Ben Zion Katz

Summary

Country: Israel

Publications

  1. doi The stromal derived factor-1\CXCR4 axis--a legitimate therapeutic target in multiple myeloma?
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Leuk Lymphoma 50:1067-8. 2009
  2. doi Adhesion molecules--The lifelines of multiple myeloma cells
    Ben Zion Katz
    Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Semin Cancer Biol 20:186-95. 2010
  3. doi Side populations--following the footprints of the elusive multiple myeloma stem cells?
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Leuk Lymphoma 49:1657-8. 2008
  4. ncbi Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Thromb Haemost 98:1193-9. 2007
  5. doi Integration of automated morphological features resolves a distinct group of atypical chronic lymphocytic leukemias with chromosomal aberrations
    Yair Herishanu
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Leuk Res 38:484-9. 2014
  6. doi Absolute monocyte count trichotomizes chronic lymphocytic leukemia into high risk patients with immune dysregulation, disease progression and poor survival
    Yair Herishanu
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leuk Res 37:1222-8. 2013
  7. doi Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood
    Varda Deutsch
    Department of Haematology and Bone Marrow Transplant, Tel Aviv Medical Centre, Tel Aviv University, Israel
    Br J Haematol 149:137-49. 2010
  8. doi Measurement of lymphocyte aggregation by flow cytometry-physiological implications in chronic lymphocytic leukemia
    Nili Dezorella
    The Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 64239
    Cytometry B Clin Cytom 90:257-66. 2016
  9. ncbi Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts
    Liat Nadav
    Tel Aviv Sourasky Medical Center, Israel
    J Cell Sci 115:2179-87. 2002
  10. ncbi Resolving and classifying haematopoietic bone-marrow cell populations by multi-dimensional analysis of flow-cytometry data
    Eli Zamir
    The Haematology Institute, Tel Aviv Sourasky Medical Centre, Tel Aviv 64239, Israel
    Br J Haematol 129:420-31. 2005

Collaborators

Detail Information

Publications31

  1. doi The stromal derived factor-1\CXCR4 axis--a legitimate therapeutic target in multiple myeloma?
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Leuk Lymphoma 50:1067-8. 2009
  2. doi Adhesion molecules--The lifelines of multiple myeloma cells
    Ben Zion Katz
    Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Semin Cancer Biol 20:186-95. 2010
    ..These potential novel therapeutics may be incorporated into current treatment schemes, or directed against minimal residual malignant cells during remission...
  3. doi Side populations--following the footprints of the elusive multiple myeloma stem cells?
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Leuk Lymphoma 49:1657-8. 2008
  4. ncbi Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Thromb Haemost 98:1193-9. 2007
    ..Altogether, heparanase pro-coagulant activities that were also demonstrated in plasma samples from patients under LMWH treatment, point to a possible use of this molecule as antagonist for heparinoid treatment...
  5. doi Integration of automated morphological features resolves a distinct group of atypical chronic lymphocytic leukemias with chromosomal aberrations
    Yair Herishanu
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Leuk Res 38:484-9. 2014
    ..Integration of the automated morphological features discriminates between different CLL phenotypes and distinct chromosomal aberrations. ..
  6. doi Absolute monocyte count trichotomizes chronic lymphocytic leukemia into high risk patients with immune dysregulation, disease progression and poor survival
    Yair Herishanu
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leuk Res 37:1222-8. 2013
    ..In conclusion, AMC quantification during the disease course classifies CLL patients into subgroups with unique clinical features and outcomes. ..
  7. doi Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood
    Varda Deutsch
    Department of Haematology and Bone Marrow Transplant, Tel Aviv Medical Centre, Tel Aviv University, Israel
    Br J Haematol 149:137-49. 2010
    ....
  8. doi Measurement of lymphocyte aggregation by flow cytometry-physiological implications in chronic lymphocytic leukemia
    Nili Dezorella
    The Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 64239
    Cytometry B Clin Cytom 90:257-66. 2016
    ....
  9. ncbi Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts
    Liat Nadav
    Tel Aviv Sourasky Medical Center, Israel
    J Cell Sci 115:2179-87. 2002
    ..Cellular binding and uptake of extracellular heparanase control its activation, clearance rate and storage within the cells...
  10. ncbi Resolving and classifying haematopoietic bone-marrow cell populations by multi-dimensional analysis of flow-cytometry data
    Eli Zamir
    The Haematology Institute, Tel Aviv Sourasky Medical Centre, Tel Aviv 64239, Israel
    Br J Haematol 129:420-31. 2005
    ..This should enhance the ability to study normal haematopoiesis, and to identify and monitor haematopoietic disorders...
  11. doi Mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6
    Nili Dezorella
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Exp Cell Res 315:1904-13. 2009
    ..Overall, the data indicate that the bone marrow-derived mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6...
  12. doi Divergence in CD19-mediated signaling unfolds intraclonal diversity in chronic lymphocytic leukemia, which correlates with disease progression
    Yair Herishanu
    Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    J Immunol 190:784-93. 2013
    ..This signaling diversity is associated with physiological implications, including the location of the cells, their responses to anti-CLL therapeutics, and disease progression...
  13. pmc SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course
    Nili Dezorella
    Department of Hematology, Tel Aviv Sourasky Medical Center, Jerusalem, Israel
    Haematologica 101:1553-1562. 2016
    ..Consistent with our biochemical findings, high total SLP76 expression in chronic lymphocytic leukemia cells correlated with a more aggressive disease course...
  14. ncbi Heparinoids: integrated control of hemostasis and metastasis
    Liat Nadav
    Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 4:1046-9. 2002
  15. ncbi Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells
    Rinat Eshel
    The Hematology Institute, Sourasky Medical Center, Tel Aviv, Israel
    Biochem Biophys Res Commun 335:1115-22. 2005
    ..In summary, we have characterized a link between leukomogenic factors and the downregulation of heparanase in myeloid leukemic cells...
  16. doi Plasma levels of microparticles at 24 weeks of gestation do not predict subsequent pregnancy complications
    Ophira Salomon
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Fertil Steril 92:682-7. 2009
    ..To discern whether plasma levels of microparticles (MPs) measured at 24 weeks of gestation predict late complications of pregnancy...
  17. ncbi Effects of 5-fluorouracil on human mitogen-activated peripheral blood lymphocytes from healthy individuals
    Avi Eisenthal
    Department of Pathology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Anticancer Res 28:3785-91. 2008
    ..The effect of 5-fluorouracil (5-FU) on activated lymphocytes was explored...
  18. ncbi [Laboratory evaluation of lupus anticoagulant in Israel]
    Galit Sarig
    Harefuah 149:288-90, 336. 2010
    ....
  19. pmc Biology of chronic lymphocytic leukemia in different microenvironments: clinical and therapeutic implications
    Yair Herishanu
    Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Hematol Oncol Clin North Am 27:173-206. 2013
    ..This article discusses the role of the microenvironment in the context of efforts to develop novel therapeutics that target the biology of CLL...
  20. ncbi [Megakaryocyte development and platelet production in normal and disease states]
    Varda Deutsch
    The Hematology Institute, Tel Aviv Medical Center, Tel Aviv
    Harefuah 149:291-7, 336. 2010
    ..In this article, the authors review the regulation of megakaryocytopoiesis and platelet production in normal and disease states, and new approaches of thrombopoietic therapy...
  21. ncbi Discrepancies in quantitative assessment of bone marrow involvement in lymphoma: do they reflect specialized micro-environmental cellular niches and cell-stromal interactions?
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Medical Center, Tel Aviv, Israel
    Leuk Lymphoma 47:1730-1. 2006
  22. doi Predictive value of TP53 fluorescence in situ hybridization in cytogenetic subgroups of acute myeloid leukemia
    Sigal Tavor
    Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Israel
    Leuk Lymphoma 52:642-7. 2011
    ..TP53 FISH analysis carried out at diagnosis has a predictive value with respect to chemotherapy response and can therefore facilitate a rapid decision on treatment strategies...
  23. doi Therapeutic targeting of CD19 in hematological malignancies: past, present, future and beyond
    Ben Zion Katz
    Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Leuk Lymphoma 55:999-1006. 2014
    ..g. significant immunosuppression) were also recorded. These novel successful anti-CD19 agents may have the potential to be used in other fields, such as autoimmunity. ..
  24. doi Systematic antigenic profiling of hematopoietic antigens on ovarian carcinoma cells identifies membrane proteins for targeted therapy development
    Limor Helpman
    Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Am J Obstet Gynecol 201:196.e1-7. 2009
    ..We studied ovarian cancers for the expression of membrane markers of hematopoietic origin...
  25. ncbi Heparanase expression in human leukemias is restricted to acute myeloid leukemias
    Menachem Bitan
    Department of Pediatrics, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Exp Hematol 30:34-41. 2002
    ..We evaluated heparanase expression, at the levels of gene and protein expression and activity in a variety of leukemias, and compared it with normal hematopoietic cells...
  26. ncbi Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation
    Ben Zion Katz
    Craniofacial Developmental Biology and Regeneration Branch, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Biochim Biophys Acta 1592:141-52. 2002
    ..This study identifies a proximity mechanism for regulating the initiation of FAK-mediated biochemical signaling...
  27. ncbi Heparanase mediates cell adhesion independent of its enzymatic activity
    Orit Goldshmidt
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    FASEB J 17:1015-25. 2003
    ....
  28. ncbi Diverse niches within multiple myeloma bone marrow aspirates affect plasma cell enumeration
    Liat Nadav
    The Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel
    Br J Haematol 133:530-2. 2006
    ..In contrast, flow cytometry is performed on the BM fluid, which is depleted of the lipid-adhesive plasma cells. This discrepancy may point to different plasma cell subpopulations associated with diverse niches within the BM...
  29. ncbi The generation and regulation of functional diversity of malignant plasma cells
    Liat Nadav
    The Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot, Israel
    Cancer Res 66:8608-16. 2006
    ..Diverse subpopulations of malignant plasma cells may play distinct roles in the different biological and clinical manifestations of plasma cell dyscrasias, including bone dissemination and selective adhesion to bone marrow compartments...
  30. ncbi MUC1/X protein immunization enhances cDNA immunization in generating anti-MUC1 alpha/beta junction antibodies that target malignant cells
    Daniel B Rubinstein
    Food and Drug Administration, Silver Spring, Maryland, USA
    Cancer Res 66:11247-53. 2006
    ..Lastly, sequential immunization with MUC1/TM cDNA acting as a nonspecific adjuvant followed by protein of interest may prove to be a generalizable method to yield high-titer specific antibodies...
  31. ncbi Heparanase, heparin and the coagulation system in cancer progression
    Israel Vlodavsky
    Cancer and Vascular and Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Thromb Res 120:S112-20. 2007
    ....