V Calderone

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Naunyn Schmiedebergs Arch Pharmacol 370:290-8. 2004
  2. ncbi request reprint Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias: the case of antipsychotics
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Via Bonanno 6, I 56126, Pisa, Italy
    J Pharm Pharmacol 57:151-61. 2005
  3. doi request reprint An update on hybrid drugs in cardiovascular drug research
    Vincenzo Calderone
    Universita di Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Via Bonanno 6, I 56126 Pisa Italy 39 050 2219589 39 050 2219609
    Expert Opin Drug Discov 3:1397-408. 2008
  4. ncbi request reprint New amido derivatives as potential BKCa potassium channel activators. XI
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 43:792-9. 2008
  5. ncbi request reprint Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 41:761-7. 2006
  6. ncbi request reprint Structural modifications of benzanilide derivatives, effective potassium channel openers. X
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 41:1421-9. 2006
  7. ncbi request reprint Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Naunyn Schmiedebergs Arch Pharmacol 375:73-80. 2007
  8. doi request reprint Evaluation of the NO-releasing properties of NO-donor linkers
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Pharm Pharmacol 60:189-95. 2008
  9. doi request reprint 1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 43:2618-26. 2008
  10. doi request reprint NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia, Biotecnologie, Universita di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Bioorg Med Chem 17:5426-32. 2009

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Naunyn Schmiedebergs Arch Pharmacol 370:290-8. 2004
    ..Finally, glibenclamide inhibited the vasorelaxing action of luteolin and 5-hydroxyflavone, suggesting that ATP-sensitive potassium channels may also be involved in their mechanism of action...
  2. ncbi request reprint Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias: the case of antipsychotics
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Via Bonanno 6, I 56126, Pisa, Italy
    J Pharm Pharmacol 57:151-61. 2005
    ..Attention is focused on antipsychotics, with a deeper overview on the experimental and clinical reports about their torsadogenic properties...
  3. doi request reprint An update on hybrid drugs in cardiovascular drug research
    Vincenzo Calderone
    Universita di Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Via Bonanno 6, I 56126 Pisa Italy 39 050 2219589 39 050 2219609
    Expert Opin Drug Discov 3:1397-408. 2008
    ..Some examples of pharmacodynamic hybrids compounds, in which a suitable nitric oxide releasing functionality has been added to known cardiovascular drugs, are also shown...
  4. ncbi request reprint New amido derivatives as potential BKCa potassium channel activators. XI
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 43:792-9. 2008
    ....
  5. ncbi request reprint Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 41:761-7. 2006
    ....
  6. ncbi request reprint Structural modifications of benzanilide derivatives, effective potassium channel openers. X
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 41:1421-9. 2006
    ..This approach seems to represent a further contribution for the development of new BK-activators, designed on the basis of the pharmacophoric model above-mentioned...
  7. ncbi request reprint Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Naunyn Schmiedebergs Arch Pharmacol 375:73-80. 2007
    ..Therefore, an eventual therapy with a BK-opener could promote a series of cardiovascular impacts not confined to the only direct vasorelaxing effects, but also due to a significant contribution of endothelial NO...
  8. doi request reprint Evaluation of the NO-releasing properties of NO-donor linkers
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Pharm Pharmacol 60:189-95. 2008
    ....
  9. doi request reprint 1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 43:2618-26. 2008
    ..Therefore, it can be hypothesized that the increase of the steric hindrance of the linker and/or the increase of the distance between the two aromatic portions are negative for the interaction with the biological target...
  10. doi request reprint NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia, Biotecnologie, Universita di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Bioorg Med Chem 17:5426-32. 2009
    ....
  11. doi request reprint Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia, Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Biochem Pharmacol 79:39-47. 2010
    ....
  12. doi request reprint Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia, Biotecnologie, Universita di Pisa, Pisa, Italy
    J Pharm Pharmacol 62:107-13. 2010
    ..In this paper, the inhibitory effects of the new pyrido[1,2-a]-pyrimidin-4-one derivative PPO, whose aldose reductase-inhibitory and antioxidant effects were shown in a previous study, were evaluated...
  13. ncbi request reprint [Ventricular arrhythmias. A potential risk associated with the use of non-cardiovascular drugs prolonging the QT interval]
    V Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Sezione di Farmacologia, Universita degli Studi, Pisa, Italy
    Minerva Med 93:181-97. 2002
    ....
  14. ncbi request reprint Large-conductance, ca(2+)-activated k(+) channels: function, pharmacology and drugs
    V Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Sezione di Farmacologia, Universit degli Studi di Pisa, Via Bonanno, 6, Pisa, I 56126, Italy
    Curr Med Chem 9:1385-95. 2002
    ..The "state of the art" in the pharmaceutical development of natural and synthetic BK-activators, with a description of the lead chemical structures, will be also described...
  15. ncbi request reprint Experimental and theoretical comparisons between the classical Schild analysis and a new alternative method to evaluate the pA2 of competitive antagonists
    V Calderone
    Dipartimento di Scienze Farmaceutiche, Pisa, Italy
    Naunyn Schmiedebergs Arch Pharmacol 360:477-87. 1999
    ..Indeed, it allows to calculate the antagonist potency, after the evaluation of a slope parameter giving an important information about the possible nature of the antagonism...
  16. ncbi request reprint Hormonal influence on the release of endothelial nitric oxide: gender-related dimorphic sensitivity of rat aorta for noradrenaline
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Italy
    J Pharm Pharmacol 54:523-8. 2002
    ..The gender-related difference in NO release was influenced by gonadal hormones, with the female hormones inducing an increase and the male hormones causing a reduction...
  17. ncbi request reprint Intrinsic activity and EC50: the simplest tools for the evaluation of the dissociation constant of a partial agonist
    V Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Italy
    J Pharmacol Toxicol Methods 40:207-10. 1998
    ..The results obtained by the new approach, both for the computer-generated and for the experimentally studied partial agonists, showed a high level of accuracy, when compared with the classical Waud's analysis...
  18. ncbi request reprint Some structural changes on triazolyl-benzotriazoles and triazolyl-benzimidazolones as potential potassium channel activators. III
    G Biagi
    Dipartimento di Scienze Farmaceutiche, , Italy
    Farmaco 56:841-9. 2001
    ..However, these results provide useful information about structure-activity relationships...
  19. pmc Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO
    P Nieri
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via Bonanno 6 56126, Pisa, Italy
    Br J Pharmacol 134:745-52. 2001
    ..Finally, an 8-pSPT-resistant hypotensive response not attributable to A(3) receptor-stimulation or to release of histamine by mastocytes or other immune cells was observed...
  20. ncbi request reprint QT prolongation in guinea pigs for preliminary screening of torsadogenicity of drugs and drug-candidates. II
    L Testai
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, UniversitĂ  di Pisa Via Bonanno, 6 I 56126 Pisa, Italy
    J Appl Toxicol 27:270-5. 2007
    ..Together with the findings reported by many authors, these data suggest that ECG recording in anaesthetised guinea pigs is a reliable model for cardiac safety studies evaluating the influence of drugs on the repolarisation process...
  21. ncbi request reprint New 5-substituted-1-(2-hydroxybenzoyl)-benzotriazoles, potassium channel activators. IV
    G Biagi
    Dipartimento di Scienze Farmaceutiche, , Italy
    Farmaco 56:827-34. 2001
    ..In such an experimental condition, 3b showed an interesting cardioprotective activity. All the above observations are in agreement with the hypothesis of a mechanism linked to the activation of potassium channels...
  22. doi request reprint The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia/reperfusion injury
    L Testai
    Dipartimento di Farmacia, Universita di Pisa, Via Bonanno, 6 I 56126 Pisa, Italy
    Biochem Pharmacol 85:1634-43. 2013
    ..In conclusion, NAR exerts anti-ischemic effects through a "pharmacological preconditioning" that it is likely to be mediated, at least in part, by the activation of mitochondrial BK channels...
  23. doi request reprint Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels
    A Martelli
    Department of Pharmacy, University of Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Pharmacol Res 70:27-34. 2013
    ..4 channels as novel targets for therapeutic approaches via the "H2S-system"...
  24. ncbi request reprint Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2, 3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2, 3-b]pyridine:potential antihypertensive agents - part IX
    P L Ferrarini
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Eur J Med Chem 35:815-26. 2000
    ..Substitution of the N(1)-R group with a sulfur atom led to compounds possessing beta(1)-, beta(2)- and beta(3)-blocking properties. Compounds 9c(1) and 10a(1) showed a beta(3)-antagonist activity slightly lower than that of propranolol...
  25. ncbi request reprint Torsadogenic cardiotoxicity of antipsychotic drugs: a structural feature, potentially involved in the interaction with cardiac HERG potassium channels
    L Testai
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Via Bonanno, 6, I 56126 Pisa Italy
    Curr Med Chem 11:2691-706. 2004
    ....
  26. ncbi request reprint Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. V
    Giuliana Biagi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 39:491-8. 2004
    ..The best compound of the series was N-(2-hydroxy-5-phenyl)-(2-methoxy-5-chloro)-benzamide (16b) showing a full vasorelaxant efficacy and almost nanomolar potency index...
  27. ncbi request reprint New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties
    Maria C Breschi
    Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    J Med Chem 49:7600-2. 2006
    ..Some of the new compounds (1b, 2b, and 4b) exhibited interesting anti-ischemic properties without affecting significantly the blood pressure parameters...
  28. ncbi request reprint Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of beta 3-antagonists
    Giuseppe Saccomanni
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Bioorg Med Chem 11:4921-31. 2003
    ....
  29. ncbi request reprint Cardiac ATP-sensitive potassium channels: a potential target for an anti-ischaemic pharmacological strategy
    L Testai
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Cardiovasc Hematol Agents Med Chem 5:79-90. 2007
    ....
  30. ncbi request reprint Vasodilator activity of Michelia figo Spreng. (Magnoliaceae) by in vitro functional study
    Silvio Chericoni
    Dipartimento di Chimica Bioorganica e Biofarmacia, Universita di Pisa, Via Bonanno, 33, 56126 Pisa, Italy
    J Ethnopharmacol 91:263-6. 2004
    ....
  31. doi request reprint Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel
    Maria C Breschi
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 51:6945-54. 2008
    ..Furthermore, these effects were not associated with significant hypotensive and vasorelaxing properties, which represent one of the main limiting factors for the clinical use of nonselective K ATP-openers against myocardial ischemia...
  32. doi request reprint Mitochondrial potassium channels as pharmacological target for cardioprotective drugs
    L Testai
    Department of Pharmacy, University of Pisa, Pisa, Italy
    Med Res Rev 35:520-53. 2015
    ..Finally, an appendix describing the main experimental approaches usually employed to study mitoK in isolated mitochondria or in intact cells has been added...
  33. doi request reprint The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endotheli
    A Martelli
    Dipartimento di Farmacia, Universita di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Pharmacol Res 78:1-9. 2013
    ..In conclusion, VA694 is a promising COX2-inhibiting hybrid drug, showing NO releasing properties which may mitigate the CV deleterious effects associated with the COX2-inhibition. ..
  34. ncbi request reprint Hydrogen sulphide: biopharmacological roles in the cardiovascular system and pharmaceutical perspectives
    A Martelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Curr Med Chem 19:3325-36. 2012
    ..Some hybrid drugs are also addressed in this review. In such compounds opportune H(2)S-releasing moieties are conjugated to well-known drugs to improve their pharmacodynamic profile or to reduce the potential for adverse effects...
  35. ncbi request reprint QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates
    L Testai
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Appl Toxicol 24:217-22. 2004
    ..It can be concluded that this method represents a rapid and low-cost procedure to evaluate the cardiac safety pro fi le in the preliminary screening of a high number of drugs or drug candidates...
  36. ncbi request reprint Pharmacodynamic hybrids coupling established cardiovascular mechanisms of action with additional nitric oxide releasing properties
    Alma Martelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Pisa, Italy
    Curr Pharm Des 15:614-36. 2009
    ..This review presents the chemical features of many examples of NO-releasing hybrids of cardiovascular drugs and explains the pharmacological improvements conferred by the addition of such NO-donor properties...
  37. doi request reprint Enantioselectivity in cardioprotection induced by (S)- (-)-2,2-dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane
    Simona Rapposelli
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    J Med Chem 52:1477-80. 2009
    ..The (S)-(-)-1a enantiomer, evaluated for its anti-ischemic activity, showed significant cardioprotective effects, whereas the (R)-(+)-1a enantiomer was completely lacking in anti-ischemic effects...
  38. ncbi request reprint N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors
    Irene Giorgi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 43:1639-47. 2008
    ..This evidence was also strengthened by functional data. Other compounds can act as negative modulators. Furthermore these compounds show inhibitory properties for A(1) and A(3) adenosine receptors...
  39. ncbi request reprint In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma
    Maria Cristina Breschi
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno 6, I 56126, Pisa, Italy
    Eur J Pharmacol 575:149-57. 2007
    ..These findings can be relevant to better understand adenosine functions in airways as well as mechanisms of action of asthma therapies targeting the adenosine system...
  40. doi request reprint Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia
    Simona Rapposelli
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 46:966-73. 2011
    ..This anti-ischemic activity was antagonized by 5-hydroxydecanoic acid, a selective blocker of mito-K(ATP) channels, confirming the involvement of this channel in the cardioprotective activity...
  41. ncbi request reprint Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands
    Giampaolo Primofiore
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 50:1627-34. 2007
    ....
  42. ncbi request reprint Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
    Pier Luigi Ferrarini
    Dipartimento di Scienze Farmaceutiche, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 12:1921-33. 2004
    ..5 and 8.0 nM respectively; also compounds 4a, 5a and 8a exhibit a good CB(2) affinity, with K(i) values in the range of 10-44 nM. Furthermore, compounds 3g-i and 18 revealed a good CB(2) selectivity, with a CB(1)/CB(2) ratio >20...
  43. ncbi request reprint Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines]
    Aldo Balsamo
    Dipartimento di Scienze Farmaceutiche, Facolta di Farmacia, Universita di Pisa, Via Bonanno 6, 56100 Pisa, Italy
    Eur J Med Chem 37:11-22. 2002
    ....
  44. ncbi request reprint Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies
    Lara Testai
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Ethnopharmacol 81:105-9. 2002
    ..It is concluded that U. dioica can produce hypotensive responses, through a vasorelaxing effect mediated by the release of endothelial nitric oxide and the opening of potassium channels, and through a negative inotropic action...
  45. ncbi request reprint R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors
    Paola Nieri
    Department of Psychiatry, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Eur J Pharmacol 459:75-81. 2003
    ....
  46. doi request reprint Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions
    L Testai
    Department of Pharmacy, University of Pisa, Via Bonanno, 6 I 56126 Pisa, Italy
    Nitric Oxide 47:25-33. 2015
    ..These results represent the first step for understanding pathophysiological mechanisms of NO/H2S interplays under both normotensive and hypertensive conditions. ..
  47. ncbi request reprint NO-releasing hybrids of cardiovascular drugs
    A Martelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Curr Med Chem 13:609-25. 2006
    ..The aim of this review is to present the chemical features of NO-releasing hybrids of cardiovascular drugs, and to explain the pharmacological improvements obtained by the addition of the NO-donor properties...
  48. ncbi request reprint Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Facolta di Farmacia, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Eur J Med Chem 40:521-8. 2005
    ..In addition such substituents appear more flexible and able to take different conformations with respect to phenyl groups which have higher trend to coplanar conformations...
  49. ncbi request reprint New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties
    Maria C Breschi
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 49:2628-39. 2006
    ..Furthermore, the additional anti-ischemic cardio-protective properties and antiplatelet effects of 4a have been preliminarily investigated...
  50. doi request reprint Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers
    Alessio Coi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 17:5565-71. 2009
    ..They were proven to ensure successful applications in the field of cardioprotective agent design...
  51. ncbi request reprint Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae)
    Barbara Baragatti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Ethnopharmacol 79:369-72. 2002
    ..A possible involvement of the ryanodine-sensitive Ca2+ channels is suggested...
  52. ncbi request reprint New emerging prospects in the pharmacotherapy of hypertension
    A Balsamo
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Pisa, Via Bonanno, 6, I 56126 Pisa, Italy
    Cardiovasc Hematol Agents Med Chem 6:1-19. 2008
    ....
  53. ncbi request reprint The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana
    Silvio Chericoni
    Dipartimento di Chimica Bioorganica, Universita di Pisa, Pisa, Italy
    Planta Med 69:770-2. 2003
    ..In conclusion, gentiacaulein and gentiakochianin seem to be the compounds responsible for the vasorelaxing properties of the crude extract of Gentiana kochiana roots...
  54. doi request reprint Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties
    Simone Bertini
    Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 18:6715-24. 2010
    ..Furthermore, the vasorelaxing properties showed a good correlation with the electronic properties measured through the electrostatic molecular potential (ESP)...
  55. ncbi request reprint 1,4- and 2,4-substituted-1,2,3-triazoles as potential potassium channel activators. VII
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Facolta di Farmacia, Universita di Pisa, Via Bonanno 6, I 56126 Pisa, Italy
    Farmaco 60:367-75. 2005
    ..The new compounds tested on rat aortic rings did not exhibit any significant vasorelaxing activity...
  56. doi request reprint Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation
    Alessio Coi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 43:2479-88. 2008
    ..Moreover, additional hydrophobic moieties interacting with one of the equatorial cavities located in the area near-by Tyr652 residues and/or with a hydrophobic ring defined by Phe656 residues should be avoided...
  57. ncbi request reprint Proposal of a new binding orientation for non-peptide AT1 antagonists: homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis
    Tiziano Tuccinardi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 49:4305-16. 2006
    ....
  58. ncbi request reprint NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs
    Maria C Breschi
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 47:5597-600. 2004
    ..In vivo, the antihypertensive effects of 2a were similar to those of losartan and captopril...
  59. doi request reprint Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers
    Vincenzo Calderone
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita degli Studi di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 51:5085-92. 2008
    ....
  60. ncbi request reprint 1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators. VI
    Giuliana Biagi
    Dipartimento di Scienze Farmaceutiche, Via Bonanno 6, 56126 Pisa, Italy
    Farmaco 59:397-404. 2004
    ..Among the target compounds, only 16 showed appreciable effectiveness, exhibiting an efficacy parameter (57%) lower than that of NS1619 and a comparable potency index (pIC50: 5.58)...
  61. ncbi request reprint Prediction of hERG potassium channel affinity by the CODESSA approach
    Alessio Coi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 14:3153-9. 2006
    ....
  62. ncbi request reprint Natural modulators of large-conductance calcium-activated potassium channels
    Antonio Nardi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    Planta Med 69:885-92. 2003
    ....
  63. doi request reprint Quantitative structure-activity relationship models for predicting biological properties, developed by combining structure- and ligand-based approaches: an application to the human ether-a-go-go-related gene potassium channel inhibition
    Alessio Coi
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, 56126 Pisa, Italy
    Chem Biol Drug Des 74:416-33. 2009
    ..Finally, pIC(50) values of a prediction set, external to the initial dataset, were predicted and the results confirmed the high predictive power of the model within a quite wide chemical space...
  64. ncbi request reprint Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers
    Violetta Cecchetti
    Dipartimento di Chimica e Tecnologia del Farmaco, Universita degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy
    J Med Chem 46:3670-9. 2003
    ..Compounds 4c, 5c, and 6c displayed a vasorelaxant potency at least 10 000 times greater than that of LCRK, thus becoming the most potent KCOs identified to date...
  65. ncbi request reprint Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor
    Paolo Grieco
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Napoli Federico II, I 80131 Napoli, Italy
    J Med Chem 48:3153-63. 2005
    ....