A Cataldi

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi Cyclic nucleotide Response Element Binding protein (CREB) activation promotes survival signal in human K562 erythroleukemia cells exposed to ionising radiation/etoposide combined treatment
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Italy
    J Radiat Res 47:113-20. 2006
  2. pmc p53 and telomerase control rat myocardial tissue response to hypoxia and ageing
    A Cataldi
    Dipartimento di Biomorfologia, Istituto di Genetica Molecolare del CNR, Chieti, Italy
    Eur J Histochem 53:e25. 2009
  3. ncbi NF-kappaB activation plays an antiapoptotic role in human leukemic K562 cells exposed to ionizing radiation
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, 66100 Chieti, Italy
    J Cell Biochem 89:956-63. 2003
  4. ncbi Role of nuclear PKC delta in mediating caspase-3-upregulation in Jurkat T leukemic cells exposed to ionizing radiation
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti, Italy
    J Cell Biochem 86:553-60. 2002
  5. ncbi p53 and telomerase control rat myocardial tissue response to hypoxia and ageing
    A Cataldi
    Dipartimento di Biomorfologia, Universita, G D Annunzio, Chieti Pescara, Italy
    Eur J Histochem 53:209-16. 2009
  6. ncbi Balance between hypertrophic and hypoxic stimulus in caspase-3 activation during rat heart development
    A Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Via dei Vestini 6, Chieti Pescara 66100, Italy
    J Mol Histol 36:217-24. 2005
  7. ncbi Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells
    A Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti, Italy
    J Cell Biochem 88:144-51. 2003
  8. ncbi Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    Biol Bull 217:202-12. 2009
  9. ncbi Cell responses to oxidative stressors
    Amelia Cataldi
    Dipartimento di Biomorfologia, Cattedra di Anatomia Umana, Facolta di Farmacia, Universita G D Annunzio, Chieti Pescara, Via dei Vestini, 6, 66100, Chieti Italy
    Curr Pharm Des 16:1387-95. 2010
  10. ncbi Molecular and morphological modifications occurring in rat heart exposed to intermittent hypoxia: role for protein kinase C alpha
    Amelia Cataldi
    Dipartimento di Biomorfologia, Facoltà di Farmacia Università G D Annunzio, Via dei Vestini 6, Chieti 66100, Italy
    Exp Gerontol 39:395-405. 2004

Collaborators

Detail Information

Publications60

  1. ncbi Cyclic nucleotide Response Element Binding protein (CREB) activation promotes survival signal in human K562 erythroleukemia cells exposed to ionising radiation/etoposide combined treatment
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Italy
    J Radiat Res 47:113-20. 2006
    ..5 Gy with or without etoposide, led us to suggest that using specific inhibitors against CREB, such as modified phosphorothionate oligodeoxynucleotides (ODN) corresponding to CREB-1 sequence, anticancer therapy efficacy could be improved...
  2. pmc p53 and telomerase control rat myocardial tissue response to hypoxia and ageing
    A Cataldi
    Dipartimento di Biomorfologia, Istituto di Genetica Molecolare del CNR, Chieti, Italy
    Eur J Histochem 53:e25. 2009
    ..Moreover, by preventing TERT enzyme down-regulation, cell cycle exit and apoptosis occurrence could be delayed and new possibilities for intervention against cell ageing and hypoxia could be opened...
  3. ncbi NF-kappaB activation plays an antiapoptotic role in human leukemic K562 cells exposed to ionizing radiation
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, 66100 Chieti, Italy
    J Cell Biochem 89:956-63. 2003
    ..Thus NF-kappaB activation explains the resistance displayed by K562 to IR and drug potential interference directed to this protein could overcome apoptosis resistance in clinical settings...
  4. ncbi Role of nuclear PKC delta in mediating caspase-3-upregulation in Jurkat T leukemic cells exposed to ionizing radiation
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti, Italy
    J Cell Biochem 86:553-60. 2002
    ..Altogether these results let us to conclude that PKC delta, potentiating the pro-apoptotic effect of caspase 3, plays a key role in the cellular response to IR and thus can be considered a molecular target for therapy...
  5. ncbi p53 and telomerase control rat myocardial tissue response to hypoxia and ageing
    A Cataldi
    Dipartimento di Biomorfologia, Universita, G D Annunzio, Chieti Pescara, Italy
    Eur J Histochem 53:209-16. 2009
    ..Moreover, by preventing TERT enzyme down-regulation, cell cycle exit and apoptosis occurrence could be delayed and new possibilities for intervention against cell ageing and hypoxia could be opened...
  6. ncbi Balance between hypertrophic and hypoxic stimulus in caspase-3 activation during rat heart development
    A Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Via dei Vestini 6, Chieti Pescara 66100, Italy
    J Mol Histol 36:217-24. 2005
    ..Thus, a regulation carried out by NF-kB and JNK/SAPK pathways on caspase-3 activation at day 8 of neonatal life can be suggested as the main factor for the heart 'adaptive' response to hypoxia...
  7. ncbi Protein kinase C zeta nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells
    A Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti, Italy
    J Cell Biochem 88:144-51. 2003
    ....
  8. ncbi Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells
    Amelia Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    Biol Bull 217:202-12. 2009
    ....
  9. ncbi Cell responses to oxidative stressors
    Amelia Cataldi
    Dipartimento di Biomorfologia, Cattedra di Anatomia Umana, Facolta di Farmacia, Universita G D Annunzio, Chieti Pescara, Via dei Vestini, 6, 66100, Chieti Italy
    Curr Pharm Des 16:1387-95. 2010
    ....
  10. ncbi Molecular and morphological modifications occurring in rat heart exposed to intermittent hypoxia: role for protein kinase C alpha
    Amelia Cataldi
    Dipartimento di Biomorfologia, Facoltà di Farmacia Università G D Annunzio, Via dei Vestini 6, Chieti 66100, Italy
    Exp Gerontol 39:395-405. 2004
    ..In addition, since no modifications concerning PKC alpha driven signalling system are evidenced in both the experimental conditions, we suggest an oxygen impaired sensing during ageing...
  11. ncbi Protein kinase C zeta regulation of hypertrophic and apoptotic events occurring during rat neonatal heart development and growth
    L Centurione
    Dipartimento di Biomorfologia, Facolta di Farmacia, Cattedra di Anatomia Umana, University of Chieti, Italy
    Int J Immunopathol Pharmacol 18:49-58. 2005
    ..Thus a key role for PKC zeta in regulating the hypertrophic and apoptotic events leading to establishment of complete function in rat neonatal heart is here suggested...
  12. ncbi Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation
    A Cataldi
    Dipartimento di Biomorfologia, Facolta di Medicina e Chirurgia, Universita di Chieti, Via dei Vestini, 6, 66100, Chieti, Italy
    Cell Signal 13:369-75. 2001
    ..Thus, we suggest a role for these enzymes in maintaining survival programs upon exposure to ionizing radiation and in giving to these cells a chance to recover from this stress...
  13. ncbi PI-3-kinase/NF-kappaB mediated response of Jurkat T leukemic cells to two different chemotherapeutic drugs, etoposide and TRAIL
    N Sabatini
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    J Cell Biochem 93:301-11. 2004
    ..Thus, the existence of a balance between apoptotic and rescue response in 20% of cells surviving to TRAIL suggests the possibility of pushing it in favor of cell death in order to improve the yield of pharmacological strategies...
  14. ncbi Correlations between protein kinase C zeta signaling and morphological modifications during rat heart development and aging
    L Centurione
    Dipartimento di Biomorfologia, Universita G D Annunzio, Via dei Vestini, 6, 66100 Chieti, Italy
    Mech Ageing Dev 124:957-66. 2003
    ..Further, we underline that in the aged heart, where this pathway is not activated, such balance is not maintained...
  15. ncbi TRAIL promotes a pro-survival signal in erythropoietin-deprived human erythroblasts through the activation of an NF-kB/IkBalpha pathway
    S Sancilio
    Dipartimento di Medicina e Scienze dell Invecchiamento, Università G D Annunzio Chieti Pescara, Chieti, Italy
    J Biol Regul Homeost Agents 25:375-86. 2011
    ....
  16. doi 2-Hydroxyethyl methacrylate inflammatory effects in human gingival fibroblasts
    C Di Nisio
    Dipartimento di Farmacia, Universita G D Annunzio, Chieti Pescara, Italy
    Int Endod J 46:466-76. 2013
    ....
  17. doi Cytoglobin and neuroglobin in the human brainstem and carotid body
    C Di Giulio
    Department of Neurosciences and Imaging, University of Chieti, 31 Via dei Vestini, 66100, Chieti, Italy
    Adv Exp Med Biol 788:59-64. 2013
    ..Because the STN plays an important role in the processing of cardiovascular and respiratory reflex inputs, Ngb and Cygb may play an integrative central modulatory action for the two systems. ..
  18. doi Development and aging are oxygen-dependent and correlate with VEGF and NOS along life span
    S Zara
    Department of Drug Sciences, University of Chieti, Chieti, Italy
    Adv Exp Med Biol 756:223-8. 2013
    ..2 ± 0.02%). Prevention of oxygen desaturation, reducing all causes of hypoxemia from neonatal life to aging would decrease the incidence of diseases in the elderly population with lifespan extension...
  19. ncbi Ultrastructural modifications and phosphatidylinositol-3-kinase expression and activity in myocardial tissue deriving from rats in different experimental conditions
    A Cataldi
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti, Italy
    Cell Struct Funct 26:87-93. 2001
    ..In particular, down regulation of this pathway, which when activated is known to deliver an anti-apoptotic signal, is concomitant to the maintenance of the apoptotic events occurring in these cells in response to oxidative stresses...
  20. ncbi Age-dependent variations in the expression of PLC isoforms upon mitogenic stimulation of peripheral blood T cells from healthy donors
    R Di Pietro
    Istituto di Morfologia Umana Normale, Universita G D Annunzio, Chieti Scalo, Italy
    Br J Haematol 111:1209-14. 2000
    ....
  21. ncbi Phospholipase C gamma 1 overexpression and activation induced by interferon beta in human T lymphocytes: an ISGF3-independent response
    S Miscia
    Istituto di Morfologia Umana, Universita G D Annunzio, Chieti, Italy
    Cytokine 9:660-5. 1997
    ..In addition, the ability of this enzyme to hydrolyse PIP2, also in the presence of genistein, implies the possibility that this enzyme can exert its hydrolytic activity independently of protein tyrosine kinase activation...
  22. doi Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model
    S Zara
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti Pescara, Italy
    Brain Res 1412:79-87. 2011
    ..Interestingly codrug 1, lowering metalloproteinases expression via PKC ε down-modulation, seems to control Alzheimer's disease induced cerebral amyloid deposits, neuronal death and, lastly, behavioral deterioration...
  23. ncbi Shift of DNA polymerase alpha nuclear distribution and activity in apoptotic human leukaemia cells
    S Miscia
    Istituto di Morfologia Umana Normale, Universita G D Annunzio, Chieti, Italy
    Biochem Biophys Res Commun 234:303-8. 1997
    ....
  24. ncbi Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development
    S Zara
    Dipartimento Biomorfologia, Facolta di Farmacia, Universita G D Annunzio, Chieti Pescara, Italy
    J Biol Regul Homeost Agents 23:45-54. 2009
    ....
  25. doi A dual role for β1 integrin in an in vitro Streptococcus mitis/human gingival fibroblasts co-culture model in response to TEGDMA
    C Di Nisio
    Department of Pharmacy, University G D Annunzio Chieti Pescara, Chieti, Italy
    Int Endod J 48:839-49. 2015
    ..To evaluate the effect of TEGDMA on human gingival fibroblasts (HGFs) in vitro co-cultured with Streptococcus mitis, focusing on the signalling pathways underlying cell tissue remodelling and inflammatory response processes...
  26. doi Overexpression of interleukin-6 and -8, cell growth inhibition and morphological changes in 2-hydroxyethyl methacrylate-treated human dental pulp mesenchymal stem cells
    O Trubiani
    Department of Oral Science, Nano and Biotechnology, University G D Annunzio, Via Vestini 11, Chieti Pescara, Italy
    Int Endod J 45:19-25. 2012
    ..To evaluate morphological features, cell growth and interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion in expanded ex vivo human dental pulp mesenchymal stem cells (DP-MSCs) after exposure to 2-hydroxyethyl methacrylate (HEMA)...
  27. doi Inducible nitric oxide synthase-activated mitochondrial apoptotic pathway in hypoxic and aged rat hearts
    S Zara
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    Gerontology 56:544-52. 2010
    ....
  28. ncbi Phosphatidylinositol-3-kinase activation and atypical protein kinase C zeta phosphorylation characterize the DMSO signalling in erythroleukemia cells
    A Cataldi
    Istituto di Morfologia Umana Normale, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Via dei Vestini, 6, 66100, Chieti, Italy
    Cell Signal 12:667-72. 2000
    ....
  29. ncbi Regulation of CREB activation by p38 mitogen activated protein kinase during human primary erythroblast differentiation
    V Di Giacomo
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    Int J Immunopathol Pharmacol 22:679-88. 2009
    ..All in all, our results evidence a role for p38 MAPK in activating CREB metabolic pathway in the events leading to erythroid differentiation...
  30. doi Dual role of HIF-1alpha in delivering a survival or death signal in hypoxia exposed human K562 erythroleukemia cells
    Viviana Di Giacomo
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    Cell Biol Int 33:49-56. 2009
    ..We suggest a dual role for HIF-1alpha in providing a survival or death signal, based on hypoxia duration, and consider the nuclear transcription factor, CREB, to be a possible target for hypoxic therapy against leukemia disease...
  31. doi Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue
    Amelia Cataldi
    Cattedra di Anatomia Umana, Facolta di Farmacia, Universita G D Annunzio, Chieti Pescara, Chieti, Italy
    Anat Rec (Hoboken) 292:1135-42. 2009
    ....
  32. ncbi HIF-1alpha cytoplasmic accumulation is associated with cell death in old rat cerebral cortex exposed to intermittent hypoxia
    Cinzia Rapino
    Dipartimento di Scienze Biomediche, Facolta di Farmacia, Universita G D Annunzio, 66100 Chieti Pescara, Italy
    Aging Cell 4:177-85. 2005
    ..These observations are associated with a low level of cell death induced by hypoxia, suggesting that HIF-1alpha activation in cortical neurons may produce rescue proteins in response to intermittent hypoxia...
  33. doi pPKC α regulates through integrin β 1 human gingival fibroblasts/Streptococcus mitis adhesion in response to HEMA
    V Di Giacomo
    Dipartimento di Farmacia, Universita G D Annunzio, Chieti Pescara, Italy
    Int Endod J 46:1164-72. 2013
    ....
  34. pmc Maxillary sinus augmentation procedures through equine-derived biomaterial or calvaria autologous bone: immunohistochemical evaluation of OPG/RANKL in humans
    S Tete
    Department of Medical, Oral and Biotechnological Sciences, University G D Annunzio Chieti Pescara, Chieti, Scalo, Italy
    Eur J Histochem 57:e10. 2013
    ..According to these observations, the clinical use of heterologous particulate equine-derived biomaterial may ensure long-term predictability of implant-prosthetic rehabilitation, comparable to that obtained with autologous bone graft...
  35. pmc pPKCα mediated-HIF-1α activation related to the morphological modifications occurring in neonatal myocardial tissue in response to severe and mild hyperoxia
    S Zara
    Section of Human Anatomy, Faculty of Pharmacy, University G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Eur J Histochem 56:e2. 2012
    ..This intracellular signalling can switch molecular events leading to blood vessels development in parallel to pro-apoptotic events due to an immature anti-oxidant defensive system in newborn rat hearts...
  36. ncbi Immunocytochemical detection of phosphatidylinositol 3 kinase in Burkitt lymphoma cells
    S Miscia
    Istituto di Morfologia Umana Normale, Universita G D Annunzio, Chieti, Italy
    Cell Struct Funct 23:17-22. 1998
    ....
  37. pmc NF-kB mediated down-regulation of collagen synthesis upon HEMA (2-hydroxyethyl methacrylate) treatment of primary human gingival fibroblast/Streptococcus mutans co-cultured cells
    R Grande
    Dipartimento di Farmacia, Universita G D Annunzio, Chieti Pescara, 66100, Chieti, Italy
    Clin Oral Investig 19:841-9. 2015
    ....
  38. ncbi Age-related death-survival balance in myocardium: an immunohistochemical and biochemical study
    Lucia Centurione
    Dipartimento di Biomorfologia, Universita G D Annunzio, 66100, Chieti, Italy
    Mech Ageing Dev 123:341-50. 2002
    ....
  39. ncbi PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue
    Camillo Di Giulio
    Dipartimento di Scienze Mediche di Base ed Applicate, Universita G D Annunzio, Chieti Pescara, Chieti, Italy
    Histochem Cell Biol 127:327-33. 2007
    ....
  40. doi Human carotid body HIF and NGB expression during human development and aging
    Camillo Di Giulio
    Department of Neurosciences and Imaging, University of Chieti, Chieti, Italy
    Adv Exp Med Biol 758:265-71. 2012
    ..Even though the physiological role of NGB is not well understood, it could be suggested that is act as a respiratory protein connected with HIF...
  41. ncbi pPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes
    P Sozio
    Dipartimento di Scienze del Farmaco, Universit and x00E0 di Chieti, Chieti, Italy
    J Biol Regul Homeost Agents 26:245-51. 2012
    ..Thus gamma secretase inhibitor, activating pPKC alpha intracellular pathway could be suggested to prevent or reduce downstream toxic events, representing a useful strategy to counteract Alzheimer's disease...
  42. pmc Anti-adhesive and pro-apoptotic effects of 2-hydroxyethyl methacrylate on human gingival fibroblasts co-cultured with Streptococcus mitis strains
    S Zara
    Department of Drug Sciences, University G D Annunzio Chieti Pescara, Chieti, Italy
    Int Endod J 44:1145-54. 2011
    ....
  43. ncbi Engagement of DNA polymerases during apoptosis
    S Miscia
    Istituto di Morfologia Umana Normale, Universita G D Annunzio, Chieti, Italy
    Cell Prolif 30:325-40. 1997
    ....
  44. ncbi Vascular endothelial growth factor and e-nitric oxide synthase-mediated regenerative response occurring upon autologous and heterologous bone grafts
    S Tete
    Department of Oral Science, University G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 22:1105-16. 2009
    ....
  45. ncbi pPKCδ activates SC35 splicing factor during H9c2 myoblastic differentiation
    Susi Zara
    Department of Drug Sciences, Faculty of Pharmacy, University G D Annunzio, Chieti Pescara, Italy
    Histol Histopathol 26:59-69. 2011
    ..Furthermore, this co-localization represents a crucial event resulting in downstream changes in transcription of components which determine the morphological modifications related to cardiomyoblast differentiated phenotype...
  46. ncbi PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL
    Luciana Caravatta
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    J Cell Physiol 214:192-200. 2008
    ..These results let us hypothesize that CREB activation can be an important player in the complex cross-talk among pro- and anti-apoptotic pathways in this peculiar cell model...
  47. ncbi Engagement of PI-3-kinase mediated protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis
    Amelia Cataldi
    Dipartimento di Biomorfologia, Facolta di Medicina e Chirurgia, Universita G D Annunzio, I 66100 Chieti, Italy
    Int J Oncol 22:129-35. 2003
    ....
  48. ncbi A flow cytometry procedure for simultaneous characterization of cell DNA content and expression of intracellular protein kinase C-zeta
    Paola Lanuti
    Cell Signalling Unit at the Department of Biomorphology, University G D Annunzio Chieti Pescara, Chieti, Italy
    J Immunol Methods 315:37-48. 2006
    ..The method here described, therefore, represents a simple, reproducible and conservative assay for a simultaneous assessment of intracellular PKC or P-PKC modulations within each cell cycle phase...
  49. ncbi "Oxygen supply" as modulator of aging processes: hypoxia and hyperoxia models for aging studies
    Amelia Cataldi
    Department of Biomorphology and Human Anatomy Section, Faculty of Pharmacy, Pescara, Italy
    Curr Aging Sci 2:95-102. 2009
    ..In other words, to better understand aging we need to know what O(2) species are being sensed by cells. In conclusion, hypoxia and hyperoxia represent an experimental model adequate for studying aging processes...
  50. pmc Phospholipase C delta2 expression characterizes the neoplastic transformation of the human gastric mucosa
    M Marchisio
    Section of Human Anatomy at the Department of Biomorphology, School of Medicine, University of Chieti, Chieti, Italy
    Am J Pathol 159:803-8. 2001
    ..These results therefore readdress the question of surveillance of the patients with type I intestinal metaplasia and suggest that PLC delta2 expression might be a possible marker of gastric malignant transformation...
  51. pmc Reduced pulmonary function is age-dependent in the rat lung in normoxia
    G Petruccelli
    Department of Neuroscience and Imaging, G D Annunzio University, Campus Madonna delle Piane, Chieti, Italy
    Eur J Med Res 15:108-11. 2010
    ..During development and aging, redundant cells and exhausted cells are eliminated, respectively, whereas others can adapt to the stressful environment and survive...
  52. doi Proteome analysis of X-ray irradiated human erythroleukemia cells
    Enrica Eleuterio
    Department of Biomedical Science, G D Annunzio University, Chieti Pescara, Italy
    Biochim Biophys Acta 1784:611-20. 2008
    ..This data set may provide a useful tool to design a combined chemo- and radiotherapic strategy against leukemia disease...
  53. ncbi JNK/p53 mediated cell death response in K562 exposed to etoposide-ionizing radiation combined treatment
    Nadia Sabatini
    Dipartimento di Biomorfologia, Universita G D Annunzio, Chieti Pescara, Italy
    J Cell Biochem 95:611-9. 2005
    ..Thus further investigation on these and other molecular mechanisms underlying the cell death response following etoposide and ionizing radiation exposure could be useful to overcome resistance mechanisms in tumor cells...
  54. ncbi Cyclic nucleotide response element binding (CREB) protein activation is involved in K562 erythroleukemia cells differentiation
    Roberta Di Pietro
    Dipartimento di Biomorfologia, Chieti Pescara, Italy
    J Cell Biochem 100:1070-9. 2007
    ..All in all these results document a novel relationship between CREB activation and differentiation-related apoptotic cell death and assign a role to p38 MAP kinase pathway in determining these events in K562 erythroleukemia cells...
  55. ncbi Ibuprofen and lipoic acid diamide as co-drug with neuroprotective activity: pharmacological properties and effects in beta-amyloid (1-40) infused Alzheimer's disease rat model
    A Di Stefano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 23:589-99. 2010
    ..Thus, co-drug 1 could prove useful as a tool for controlling Alzheimer's disease-induced cerebral amyloid deposits and behavioural deterioration...
  56. doi HEMA-induced cytotoxicity: oxidative stress, genotoxicity and apoptosis
    M Gallorini
    Department of Pharmacy, University G D Annunzio, Chieti, Italy
    Int Endod J 47:813-8. 2014
    ..This minireview collects the most significant papers on HEMA and tries to make an overview of its cytotoxicity on different cell types and experimental models. ..
  57. doi Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity
    Piera Sozio
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 343:133-42. 2010
    ....
  58. ncbi p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia
    Giuseppina Bianchi
    Dipartimento di Scienze Biomediche, Università G d Annunzio Chieti e Pescara, Chieti, Italia
    Gerontology 52:17-23. 2006
    ..In particular, intermittent hypoxia, i.e., hypoxia followed by reoxygenation, determines different responses in young and adult myocardia...
  59. ncbi Effect of chronic hypoxia on inducible nitric oxide synthase expression in rat myocardial tissue
    Alfredo Grilli
    Department of Biomorphology, University G D Annunzio, 66013 Chieti, Italy
    Exp Biol Med (Maywood) 228:935-42. 2003
    ..1 +/- 0.01 vs 0.02 +/- 0.003). The present study shows that exposure to low oxygen tension is capable of inducing programmed cell death and activating iNOS...
  60. ncbi PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment
    Giorgio Zauli
    Dipartimento di Morfologia Umana Normale, Universita di Trieste, Via Manzoni, Trieste, Italy
    J Cell Physiol 202:900-11. 2005
    ....