Giuseppe Carruba

Summary

Affiliation: University of Palermo
Country: Italy

Publications

  1. ncbi Estrogen and prostate cancer: an eclipsed truth in an androgen-dominated scenario
    Giuseppe Carruba
    Experimental Oncology, Department of Oncology, M Ascoli Cancer Center, ARNAS Civico, Palermo, Italy
    J Cell Biochem 102:899-911. 2007
  2. ncbi Gene expression profiling of human cancers
    Giselda Bucca
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, GU2 7XH, UK
    Ann N Y Acad Sci 1028:28-37. 2004
  3. ncbi Product of aromatase activity in intact LNCaP and MCF-7 human cancer cells
    L A Castagnetta
    Experimental Oncology and Molecular Endocrinology Units, Palermo Branch of the National Cancer Institute of Genoa, c o M Ascoli Cancer Hospital Center, Sicily, Italy
    J Steroid Biochem Mol Biol 61:287-92. 1997
  4. doi Aromatase in nontumoral and malignant human liver tissues and cells
    Giuseppe Carruba
    Experimental Oncology, Department of Oncology, M Ascoli Cancer Hospital Center, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:187-93. 2009
  5. ncbi Breast cancer incidence in the city and province of Palermo in 1999-2002: a Breast Cancer Registry report
    Adele Traina
    Department of Clinical Oncology, Cancer Registry Unit, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1028:473-80. 2004
  6. ncbi Expression levels and clinical-pathological correlations of HER2/neu in primary and metastatic human breast cancer
    Rosalba Stefano
    Department of Experimental Oncology and Clinical Applications, University of Palermo, Italy
    Ann N Y Acad Sci 1028:463-72. 2004
  7. ncbi Intercellular communication and human hepatocellular carcinoma
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University Medical School, c o M Ascoli Cancer Hospital Center, ARNAS Civico, Via C Lazzaro 2, 90127 Palermo, Italy
    Ann N Y Acad Sci 1028:202-12. 2004
  8. ncbi Estrogen regulates cytokine production and apoptosis in PMA-differentiated, macrophage-like U937 cells
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo, Italy
    J Cell Biochem 90:187-96. 2003
  9. ncbi Tissue content of hydroxyestrogens in relation to survival of breast cancer patients
    Luigi A M Castagnetta
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo 90127, Italy
    Clin Cancer Res 8:3146-55. 2002
  10. ncbi A role for sex steroids in autoimmune diseases: a working hypothesis and supporting data
    Luigi Castagnetta
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo, Italy
    Ann N Y Acad Sci 966:193-203. 2002

Collaborators

Detail Information

Publications52

  1. ncbi Estrogen and prostate cancer: an eclipsed truth in an androgen-dominated scenario
    Giuseppe Carruba
    Experimental Oncology, Department of Oncology, M Ascoli Cancer Center, ARNAS Civico, Palermo, Italy
    J Cell Biochem 102:899-911. 2007
    ..In summary, although multiple consistent evidence suggests that estrogens are critical players in human prostate cancer, their role has been only recently reconsidered, being eclipsed for years by an androgen-dominated interest...
  2. ncbi Gene expression profiling of human cancers
    Giselda Bucca
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, GU2 7XH, UK
    Ann N Y Acad Sci 1028:28-37. 2004
    ..However, several issues relating to data analysis, reproducibility, cross-comparability, validation, and cost need to be resolved before the technology can be adopted broadly in this context...
  3. ncbi Product of aromatase activity in intact LNCaP and MCF-7 human cancer cells
    L A Castagnetta
    Experimental Oncology and Molecular Endocrinology Units, Palermo Branch of the National Cancer Institute of Genoa, c o M Ascoli Cancer Hospital Center, Sicily, Italy
    J Steroid Biochem Mol Biol 61:287-92. 1997
    ..Further studies should assess the regulation of aromatase expression by serum or growth factors in different human cancer cells, also using anti-aromatase and/or anti-estrogen compounds, in different culture conditions...
  4. doi Aromatase in nontumoral and malignant human liver tissues and cells
    Giuseppe Carruba
    Experimental Oncology, Department of Oncology, M Ascoli Cancer Hospital Center, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:187-93. 2009
    ..We propose here that locally elevated estrogen formation, brought about by high aromatase expression and activity, may result in the promotion of liver tumor cell growth through the induction of AREG via an ER-mediated mechanism...
  5. ncbi Breast cancer incidence in the city and province of Palermo in 1999-2002: a Breast Cancer Registry report
    Adele Traina
    Department of Clinical Oncology, Cancer Registry Unit, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1028:473-80. 2004
    ..The evidence of the different breast cancer incidence in Palermo City and in the other small municipalities of Palermo Province suggests a different cancer risk pattern that seems to be related to recent changes in lifestyle and diet...
  6. ncbi Expression levels and clinical-pathological correlations of HER2/neu in primary and metastatic human breast cancer
    Rosalba Stefano
    Department of Experimental Oncology and Clinical Applications, University of Palermo, Italy
    Ann N Y Acad Sci 1028:463-72. 2004
    ....
  7. ncbi Intercellular communication and human hepatocellular carcinoma
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University Medical School, c o M Ascoli Cancer Hospital Center, ARNAS Civico, Via C Lazzaro 2, 90127 Palermo, Italy
    Ann N Y Acad Sci 1028:202-12. 2004
    ....
  8. ncbi Estrogen regulates cytokine production and apoptosis in PMA-differentiated, macrophage-like U937 cells
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo, Italy
    J Cell Biochem 90:187-96. 2003
    ..This evidence, taken together, suggests that estrogens, but not androgens, exert a pro-inflammatory action through the modulation of TNF-alpha and IL-10, and regulate the immune effector cells by the induction of programmed cell death...
  9. ncbi Tissue content of hydroxyestrogens in relation to survival of breast cancer patients
    Luigi A M Castagnetta
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo 90127, Italy
    Clin Cancer Res 8:3146-55. 2002
    ..The main goal of our study was to assess estrogen contents of breast tumor tissues, having different estrogen receptor status, in relation to long-term follow-up of patients...
  10. ncbi A role for sex steroids in autoimmune diseases: a working hypothesis and supporting data
    Luigi Castagnetta
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo, Italy
    Ann N Y Acad Sci 966:193-203. 2002
    ..In addition, the association of autoimmunity and cancer may disclose promising new avenues of research linking steroid hormones, the immune system, and malignant transformation...
  11. ncbi Androgen receptor status in nontumoral and malignant human colorectal tissues
    L Castagnetta
    Unit of Experimental Oncology and Palermo Branch of IST GE, Department of Clinical Oncology, M Ascoli Cancer Hospital Centre, A R N A S, Civico, Palermo, Italy
    Ann N Y Acad Sci 963:322-5. 2002
    ..Studies on the relation between status of sex steroid receptors and specific biomolecular markers in human colorectal tumors are currently being carried out in our laboratories...
  12. ncbi Endocrine end-points in rheumatoid arthritis
    L Castagnetta
    Institute of Oncology, University Medical School, Palermo, Italy
    Ann N Y Acad Sci 876:180-91; discussion 191-2. 1999
    ..In this respect, definition of several endocrine end-points may have important implications for the treatment of rheumatic disease and other immunological disorders...
  13. ncbi Regulation of cell-to-cell communication in non-tumorigenic and malignant human prostate epithelial cells
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo, Italy
    Prostate 50:73-82. 2002
    ..Gap-junction-mediated intercellular communication (GJIC) is required for normal development and tissue homeostasis. However, the role of GJIC in human prostate carcinogenesis and progression remains ill-defined...
  14. ncbi Breast cancer registry in Palermo and its Province: incidence in 1999
    A Traina
    Cancer Registry, and Unit of Experimental Oncology and Palermo Branch of IST GE, Department of Clinical Oncology, M Ascoli Cancer Centre Hospital, A R N A S, Civico, Palermo, Italy
    Ann N Y Acad Sci 963:85-90. 2002
    ..These findings confirm the role of recent life style changes in the cancer risk distribution...
  15. ncbi Ligand binding and cytochemical analysis of estrogen and progesterone receptors in relation to follow-up in patients with breast cancer
    L Castagnetta
    Unit of Experimental Oncology and Palermo Branch of IST GE, Cancer Registry, and Unit of Medical Oncology, Department of Clinical Oncology, M Ascoli Cancer Hospital Centre, A R N A S, Civico, Palermo, Italy
    Ann N Y Acad Sci 963:98-103. 2002
    ..g., EGF), oncogene (e.g., Her2/Neu), or tumor suppressor gene (e.g., p53) products...
  16. ncbi Intercellular communication and human prostate carcinogenesis
    Giuseppe Carruba
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo, Italy
    Ann N Y Acad Sci 963:156-68. 2002
    ..These data suggest that agents that increase Cx43:Cx32 ratio may restore GJIC in junctionally deficient cells, providing a basis for the development of new strategies for the prevention and treatment of human prostate cancer...
  17. ncbi Estrogens and mechanisms of prostate cancer progression
    Giuseppe Carruba
    Experimental Oncology, Department of Oncology, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1089:201-17. 2006
    ..This is further complicated by the presence of receptor isoforms, distinct cofactor interaction, and potential heterodimerization. Based on this combined evidence, a hypothetical model of prostate cancer progression is presented...
  18. ncbi The Mediet Project
    L Castagnetta
    Unit of Experimental Oncology and Palermo Branch of IST GE, and Cancer Registry, Department of Clinical Oncology, M Ascoli Cancer Hospital Centre, A R N A S, Civico, Palermo, Italy
    Ann N Y Acad Sci 963:282-9. 2002
    ..The study is currently ongoing to verify the association of changes in serum and urine hormone levels and breast cancer risk in the intervention group...
  19. ncbi Connexin expression in nonneoplastic human prostate epithelial cells
    Francesca Saladino
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo, Italy
    Ann N Y Acad Sci 963:213-7. 2002
    ..Studies are currently ongoing in our laboratories to assess the potential effect of agents increasing the Cx43 to Cx32 ratio on GJIC activity in these systems...
  20. ncbi Sex steroids, carcinogenesis, and cancer progression
    Luigi Castagnetta
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo, Italy
    Ann N Y Acad Sci 1028:233-46. 2004
    ....
  21. doi Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells
    Orazia M Granata
    Experimental Oncology, Department of Oncology, M Ascoli Cancer Hospital Center, ARNAS Civico, Piazzale N Leotta 2, Palermo, Italy
    J Steroid Biochem Mol Biol 113:290-5. 2009
    ....
  22. ncbi Local estrogen formation by nontumoral, cirrhotic, and malignant human liver tissues and cells
    Luigi A M Castagnetta
    Department of Experimental Oncology and Clinical Application, University Medical School, Palermo, Italy
    Cancer Res 63:5041-5. 2003
    ....
  23. doi 16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells
    Ildegarda Campisi
    Experimental Oncology Units, Department of Oncology, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:237-41. 2009
    ..In this framework, 16alpha-OHE1 may have a potential role in human liver carcinogenesis, also through the inhibition of EST and the production of unconjugated, bioavailable estrogens...
  24. doi Estradiol decreases xanthine dehydrogenase enzyme activity and protein expression in non-tumorigenic and malignant human mammary epithelial cells
    Gennaro Taibi
    Department of Experimental Oncology and Clinical Applications, University of Palermo, Palermo, Italy
    J Cell Biochem 108:688-92. 2009
    ..In addition, estradiol treatment of MDA-MB231 and MCF7 cells decreases protein expression and activity of the enzyme, with no modification of the mRNA transcript levels, eventually leading to deteriorate further retinoic acid production...
  25. doi Aromatase and amphiregulin are correspondingly expressed in human liver cancer cells
    Vitale Miceli
    Experimental Oncology Unit, Department of Oncology, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:252-6. 2009
    ..This evidence suggests that AREG expression may be upregulated by estrogens in human HCC and that locally elevated aromatase activity also may increase malignant cell proliferation through AREG signaling...
  26. doi Expression of wild-type and variant estrogen receptor alpha in liver carcinogenesis and tumor progression
    Vitale Miceli
    Experimental Oncology, Department of Oncology, ARNAS Civico, Palermo, Italy
    OMICS 15:313-7. 2011
    ..This observation suggests that a switch from ERα66 to a predominant expression of ERα36 may be associated with development and/or progression of human HCC...
  27. ncbi Comparison of female breast cancer registration in the city and province of palermo with other italian cancer registries
    Adele Traina
    Breast Cancer Registry and Experimental Oncology, Department of Oncology, ARNAS Civico, Palermo, Italy
    Nutr Cancer 56:241-6. 2006
    ....
  28. ncbi Metabolic profiles of androgens in malignant human liver cell lines
    Orazia M Granata
    Experimental Oncology Unit, Department of Oncology, P O M Ascoli, ARNAS Civico, Piazzale N Leotta 2, 90127 Palermo, Italy
    Ann N Y Acad Sci 1089:262-7. 2006
    ....
  29. ncbi Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis
    Luigi A Castagnetta
    Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo, Italy
    J Rheumatol 30:2597-605. 2003
    ..We investigated synovial fluid (SF) concentrations of several estrogens and androgens and conversion products of the sex steroid precursor dehydroepiandrosterone (DHEA) in supernatants of mixed synoviocytes...
  30. doi Dietary enterolactone affects androgen and estrogen levels in healthy postmenopausal women
    Orazia M Granata
    Experimental Oncology Unit, Department of Oncology, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:232-6. 2009
    ..Further studies are necessary to better understand the interplay of sex hormones with dietary phytoestrogens...
  31. ncbi Altered androgen metabolism eventually leads hepatocellular carcinoma to an impaired hormone responsiveness
    Orazia M Granata
    Unit of Experimental Oncology and Palermo Branch of IST Genoa, Department of Clinical Oncology, M Ascoli Cancer Hospital Center, ARNAS, Civico, Palermo, Italy
    Mol Cell Endocrinol 193:51-8. 2002
    ..This may eventually lead biologically active androgens to be transformed into less active derivatives, as it occurs for T which is massively converted (>90% at 6 h) thus hindering the whole mechanism of action of androgens...
  32. doi Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach
    Calogero Caruso
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Cancer Immunol Immunother 58:1919-33. 2009
    ....
  33. doi Endocrine therapy in metastatic breast cancer: data from Breast Cancer Registry of Palermo, 1999-2005
    Rosalba Amodio
    Palermo Breast Cancer Registry and Experimental Oncology Unit, Department of Oncology, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:227-31. 2009
    ..5 months vs. 15 months, respectively). This evidence supports the concept that endocrine therapies impinging upon molecular targets other than hormone receptors may increase survival rates of breast cancer patients...
  34. doi Profiling cancer stem cells in androgen-responsive and refractory human prostate tumor cell lines
    Letizia Cocciadiferro
    Experimental Oncology Unit, Department of Oncology, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1155:257-62. 2009
    ....
  35. doi Sildenafil protects epithelial cell through the inhibition of xanthine oxidase and the impairment of ROS production
    Gennaro Taibi
    Dipartimento di Oncologia Sperimentale e Applicazioni Cliniche, Sezione di Biochimica e Oncologia Clinica, AOUP Paolo Giaccone, Universita di Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Free Radic Res 44:232-9. 2010
    ....
  36. ncbi A traditional Mediterranean diet decreases endogenous estrogens in healthy postmenopausal women
    Giuseppe Carruba
    Breast Cancer Registry and Experimental Oncology, Department of Oncology, ARNAS Civico, Palermo, Italy
    Nutr Cancer 56:253-9. 2006
    ..This may eventually lead to identify selected dietary components that more effectively decrease estrogens levels and, hence, provide a basis to develop dietary preventive measures for breast cancer...
  37. pmc Nutrition, aging and cancer: lessons from dietary intervention studies
    Giuseppe Carruba
    Division of Research and Internationalization, ARNAS Civico Di Cristina e Benfratelli, Palermo, Italy
    Immun Ageing 13:13. 2016
    ..Both published and unpublished results are presented and discussed. ..
  38. doi CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily
    Carmela Rita Balistreri
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Ann N Y Acad Sci 1155:289-92. 2009
    ..For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5Delta32 anti-inflammatory variant might be a resistance factor for the development of PCa...
  39. ncbi HER2/neu expression in relation to clinicopathologic features of breast cancer patients
    Adele Traina
    Experimental Oncology, Department of Oncology, P O M Ascoli, via Parlavecchio n 139, 90127 Palermo, Italy
    Ann N Y Acad Sci 1089:159-67. 2006
    ..001). In 194 patients without metastasis, with an average follow-up > or =5 years, only HER2/neu 3+ and histopathologic grading G3 were significantly associated with overall survival...
  40. doi Inflammation and prostate cancer
    Sonya Vasto
    Department of Pathobiology and Biomedical Methodologies, Immunohaemathology and Transfusion Medicine Unit, University Hospital, University of Palermo, Palermo, Italy
    Future Oncol 4:637-45. 2008
    ..Thus, it is possible that early inflammatory events stimulated by sex hormones serve as a prerequisite for the onset of prostate cancer...
  41. doi Genotyping of sex hormone-related pathways in benign and malignant human prostate tissues: data of a preliminary study
    Carmela Rita Balistreri
    Immunosenescence Group, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, Italy
    OMICS 15:369-74. 2011
    ....
  42. doi Low levels of both xanthine dehydrogenase and cellular retinol binding protein are responsible for retinoic acid deficiency in malignant human mammary epithelial cells
    Gennaro Taibi
    Department of Experimental Oncology and Clinical Applications, University of Palermo, Palermo, Italy
    Ann N Y Acad Sci 1155:268-72. 2009
    ..This defect may be the crux of the impairment to stem cell differentiation and, hence, may be primarily implicated in human mammary carcinogenesis...
  43. doi Retinol oxidation to retinoic acid in human thyroid glandular cells
    Gennaro Taibi
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Universita degli Studi di Palermo, Palermo, Italy
    J Enzyme Inhib Med Chem 29:796-803. 2014
    ..The evidence of XDH-driven formation of retinoic acid in HTGC cultures further corroborates the potential role of XDH in retinoic acid biosynthesis in the epithelia. ..
  44. pmc Nutrigerontology: a key for achieving successful ageing and longevity
    Anna Aiello
    Department of Pathobiology and Medical Biotechnologies, University of Palermo, Palermo, Italy
    Immun Ageing 13:17. 2016
    ....
  45. ncbi P/CAF-mediated spermidine acetylation regulates histone acetyltransferase activity
    Giosalba Burgio
    a Istituto Telethon Dulbecco, Palermo, Italy
    J Enzyme Inhib Med Chem 31:75-82. 2016
    ....
  46. doi Inflammation, ageing and cancer
    Sonya Vasto
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Mech Ageing Dev 130:40-5. 2009
    ..All in all, centenarians seem to carry a genetic background with a peculiar resistance to cancer which is also an anti-inflammatory profile...
  47. pmc The management of cancer in the elderly: targeted therapies in oncology
    Biagio Agostara
    Clinical Oncology, Department of Oncology, M Ascoli Cancer Hospital Center, ARNAS Civico, Palermo, Italy
    Immun Ageing 5:16. 2008
    ..The most common targeted therapies used in clinical practice, i.e. monoclonal antibodies and small molecules, are described...
  48. ncbi Red wine extract prevents neuronal apoptosis in vitro and reduces mortality of transgenic mice
    Rosalba Amodio
    Experimental Oncology Unit Department of Oncology, M Ascoli, ARNAS Civico, Palermo, Italy
    Ann N Y Acad Sci 1089:88-97. 2006
    ....
  49. ncbi Docetaxel and gemcitabine in the treatment of metastatic breast carcinoma: a dose finding study
    Vita Leonardi
    Division of Medical Oncology, P O M Ascoli, ARNAS, Civico, Palermo, Italy
    Tumori 95:427-31. 2009
    ..Therefore, new drugs or new combinations of drugs are needed. One approach has been to focus on the type of chemotherapy with low toxicity that preserves quality of life during treatment, such as weekly drug administration...
  50. ncbi Urinary estrogen metabolites and prostate cancer: a case-control study in the United States
    Paola Muti
    Department of Social and Preventive Medicine, University at Buffalo, State University of New York, NY, USA
    Cancer Causes Control 13:947-55. 2002
    ....
  51. ncbi Basal growth hormone concentrations in blood and the risk for prostate cancer: a case-control study
    Barbara Fuhrman
    Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Prostate 64:109-15. 2005
    ..To assess the relationship between basal serum growth hormone (GH) levels and prostate cancer risk...
  52. ncbi Virokines in the pathogenesis of cancer: focus on human herpesvirus 8
    Mariam Klouche
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Ann N Y Acad Sci 1028:329-39. 2004
    ..We provide an overview of the role of virokines in cancer, with a particular focus on the differences of human and viral IL-6 in the pathophysiology of HHV8-associated tumors...