M Brini

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition.
    Domenico Cieri
    Cell Death Differ . 2017
  2. pmc The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium
    Marisa Brini
    Department of Biological Chemistry, University of Padova, Viale G Colombo 3, 35131 Padova, Italy
    Cold Spring Harb Perspect Biol 3:. 2011
  3. doi request reprint Neuronal calcium signaling: function and dysfunction
    Marisa Brini
    Department of Biology, University of Padova, via U Bassi, 58 B, 35131, Padua, Italy
    Cell Mol Life Sci 71:2787-814. 2014
  4. doi request reprint Calcium in health and disease
    Marisa Brini
    Department of Biology, University of Padova, Via U Bassi 58 B, I 35131, Padova, Italy
    Met Ions Life Sci 13:81-137. 2013
  5. pmc Mitochondrial Ca(2+) and neurodegeneration
    Tito Cali
    Department of Comparative Biomedicine and Food Science, University of Padova, Padova, Italy
    Cell Calcium 52:73-85. 2012
  6. doi request reprint Calcium pumps: why so many?
    Marisa Brini
    Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro Padova, Italy
    Compr Physiol 2:1045-60. 2012
  7. doi request reprint Intracellular calcium homeostasis and signaling
    Marisa Brini
    Department of Comparative Biomedicine and Food Sciences, University of Padova, Viale G Colombo 3, I 35131, Padova, Italy
    Met Ions Life Sci 12:119-68. 2013
  8. pmc Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure
    Carlotta Giorgi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation ICSI and LTTA center, University of Ferrara, Ferrara, Italy
    BMC Cell Biol 12:27. 2011
  9. ncbi request reprint A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cells
    Marisa Brini
    Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council CNR, University of Padova, Viale G Colombo 3, Italy
    J Biol Chem 278:24500-8. 2003
  10. ncbi request reprint Ca(2+) signalling in mitochondria: mechanism and role in physiology and pathology
    Marisa Brini
    Department of Biochemistry of the National Research Council, University of Padova, 35121 Padova, Italy
    Cell Calcium 34:399-405. 2003

Collaborators

Detail Information

Publications36

  1. doi request reprint SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition.
    Domenico Cieri
    Cell Death Differ . 2017
    ..SPLICS detected contact sites in soma and axons of D. rerio Rohon Beard (RB) sensory neurons in vivo, extending its use to analyses of organelle juxtaposition in the whole animal...
  2. pmc The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium
    Marisa Brini
    Department of Biological Chemistry, University of Padova, Viale G Colombo 3, 35131 Padova, Italy
    Cold Spring Harb Perspect Biol 3:. 2011
    ....
  3. doi request reprint Neuronal calcium signaling: function and dysfunction
    Marisa Brini
    Department of Biology, University of Padova, via U Bassi, 58 B, 35131, Padua, Italy
    Cell Mol Life Sci 71:2787-814. 2014
    ..The contribution of altered Ca(2+) signaling in the most important neurological disorders will then be considered. ..
  4. doi request reprint Calcium in health and disease
    Marisa Brini
    Department of Biology, University of Padova, Via U Bassi 58 B, I 35131, Padova, Italy
    Met Ions Life Sci 13:81-137. 2013
    ..g., the nervous system. ..
  5. pmc Mitochondrial Ca(2+) and neurodegeneration
    Tito Cali
    Department of Comparative Biomedicine and Food Science, University of Padova, Padova, Italy
    Cell Calcium 52:73-85. 2012
    ....
  6. doi request reprint Calcium pumps: why so many?
    Marisa Brini
    Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro Padova, Italy
    Compr Physiol 2:1045-60. 2012
    ....
  7. doi request reprint Intracellular calcium homeostasis and signaling
    Marisa Brini
    Department of Comparative Biomedicine and Food Sciences, University of Padova, Viale G Colombo 3, I 35131, Padova, Italy
    Met Ions Life Sci 12:119-68. 2013
    ....
  8. pmc Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure
    Carlotta Giorgi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation ICSI and LTTA center, University of Ferrara, Ferrara, Italy
    BMC Cell Biol 12:27. 2011
    ..Indeed, to date, the experimental procedures available are either inadequate or complex and expensive...
  9. ncbi request reprint A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cells
    Marisa Brini
    Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council CNR, University of Padova, Viale G Colombo 3, Italy
    J Biol Chem 278:24500-8. 2003
    ..In particular, PMCA4CII(4a) was as effective as PMCA4CI(4b), even if its affinity for calmodulin is much lower. The results indicate that the availability of calmodulin may not be critical for the modulation of PMCA pumps in vivo...
  10. ncbi request reprint Ca(2+) signalling in mitochondria: mechanism and role in physiology and pathology
    Marisa Brini
    Department of Biochemistry of the National Research Council, University of Padova, 35121 Padova, Italy
    Cell Calcium 34:399-405. 2003
    ..This review analyses recent developments in the area of mitochondrial Ca(2+) signalling and attempts to summarise cell physiology and cell pathology aspects of the mitochondrial Ca(2+) transport machinery...
  11. doi request reprint Plasma membrane Ca(2+)-ATPase: from a housekeeping function to a versatile signaling role
    Marisa Brini
    Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padova, Viale G Colombo 3, 35131 Padua, Italy
    Pflugers Arch 457:657-64. 2009
    ....
  12. pmc Deletions and mutations in the acidic lipid-binding region of the plasma membrane Ca2+ pump: a study on different splicing variants of isoform 2
    Marisa Brini
    Department of Biological Chemistry, University of Padova, 35131 Padova, Italy
    J Biol Chem 285:30779-91. 2010
    ..A structural interpretation of the interplay of the pump with phospholipids, and of the mechanism of their activation, is proposed on the basis of molecular modeling studies...
  13. ncbi request reprint Plasma-membrane calcium pumps and hereditary deafness
    M Brini
    Department of Biochemistry, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    Biochem Soc Trans 35:913-8. 2007
    ..In addition, the combination of proteins obtained by alternative splicing occurring at two different sites could be responsible for different functional characteristics of the pumps...
  14. ncbi request reprint New light on mitochondrial calcium
    P Pinton
    Department of Biomedical Sciences, University of Padova, Italy
    Biofactors 8:243-53. 1998
    ..By using an imaging system endowed with high speed and sensitivity, which allows to obtain high-resolution 3D images, we could demonstrate that close contacts (< 80 nm) occur in vivo between mitochondria and the ER...
  15. pmc The prion protein and its paralogue Doppel affect calcium signaling in Chinese hamster ovary cells
    Marisa Brini
    Department of Biological Chemistry, University of Padova, CNR Institute of Neuroscience and CRIBI, 35121 Padova, Italy
    Mol Biol Cell 16:2799-808. 2005
    ..These findings are consistent with the functional interplay and antagonistic role attributed to the proteins, whereby PrP(c) protects, and Doppel sensitizes, cells toward stress conditions...
  16. pmc Effects of PMCA and SERCA pump overexpression on the kinetics of cell Ca(2+) signalling
    M Brini
    Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council CNR, University of Padova, Viale G Colombo, 3, 35121 Padova, Italy
    EMBO J 19:4926-35. 2000
    ....
  17. ncbi request reprint Targeted recombinant aequorins: tools for monitoring [Ca2+] in the various compartments of a living cell
    M Brini
    Department of Biochemistry, University of Padova, 35121 Padova, Italy
    Microsc Res Tech 46:380-9. 1999
    ....
  18. ncbi request reprint A study of the activity of the plasma membrane Na/Ca exchanger in the cellular environment
    Marisa Brini
    Department of Biochemistry and Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy
    Ann N Y Acad Sci 976:376-81. 2002
    ..The effect of the expressed NCX1 on the calcium homeostasis in the domain underneath the plasma membrane was more complex: The exchanger apparently catalyzed a reverse operation, leading to increased penetration of calcium...
  19. pmc Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase
    V Granatiero
    Department of Biomedical Sciences, University of Padova and CNR Neuroscience Institute, Padova, Italy
    Cell Death Differ 23:231-41. 2016
    ..This indicates that the higher mitochondrial turnover in complex I deficient cells with this specific mutation is a pro-survival compensatory mechanism that could contribute to the mild clinical phenotype of this patient. ..
  20. doi request reprint Calcium-sensitive photoproteins
    Marisa Brini
    Department of Biochemistry, University of Padova, Viale G Colombo 3, 35131 Padova, Italy
    Methods 46:160-6. 2008
    ....
  21. ncbi request reprint Inhibitory interaction of the 14-3-3{epsilon} protein with isoform 4 of the plasma membrane Ca(2+)-ATPase pump
    Alessandro Rimessi
    Department of Biochemistry, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    J Biol Chem 280:37195-203. 2005
    ....
  22. ncbi request reprint Ca2+ signaling in HEK-293 and skeletal muscle cells expressing recombinant ryanodine receptors harboring malignant hyperthermia and central core disease mutations
    Marisa Brini
    Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council CNR, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    J Biol Chem 280:15380-9. 2005
    ..The results suggest that local Ca(2+) derangements of different degrees account for the specific cellular phenotypes of the two disorders...
  23. ncbi request reprint Recombinant expression of the plasma membrane Na(+)/Ca(2+) exchanger affects local and global Ca(2+) homeostasis in Chinese hamster ovary cells
    Marisa Brini
    Department of Biochemistry and Center for the Study of Biomembranes of the National Research Council, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    J Biol Chem 277:38693-9. 2002
    ....
  24. pmc Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells
    M Montero
    Department of Biomedical Sciences, University of Padova, Italy
    EMBO J 14:5467-75. 1995
    ..Receptor stimulation causes, in a few seconds, a 3-fold decrease of the [Sr2+]er, whereas specific inhibition of the ER Ca2+ ATPase leads to an approximately 10-fold drop in a few minutes...
  25. ncbi request reprint Nuclear targeting of aequorin. A new approach for measuring nuclear Ca2+ concentration in intact cells
    M Brini
    Department of Biomedical Sciences, University of Padova, Italy
    Cell Calcium 16:259-68. 1994
    ....
  26. ncbi request reprint Generation, control, and processing of cellular calcium signals
    E Carafoli
    Department of Biochemistry, University of Padova, Italy
    Crit Rev Biochem Mol Biol 36:107-260. 2001
    ..When escaping control, Ca2+ also precipitates toxic cell death...
  27. doi request reprint Calcium pumps in health and disease
    Marisa Brini
    Department of Biochemistry, University of Padova, Padova, Italy
    Physiol Rev 89:1341-78. 2009
    ..They do not bring cells to immediate death but seriously compromise their normal functioning...
  28. ncbi request reprint Calcium pumps: structural basis for and mechanism of calcium transmembrane transport
    E Carafoli
    Department of Biochemistry, Center for the Study of Biomembranes of the National Council of Research CNR, University of Padova, Padova, 35121, Italy
    Curr Opin Chem Biol 4:152-61. 2000
    ..Recent advances in the field include the three-dimensional structure of the sarco(endo)plasmic reticulum and further understanding of the transcriptional regulation of the plasma membrane P-type pump by calcium...
  29. doi request reprint Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling
    Laura Fedrizzi
    Department of Biochemistry, University of Padova, Padova 35131, Italy
    J Biol Chem 283:27494-503. 2008
    ..This could be due to a direct effect of DREAM on presenilin as the two proteins interacted in a Ca(2+)-independent fashion...
  30. ncbi request reprint Functional specificity of PMCA isoforms?
    Teuta Domi
    Department of Biochemistry, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    Ann N Y Acad Sci 1099:237-46. 2007
    ..The results indicated that the combination of alternative splicing at two different sites in the pump structure was responsible for different functional characteristics of the pumps...
  31. ncbi request reprint Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins
    Maria V Pulina
    Venetian Institute of Molecular Medicine, and Department of Biochemistry, University of Padova, 35100 Padova, Italy
    J Biol Chem 281:19645-54. 2006
    ..In vitro binding experiments revealed that all three NCX isoforms interacted with multiple 14-3-3 isoforms. 14-3-3 was bound by both phosphorylated and nonphosphorylated NCX, but the phosphorylated form had much higher binding affinity...
  32. ncbi request reprint Ryanodine receptor defects in muscle genetic diseases
    Marisa Brini
    Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Biochem Biophys Res Commun 322:1245-55. 2004
    ..This review will consider the molecular and cellular effects of RyR mutations, summarizing recent data in the literature on Ca2+ dysregulation, which may lead to a better understanding of the functioning of RyRs...
  33. ncbi request reprint The role of calcium in oligogalacturonide-activated signalling in soybean cells
    Lorella Navazio
    Dipartimento di Biologia, Via U Bassi 58 B, 35131 Padova, Italy
    Planta 215:596-605. 2002
    ....
  34. ncbi request reprint Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease
    Dmitry Lim
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy
    J Biol Chem 283:5780-9. 2008
    ..The observed decrease of cell Ca2+ could be a compensatory attempt to prevent the Ca2+ stress that would irreversibly damage mitochondria and eventually lead to cell death...
  35. ncbi request reprint Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump
    Cristina I Linde
    Venetian Institute of Molecular Medicine, via G Orus 2, 35129 Padova, Italy
    Cell Calcium 43:550-61. 2008
    ....
  36. ncbi request reprint Mitochondrial calcium signalling in cell death
    Sara Leo
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Italy
    FEBS J 272:4013-22. 2005
    ....