Paolo Bianco

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Italy
    Hum Gene Ther 21:1057-66. 2010
  2. ncbi request reprint Notochordal inclusions in the vertebral bone marrow
    Alessandro Corsi
    Dipartimento di Medicina Sperimentale, Universita La Sapienza, Rome, Italy
    J Bone Miner Res 23:572-5. 2008
  3. pmc Skeletal stem cells
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy
    Development 142:1023-7. 2015
  4. doi request reprint Stem cells and bone: a historical perspective
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy Electronic address
    Bone 70:2-9. 2015
  5. doi request reprint "Mesenchymal" stem cells
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy Email
    Annu Rev Cell Dev Biol 30:677-704. 2014
  6. pmc Regulation of stem cell therapies under attack in Europe: for whom the bell tolls
    Paolo Bianco
    Department of Molecular Medicine, University of Rome La Sapienza, Rome, Italy
    EMBO J 32:1489-95. 2013
  7. pmc The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
    Paolo Bianco
    Department of Molecular Medicine, La Sapienza Universita di Roma, Rome, Italy
    Nat Med 19:35-42. 2013
  8. doi request reprint Minireview: The stem cell next door: skeletal and hematopoietic stem cell "niches" in bone
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Endocrinology 152:2957-62. 2011
  9. doi request reprint Stem cells in skeletal physiology and endocrine diseases of bone
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy
    Endocr Dev 21:91-101. 2011
  10. pmc Back to the future: moving beyond "mesenchymal stem cells"
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
    J Cell Biochem 112:1713-21. 2011

Collaborators

Detail Information

Publications24

  1. pmc "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Italy
    Hum Gene Ther 21:1057-66. 2010
    ....
  2. ncbi request reprint Notochordal inclusions in the vertebral bone marrow
    Alessandro Corsi
    Dipartimento di Medicina Sperimentale, Universita La Sapienza, Rome, Italy
    J Bone Miner Res 23:572-5. 2008
    ..Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment...
  3. pmc Skeletal stem cells
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy
    Development 142:1023-7. 2015
    ..Here and in the accompanying poster, we concisely discuss the biology of SSCs in the context of the development and postnatal physiology of skeletal lineages, to which their use in medicine must remain anchored. ..
  4. doi request reprint Stem cells and bone: a historical perspective
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy Electronic address
    Bone 70:2-9. 2015
    ..Current interest in stem cells in bone as in other fields is intertwined with that shift. New opportunities and also new challenges arise. This article is part of a Special Issue entitled "Stem cells and bone". ..
  5. doi request reprint "Mesenchymal" stem cells
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy Email
    Annu Rev Cell Dev Biol 30:677-704. 2014
    ..Here, I discuss how the two views developed, conceptually and experimentally, and attempt to clarify the confusion arising from their collision. ..
  6. pmc Regulation of stem cell therapies under attack in Europe: for whom the bell tolls
    Paolo Bianco
    Department of Molecular Medicine, University of Rome La Sapienza, Rome, Italy
    EMBO J 32:1489-95. 2013
    ....
  7. pmc The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
    Paolo Bianco
    Department of Molecular Medicine, La Sapienza Universita di Roma, Rome, Italy
    Nat Med 19:35-42. 2013
    ..These uncertainties have a major impact on their envisioned therapeutic use...
  8. doi request reprint Minireview: The stem cell next door: skeletal and hematopoietic stem cell "niches" in bone
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Endocrinology 152:2957-62. 2011
    ..This opens a new view on the manner in which the skeleton and hematopoiesis can cross-regulate via interacting stem cells but also a novel view of our general concept of stem cell niches...
  9. doi request reprint Stem cells in skeletal physiology and endocrine diseases of bone
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy
    Endocr Dev 21:91-101. 2011
    ..Skeletal stem cells represent a central model system for investigating skeletal diseases, as tools for in vitro and in vivo models, for cell therapy-based strategies, or as targets for drugs...
  10. pmc Back to the future: moving beyond "mesenchymal stem cells"
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
    J Cell Biochem 112:1713-21. 2011
    ..As a novel paradigm emerges that accounts for many facets of the biology of skeletal stem cells, a novel paradigm independently emerges for their applicative/translational use. The two paradigms meet each other back in the future...
  11. doi request reprint Osteoprogenitors and the hematopoietic microenvironment
    Paolo Bianco
    Department of Molecular Medicine, La Sapienza University, 00161 Rome, Italy Biomedical Science Park San Raffaele, 00128 Rome, Italy
    Best Pract Res Clin Haematol 24:37-47. 2011
    ..This view brings the long recognized, and somewhat mysterious, interaction between bone and bone marrow into a new perspective, where two stem cells interact with each other at the same niche...
  12. pmc Transfer, analysis, and reversion of the fibrous dysplasia cellular phenotype in human skeletal progenitors
    Stefania Piersanti
    Biomedical Science Park San Raffaele, Rome, Italy
    J Bone Miner Res 25:1103-16. 2010
    ....
  13. ncbi request reprint Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    ..Our data reveal the functional relationships between establishment of the HME in vivo, establishment of skeletal progenitors in BM sinusoids, and angiogenesis...
  14. pmc Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse
    Cristina Remoli
    Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
    J Bone Miner Res 30:1030-43. 2015
    ..These data demonstrate that effects of Gsα mutations underpinning FD-defining tissue changes and morbidity do not reflect the effects of the mutations on osteoblasts proper...
  15. doi request reprint Bone and the hematopoietic niche: a tale of two stem cells
    Paolo Bianco
    Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
    Blood 117:5281-8. 2011
    ..This development seems to represents an evolutionary advance over the deterministic stem cell niches found in archetypal invertebrate systems...
  16. pmc Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells
    Mara Riminucci
    Department of Molecular Medicine, La Sapienza University, 00161 Rome, Italy
    J Mol Endocrinol 45:355-64. 2010
    ..Placing stem cells at center stage has permitted substantial advances in one decade, and promises more for the one to come...
  17. ncbi request reprint Postnatal skeletal stem cells
    Paolo Bianco
    Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
    Methods Enzymol 419:117-48. 2006
    ..Although ex vivo expansion of BMSCs inevitably dilutes the skeletal stem cells, when used en masse, they are attractive candidates for reconstruction of segmental bone defects, and as targets for gene therapy...
  18. pmc Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history
    Isabella Saggio
    Department of Biology and Biotechnology C Darwin, Sapienza University, and IBPM CNR, Rome, Italy
    J Bone Miner Res 29:2357-68. 2014
    ..Gsα mutations are sufficient to cause FD, and are per se compatible with germline transmission and normal embryonic development in mice. Our novel murine lines constitute the first model of FD...
  19. ncbi request reprint GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha
    Stefano Michienzi
    Fondazione Parco Scientifico San Raffaele, Rome, Italy
    Hum Mol Genet 16:1921-30. 2007
    ..Furthermore, we show that normal and mutated clonogenic stromal cells express GNAS alternative transcripts other than the common Gsalpha, some of which may be relevant to the development of FD...
  20. pmc Stem cells and bone diseases: new tools, new perspective
    Mara Riminucci
    Department of Molecular Medicine, Sapienza University of Rome, Italy Electronic address
    Bone 70:55-61. 2015
    ..These, in turn, provide suitable models to investigate and manipulate the pathogenetic mechanisms of many genetic and non-genetic skeletal diseases. This article is part of a Special Issue entitled Stem cells and Bone. ..
  21. pmc A randomized, double blind, placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone
    Alison M Boyce
    Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch A M B, M H K, B A B, P G R, M T C, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 Division of Endocrinology and Diabetes A M B, Children s National Health System, Washington, DC 20010 Bone Health Program, Division of Orthopaedics and Sports Medicine A M B, Children s National Health System, Washington, DC 20010 BioMedical Computer Research Institute H K, Philadelphia, Pennsylvania 19115 Department of Pediatric Orthopedics S W, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel 64239 Department of Molecular Medicine M R, P B, La Sapienza Universita di Roma, Rome, Italy 00185
    J Clin Endocrinol Metab 99:4133-40. 2014
    ..Fibrous dysplasia (FD) is a rare skeletal disorder, resulting in deformity, fracture, functional impairment, and pain. Bisphosphonates have been advocated as a potential treatment...
  22. doi request reprint Bone ingrowth and vascular supply in experimental spinal fusion with platelet-rich plasma
    Gianluca Cinotti
    Department of Anatomy, Histology, Legal Medicine and Orthopaedics, University La Sapienza, Piazzale Aldo Moro, Rome, Italy
    Spine (Phila Pa 1976) 38:385-91. 2013
    ..Prospective investigation using a posterolateral spinal fusion (PLSF) model in rabbits...
  23. ncbi request reprint Mesoangioblasts--vascular progenitors for extravascular mesodermal tissues
    Giulio Cossu
    Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Via Castel Romano 100, 00128 Rome, Italy
    Curr Opin Genet Dev 13:537-42. 2003
    ....
  24. ncbi request reprint Monostotic fibrous dysplasia of the proximal femur and liposclerosing myxofibrous tumor: which one is which?
    Alessandro Corsi
    Dipartimento de Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    J Bone Miner Res 21:1955-8. 2006
    ..The two cases highlight how the incomplete understanding of the natural history of MFD may result in diagnostic pitfalls or incorrect classification of individual lesions...