Fabiola Olivieri

Summary

Country: Italy

Publications

  1. ncbi request reprint Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment
    Fabiola Olivieri
    Dept of Clinical and Molecular Sciences DISCLIMO, Universita Politecnica delle Marche, Via Tronto 10 A 60020 Ancona Italy
    Curr Pharm Des 19:1710-9. 2013
  2. ncbi request reprint Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools
    Francesco Prattichizzo
    Department of Clinical and Molecular Sciences DISCLIMO, Universita Politecnica delle Marche, Ancona, Via Tronto 10 A 60020 Ancona, Italy
    Curr Drug Targets 17:388-97. 2016
  3. pmc Circulating inflamma-miRs in aging and age-related diseases
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Università Politecnica delle Marche Ancona, Italy Center of Clinical Pathology and Innovative Therapy, I N R C A National Institute Ancona, Italy
    Front Genet 4:121. 2013
  4. doi request reprint Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Int J Cardiol 167:531-6. 2013
  5. doi request reprint Telomere/telomerase system impairment in circulating angiogenic cells of geriatric patients with heart failure
    F Olivieri
    Department of Molecular Pathology and Innovative Therapies, Universita Politecnica delle Marche, Ancona, Italy
    Int J Cardiol 164:99-105. 2013
  6. doi request reprint Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, 60020 Ancona, Italy
    Free Radic Biol Med 63:410-20. 2013
  7. doi request reprint Aged-related increase of high sensitive Troponin T and its implication in acute myocardial infarction diagnosis of elderly patients
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Mech Ageing Dev 133:300-5. 2012
  8. doi request reprint Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Mech Ageing Dev 133:675-85. 2012
  9. pmc Toll like receptor signaling in "inflammaging": microRNA as new players
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona Via Tronto 10 A, Ancona, 60020, Italy
    Immun Ageing 10:11. 2013
  10. pmc MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Via Tronto 10 A, 60020, Ancona, Italy
    Age (Dordr) 35:1157-72. 2013

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment
    Fabiola Olivieri
    Dept of Clinical and Molecular Sciences DISCLIMO, Universita Politecnica delle Marche, Via Tronto 10 A 60020 Ancona Italy
    Curr Pharm Des 19:1710-9. 2013
    ..Finally, interventions aimed at improving the age-related decline in vascular cells during aging and disease, as well as strategies to harness the regenerative capacity of stem cells in CVD will be discussed...
  2. ncbi request reprint Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools
    Francesco Prattichizzo
    Department of Clinical and Molecular Sciences DISCLIMO, Universita Politecnica delle Marche, Ancona, Via Tronto 10 A 60020 Ancona, Italy
    Curr Drug Targets 17:388-97. 2016
    ....
  3. pmc Circulating inflamma-miRs in aging and age-related diseases
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Università Politecnica delle Marche Ancona, Italy Center of Clinical Pathology and Innovative Therapy, I N R C A National Institute Ancona, Italy
    Front Genet 4:121. 2013
    ....
  4. doi request reprint Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Int J Cardiol 167:531-6. 2013
    ..Circulating microRNAs (miRs) have emerged as biomarkers of MI. However, their diagnostic potential needs to be determined in elderly NSTEMI patients...
  5. doi request reprint Telomere/telomerase system impairment in circulating angiogenic cells of geriatric patients with heart failure
    F Olivieri
    Department of Molecular Pathology and Innovative Therapies, Universita Politecnica delle Marche, Ancona, Italy
    Int J Cardiol 164:99-105. 2013
    ..However, the underlying mechanisms are only partly unraveled. No data are currently available regarding telomere/telomerase system in CACs of CHF patients...
  6. doi request reprint Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, 60020 Ancona, Italy
    Free Radic Biol Med 63:410-20. 2013
    ..These phenomena may play a role in preventing the endothelial dysfunction associated with major age-related diseases...
  7. doi request reprint Aged-related increase of high sensitive Troponin T and its implication in acute myocardial infarction diagnosis of elderly patients
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Mech Ageing Dev 133:300-5. 2012
    ..8 ng/L resulted the hs-cTnT cut-off value with the highest efficiency in AMI diagnosis of geriatric patients. Our data suggest that the hs-cTnT cut-off value must be age-tailored to improve the AMI diagnostic accuracy...
  8. doi request reprint Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Mech Ageing Dev 133:675-85. 2012
    ..TGF-βR2 mRNA, a validated miR-21 target, showed the highest expression in the leukocytes from a subset of the octogenarians. Our findings suggest that miR-21 may be a new biomarker of inflammation...
  9. pmc Toll like receptor signaling in "inflammaging": microRNA as new players
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona Via Tronto 10 A, Ancona, 60020, Italy
    Immun Ageing 10:11. 2013
    ..Interestingly, this impairment appears accelerated in presence of the majors age-related diseases, such as cardiovascular diseases, diabetes, neurodegenerative diseases and cancers...
  10. pmc MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Via Tronto 10 A, 60020, Ancona, Italy
    Age (Dordr) 35:1157-72. 2013
    ..Overall, our findings indicate that miR-146a is a marker of a senescence-associated pro-inflammatory status in vascular remodelling cells...
  11. ncbi request reprint Paraoxonase activity and genotype predispose to successful aging
    Francesca Marchegiani
    Center of Molecular Biology and Genetics, INRCA, Ancona, Italy
    J Gerontol A Biol Sci Med Sci 61:541-6. 2006
    ..In conclusion, we show that genetic variability at the PON1 locus is related to paraoxonase activity throughout life, and suggest that both parameters affect survival at extreme advanced age...
  12. pmc Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes
    Liana Spazzafumo
    Biostatistical Center, Polo Scientifico Tecnologico, I N R C A, Via Birarelli, 8, Ancona, Italy
    Age (Dordr) 35:419-29. 2013
    ..Structural relationship changes observed in healthy subjects appeared earlier in diabetic patients and later in centenarians...
  13. ncbi request reprint In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging
    Fabiola Olivieri
    Italian National Research Centers on Aging I N R C A, Via S Margherita, N 5, 60121, Ancona, Italy
    Mech Ageing Dev 124:549-53. 2003
    ..Thus, the EBV-immortalized B lymphocytes can be considered a useful in vitro model for studying the genetic control of IL-6 production and its changes with age...
  14. ncbi request reprint Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    Claudio Franceschi
    Italian National Research Center on Aging, Ancona, Italy
    Mech Ageing Dev 126:351-61. 2005
    ..We extensively screened Alu-rich genomic sites and found a new genomic region associated with longevity...
  15. ncbi request reprint The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians
    Giuseppina Carrieri
    I N R C A, Italian National Research Center on Aging, Ancona, Italy
    Aging Cell 3:443-8. 2004
    ..These results suggest that, at least in this population, the variability of the TGF-beta1 gene influences longevity and that the age-related increase in plasma levels of active TGF-beta1 seems not to be genetically regulated...
  16. doi request reprint The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study
    Anna Rita Bonfigli
    Metabolic Diseases and Diabetology Unit, National Institute of Health and Science on Aging INRCA, Via della Montagnola 81, 60131, Ancona, Italy
    Acta Diabetol 50:429-36. 2013
    ..034, 95 % CI = 0.09-0.91, OR = 0.37, p = 0.035, 95 % CI = 0.15-0.93, respectively). Our findings suggest that p53 codon 72 (Arg72Pro) polymorphism influences insulin resistance in type 2 diabetic patients independently of body mass...
  17. ncbi request reprint Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers
    Roberto Antonicelli
    Center of Molecular Biology, Department of Cardiology CCU and Center of Statistics, Italian National Research Centers on Aging I N R C A, Ancona, Italy
    Coron Artery Dis 16:489-93. 2005
    ....
  18. doi request reprint Combination of biomarkers to predict mortality in elderly patients with myocardial infarction
    Fabiola Olivieri
    Center of Genetic and Molecular Biology, Cardiology CCU Unit, Center of Statistics, Center of Immunology and Nutrigenomics, Center of Citology, Italian National Research Centers on Aging I N R C A, Ancona, Italy
    Mech Ageing Dev 129:231-7. 2008
    ..Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers...
  19. pmc MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells: relationship with type 2 diabetes complications
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy
    Oncotarget 6:35372-82. 2015
    ..Circulating miR-21-5p and miR-126-3p emerge as dynamic biomarkers of systemic inflammatory/angiogenic status. Their expression levels in CACs from T2DM with MACE suggest a shift from a proangiogenic to a proinflammatory profile...
  20. doi request reprint Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients
    Francesca Marchegiani
    Immunology Center, Italian National Research Center on Aging I N R C A, Ancona, Italy
    Mol Genet Metab 98:314-8. 2009
    ..Our findings suggest the need for a more careful clinical monitoring in older persons with such characteristics...
  21. doi request reprint Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction
    Fabiola Olivieri
    Dept of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
    Atherosclerosis 206:588-93. 2009
    ..Secondary end point is the identification of associations between leukocyte telomere length and selected variables related to glycemic control, pro-inflammatory status and lipidic profile...
  22. doi request reprint MicroRNAs linking inflamm-aging, cellular senescence and cancer
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy Center of Clinical Pathology and Innovative Therapy, I N R C A National Institute, Ancona, Italy
    Ageing Res Rev 12:1056-68. 2013
    ....
  23. doi request reprint The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing
    Roberto Testa
    Department of Gerontological Research, Diabetology Unit, INRCA IRCCS, Polytechnic University of Marche, Ancona, Italy
    Mech Ageing Dev 130:497-500. 2009
    ..In particular, our results indicate that Pro/Pro genotype plays a pivotal role in determining PAI-1 levels in aged subjects, while in Arg carriers PAI-1 levels are associated to the known insulin related determinants...
  24. pmc Leukocyte telomere length and mortality risk in patients with type 2 diabetes
    Anna Rita Bonfigli
    Scientific Direction, INRCA IRCCS National Institute, Ancona, Italy
    Oncotarget . 2016
    ..In conclusion, LTL combined with clinical parameters can provide additive prognostic information on mortality risk in T2DM patients...
  25. pmc Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy Center of Clinical Pathology and Innovative Therapy, National Institute INRCA IRCCS, Ancona, Italy
    Aging (Albany NY) 6:771-87. 2014
    ....
  26. ncbi request reprint Telomere/Telomerase system: a new target of statins pleiotropic effect?
    Fabiola Olivieri
    Cardiology Unit, I N R C A Hospital, Via della Montagnola, Ancona, Italy
    Curr Vasc Pharmacol 10:216-24. 2012
    ..We will also present our current findings regarding leukocyte telomere length in very old people with myocardial infarction on statin therapy...
  27. doi request reprint Paraoxonase 1: genetics and activities during aging
    Francesca Marchegiani
    Center of Molecular Biology and Genetics, INRCA, Ancona, Italy
    Rejuvenation Res 11:113-27. 2008
    ....
  28. ncbi request reprint Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly
    Fabiola Olivieri
    Centre of Genetic and Molecular Biology, Research Department, Italian National Research Centre on Aging, Ancona, Italy
    Mech Ageing Dev 127:552-9. 2006
    ....
  29. doi request reprint Conventional and novel diagnostic biomarkers of acute myocardial infarction: a promising role for circulating microRNAs
    Rina Recchioni
    Center of Clinical Pathology and Innovative Therapy, Italian National Research Center on Aging I N R C A IRCCS, Ancona, Italy
    Biomarkers 18:547-58. 2013
    ..We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs...
  30. ncbi request reprint The PON1192RR genotype is associated with a higher prevalence of arterial hypertension
    Maurizio Marra
    Diabetology Unit, INRCA, Ancona, Italy
    J Hypertens 24:1293-8. 2006
    ..To investigate whether genetic polymorphism of paraoxonase (PON1192), an enzyme which protects low density lipoprotein from oxidation, is related to the prevalence of arterial hypertension...
  31. pmc Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
    Francesco Prattichizzo
    Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy
    Oncotarget 7:11945-58. 2016
    ..Our findings suggest that adalimumab can induce epigenetic modifications in cells undergoing senescence, thus contributing to the attenuation of SASP tumor-promoting effects. ..
  32. doi request reprint MitomiRs in human inflamm-aging: a hypothesis involving miR-181a, miR-34a and miR-146a
    Maria Rita Rippo
    Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy Electronic address
    Exp Gerontol 56:154-63. 2014
    ..Their modulation could thus mediate the loss of mitochondrial integrity and function in aging cells, inducing or contributing to the inflammatory response and to age-related diseases...
  33. doi request reprint Frailty and safety: the example of diabetes
    Angela M Abbatecola
    Scientific Direction, Italian National Research Center on Aging INRCA, Ancona, Italy
    Drug Saf 35:63-71. 2012
    ..This review will underline the association between diabetes and some frailty components in old patients and how specific antidiabetic agents may play a specific role in improving outcomes...
  34. pmc DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences DISCLIMO, Universita Politecnica delle Marche, Ancona, Italy
    Oncotarget 6:35509-21. 2015
    ..The identification of the functions of shuttled senescence-associated miRNAs is expected to shed light on the aging process and on how to delay ARD development. ..
  35. pmc N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters
    Roberto Testa
    Experimental models in Clinical Pathology, Italian National Research Center on Aging INRCA, Ancona, 60127, Italy
    PLoS ONE 10:e0119983. 2015
    ....
  36. pmc Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis
    Luigina Micolucci
    Computational Pathology Unit, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Oncotarget 7:58606-58637. 2016
    ..A systematic review and a qualitative meta-analysis were conducted to identify high-confidence miRNAs that can serve as biomarkers of asbestos exposure and MM...
  37. pmc "Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes
    Francesco Prattichizzo
    August Pi i Sunyer Biomedical Research Institute IDIBAPS and Centre of Biomedical Investigation on Diabetes and Associated Metabolic Disorders Network CIBERDEM, 08036 Barcelona, Spain Department of Clinical and Molecular Sciences, DISCLIMO, Universita Politecnica delle Marche, 60126 Ancona, Italy
    Oxid Med Cell Longev 2016:1810327. 2016
    ....
  38. doi request reprint MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma
    Massimo Re
    Department of Otorhinolaryngology, Umberto I University General Hospital, Polytechnic University of the Marches, Ancona, Italy
    Laryngoscope 125:E306-12. 2015
    ..Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC-related miR-34c-5p with disease-free survival and overall survival...
  39. pmc Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: a study on postmenopausal monozygotic twin pairs
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Division of Pathology, Universita Politecnica delle Marche, Ancona, Italy Department of Clinical Pathology and Innovative Therapy, Advanced Technology Center for Aging Research, INRCA IRCCS, Ancona, Italy
    Aging Cell 13:850-61. 2014
    ....
  40. ncbi request reprint Genome-wide association studies: is there a genotype for cognitive decline in older persons with type 2 diabetes?
    Angela Marie Abbatecola
    Italian National Research Center on Aging INRCA, Scientific Direction, Ancona, Italy
    Curr Pharm Des 17:347-56. 2011
    ....
  41. pmc Exercise: a "new drug" for elderly patients with chronic heart failure
    Roberto Antonicelli
    Department of Cardiology, INRCA IRCCS National Institute, Ancona, Italy
    Aging (Albany NY) 8:860-72. 2016
    ..6±12.3 vs. 44.5±12.3, p=0.001). In hospital and home-based telemonitored exercise confer significant benefits on the oldest CHF patients, improving functional capacity and subjective QoL and reducing risk of rehospitalisation. ..
  42. pmc Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Via Tronto 10 A, Ancona, Italy Center of Clinical Pathology and Innovative Therapy, Italian National Research Center on Aging, INRCA IRCCS, Ancona, Italy
    Mech Ageing Dev . 2016
    ....
  43. doi request reprint Progress of research on microRNAs with diagnostic value in asbestos exposure: A call for method standardization
    Luigina Micolucci
    Computational Pathology Unit, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche
    Biosci Trends . 2017
    ....
  44. pmc Bioinformatic tools for microRNA dissection
    Most Mauluda Akhtar
    Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona 60100, Italy Computational Pathology Unit, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona 60100, Italy
    Nucleic Acids Res 44:24-44. 2016
    ..We analyze 129 miRNA tools that are being used in diverse areas of miRNA research, to assist investigators in choosing the most appropriate tools for their needs...
  45. doi request reprint Prevention of cardiovascular events in early menopause: a possible role for hormone replacement therapy
    Roberto Antonicelli
    Division of Cardiology, Italian National Research Centre on Ageing, Ancona, Italy
    Int J Cardiol 130:140-6. 2008
    ....
  46. ncbi request reprint The role of IL-1 gene cluster in longevity: a study in Italian population
    Luca Cavallone
    Direzione Scientifica, Italian National Research Center on Aging, Villa Gusso, Via S Margherita, n 5 60121, Ancona, Italy
    Mech Ageing Dev 124:533-8. 2003
    ....
  47. pmc Effect of aging on microRNAs and regulation of pathogen recognition receptors
    Fabiola Olivieri
    Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy Center of Clinical Pathology and Innovative Therapy, INRCA IRCCS Italian National Institute, Ancona, Italy
    Curr Opin Immunol 29:29-37. 2014
    ....
  48. doi request reprint mRNAs and miRNAs profiling of mesenchymal stem cells derived from amniotic fluid and skin: the double face of the coin
    Raffaella Lazzarini
    Department of Clinical and Molecular Sciences Histology, Universita Politecnica delle Marche, Via Tronto 10 A, 60020, Ancona, Italy
    Cell Tissue Res 355:121-30. 2014
    ..In conclusion, even if further studies are necessary to improve the knowledge about the role of each dysregulated miRNAs gene, these differences may actually strengthen the question about the importance of tissue origin. ..