Massimo Collino

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. doi PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Ther Adv Cardiovasc Dis 2:179-97. 2008
  2. doi Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Turin, Italy Electronic address
    Pharmacol Ther 151:32-40. 2015
  3. pmc Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, via P Giuria 9, 10125 Turin, Italy
    Dis Model Mech 6:1012-20. 2013
  4. pmc Erythropoietin in the intensive care unit: beyond treatment of anemia
    Nimesh Sa Patel
    Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and The London, London, UK
    Ann Intensive Care 1:40. 2011
  5. doi Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Turin, Italy
    Biochem Pharmacol 85:257-64. 2013
  6. doi Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury
    Massimo Collino
    Department of Anatomy, University of Turin, Torino, Italy
    Thromb Haemost 102:837-45. 2009
  7. doi Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Free Radic Biol Med 50:345-53. 2011
  8. pmc Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Br J Pharmacol 160:1892-902. 2010
  9. pmc Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Diabetes 58:235-42. 2009
  10. doi Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Shock 30:299-307. 2008

Collaborators

Detail Information

Publications39

  1. doi PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Ther Adv Cardiovasc Dis 2:179-97. 2008
    ..This paper reviews the evidence and recent developments relating to the potential therapeutic effects of PPAR-agonists in the treatment of cerebral I/R injury...
  2. doi Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Turin, Italy Electronic address
    Pharmacol Ther 151:32-40. 2015
    ..This review summarizes pharmacokinetic and pharmacodynamic data and discusses the molecular mechanisms underlying the long-lasting effects of this short-lived peptide. ..
  3. pmc Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, via P Giuria 9, 10125 Turin, Italy
    Dis Model Mech 6:1012-20. 2013
    ....
  4. pmc Erythropoietin in the intensive care unit: beyond treatment of anemia
    Nimesh Sa Patel
    Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and The London, London, UK
    Ann Intensive Care 1:40. 2011
    ..This review article summarizes what is known in preclinical models of critical illness and discusses why this does not correlate with randomized, controlled clinical trials...
  5. doi Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Turin, Italy
    Biochem Pharmacol 85:257-64. 2013
    ....
  6. doi Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury
    Massimo Collino
    Department of Anatomy, University of Turin, Torino, Italy
    Thromb Haemost 102:837-45. 2009
    ....
  7. doi Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Free Radic Biol Med 50:345-53. 2011
    ..Thus, we report herein that PPARβ/δ activation protects the diabetic kidney against I/R injury by a mechanism that may involve changes in renal expression of SOCS-3 resulting in a reduced local inflammatory response...
  8. pmc Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Br J Pharmacol 160:1892-902. 2010
    ..This study aimed to investigate the hepatic signalling pathway activated by PPARgamma activation in a non-genetic insulin-resistant animal model...
  9. pmc Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Diabetes 58:235-42. 2009
    ..Insulin is a well-known inhibitor of glycogen synthase kinase-3beta (GSK-3beta). Here, we investigate the role of GSK-3beta inhibition on I/R-induced cerebral injury in a rat model of insulinopenic diabetes...
  10. doi Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Shock 30:299-307. 2008
    ..The present study demonstrates that TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. Collectively, our data may contribute to focus the role of GSK-3beta in cerebral I/R...
  11. ncbi Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, 10125 Turin, Italy
    Free Radic Biol Med 41:579-89. 2006
    ..We propose that WY14643 protects the brain against excessive oxidative stress and inflammation and may thus be useful in treating stroke...
  12. ncbi Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Torino, Italy
    Eur J Pharmacol 530:70-80. 2006
    ..Taken together, the results provide convincing evidence that PPAR-gamma agonists exert protective effects in a rat model of mild forebrain ischemia/reperfusion injury by inhibiting oxidative stress and excessive inflammatory response...
  13. pmc Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Turin, Italy
    J Cell Mol Med 17:1494-505. 2013
    ..Thus, we report herein that rhRLX protects the kidney against I/R injury by a mechanism that involves changes in nitric oxide signalling pathway. ..
  14. pmc High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- δ agonism
    Elisa Benetti
    Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy
    Mediators Inflamm 2013:509502. 2013
    ..Overall, here we show that PPAR- δ activation protects the skeletal muscle against the metabolic abnormalities caused by chronic HFCS exposure by affecting multiple levels of the insulin and inflammatory cascades...
  15. pmc Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Torino, Italy
    Oxid Med Cell Longev 2016:3480637. 2016
    ..The common mechanisms of damage here reported lead to a better understanding of the cross-talk among prosurvival and detrimental pathways leading to the development of cardiovascular disorders associated with metabolic diseases. ..
  16. doi PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss
    Gianluca Miglio
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Italy
    Neurochem Int 55:496-504. 2009
    ..In addition, they suggest that mitochondrial biogenesis may contribute to these effects...
  17. doi Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice
    Raffaella Mastrocola
    Dept of Clinical and Biological Sciences, Experimental Medicine and Clinical Pathology Unit, Univ of Turin, C so Raffaello 30, 10125 Torino, Italy
    Am J Physiol Gastrointest Liver Physiol 305:G398-407. 2013
    ..Overall, the high levels of CML and activation of SCAP/SREBP pathway associated to high fructose exposure here reported may suggest a key role of this signaling pathway in mediating fructose-induced lipogenesis...
  18. pmc Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells
    Margherita Gallicchio
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Via Pietro Giuria, 9, 10125 Torino, Italy
    Br J Pharmacol 147:681-9. 2006
    ..The study shows HUVEC to possess functional NK(1) and NK(2) receptors, which mediate the ability of SP to induce expression of COX-2 in HUVEC, thus showing a previously-undetected effect of SP on endothelial cells...
  19. ncbi Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation
    Regina Sordi
    Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK Department of Drug Science and Technology, University of Turin, Turin, Italy Department of Clinical Pharmacology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK Centre for Trauma Sciences, Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    Ann Surg . 2016
    ..To evaluate the effects of artesunate on organ injury and dysfunction associated with hemorrhagic shock (HS) in the rat...
  20. doi SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, 10125 Turin, Italy
    Free Radic Biol Med 47:1067-74. 2009
    ..DHEA supplementation of the HF-F diet reduced de novo lipogenesis and delayed progression of nonalcoholic fatty liver disease, demonstrating a relationship between oxidative stress and nonalcoholic fatty liver disease via SREBP-1c...
  21. doi High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy Electronic address
    Neurobiol Dis 89:65-75. 2016
    ....
  22. doi Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat
    Kiran K Nandra
    The William Harvey Research Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK
    Shock 37:592-8. 2012
    ....
  23. ncbi Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines
    Chiara Dianzani
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy
    J Pharm Pharmacol 58:219-26. 2006
    ..Indeed, when both cell populations were activated contemporarily, the anti-adhesive effect was enhanced. The study suggests that 2-aryl-4,6-dimethoxy-1,3,5-triazines deserve further evaluation as anti-inflammatory agents...
  24. pmc Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice
    Fausto Chiazza
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, Turin, Italy
    Mol Med . 2015
    ....
  25. pmc The non-anticoagulant heparin-like K5 polysaccharide derivative K5-N,OSepi attenuates myocardial ischaemia/reperfusion injury
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    J Cell Mol Med 16:2196-207. 2012
    ..In conclusion, we demonstrate that the cardioprotective effect of the non-anticoagulant K5 derivative K5-N,OSepi is secondary to a combination of anti-apoptotic and anti-inflammatory effects...
  26. doi Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes
    Arianna Carolina Rosa
    Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Corso Raffaello 33, 10125 Turin, Italy
    Inflamm Res 61:311-7. 2012
    ..The aim of this study was to investigate the Ang II-TNF-α relationship in human podocytes...
  27. pmc Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    PLoS ONE 10:e0119587. 2015
    ....
  28. pmc Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
    Oxid Med Cell Longev 2016:5271251. 2016
    ....
  29. doi Empagliflozin Protects against Diet-Induced NLRP-3 Inflammasome Activation and Lipid Accumulation
    Elisa Benetti
    Departments of Drug Science and Technology E B, G V, F C, M C, R F, Clinical and Biological Sciences R M, D N, and Biotechnology and Sciences for the Health J C C, University of Turin, Turin, Italy and Boehringer Ingelheim Pharma, Biberach an der Riss, Germany E M
    J Pharmacol Exp Ther 359:45-53. 2016
    ..Most notably, empagliflozin treatment was associated with NLRP-3 inflammasome signaling modulation, suggesting that this inhibition may contribute to the drug therapeutic effects. ..
  30. pmc The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders
    Elisa Benetti
    Department of Drug Science and Technology, University of Turin, via P Giuria 9, 10125 Torino, Italy
    Mediators Inflamm 2013:678627. 2013
    ..We will provide here a perspective on the current research on NLRP3 inflammasome, which may represent an innovative therapeutic target to reverse the detrimental metabolic consequences of the metabolic inflammation. ..
  31. pmc The subtypes of peroxisome proliferator-activated receptors expressed by human podocytes and their role in decreasing podocyte injury
    Gianluca Miglio
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Br J Pharmacol 162:111-25. 2011
    ..However, both the I/R effects and the effects of PPAR agonists on podocytes, an integral cellular part of the glomerular filtration barrier, remain to be established...
  32. ncbi The role of PPARβ/δ in the management of metabolic syndrome and its associated cardiovascular complications
    Elisa Benetti
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, via P Giuria 9, 10125 Torino, Italy
    Endocr Metab Immune Disord Drug Targets 11:273-84. 2011
    ..This paper reviews the evidence and recent developments relating to the potential therapeutic effects of PPARβ/δ agonists in the treatment of metabolic syndrome and its associated cardiovascular risk factors...
  33. pmc A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion
    Fausto Chiazza
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, via P Giuria 9, 10125 Torino, Italy
    Oxid Med Cell Longev 2015:804659. 2015
    ..Overall, these findings demonstrate that the NO-donor moiety contributes to the protection against early renal I/R injury and suggest that NO-donor EDV codrugs are worthy of additional study as innovative pharmacological tools...
  34. pmc Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Turin, Italy
    Biomed Res Int 2014:569623. 2014
    ..Overall, these results show that adaptive responses to dietary manipulation occur in a muscle-specific pattern. ..
  35. doi Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock
    Regina Sordi
    Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK Department of Drug Science and Technology, University of Turin, Turin, Italy Department of Pharmacology, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Shock 45:525-33. 2016
    ..Thus, nNOS inhibitors may be useful as an adjunct therapy before fluids and blood administration in HS patients to avoid the MOF associated with reperfusion injury during resuscitation...
  36. pmc Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study
    Chiara Dianzani
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, V P Giuria 9, 10125 Torino, Italy
    J Inflamm (Lond) 3:4. 2006
    ..Both NF161 and NF177 appeared to be anti-inflammatory and analgesic agents without toxic effects or acute gastrolesivity, but NF161 showed stronger anti-inflammatory activity, whereas NF177 was more active as analgesic...
  37. doi Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile
    Massimo Bertinaria
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, via P Giuria 9, I 10125 Torino, Italy
    Eur J Med Chem 54:103-12. 2012
    ..This class of NO-donor carnosine amides is worthy of further study as potential tools for treating a wide range of chronic vascular and neurodegenerative diseases in which NO-bioavailability is reduced...
  38. doi Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation
    Regina Sordi
    Centre for Translational Medicine and Therapeutics, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK Department of Drug Science and Technology, University of Turin, Turin, Italy Department of Clinical Pharmacology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK Centre for Trauma Sciences, Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    Ann Surg 265:408-417. 2017
    ..To evaluate the effects of artesunate on organ injury and dysfunction associated with hemorrhagic shock (HS) in the rat...
  39. pmc Substance P increases neutrophil adhesion to human umbilical vein endothelial cells
    Chiara Dianzani
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, 10125 Torino, Italy
    Br J Pharmacol 139:1103-10. 2003
    ..7. These results indicate that SP induced a proadhesive effect during inflammatory processes, which was mediated by NK(1) and NK(2) receptors...