Michal Taler

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. doi request reprint Attenuated Weight Gain with the Novel Analog of Olanzapine Linked to Sarcosinyl Moiety (PGW5) Compared to Olanzapine
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Mol Neurosci 58:66-73. 2016
  2. doi request reprint Neuroprotective and procognitive effects of sertraline: in vitro and in vivo studies
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurosci Lett 550:93-7. 2013
  3. ncbi request reprint Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur Neuropsychopharmacol 17:774-80. 2007
  4. doi request reprint Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: possible relevance to depression and hyperactive-immune disorders
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Int Immunopharmacol 8:526-33. 2008
  5. doi request reprint The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
    Neuroimmunomodulation 18:117-22. 2011
  6. doi request reprint Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma/leukemia (Jurkat) in vitro
    Ben Hayman Amit
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Eur Neuropsychopharmacol 19:726-34. 2009
  7. doi request reprint The effects of reboxetine treatment on depression-like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva 49100, Israel
    J Mol Neurosci 50:88-97. 2013
  8. ncbi request reprint Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsentein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University and Campus Rabin, Petah Tikva 49100, Israel
    Int J Oncol 33:277-86. 2008
  9. ncbi request reprint Relationship between antidepressants and IGF-1 system in the brain: possible role in cognition
    Nurit Grunbaum-Novak
    Lab of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel
    Eur Neuropsychopharmacol 18:431-8. 2008
  10. doi request reprint The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders
    Sarah Hollander
    Sackler Faculty of Medicine, Tel Aviv University, Israel Electronic address
    Psychiatry Res 238:333-7. 2016

Collaborators

Detail Information

Publications18

  1. doi request reprint Attenuated Weight Gain with the Novel Analog of Olanzapine Linked to Sarcosinyl Moiety (PGW5) Compared to Olanzapine
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Mol Neurosci 58:66-73. 2016
    ..The differential modulation of brain peptides associated with appetite regulation is possibly involved in the attenuation of metabolic effects by PGW5...
  2. doi request reprint Neuroprotective and procognitive effects of sertraline: in vitro and in vivo studies
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurosci Lett 550:93-7. 2013
    ..Sertraline treatment resulted in up-regulation of brain BDNF, phospho-ERK and Bcl-2 that may be involved in the pro-cognitive effect of sertraline...
  3. ncbi request reprint Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur Neuropsychopharmacol 17:774-80. 2007
    ..These findings reveal an immunomodulatory effect of the SSRIs paroxetine and sertraline in human T cells. The clinical implications of our findings merit further investigation...
  4. doi request reprint Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: possible relevance to depression and hyperactive-immune disorders
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Int Immunopharmacol 8:526-33. 2008
    ..These findings reveal the immunomodulatory effect of the selected antidepressants. These data suggest a novel use of antidepressants or their derivatives...
  5. doi request reprint The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
    Neuroimmunomodulation 18:117-22. 2011
    ..We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors...
  6. doi request reprint Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma/leukemia (Jurkat) in vitro
    Ben Hayman Amit
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Eur Neuropsychopharmacol 19:726-34. 2009
    ..5 microM) markedly enhanced the effects of both vincristine and doxorubicin, suggesting SSRI antidepressants as potential new chemosensitizers in chemotherapeutic regimens, pending further in vivo research...
  7. doi request reprint The effects of reboxetine treatment on depression-like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva 49100, Israel
    J Mol Neurosci 50:88-97. 2013
    ..In conclusion, our study shows that BDNF, its receptor TrkB, and ERK participate in the neurobiological response to chronic stress and in the molecular and cellular activities of REB in the hippocampus...
  8. ncbi request reprint Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsentein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University and Campus Rabin, Petah Tikva 49100, Israel
    Int J Oncol 33:277-86. 2008
    ..Since SSRI therapy is frequently indicated in cancer patients, the use of sertraline in colon cancer patients with co-morbidity of depression seems attractive...
  9. ncbi request reprint Relationship between antidepressants and IGF-1 system in the brain: possible role in cognition
    Nurit Grunbaum-Novak
    Lab of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel
    Eur Neuropsychopharmacol 18:431-8. 2008
    ..FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system...
  10. doi request reprint The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders
    Sarah Hollander
    Sackler Faculty of Medicine, Tel Aviv University, Israel Electronic address
    Psychiatry Res 238:333-7. 2016
    ..After controlling for confounders, it seems that sCK level is associated with the both affective and psychotic components. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis...
  11. doi request reprint Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro
    Ran Barzilay
    Laboratory of Neuroscience, Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel Research Unit at Geha Mental Health Center, Israel Electronic address
    Eur Neuropsychopharmacol 23:1115-23. 2013
    ..The mechanism underlying the beneficial behavioral effect may involve modulation of host astrocyte functioning, including glutamate processing and antioxidant capacity...
  12. doi request reprint The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, 49100 Petah Tikva, Israel
    J Mol Neurosci 45:246-55. 2011
    ..This study suggests that IGF-1R and ERK may have a role in mediating the neural stress response and the mode of action of FLX. This role seems to be independent of the BDNF alterations...
  13. doi request reprint Intracranial pancreatic islet transplantation increases islet hormone expression in the rat brain and attenuates behavioral dysfunctions induced by MK-801 (dizocilpine)
    Konstantin Bloch
    Laboratory of Diabetes and Obesity Research, Felsenstein Medical Research Center, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel Electronic address
    Horm Behav 72:1-11. 2015
    ....
  14. doi request reprint Effects of the anti-multiple sclerosis immunomodulator laquinimod on anxiety and depression in rodent behavioral models
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    J Mol Neurosci 55:552-60. 2015
    ..05). In conclusion, laquinimod may possess anxiolytic and antidepressant effects, possibly associated with hippocampal BDNF increase, offering promise for MS patients suffering from psychiatric co-morbidity...
  15. doi request reprint A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia
    Irit Gil-Ad
    Felsenstein Medical Research Center, Campus Rabin, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur Neuropsychopharmacol 24:425-36. 2014
    ..Mice treated with PGW5 (25 and 50mg/kg/d) for 28 days did not show toxic effects in terms of weight gain and blood-chemistry analysis...
  16. doi request reprint Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression
    Ayelet Kaminitz
    Biological Psychiatry Lab, Felsenstein Medical Research Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Israel
    World J Biol Psychiatry 15:76-82. 2014
    ..In this study, we aimed to characterize behavioural and brain biochemical traits in a mouse expressing a dominant negative DISC1mutant (DN-DISC1)...
  17. doi request reprint Immunomodulatory effect of sertraline in a rat model of rheumatoid arthritis
    Ehud Baharav
    Laboratory of Joint Pathophysiology and Inflammation, Department of Medicine C, Rabin Medical Center, Petach Tikva, Israel
    Neuroimmunomodulation 19:309-18. 2012
    ..SSRIs are the preferred treatment for major depressive disorder (MDD). A high rate of MDD is observed in rheumatoid arthritis (RA) patients. The aim of this study was to evaluate immunological effects of SSRIs in a rat model of RA...
  18. ncbi request reprint Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Oncol Rep 15:107-12. 2006
    ..resulted in the reduction of lung tumor burden and an increase in mice survival. In conclusion, several phenothiazines, and particularly thioridazine, induced apoptosis of B16 melanoma cells and demonstrated in vivo anti-tumor activity...