Research Topics
| A R BiliaSummaryAffiliation: University of Florence Country: Italy Publications
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Detail Information
Publications
Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituentsAnna Rita Bilia
Department of Pharmaceutical Sciences, University of Florence, Firenze, Italy
Life Sci 70:769-78. 2002....- NMR spectroscopy: a useful tool for characterisation of plant extracts, the case of supercritical CO2 arnica extractAnna Rita Bilia
Department of Pharmaceutical Sciences, University of Florence, Via G Capponi 9, 50121 Florence, Italy
J Pharm Biomed Anal 30:321-30. 2002..Identification of constituents was performed by combining literature data and information obtained by 2D-NMR experiments... - Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MSAnna Rita Bilia
Department of Pharmaceutical Science, University of Florence, Via Gino Capponi 9, 50121 Firenze, Italy
J Pharm Biomed Anal 30:613-24. 2002..Thus, shelf-lives at 25 degrees C of the most stable tincture (Passionflower 60% v/v) was about 6 months and only about 3 months the stability of Milk-thistle tinctures... - Development and stability of semisolid preparations based on a supercritical CO2 Arnica extractAnna Rita Bilia
Department of Pharmaceutical Sciences, University of Florence, via U Schiff 6, 50019 Sesto Fiorentino Florence, Italy
J Pharm Biomed Anal 41:449-54. 2006..The cetomacrogol showed the best release profile in the in vitro test, while in the in vivo test the best preparation resulted polysorbate 60 and polawax... - HPLC-DAD-ESI-MS analysis of the constituents of aqueous preparations of verbena and lemon verbena and evaluation of the antioxidant activityA R Bilia
Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, FI, Italy
J Pharm Biomed Anal 46:463-70. 2008..In addition, the antioxidant property of the lemon verbena infusion was evaluated by the DPPH test using Trolox as the reference compound... 
Science meets regulationAnna Rita Bilia
Department of Chemistry, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Fl 50019, Italy Electronic address
J Ethnopharmacol 158:487-94. 2014....
Study protocol: safety and efficacy of propranolol in newborns with Retinopathy of Prematurity (PROP-ROP): ISRCTN18523491Luca Filippi
Neonatal Intensive Care Unit, Department of Perinatal Medicine, A, Meyer University Children s Hospital, Florence, Italy
BMC Pediatr 10:83. 2010..The purpose of this study is to evaluate the propranolol administration in preterm newborns suffering from a precocious phase of ROP in terms of safety and efficacy in counteracting the progression of retinopathy...- Analysis of kavalactones from Piper methysticum (kava-kava)Anna Rita Bilia
Department of Pharmaceutical Science, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 812:203-14. 2004.... - Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivarA R Bilia
Department of Pharmaceutical Sciences, University of Florence, via U Schiff 6, 50019 Sesto Fiorentino Florence, Italy
Phytomedicine 13:487-93. 2006..Qualitative and quantitative results obtained using an HPLC method are described, which will be useful for developing highly effective herbal drug preparations... - Kava-kava and anxiety: growing knowledge about the efficacy and safetyAnna Rita Bilia
Department of Pharmaceutical Science, University of Florence, Firenze, Italy
Life Sci 70:2581-97. 2002..On the other hand, it should be possible that unknown or unexpected constituents are the responsible or contributed to the liver toxicity... - Hypericins as potential leads for new therapeuticsAnastasia Karioti
Department of Pharmaceutical Sciences, University of Florence, Italy
Int J Mol Sci 11:562-94. 2010..perforatum were not considered, nor pharmakokinetic or clinical data. Computerised literature searches were performed using the Medline (PubMed), ChemSciFinder and Scirus Library databases. No language restrictions were imposed... - Analysis and stability of the constituents of artichoke and St. John's wort tinctures by HPLC-DAD and HPLC-MSA R Bilia
Department of Pharmaceutical Sciences, University of Florence, Via G Capponi 9, 50121 Firenze, Italy
Drug Dev Ind Pharm 28:609-19. 2002..From the results it was evidenced that constituent content depends on the solvent used for the extraction. The stability was also shown to be very different and seems to be related to the water content of the tinctures... - Ginkgo biloba LAnna Rita Bilia
Dipartimento di Scienze Farmaceutiche, via Gino Capponi, 9, 50121, Firenze, Italy
Fitoterapia 73:276-9. 2002 - St. John's wort and depression: efficacy, safety and tolerability-an updateAnna Rita Bilia
Department of Pharmaceutical Science, University of Florence, Via Gino Capponi 9, 50121, Firenze, Italy
Life Sci 70:3077-96. 2002..So, even if its safety has been well established, physicians should be aware that St. John's wort administration might significantly affect other prescribed medicines... - Evaluation of the content and stability of the constituents of mother tinctures and tinctures: the case of Crataegus oxyacantha L. and Hieracium pilosella LAnna Rita Bilia
Department of Pharmaceutical Sceinces, University of Florence, 50019 Sesto Fiorentino, Florence, Italy
J Pharm Biomed Anal 44:70-8. 2007..The concentrations of flavonoids and umbelliferone were two times as much in the tincture with respect to the mother tincture. Stability of these two classes of constituents was good for both preparations over a 9-month period... - Analysis of plant complex matrices by use of nuclear magnetic resonance spectroscopy: St. John's wort extractA R Bilia
Dipartimento di Scienze Farmaceutiche, Via Gino Capponi 9, 50121 Florence, Italy
J Agric Food Chem 49:2115-24. 2001.... - Evaluation of chemical stability of St. John's wort commercial extract and some preparationsA R Bilia
Department of Pharmaceutical Science, University of Florence, Via Gino Capponi 9, 50121 Firenze, Italy
Int J Pharm 213:199-208. 2001..John's wort preparations, a mere translation of the ICH guidelines to the field of herbal products, as suggested by the WPHMP of the EMEA, cannot be accepted. A revision and adaptation of the storage conditions should be elaborated... - Characterization of commercial kava-kava herbal drug and herbal drug preparations by means of nuclear magnetic resonance spectroscopyAnna Rita Bilia
Department of Pharmaceutical Sciences, University of Florence, Via Gino Capponi 9, Italy
J Agric Food Chem 50:5016-25. 2002..These experiments can be considered a very simple and fast analytical method to obtain a fingerprint of the herbal drugs and their preparations, and to quantify the content of the active principles of the extract... - Evaluation of the dissolution behaviour of some commercial herbal drugs and their preparationsV Taglioli
Department of Pharmaceutical Sciences, University of Florence, Italy
Pharmazie 56:868-70. 2001.... - Pharmacological in vivo test to evaluate the bioavailability of some St John's Wort innovative oral preparationsB Isacchi
Department of Pharmaceutical Sciences, University of Florence, Italy
Phytother Res 23:197-205. 2009.... - Variability in the content of the constituents of Hypericum perforatum L. and some commercial extractsM C Bergonzi
Department of Pharmaceutical Sciences, University of Florence, Firenze, Italy
Drug Dev Ind Pharm 27:491-7. 2001..In addition, the contents of the constituents of the products available to the consumer that were related to quality and the relation of this to safety and efficacy were also evaluated... - Analysis and stability of the constituents of St. John's wort oils prepared with different methodsB Isacchi
Department of Pharmaceutical Sciences, University of Florence, via U Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
J Pharm Biomed Anal 45:756-61. 2007..The stability of these oils during 1 year was also tested... - Evaluation of skin permeability of sesquiterpenes of an innovative supercritical carbon dioxide Arnica extract by HPLC/DAD/MSM C Bergonzi
Dipartimento Scienze Farmaceutiche, Universita di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy
Pharmazie 60:36-8. 2005..The study evidenced that among the selected skin permeation enhancers, DMSO and OA canbe considered as good candidates to be used in preparations for cutaneous application... - Identification by HPLC-DAD and HPLC-MS analyses and quantification of constituents of fennel teas and decoctionsA R Bilia
Dipartimento di Scienze Farmaceutiche, University of Florence, Via Gino Capponi 9, 50121 Florence, Italy
J Agric Food Chem 48:4734-8. 2000..In addition, minor unidentified flavonol constituents were found in two teas. Quality, activity, and safety of the content of the investigated preparations are also discussed... - Chemical composition of some traditional herbal drug preparations: essential oil and aromatic water of costmary (Balsamita suaveolens Pers.)S Gallori
Department of Pharmaceutical Sciences, University of Florence, Via Gino Capponi 9, 50121 Florence, Italy
J Agric Food Chem 49:5907-10. 2001..In addition, solid phase microextraction was used to sample the volatile organic compounds emitted from the fresh plant and from the aromatic water, and carvone was again the main component, amounting to 46.2 and 41.3%, respectively... - Novel artemisinin and curcumin micellar formulations: drug solubility studies by NMR spectroscopySilvia Lapenna
Department of Pharmaceutical Sciences, University of Florence, 50019 Sesto Fiorentino, FI, Italy
J Pharm Sci 98:3666-75. 2009.... - A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in miceNicoletta Galeotti
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50 139 Florence, Italy
J Pain 11:149-59. 2010..In particular, the presence of hypericin was fundamental to induce both thermal and chemical antinociception through the inhibition of the PKC activity, whereas hyperforin selectively produced a thermal opioid antinociception... - St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activityNicoletta Galeotti
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
Biochem Pharmacol 79:1327-36. 2010..Our results indicate SJW as a prolonged antihyperalgesic treatment through inhibition of PKC isoforms and their phosphorylation... - Analysis of the constituents of aqueous preparations of Stachys recta by HPLC-DAD and HPLC-ESI-MSAnastasia Karioti
Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino FI, Firenze, Italy
J Pharm Biomed Anal 53:15-23. 2010..Among the investigated preparations, the infusion seems to be the best method to extract the native constituents of the plant, while decoction is a more aggressive treatment and causes partial degradation of some acylated flavonoids... - X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)Marta Ferraroni
Department of Chemistry Ugo Schiff, University of Firenze, Via della Lastruccia 3 13, I 50019 Sesto Fiorentino, Firenze, Italy
Chem Commun (Camb) 47:4917-9. 2011..3 Å resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form... - Spectrophotometric and ESI-MS/HPLC studies reveal a common mechanism for the reaction of various artemisinin analogues with heminLuigi Messori
Department of Chemistry, University of Florence, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Florence, Italy
Bioorg Med Chem Lett 13:4055-7. 2003..In the course of the reaction characteristic isomeric 1:1 drug-hemin adducts are formed as in the case of artemisinin; eventual disruption of the porphyrin ring takes place in all cases, most likely through oxidative degradation... - The reaction of artemisinins with hemoglobin: a unified pictureLuigi Messori
Department of Chemistry, University of Florence, Florence, Italy
Bioorg Med Chem 14:2972-7. 2006..A unified description for the reactions of artemisinins with hemoglobin is given... - Antihyperalgesic activity of verbascoside in two models of neuropathic painBenedetta Isacchi
Department of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
J Pharm Pharmacol 63:594-601. 2011..This study reports on the rapid isolation of verbascoside from Lippia citriodora H.B.K. (Verbenaceae), an inexpensive and widespread source, and the evaluation of its antihyperalgesic activity... - Studies on the interactions between some flavonols and cyclodextrinsMaria Camilla Bergonzi
Dipartimento di Scienze Farmaceutiche, Universita di Firenze, via U Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy
Bioorg Med Chem Lett 17:5744-8. 2007..For all three guests, multidimensional NMR experiments in DMSO and water are consistent with dynamic binding processes, dominated by insertion of the B ring into the wider rim of the Cd cavity... - Combined HPLC-DAD-MS, HPLC-MS(n) and NMR spectroscopy for quality control of plant extracts: the case of a commercial blend sold as dietary supplementA Karioti
Department of Chemistry, Building of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy Electronic address
J Pharm Biomed Anal 88:7-15. 2014..such as ajmaline, reserpine and yohimbine. Quantitative HPLC analysis showed that the content of reserpine in the product was in the therapeutic range and therefore responsible for the collapses of the patients. .. - A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micellesAnna Rita Bilia
Department of Pharmaceutical Sciences, University of Florence, Via Gino Capponi 9, 50121 Firenze, Italy
J Pharm Sci 91:2265-70. 2002..QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation... - HPLC-DAD and HPLC-ESI-MS analyses of Tiliae flos and its preparationsA Karioti
Department of Chemistry, Building of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino FI, Firenze, Italy Electronic address
J Pharm Biomed Anal 100:205-14. 2014..Finally, the HPLC method was validated and complied with ICH guidelines. This is the first report of detailed analysis of the chemical composition of Tiliae flos. .. - Identification and quantification of constituents of Gardenia jasminoides Ellis (Zhizi) by HPLC-DAD-ESI-MSM C Bergonzi
University of Florence, Dept of Pharmaceutical Sciences, via U Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
Food Chem 134:1199-204. 2012..This assay was successfully applied for qualitative and quantitative analysis of five commercial samples of G. jasminoides Ellis... - Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymersD Voinovich
Department of Pharmaceutical Sciences, University of Trieste, P le Europa 1, I 34127 Trieste, Italy
J Pharm Sci 98:215-28. 2009..The highest bioavailability improvement was obtained with Ac-Di-Sol(R), with a relative bioavailability of 88.6, 17.96, and 16.4 compared to the extract for silybin A, silybine B, and silychristine, respectively... - Effect of surfactants and solutes (glucose and NaCl) on solubility of Kavain--a technical noteAnna Rita Bilia
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Firenze, Via Ugo Schiff, 6, 50019 Sesto Fiorentino, Firenze, Italy
AAPS PharmSciTech 9:444-8. 2008 - SPR in drug discovery: searching bioactive compounds in plant extractsMaria Minunni
Dipartimento di Chimica Facoltà di Scienze Matematiche Fisiche e Naturali, Università degli Studi di Firenze Polo Scientifico, Sesto Fiorentino, Italy
Methods Mol Biol 572:203-18. 2009..e. of Chelidonium majus L.) as a paradigmatic example for the search of bioactive compounds able to interact with DNA, is also discussed... - Antimalarial properties of green teaAnna Rosa Sannella
Department of Infectious, Parasitic and Immunomediated Diseases, Vector Borne Diseases and International Health Section, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Biochem Biophys Res Commun 353:177-81. 2007..The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies... - Novel Secoiridoid glucosides in Olea europaea leaves suffering from boron deficiencyAnastasia Karioti
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, Athens, Greece
Biosci Biotechnol Biochem 70:1898-903. 2006..The structures of the isolated compounds were established by means of NMR and MS spectral analyses. The above novel secoiridoids were synthesized by the plant as a physiological response to nutrient stress... - New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implicationsAnna Rosa Sannella
Department of Infectious, Parasitic and Immunomediated Diseases, Vector Borne Diseases and International Health Section, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
FEBS Lett 582:844-7. 2008..falciparum thioredoxin reductase. The above findings and the safe toxicity profile of auranofin warrant rapid evaluation of AF for malaria treatment in animal models... - Enantioseparation of kavain on Chiralpak IA under normal-phase, polar organic and reversed-phase conditionsRoberto Cirilli
Dipartimento del Farmaco, Istituto Superiore di Sanita, Rome, Italy
J Sep Sci 31:2206-10. 2008..A water-dependent enantioselectivity was clearly demonstrated. Performance of the Chiralpak IA CSP in polar organic and RP conditions was compared with that of five coated polysaccharide-derived CSPs used in normal-phase mode...