Teresa Spanu

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. doi request reprint High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria.
    Gennaro De Pascale
    Crit Care 18:R90. 2014
  2. pmc Ventriculitis due to Staphylococcus lugdunensis: two case reports
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    J Med Case Rep 2:267. 2008
  3. pmc Evaluation of the New NucliSENS EasyQ KPC test for rapid detection of Klebsiella pneumoniae carbapenemase genes (blaKPC)
    Teresa Spanu
    Institutes of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 50:2783-5. 2012
  4. pmc An uncommon presentation for a severe invasive infection due to methicillin-resistant Staphylococcus aureus clone USA300 in Italy: a case report
    Piero Valentini
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Clin Microbiol Antimicrob 7:11. 2008
  5. ncbi request reprint Antibiotic therapy for severe bacterial infections: correlation between the inhibitory quotient and outcome
    Teresa Spanu
    Department of Microbiology, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    Int J Antimicrob Agents 23:120-8. 2004
  6. ncbi request reprint Identification of methicillin-resistant isolates of Staphylococcus aureus and coagulase-negative staphylococci responsible for bloodstream infections with the Phoenix system
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    Diagn Microbiol Infect Dis 48:221-7. 2004
  7. pmc Direct maldi-tof mass spectrometry assay of blood culture broths for rapid identification of Candida species causing bloodstream infections: an observational study in two large microbiology laboratories
    Teresa Spanu
    Istituto di Microbiologia, a Istituto di Clinica delle Malattie Infettive, Rome, Italy
    J Clin Microbiol 50:176-9. 2012
  8. ncbi request reprint Recurrent ventriculoperitoneal shunt infection caused by small-colony variants of Staphylococcus aureus
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    Clin Infect Dis 41:e48-52. 2005
  9. pmc Use of the VITEK 2 system for rapid identification of clinical isolates of Staphylococci from bloodstream infections
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 41:4259-63. 2003
  10. pmc Evaluation of the new VITEK 2 extended-spectrum beta-lactamase (ESBL) test for rapid detection of ESBL production in Enterobacteriaceae isolates
    Teresa Spanu
    Institute of Microbiology, Caholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 44:3257-62. 2006

Collaborators

Detail Information

Publications45

  1. doi request reprint High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria.
    Gennaro De Pascale
    Crit Care 18:R90. 2014
    ..In the VAP subgroup the high-dose regimen was associated with better outcomes than conventional administration due to Gram-negative MDR bacteria...
  2. pmc Ventriculitis due to Staphylococcus lugdunensis: two case reports
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    J Med Case Rep 2:267. 2008
    ..Staphylococcus lugdunensis is an unusually virulent coagulase-negative staphylococcus that has rarely been implicated in central nervous system infections...
  3. pmc Evaluation of the New NucliSENS EasyQ KPC test for rapid detection of Klebsiella pneumoniae carbapenemase genes (blaKPC)
    Teresa Spanu
    Institutes of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 50:2783-5. 2012
    ..The EasyQ assay correctly detected all of the 111 isolates harboring bla(KPC) genes, with no false positives, and results were available within 2 h...
  4. pmc An uncommon presentation for a severe invasive infection due to methicillin-resistant Staphylococcus aureus clone USA300 in Italy: a case report
    Piero Valentini
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Clin Microbiol Antimicrob 7:11. 2008
    ..More commonly, community-acquired (CA)-MRSA is a cause of infections of the skin and soft-tissues, but life-threatening infections such as necrotizing pneumonia and sepsis can occasionally occur...
  5. ncbi request reprint Antibiotic therapy for severe bacterial infections: correlation between the inhibitory quotient and outcome
    Teresa Spanu
    Department of Microbiology, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    Int J Antimicrob Agents 23:120-8. 2004
    ..001-0.002): values <4 predicted failure, and those >or=6 cure. This simple parameter could be routinely used to guide effective antibiotic therapy...
  6. ncbi request reprint Identification of methicillin-resistant isolates of Staphylococcus aureus and coagulase-negative staphylococci responsible for bloodstream infections with the Phoenix system
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    Diagn Microbiol Infect Dis 48:221-7. 2004
    ..7%; negative predictive value 96.5%). The Phoenix system can provide accurate and reliable identification of methicillin-resistant staphylococci responsible for bloodstream infections...
  7. pmc Direct maldi-tof mass spectrometry assay of blood culture broths for rapid identification of Candida species causing bloodstream infections: an observational study in two large microbiology laboratories
    Teresa Spanu
    Istituto di Microbiologia, a Istituto di Clinica delle Malattie Infettive, Rome, Italy
    J Clin Microbiol 50:176-9. 2012
    ..5% of non-albicans Candida species (128/148). Results were available in 30 min (median), suggesting that this approach is a reliable, time-saving tool for routine identification of Candida species causing bloodstream infection...
  8. ncbi request reprint Recurrent ventriculoperitoneal shunt infection caused by small-colony variants of Staphylococcus aureus
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    Clin Infect Dis 41:e48-52. 2005
    ..aureus (which were misidentified by 3 widely used automated identification systems as methicillin-susceptible coagulase-negative staphylococci) as the cause of recurrent ventriculoperitoneal shunt-related meningitis...
  9. pmc Use of the VITEK 2 system for rapid identification of clinical isolates of Staphylococci from bloodstream infections
    Teresa Spanu
    Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 41:4259-63. 2003
    ..hominis...
  10. pmc Evaluation of the new VITEK 2 extended-spectrum beta-lactamase (ESBL) test for rapid detection of ESBL production in Enterobacteriaceae isolates
    Teresa Spanu
    Institute of Microbiology, Caholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 44:3257-62. 2006
    ..VITEK 2 ESBL testing took 6 to 13 h (median, 7.5 h; mean +/- SD, 8.2 +/- 2.39 h). This automated short-incubation system appears to be a rapid and reliable tool for routine identification of ESBL-producing isolates of Enterobacteriaceae...
  11. pmc Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment
    Mario Tumbarello
    Istituto Malattie Infettive, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 51:1987-94. 2007
    ..Prompt initiation of effective antimicrobial treatment is essential in patients with ESBL-BSI, and empirical decisions must be based on a sound knowledge of the local distribution of pathogens and their susceptibility patterns...
  12. pmc Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy
    Mario Tumbarello
    Institute of Infectious Diseases, Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy
    Antimicrob Agents Chemother 52:3244-52. 2008
    ....
  13. pmc Biofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia
    Mario Tumbarello
    Institute of Infectious Diseases, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    J Clin Microbiol 45:1843-50. 2007
    ..Together with well-established factors, Candida biofilm production was therefore shown to be associated with greater mortality of patients with candidemia, probably by preventing complete organism eradication from the blood...
  14. doi request reprint Prediction models to identify hospitalized patients at risk of being colonized or infected with multidrug-resistant Acinetobacter baumannii calcoaceticus complex
    Evelina Tacconelli
    Department of Infectious Diseases, Universita Cattolica Sacro Cuore, 00168 Rome, Italy
    J Antimicrob Chemother 62:1130-7. 2008
    ....
  15. pmc Characterization of clinical isolates of Enterobacteriaceae from Italy by the BD Phoenix extended-spectrum beta-lactamase detection method
    Maurizio Sanguinetti
    Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Clin Microbiol 41:1463-8. 2003
    ..9% specificity. These findings suggest that the Phoenix ESBL test can be a rapid and reliable method for laboratory detection of ESBL resistance in gram-negative bacteria...
  16. doi request reprint Factors associated with mortality in bacteremic patients with hematologic malignancies
    Mario Tumbarello
    Institute of Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
    Diagn Microbiol Infect Dis 64:320-6. 2009
    ..Future infection trends must be carefully monitored and treatment guidelines adjusted accordingly...
  17. pmc Azole resistance of Candida glabrata in a case of recurrent fungemia
    Brunella Posteraro
    Department of Microbiology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, Rome 00168, Italy
    J Clin Microbiol 44:3046-7. 2006
    ..Amphotericin B therapy eradicated the infection...
  18. doi request reprint Incidence and clinical impact of extended-spectrum-beta-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies
    Enrico M Trecarichi
    Institute of Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
    J Infect 58:299-307. 2009
    ..Particular attention was focused on defining the impact of extended-spectrum-beta-lactamase (ESBL) production and fluoroquinolone resistance by the bacterial isolates on mortality...
  19. pmc In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli
    Teresa Spanu
    Institute of Microbiology, Catholic University, Rome, Italy
    Antimicrob Agents Chemother 56:4516-8. 2012
    ..The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure...
  20. pmc Multidrug-resistant Proteus mirabilis bloodstream infections: risk factors and outcomes
    Mario Tumbarello
    Faculty of Medicine, Institutes of Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
    Antimicrob Agents Chemother 56:3224-31. 2012
    ..mirabilis BSIs likely to be MDR, thereby reducing the risk of IIAT--a major risk factor for mortality in these cases--and facilitating the prompt implementation of appropriate infection control measures...
  21. doi request reprint Clinical outcomes of Pseudomonas aeruginosa pneumonia in intensive care unit patients
    Mario Tumbarello
    Institute of Infectious Diseases, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168, Rome, Italy
    Intensive Care Med 39:682-92. 2013
    ....
  22. pmc Antifungal susceptibility profiles of bloodstream yeast isolates by Sensititre YeastOne over nine years at a large Italian teaching hospital
    Brunella Posteraro
    Institute of Public Health Section of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy
    Antimicrob Agents Chemother 59:3944-55. 2015
    ..8%. In summary, the SYO method proved to be able to detect yeast species showing antifungal resistance or reduced susceptibility...
  23. doi request reprint Catheter-related bacteremia by Cupriavidus metallidurans
    Tiziana D'Inzeo
    Institutes of Microbiology, Catholic University School of Medicine, 00168 Roma, Italy
    Diagn Microbiol Infect Dis 81:9-12. 2015
    ..To our knowledge, these are the first cases of C. metallidurans catheter-related infections. Patients were successfully treated with antibiotic therapy and catheter removal. ..
  24. doi request reprint Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy
    Mario Tumbarello
    Institute of Infectious Diseases, Catholic University of the Sacred Heart, A Gemelli Hospital, Rome
    Clin Infect Dis 55:943-50. 2012
    ..The spread of Klebsiella pneumoniae (Kp) strains that produce K. pneumoniae carbapenemases (KPCs) has become a significant problem, and treatment of infections caused by these pathogens is a major challenge for clinicians...
  25. pmc Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome
    Mario Tumbarello
    Departments of Infectious Diseases, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 50:498-504. 2006
    ..62; 95% CI, 1.28 to 5.35). In summary, this investigation identifies epidemiological characteristics that distinguish ESBL-producing K. pneumoniae infections from non-ESBL-producing K. pneumoniae ESBL bloodstream infections...
  26. pmc Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy
    Mario Tumbarello
    Institutes of Infectious Diseases, Hospital Pharmacy, 5 Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Antimicrob Agents Chemother 54:4085-91. 2010
    ..00) post-BSI-onset hospital stays and increased 21-day mortality (29.7% versus 6.1%). These findings confirm that the hospital costs and mortality associated with E. coli BSIs are significantly increased by ESBL production and by IIAT...
  27. doi request reprint Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study
    Mario Tumbarello
    Institute of Infectious Diseases, Catholic University of the Sacred Heart, A Gemelli Hospital, Roma, Italy
    J Antimicrob Chemother 70:2133-43. 2015
    ..To assess their outcomes and identify risk factors for 14 day mortality, we conducted a 4 year (2010-13) retrospective cohort study in five large Italian teaching hospitals...
  28. pmc Identification of coagulase-negative Staphylococci by using the BD phoenix system in the low-inoculum mode
    Gioconda Brigante
    Department of Microbiology, University of Catania, Via Androne 81, 95124 Catania, Italy
    J Clin Microbiol 46:3826-8. 2008
    ..The system correctly identified 90.5% of isolates, with a mean time of 10.2 h. Accuracy was satisfactory for Staphylococcus epidermidis, S. saprophyticus, and S. haemolyticus...
  29. pmc Identifying patients harboring extended-spectrum-beta-lactamase-producing Enterobacteriaceae on hospital admission: derivation and validation of a scoring system
    Mario Tumbarello
    Institute of Infectious Diseases, Agostino Gemelli Hospital, Catholic University of the Sacred Heart, Rome, Italy
    Antimicrob Agents Chemother 55:3485-90. 2011
    ..Further study is needed to confirm this model's potential as a guide for prescribing empirical antibiotic therapy...
  30. pmc Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study
    Evelina Tacconelli
    Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
    Antimicrob Agents Chemother 53:4264-9. 2009
    ..Identifying ARB colonization early during antibiotic therapy could target a high-risk hospitalized population that may benefit from intervention to decrease the risk of subsequent nosocomial infections...
  31. pmc Deep neck infection complicating lymphadenitis caused by Streptococcus intermedius in an immunocompetent child
    Donato Rigante
    Department of Pediatric Sciences, Universita Cattolica Sacro Cuore, Rome, Italy
    BMC Infect Dis 6:61. 2006
    ..Streptococcus intermedius belongs to the Streptococcus anginosus group. It is part of the normal flora of the human mouth, but it can be etiologically associated with deep-site infections...
  32. pmc Performance of two resin-containing blood culture media in detection of bloodstream infections and in direct matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) broth assays for isolate identification: clinical comp
    Barbara Fiori
    Institute of Microbiology, Catholic University of the Sacred Heart, Gemelli Hospital, Rome, Italy
    J Clin Microbiol 52:3558-67. 2014
    ..The BacT/Alert Plus media line appears to be a reliable, timesaving tool for routine detection of BSIs in the population we studied, although further studies are needed to evaluate their performance in other settings...
  33. pmc Predictive models for identification of hospitalized patients harboring KPC-producing Klebsiella pneumoniae
    Mario Tumbarello
    Institute of Infectious Diseases, Catholic University of the Sacred Heart, A Gemelli Hospital, Rome, Italy
    Antimicrob Agents Chemother 58:3514-20. 2014
    ..80 to 0.84) and 0.82 (95% CI, 0.80 to 0.85), respectively. This study provides novel information which might be useful for the clinical management of patients harboring KPCKP and for controlling the spread of this organism...
  34. pmc Molecular identification of Leuconostoc mesenteroides as a cause of brain abscess in an immunocompromised patient
    Alessio Albanese
    Department of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy
    J Clin Microbiol 44:3044-5. 2006
    ..Using molecular methods, we identified Leuconostoc mesenteroides as the cause of a brain abscess which was successfully treated by surgery and antimicrobial treatment. This is the first report of brain abscess caused by this species...
  35. ncbi request reprint Antimicrobial resistance among non-fermentative Gram-negative bacilli isolated from the respiratory tracts of Italian inpatients: a 3-year surveillance study by the Italian Epidemiological Survey
    Giovanni Fadda
    Institute of Microbiology, Catholic University of the Sacred Hearth, Largo F Vito 1, 00168 Rome, Italy
    Int J Antimicrob Agents 23:254-61. 2004
    ..Resistance rates and trends showed consistent regional variations, including sharp increases from 1997 to 1999 in imipenem resistance among P. aeruginosa isolates from central and southern Italy...
  36. ncbi request reprint Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes
    Brunella Posteraro
    Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy, and Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    J Antimicrob Chemother 58:458-61. 2006
    ..The aim of the present study was to expand the data on the in vitro activity of caspofungin against azole-resistant isolates of C. glabrata...
  37. doi request reprint Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples
    Tiziana D'Inzeo
    Institute of Microbiology, Catholic University, Rome, Italy
    J Infect Dev Ctries 11:98-101. 2017
    ..We assessed the laboratory performances of Mycoplasma IES (IES), the Mycofast Revolution (REV) and Mycoplasma IST 2 (IST2) compared to A7 agar plates for the detection of Ureaplasma urealyticum and Mycoplasma hominis in clinical samples...
  38. doi request reprint Application of MALDI-TOF mass spectrometry in clinical diagnostic microbiology
    Elena De Carolis
    Catholic University of the Sacred Hearth, Rome, Italy
    J Infect Dev Ctries 8:1081-8. 2014
    ....
  39. doi request reprint Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration
    Gennaro De Pascale
    Department of Intensive Care and Anesthesiology, Agostino Gemelli Hospital, Catholic University of the Sacred Heart, Rome, Italy
    Intensive Care Med 41:103-10. 2015
    ..No data are available on the use of linezolid (LNZ) continuous infusion in critically ill obese patients affected by ventilator-associated pneumonia (VAP)...
  40. ncbi request reprint ESBL-producing multidrug-resistant Providencia stuartii infections in a university hospital
    Mario Tumbarello
    Departments of Infectious Diseases and Microbiology, Universita Cattolica, Largo A Gemelli 8, 00168 Roma, Italy
    J Antimicrob Chemother 53:277-82. 2004
    ..To investigate the epidemiological and clinical findings of extended-spectrum beta-lactamase (ESBL)-producing Providencia stuartii infections in a large Italian university hospital...
  41. ncbi request reprint Risk factors and predictors of mortality of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in HIV-infected patients
    Mario Tumbarello
    Department of Infectious Diseases and Microbiology, Catholic University, Largo A Gemelli 8, 00168 Roma, Italy
    J Antimicrob Chemother 50:375-82. 2002
    ..To define the incidence, risk factors and short-term predictors of mortality of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia in HIV-infected patients...
  42. doi request reprint Resource-saving advice from an infectious diseases specialist team in a large university hospital: an exportable model?
    Massimo Fantoni
    Institute of Infectious Diseases, Risk Management Unit, Institute of Microbiology, Catholic University of Rome, Rome, Italy
    Future Microbiol 10:15-20. 2015
    ....
  43. pmc Empyema caused by Prevotella bivia complicating an unusual case of spontaneous chylothorax
    Alessandro Di Marco Berardino
    Pulmonary Medicine Department, Policlinico Universitario A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Clin Microbiol 52:1284-6. 2014
    ..Spontaneous chylothorax is rare in adults. We present an unusual case that was complicated by Prevotella bivia empyema. Full recovery was achieved with chest tube drainage and prompt treatment with intravenous clindamycin. ..
  44. ncbi request reprint High levels of dual resistance to clarithromycin and metronidazole and in vitro activity of levofloxacin against Helicobacter pylori isolates from patients after failure of therapy
    Giovanna Branca
    Institute of Microbiology, Catholic University of the Sacred Hearth, Rome, Italy
    Int J Antimicrob Agents 24:433-8. 2004
    ..Levofloxacin may be an option for refractory H. pylori infections, but the choice should be based on in vitro susceptibility data, and physicians should consider local resistance patterns when treating these infections empirically...
  45. pmc Multidrug-resistant Pseudomonas aeruginosa bloodstream infections: analysis of trends in prevalence and epidemiology
    Evelina Tacconelli
    Emerg Infect Dis 8:220-1. 2002