5740-7. 2007
  5. pmc The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus
    Emma Jane Smith
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 79:3801-9. 2011
  6. pmc Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii
    Ciara Keane
    Cardiovascular Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin
    Arterioscler Thromb Vasc Biol 30:2408-15. 2010
  7. doi request reprint Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets
    Helen Miajlovic
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    Microbiology 156:920-8. 2010
  8. doi request reprint Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection
    Tania Claro
    Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Microbiology 159:147-54. 2013
  9. pmc Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis
    Amro Widaa
    Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e40586. 2012
  10. ncbi request reprint Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Arterioscler Thromb Vasc Biol 28:335-40. 2008

Collaborators

Detail Information

Publications24

  1. doi request reprint Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis.
    Carolina D Garciarena
    Cardiovascular Infection Research Group, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Crit Care 21:246. 2017
  2. doi request reprint Dysregulation of the endothelium following Staphylococcus aureus infection
    Steven W Kerrigan
    School of Pharmacy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Biochem Soc Trans 43:715-9. 2015
    ..Here, we review the interactions between S. aureus and endothelial cells and discuss the implications of these interactions in the progression of cardiovascular infection. ..
  3. pmc Multiple sites on Streptococcus gordonii surface protein PadA bind to platelet GPIIbIIIa
    Ciara Keane
    Dr Steve Kerrigan, Cardiovascular Infection Group, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland, E mail
    Thromb Haemost 110:1278-87. 2013
    ..These results suggest that multiple sites on S. gordonii PadA interact with GPIIb/IIIa to mediate a number of platelet responses that likely contribute to the thrombotic complications of infective endocarditis...
  4. pmc Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Infect Immun 75:5740-7. 2007
    ..Differential protein expression between strains may be important for the pathogenesis of invasive diseases such as infective endocarditis...
  5. pmc The Sbi protein is a multifunctional immune evasion factor of Staphylococcus aureus
    Emma Jane Smith
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 79:3801-9. 2011
    ..Both the secreted and envelope-associated forms of Sbi contributed to immune evasion. The IgG-binding domains contributed only when Sbi was attached to the cell, while only the secreted C3-binding domains were biologically active...
  6. pmc Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii
    Ciara Keane
    Cardiovascular Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin
    Arterioscler Thromb Vasc Biol 30:2408-15. 2010
    ..The mechanism of platelet recruitment and activation by S. gordonii is poorly understood...
  7. doi request reprint Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets
    Helen Miajlovic
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    Microbiology 156:920-8. 2010
    ..Antibodies to the platelet integrin GPIIb/IIIa inhibited platelet adhesion by IsdB-expressing strains, as did antagonists of GPIIb/IIIa. Surface plasmon resonance demonstrated that recombinant IsdB interacts directly with GPIIb/IIIa...
  8. doi request reprint Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection
    Tania Claro
    Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Microbiology 159:147-54. 2013
    ..Anti-inflammatory drug therapy could be used either alone or in conjunction with antibiotics to treat osteomyelitis or for prophylaxis in high-risk patients...
  9. pmc Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis
    Amro Widaa
    Microbial Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e40586. 2012
    ..A better understanding of the mechanisms through which S. aureus leads to bone infection may improve treatment or lead to the development of better therapeutic agents to treat this notoriously difficult disease...
  10. ncbi request reprint Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Arterioscler Thromb Vasc Biol 28:335-40. 2008
    ..Previously, we showed that S. aureus clumping factor A (ClfA) and fibronectin-binding protein A (FnBPA) can stimulate rapid platelet aggregation...
  11. doi request reprint Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction
    Nicholas P Tobin
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 295:H1403-13. 2008
    ..Specifically, the VacA-dependent reduction in endothelial NO is indicated in these events. The atheroprotective impact of laminar shear stress in this context is also evident...
  12. pmc Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis
    Tania Claro
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 6:e18748. 2011
    ..This new information may pave the way for the development of new and improved therapeutic agents to treat this disease...
  13. ncbi request reprint Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation
    Michael F Byrne
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Gastroenterology 124:1846-54. 2003
    ..Clinical studies have suggested an association between cardiovascular disease and infection with Helicobacter pylori. We examined the effect of H. pylori on platelets and the mechanism of the interaction...
  14. ncbi request reprint Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions
    Maghnus O'Seaghdha
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    FEBS J 273:4831-41. 2006
    ..This indicated that both vWF regions recognized a region on helices I and II that overlapped the IgG Fc binding site...
  15. ncbi request reprint A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation
    Steven W Kerrigan
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Blood 100:509-16. 2002
    ..It is suggested that the interaction between S sanguis and GPIb is important in the pathogenesis of infective endocarditis and may also play a contributory role in some cases of myocardial infarction...
  16. doi request reprint Platelet-bacterial interactions
    Steven W Kerrigan
    School of Pharmacy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Cell Mol Life Sci 67:513-23. 2010
    ..Secreted bacterial products such as gingipains and lipopolysaccharide may also be capable of triggering platelet activation...
  17. ncbi request reprint Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A
    Louise O'Brien
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 44:1033-44. 2002
    ..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
  18. pmc Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream Infection
    Carolina D Garciarena
    Cardiovascular Infection Research Group, School of Pharmacy and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Pathogens 4:869-82. 2015
    ..In this review, we will illustrate how S. aureus establish intimate interactions with both endothelial cells and platelets leading to cardiovascular dysregulation. ..
  19. doi request reprint Towards 3D in vitro models for the study of cardiovascular tissues and disease
    Alan J Ryan
    Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152 160 Pearse Street, Dublin 2, Ireland Advanced Materials and Bioengineering Research AMBER Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland
    Drug Discov Today 21:1437-45. 2016
    ..Here, we outline the progress to date and the requirements for the development of ideal in vitro 3D models for blood vessels, heart valves, and myocardial tissue. ..
  20. doi request reprint A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function
    Roisin Moriarty
    Dermot Cox, Bsc, PhD, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland, Tel 35 3 1 402 2152, Fax 35 3 1 402 2453, E mail
    Thromb Haemost 113:290-304. 2015
    ..Thus, the NGR motif in fibrinogen is the site that is primarily responsible for the interaction with resting αIIbβ3 and is responsible for triggering platelet activation. ..
  21. pmc Functions of cell surface-anchored antigen I/II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors
    Nicholas S Jakubovics
    Department of Oral and Dental Science, University of Bristol, UK
    Infect Immun 73:6629-38. 2005
    ..AgI/II polypeptides direct gp340-mediated aggregation, facilitate multimodal interactions necessary for platelet aggregation, and modulate S. gordonii-host engagements into biologically productive phenomena...
  22. ncbi request reprint A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb
    Christopher Plummer
    Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    Br J Haematol 129:101-9. 2005
    ..Platelets did not bind to wild-type bacterial cells at high shear (1500/s). These findings help to understand the mechanisms by which the organism might colonize platelet-fibrin vegetations...
  23. ncbi request reprint Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation
    Steven W Kerrigan
    Department of Laboratory Medicine, University of California San Francisco, 513 Parnassus Ave, Rm S 577, San Francisco, CA 94143 0100, USA
    Blood 104:1327-34. 2004
    ....