Giuseppe Biamonti

Summary

Affiliation: Istituto di Genetica Molecolare
Country: Italy

Publications

  1. pmc Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins
    Isabelle Frouin
    Istituto di Genetica Molecolare CNR, Pavia, Italy
    EMBO J 21:2485-95. 2002
  2. pmc Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression
    Davide Gabellini
    Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, I 27100 Pavia, Italy
    EMBO J 22:3715-24. 2003
  3. ncbi Cellular response to etoposide treatment
    Alessandra Montecucco
    Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, 27100 Pavia, Italy
    Cancer Lett 252:9-18. 2007
  4. doi The alternative splicing side of cancer
    Giuseppe Biamonti
    Istituto di Genetica Molecolare CNR, via Abbiategrasso 207, 27011 Pavia, Italy Electronic address
    Semin Cell Dev Biol 32:30-6. 2014
  5. doi Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)
    Giuseppe Biamonti
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche, Pavia, Italy
    Cell Mol Life Sci 69:2515-26. 2012
  6. doi Cellular stress and RNA splicing
    Giuseppe Biamonti
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche Via Abbiategrasso 207, 27100 Pavia, Italy
    Trends Biochem Sci 34:146-53. 2009
  7. ncbi Nuclear stress bodies: a heterochromatin affair?
    Giuseppe Biamonti
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Via Ferrata 1, 27100 Pavia, Italy
    Nat Rev Mol Cell Biol 5:493-8. 2004
  8. ncbi Is DNA sequence sufficient to specify DNA replication origins in metazoan cells?
    Giuseppe Biamonti
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, 27100 Pavia, Italy
    Chromosome Res 11:403-12. 2003
  9. pmc Nuclear stress bodies
    Giuseppe Biamonti
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, Pavia, Italy
    Cold Spring Harb Perspect Biol 2:a000695. 2010
  10. pmc Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells
    Rut Valgardsdottir
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Mol Biol Cell 16:2597-604. 2005

Collaborators

Detail Information

Publications31

  1. pmc Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins
    Isabelle Frouin
    Istituto di Genetica Molecolare CNR, Pavia, Italy
    EMBO J 21:2485-95. 2002
    ....
  2. pmc Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression
    Davide Gabellini
    Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, I 27100 Pavia, Italy
    EMBO J 22:3715-24. 2003
    ..These data imply that HOXC10 is a homeoprotein with the potential to influence mitotic progression, and might provide a link between developmental regulation and cell cycle control...
  3. ncbi Cellular response to etoposide treatment
    Alessandra Montecucco
    Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, 27100 Pavia, Italy
    Cancer Lett 252:9-18. 2007
    ..The elucidation of the effects of etoposide on cell metabolism will increase our ability to exploit this drug in cancer therapy and will expand our comprehension of the cancerous cell...
  4. doi The alternative splicing side of cancer
    Giuseppe Biamonti
    Istituto di Genetica Molecolare CNR, via Abbiategrasso 207, 27011 Pavia, Italy Electronic address
    Semin Cell Dev Biol 32:30-6. 2014
    ..Finally, we focus on the recently described interplay between splicing and chromatin organization which is expected to shed new lights into gene expression regulation in normal and cancer cells. ..
  5. doi Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)
    Giuseppe Biamonti
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche, Pavia, Italy
    Cell Mol Life Sci 69:2515-26. 2012
    ..Next, we discuss alternative splicing factors that regulate EMT. Finally, we provide examples of target genes presenting alternative splicing changes that contribute to the morphological conversions in the EMT process...
  6. doi Cellular stress and RNA splicing
    Giuseppe Biamonti
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche Via Abbiategrasso 207, 27100 Pavia, Italy
    Trends Biochem Sci 34:146-53. 2009
    ..This could be important to modulate gene expression during recovery from stress. Thus, pre-mRNA splicing emerges as a central mechanism to integrate cellular and metabolic stresses into gene-expression profiles...
  7. ncbi Nuclear stress bodies: a heterochromatin affair?
    Giuseppe Biamonti
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Via Ferrata 1, 27100 Pavia, Italy
    Nat Rev Mol Cell Biol 5:493-8. 2004
  8. ncbi Is DNA sequence sufficient to specify DNA replication origins in metazoan cells?
    Giuseppe Biamonti
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, 27100 Pavia, Italy
    Chromosome Res 11:403-12. 2003
    ..In this manner they can also affect gene expression. In this review we focus on DNA replication origins in metazoan cells and on the relationship between these elements and the structural and functional organization of the genome...
  9. pmc Nuclear stress bodies
    Giuseppe Biamonti
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, Pavia, Italy
    Cold Spring Harb Perspect Biol 2:a000695. 2010
    ..The analysis of these atypical and intriguing structures uncovers new facets of the relationship between nuclear organization and nuclear function...
  10. pmc Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells
    Rut Valgardsdottir
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Mol Biol Cell 16:2597-604. 2005
    ..Thus, satellite III RNAs have a major role in the formation of nSBs...
  11. ncbi Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle
    Maria Rosa Lidonnici
    Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, 27100 Pavia, Italy
    J Cell Sci 117:5221-31. 2004
    ..Our data suggest a role of HP1 in the recruitment but not in the stable association of Orc1p with heterochromatin. Indeed, the subnuclear distribution of Orc1p is not affected by treatments that trigger the dispersal of HP1...
  12. pmc RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies
    Ilaria Chiodi
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, 27100 Pavia, Italy
    Nucleic Acids Res 32:4127-36. 2004
    ..Our analysis suggests that the recruitment of SF2/ASF to nSBs is mediated by a direct interaction with satellite III transcripts and points to the second RNA-binding domain of the protein as the major determinant of this interaction...
  13. pmc Transcription of Satellite III non-coding RNAs is a general stress response in human cells
    Rut Valgardsdottir
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche Via Abbiategrasso 207, 27100 Pavia
    Nucleic Acids Res 36:423-34. 2008
    ..This is the first example of a non-coding RNA whose transcription is controlled by different transcription factors under different growth conditions...
  14. pmc DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression
    Samuela Soza
    Istituto di Genetica Molecolare, Consiglio Nazionale della Ricerche, Pavia, Italy
    Mol Cell Biol 29:2032-41. 2009
    ..Notably, the expression of the phosphomimetic mutant drastically affects cell morphology and the organization of the cytoskeleton, unveiling an unexpected link between endogenous DNA damage and the structural organization of the cell...
  15. ncbi The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway
    Rossella Rossi
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, I 27100 Pavia, Italy
    Cancer Res 66:1675-83. 2006
    ..Finally, our analysis evidences a critical role of Nbs1 in the etoposide-induced inhibition of DNA replication in early S phase...
  16. ncbi DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories
    Riccardo Vago
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy
    Cell Cycle 8:2600-7. 2009
    ....
  17. pmc Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock
    Nicoletta Rizzi
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Mol Biol Cell 15:543-51. 2004
    ..This is the first report of a transcriptional activation of a constitutive heterochromatic portion of the genome in response to stress stimuli...
  18. pmc Phosphorylation of SRSF1 is modulated by replicational stress
    Valentina Leva
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Nucleic Acids Res 40:1106-17. 2012
    ....
  19. pmc Modular structure of the human lamin B2 replicator
    Sónia Paixão
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Mol Cell Biol 24:2958-67. 2004
    ..This analysis reveals the modular structure of the lamin B2 origin and supports the idea that sequence elements close to the replication start site play an important role in origin activation...
  20. pmc Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene
    Cristina Valacca
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche IGM CNR, 27100 Pavia, Italy
    J Cell Biol 191:87-99. 2010
    ..Collectively, our results reveal a hierarchy of splicing factors that integrate splicing decisions into EMT/MET programs in response to extracellular stimuli...
  21. ncbi Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: therapeutic potential of bifunctional oligonucleotides and indole derivatives
    Claudia Ghigna
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche IGM CNR, Pavia, Italy
    RNA Biol 7:495-503. 2010
    ..Notably, indole derivatives are also able to affect the invasive phenotype of the cells. Thus, these treatments may have therapeutic applications for anti-cancer purposes...
  22. pmc HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition
    Serena Bonomi
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche IGM CNR, 27100 Pavia, Italy, International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy and Division of Regenerative Medicine, Stem Cells, and Gene Therapy, Dulbecco Telethon Institute at San Raffaele Scientific Institute, 20132 Milan, Italy
    Nucleic Acids Res 41:8665-79. 2013
    ..These results shed light on how splicing regulation contributes to the tumor progression and provide potential targets to develop anticancer therapies. ..
  23. ncbi Cell cycle-dependent phosphorylation of human DNA ligase I at the cyclin-dependent kinase sites
    Giovanni Ferrari
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, 27100 Pavia, Italy
    J Biol Chem 278:37761-7. 2003
    ..We suggest that the phosphorylation of DNA ligase I and possibly other replicative enzymes is part of the mechanism that directs the disassembly of the replication machinery at the completion of S-phase...
  24. pmc Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies
    Marco Denegri
    Istituto di Genetica Molecolare del Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Mol Biol Cell 13:2069-79. 2002
    ..Our data indicate that human chromosomes 9, 12, and 15 contain the nucleation sites of stress bodies in heat-shocked HeLa cells...
  25. ncbi Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene
    Claudia Ghigna
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy
    Mol Cell 20:881-90. 2005
    ..This demonstrates a direct link between SF2/ASF-regulated splicing and cell motility, an activity important for embryogenesis, tissue formation, and tumor metastasis...
  26. pmc Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells
    Paolo Cremaschi
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche CNR, Pavia, Italy Dipartimento di Biologia e Biotecnologie L Spallanzani, Universita degli Studi di Pavia, Pavia, Italy
    PLoS ONE 10:e0130561. 2015
    ..These observations extend the influence of the DNA damage response checkpoint pathways and unveil a role for ATM kinase activity in modulating cell biology parameters relevant to cancer progression. ..
  27. doi Alternative splicing of tumor suppressors and oncogenes
    Claudia Ghigna
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, 27100, Italy
    Cancer Treat Res 158:95-117. 2013
    ..Thus, a change in their activity deeply affects alternative splicing profiles and hence the cell behavior. Here, we discuss a number of cases that exemplify the involvement of deregulated alternative splicing in tumor progression. ..
  28. pmc Pre-mRNA processing factors meet the DNA damage response
    Alessandra Montecucco
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche Pavia, Italy
    Front Genet 4:102. 2013
    ..In this review we provide a comprehensive overview of the role played by pre-mRNA processing factors in the cell response to DNA damage and in the maintenance of genome stability...
  29. pmc Alternative splicing and tumor progression
    Claudia Ghigna
    Istituto di Genetica Molecolare Consiglio Nazionale delle Ricerche, Via Abbiategrasso 207 27100 Pavia, Italy
    Curr Genomics 9:556-70. 2008
    ....
  30. pmc Functional interactions of DNA topoisomerases with a human replication origin
    Gulnara Abdurashidova
    Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    EMBO J 26:998-1009. 2007
    ..Inhibition of topoisomerase I activity abolishes origin firing. Thus, the two topoisomerases are closely associated with the replicative complexes, and DNA topology plays an essential functional role in origin activation...
  31. ncbi Molecular and structural transactions at human DNA replication origins
    Arturo Falaschi
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Cell Cycle 6:1705-12. 2007
    ....