Salvatore Cuzzocrea

Summary

Affiliation: University of Messina
Country: Italy

Publications

  1. ncbi request reprint Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi 98100 Messina Italy
    J Pharmacol Exp Ther 318:79-89. 2006
  2. doi request reprint A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models
    Domenico Britti
    Department of Health Sciences V le Europa, Campus S Venuta, Germaneto, 88100, Catanzaro, Italy
    BMC Vet Res 13:229. 2017
  3. doi request reprint Erratum to: Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice.
    Daniela Impellizzeri
    Department of Biological and Environmental Sciences, University of Messina, Messina, Italy
    Arthritis Res Ther 18:101. 2016
  4. doi request reprint Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice.
    Daniela Impellizzeri
    Arthritis Res Ther 15:R192. 2013
  5. pmc Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats
    Rosanna Di Paola
    Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, n 31, Messina, 98166, Italy
    Arthritis Res Ther 18:291. 2016
  6. ncbi request reprint Neuroinflammation and Immunity: A New Pharmacological Target in Depression
    Rosalia Crupi
    Department of Biological and Environmental Sciences, University of Messina, Messina, Italy
    CNS Neurol Disord Drug Targets 15:464-76. 2016
  7. doi request reprint Emerging pharmacotherapy for treatment of traumatic brain injury: targeting hypopituitarism and inflammation
    Irene Paterniti
    a 1 University of Messina, Department of Biological and Environmental Sciences, Viale Ferdinando Stagno d Alcontres, 31 98166 Messina, Italy 390906765208
    Expert Opin Emerg Drugs 20:583-96. 2015
  8. ncbi request reprint Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation
    Irene Paterniti
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, 31 98166 Messina, Italy
    CNS Neurol Disord Drug Targets 13:1530-41. 2014
  9. pmc Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain
    Daniela Impellizzeri
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, No 31, Messina 98166, Italy
    J Neuroinflammation 11:136. 2014
  10. ncbi request reprint Phosphodiesterase as a new therapeutic target for the treatment of spinal cord injury and neurodegenerative diseases
    Irene Paterniti
    Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina Italy
    Curr Med Chem 21:2830-8. 2014

Collaborators

Detail Information

Publications180 found, 100 shown here

  1. ncbi request reprint Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi 98100 Messina Italy
    J Pharmacol Exp Ther 318:79-89. 2006
    ..Taken together, our results clearly demonstrate that treatment with TDZD-8 reduces the development of inflammation and tissue injury associated with spinal cord trauma...
  2. doi request reprint A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models
    Domenico Britti
    Department of Health Sciences V le Europa, Campus S Venuta, Germaneto, 88100, Catanzaro, Italy
    BMC Vet Res 13:229. 2017
    ..Oral treatment with meloxicam was used as benchmark...
  3. doi request reprint Erratum to: Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice.
    Daniela Impellizzeri
    Department of Biological and Environmental Sciences, University of Messina, Messina, Italy
    Arthritis Res Ther 18:101. 2016
  4. doi request reprint Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice.
    Daniela Impellizzeri
    Arthritis Res Ther 15:R192. 2013
    ..We demonstrated that PEA co-ultramicronized with luteolin exerts an antiinflammatory effect during chronic inflammation and ameliorates CIA...
  5. pmc Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats
    Rosanna Di Paola
    Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, n 31, Messina, 98166, Italy
    Arthritis Res Ther 18:291. 2016
    ....
  6. ncbi request reprint Neuroinflammation and Immunity: A New Pharmacological Target in Depression
    Rosalia Crupi
    Department of Biological and Environmental Sciences, University of Messina, Messina, Italy
    CNS Neurol Disord Drug Targets 15:464-76. 2016
    ..This review highlights the role of neuroinflammation and immunity in the pathophysiology of psychiatric disorders such as MDD...
  7. doi request reprint Emerging pharmacotherapy for treatment of traumatic brain injury: targeting hypopituitarism and inflammation
    Irene Paterniti
    a 1 University of Messina, Department of Biological and Environmental Sciences, Viale Ferdinando Stagno d Alcontres, 31 98166 Messina, Italy 390906765208
    Expert Opin Emerg Drugs 20:583-96. 2015
    ..In particular, TBI is an important cause of death and disability in young adults with consequences ranging from physical disabilities to long-term cognitive, behavioural, psychological and social defects...
  8. ncbi request reprint Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation
    Irene Paterniti
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, 31 98166 Messina, Italy
    CNS Neurol Disord Drug Targets 13:1530-41. 2014
    ..These findings suggest that the association of co-ultraPEALut may provide an effective strategy for AD...
  9. pmc Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain
    Daniela Impellizzeri
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, No 31, Messina 98166, Italy
    J Neuroinflammation 11:136. 2014
    ..The present study was thus designed to evaluate the oral anti-inflammatory efficacy of micronized/ultramicronized versus nonmicronized PEA formulations...
  10. ncbi request reprint Phosphodiesterase as a new therapeutic target for the treatment of spinal cord injury and neurodegenerative diseases
    Irene Paterniti
    Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina Italy
    Curr Med Chem 21:2830-8. 2014
    ..In this article, we review the current state of art of PDEs in the CNS diseases associated with neuroinflammation. ..
  11. pmc PPAR-alpha Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, 98123 Messina, Italy
    PPAR Res 2010:917312. 2010
    ..These results indicate that PPAR-alpha can contribute to the anti-inflammatory activity of VB in inflammatory bowel disease...
  12. pmc WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
    Enrico Briguglio
    Istituto Policattedra di Odontostomatologia, Universita degli Studi di Messina, 98100 Messina, Italy
    PPAR Res 2010:193019. 2010
    ..These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage...
  13. pmc Antiinflammatory activity of melatonin in central nervous system
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Curr Neuropharmacol 8:228-42. 2010
    ....
  14. pmc Pharmacological and clinical overview of cloperastine in treatment of cough
    Maria Antonietta Catania
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina
    Ther Clin Risk Manag 7:83-92. 2011
    ..Here we review the preclinical and clinical evidence of the efficacy and tolerability of cloperastine...
  15. pmc Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    PLoS ONE 7:e41880. 2012
    ..Our results indicate that PEA protects against MPTP-induced neurotoxicity and the ensuing functional deficits even when administered once the insult has been initiated...
  16. pmc Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice
    Akbar Ahmad
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, Messina, Italy
    PLoS ONE 8:e57208. 2013
    ..We have therefore investigated the role played by TLR4 signaling pathway in the development of mechanisms of secondary inflammatory process in traumatic brain injury (TBI) differ in mice that lack a functional TLR4 signaling pathway...
  17. pmc Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies
    Irene Paterniti
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, 98166 Messina, Italy
    J Neuroinflammation 11:6. 2014
    ..The aim of this study was to analyze the mechanism of action of ω-3 PUFAs, such as DHA, in a mouse model of SCI, with a focus on the early pathophysiological processes...
  18. ncbi request reprint Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression
    Rosalia Crupi
    Department of Biological and Environmental Science, Viale Stagno d Alcontres, 31, 98166 Messina, Italy
    CNS Neurol Disord Drug Targets 12:989-1001. 2013
    ..For the first time we demonstrated that PEA+luteolin compound exerts a significant antidepressant effect a low dose and may be considered as a novel therapeutic strategy in depression. ..
  19. pmc A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
    Irene Paterniti
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, 98166 Messina, Italy
    J Neuroinflammation 10:91. 2013
    ..We investigated the effect of co-ultraPEALut (in the respective fixed doses of 10:1 in mass) in both an ex vivo organotypic spinal cord culture model and an in vivo model of SCI...
  20. ncbi request reprint n-3 fatty acids: role in neurogenesis and neuroplasticity
    R Crupi
    Institute of Pharmacology, School of Medicine, University of Messina, Policlinico Universitario, Torre Biologica 98123 Messina, Italy
    Curr Med Chem 20:2953-63. 2013
    ..On this basis we review the effect of n-3 fatty acids on adult hippocampal neurogenesis and neuroplasticity. Moreover their possible use as a new therapeutic approach for neurodegenerative diseases is pointed out...
  21. ncbi request reprint Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries
    Emanuela Esposito
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, 31 98166 Messina, Italy
    CNS Neurol Disord Drug Targets 12:55-61. 2013
    ..The diverse signaling mechanisms are also summarized...
  22. ncbi request reprint Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma
    Emanuela Esposito
    Department of Biological and Environmental Sciences, Viale Ferdinando Stagno d Alcontres, 31, 98166, University of Messina, Messina, Italy
    Mini Rev Med Chem 13:237-55. 2013
    ..In this review, we discuss briefly the present understanding therapeutic mechanisms of PEA and the novel possible PEA clinical use for the treatment of several inflammatory diseases and trauma...
  23. pmc Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
    Irene Paterniti
    Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d Alcontres, Messina 31 98166, Italy
    J Neuroinflammation 10:20. 2013
    ....
  24. doi request reprint Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury
    Michela Campolo
    Department of Biological and Environmental Sciences, University of Messina, Messina, Italy
    J Leukoc Biol 93:277-87. 2013
    ..In conclusion, we propose that the olive oil compounds, in particular, the Ole aglycone, could represent a possible treatment against secondary events of intestinal IRI...
  25. doi request reprint Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    J Pharmacol Exp Ther 343:21-33. 2012
    ..Our results indicate that inhibition of ROK by fasudil may represent a useful therapeutic perspective in the treatment of inflammation associated with spinal cord trauma...
  26. ncbi request reprint Reactive oxygen species, inflammation, and lung diseases
    Di Paola Rosanna
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria Gazzi 98100 Messina, Italy
    Curr Pharm Des 18:3889-900. 2012
    ..In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease pathogenesis and exacerbation...
  27. pmc Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, 98125 Messina, Italy
    J Neuroinflammation 9:81. 2012
    ..Moreover, previous results suggest that PPAR-α plays a role in control of secondary inflammatory process associated with spinal cord injury (SCI)...
  28. doi request reprint Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice
    Rosanna Di Paola
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, Messina, Italy
    J Leukoc Biol 91:911-20. 2012
    ..The results clearly indicate that PEA exerts an anti-inflammatory effect, also in a SAO shock model, which could imply a future use of PEA in the treatment of I/R shock...
  29. pmc The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario Via C, Valeria Gazzi, 98100 Messina, Italy
    J Neuroinflammation 9:66. 2012
    ..Given the role of inflammatory responses in spinal cord injury (SCI), the effect of NAMPT inhibitors was examined in this setting...
  30. pmc Characterization of a novel and spontaneous mouse model of inflammatory arthritis
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario, Via C, Valeria, Gazzi, 98100 Messina, Italy
    Arthritis Res Ther 13:126. 2011
    ....
  31. pmc Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis
    Rosanna Di Paola
    IRCCS Centro Neurolesi Bonino Pulejo, S, S, 113 Via Palermo, CTR Casazza, Messina, Italy
    Respir Res 12:41. 2011
    ..AM are widely distributed in various tissues and acts as a local vasoactive hormone in various conditions...
  32. pmc Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury
    Tiziana Genovese
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Respir Res 6:58. 2005
    ....
  33. pmc Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation
    Concetta Crisafulli
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Respir Res 11:19. 2010
    ..There is limited evidence that LXL activation may reduces acute lung inflammation. The aim of this study was to investigate the effects of T0901317, a potent LXR receptor ligand, in a mouse model of carrageenan-induced pleurisy...
  34. pmc Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury
    Marco Failla
    Department of Internal Medicine and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy
    Respir Res 7:137. 2006
    ..Given our results as well as those coming from genetic studies, it might be considered meaningful to trial this drug class in the treatment of pulmonary fibrosis, a disease that still represents a major challenge to medical treatment...
  35. pmc Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation
    Emanuela Mazzon
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Respir Res 8:75. 2007
    ....
  36. pmc Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Gazzi, Messina, Italy
    Naunyn Schmiedebergs Arch Pharmacol 380:179-92. 2009
    ..p < 0.01 versus sham, degrees p < 0.01 versus spinal cord injury. Taken together, our results clearly demonstrate that green tea extract treatment ameliorates spinal cord injury oxidative stress...
  37. pmc MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    BMC Neurosci 12:31. 2011
    ..The spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy...
  38. pmc Effects of Hypericum Perforatum, in a rodent model of periodontitis
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    BMC Complement Altern Med 10:73. 2010
    ..Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis...
  39. ncbi request reprint The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Mol Pharmacol 61:997-1007. 2002
    ..Thus, 15d-PGJ(2) reduces the development of acute and chronic inflammation. Therefore, the cyclopentenone prostaglandin 15d-PGJ(2) may be useful in the therapy of acute and chronic inflammation...
  40. ncbi request reprint Inducible nitric oxide synthase mediates bone loss in ovariectomized mice
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, 98100 Messina, Italy
    Endocrinology 144:1098-107. 2003
    ....
  41. pmc The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat
    Salvatore Cuzzocrea
    Institute of Pharmacology, University of Messina, Italy
    Br J Pharmacol 138:678-88. 2003
    ..Furthermore, 15d-PGJ(2) stimulates the activation of heat shock protein 72 (hsp72) in the inflamed colon, as assessed by Western blot analysis. 7. In conclusion, 15d-PGJ(2) reduces the development of experimental colitis...
  42. ncbi request reprint 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine, University Federico II, Napoli, Italy
    J Leukoc Biol 73:739-46. 2003
    ..Taken together, our results clearly demonstrate that 5-LO modulates neutrophil infiltration in the acute lung inflammation...
  43. ncbi request reprint 5-lipoxygenase knockout mice exhibit a resistance to splanchnic artery occlusion shock
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Shock 20:230-6. 2003
    ..Part of this effect may be due to inhibition of the expression of adhesion molecules and subsequent reduction of neutrophil-mediated cellular injury...
  44. pmc 5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Policlinico Universitario, Messina, Italy
    Immunology 110:120-30. 2003
    ..These findings support the view that 5-LO plays an important, pro-inflammatory role in the acute pancreatitis caused by cerulein in mice...
  45. ncbi request reprint Emerging biotherapies for inflammatory bowel disease
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi, 98100 Messina, Italy
    Expert Opin Emerg Drugs 8:339-47. 2003
    ..In fact, the most successful approaches so far in the treatment of IBD have been anti-TNF strategies. In contrast, the use of antiadhesion molecules strategies has been demonstrated to be ineffective in IBD...
  46. ncbi request reprint Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma
    Salvatore Cuzzocrea
    University of Messina, Messina, Italy
    Arthritis Rheum 48:3544-56. 2003
    ..The aim of this study was to investigate the effects of rosiglitazone on the inflammatory response in mice with collagen-induced arthritis (CIA)...
  47. ncbi request reprint Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    Eur J Pharmacol 483:79-93. 2004
    ..We propose that rosiglitazone and other potent PPAR-gamma agonists may be useful in the therapy of inflammation...
  48. ncbi request reprint Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Intensive Care Med 30:951-6. 2004
    ..In the present study, we investigated the effects of rosiglitazone (10 mg/kg, i.p.), a PPAR-gamma agonist, on the development of acute pancreatitis...
  49. ncbi request reprint Potential therapeutic effect of antioxidant therapy in shock and inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Curr Med Chem 11:1147-62. 2004
    ..Antioxidant treatment inhibits the activation of PARS, and prevents the organ injury associated with acute and chronic inflammation...
  50. ncbi request reprint High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitis
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, 98100 Messina, Italy
    Shock 21:342-51. 2004
    ..Thus, recHDL reduces the inflammation caused by intestinal I/R and colitis. HDLs may represent a novel therapeutic approach for the therapy of inflammation of the gut...
  51. ncbi request reprint Role of 5-lipoxygenase in the multiple organ failure induced by zymosan
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Intensive Care Med 30:1935-43. 2004
    ..This study investigated the role of 5-lipoxygenase in the pathogenesis of multiple organ failure (MOF) induced by zymosan...
  52. ncbi request reprint Erythropoietin reduces the development of experimental inflammatory bowel disease
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policino Universitario, Italy
    J Pharmacol Exp Ther 311:1272-80. 2004
    ..Thus, treatment of rat with EPO reduces the degree of colitis caused by DNBS. We propose that EPO may be useful in the treatment of inflammatory bowel disease...
  53. ncbi request reprint Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock
    Salvatore Cuzzocrea
    Dipartimento Clinico, Sperimentale di Medicina, Farmacologia, Torre Biologica, Policlinico Universitario, Messina, Messina, Italy
    J Leukoc Biol 76:933-40. 2004
    ..Taken together, our results clearly demonstrate that GITR plays an important role in the ischemia and reperfusion injury and put forward the hypothesis that modulation of GITR expression may represent a novel and possible strategy...
  54. ncbi request reprint WY 14643, a potent exogenous PPAR-alpha ligand, reduces intestinal injury associated with splanchnic artery occlusion shock
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Shock 22:340-6. 2004
    ..These results demonstrate that the PPAR-alpha agonist WY 14643 significantly reduces I/R injury of the intestine...
  55. ncbi request reprint Role of endogenous and exogenous ligands for the peroxisome proliferators activated receptors alpha (PPAR-alpha) in the development of inflammatory bowel disease in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Policlinico Universitario, Messina, Italy
    Lab Invest 84:1643-54. 2004
    ..Thus, endogenous and exogenous PPAR-alpha ligands reduce the degree of colitis caused by DNBS. We propose that PPAR-alpha ligand may be useful in the treatment of inflammatory bowel disease...
  56. ncbi request reprint Tempol reduces the activation of nuclear factor-kappaB in acute inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Free Radic Res 38:813-9. 2004
    ..These data confirm that Tempol exerts potent anti-inflammatory properties and clearly demonstrates for the first time that Tempol reduces the activation of NF-kappaB in vivo...
  57. ncbi request reprint 5-Aminoisoquinolinone reduces colon injury by experimental colitis
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Naunyn Schmiedebergs Arch Pharmacol 370:464-73. 2004
    ..Thus, 5-AIQ treatment reduces the degree of colitis caused by DNBS. We propose that 5-AIQ treatment may be useful in the treatment of inflammatory bowel disease...
  58. ncbi request reprint Effect of methylguanidine in a model of septic shock induced by LPS
    Stefania Marzocco
    Department of Pharmaceutical Sciences, University of Salerno, via Ponte Don Melillo 11 c, 84084 Fisciano Salerno, Italy
    Free Radic Res 38:1143-53. 2004
    ..The mechanisms of the anti-inflammatory effect of MG is, at least in part, dependent on the inhibition of NO formation...
  59. ncbi request reprint Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Vascul Pharmacol 41:187-95. 2004
    ..The potential utility of PPAR-gamma ligands in ischemia and reperfusion will be discussed in this review...
  60. ncbi request reprint Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    University of Messina, Messina, Italy
    Arthritis Rheum 52:940-50. 2005
    ..Erythropoietin (EPO) is a potent stimulator of erythroid progenitor cells, and its expression is enhanced by hypoxia. The aim of this study was to investigate the effect of EPO on collagen-induced arthritis (CIA) in the mouse...
  61. ncbi request reprint PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, Messina, Italy
    FASEB J 19:558-66. 2005
    ..These results suggest that PARG activity modulates the inflammatory response in ischemia/reperfusion and participates in end (target) organ damage under these conditions...
  62. ncbi request reprint 5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina Torre Biologica, Policlinico Universitario, Messina, Italy
    Lab Invest 85:808-22. 2005
    ..Taken together, our results clearly demonstrate that 5-LO modulates neutrophil infiltration in experimental colitis through the expression of adhesion molecules...
  63. ncbi request reprint Shock, inflammation and PARP
    Salvatore Cuzzocrea
    Institute of Pharmacology, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    Pharmacol Res 52:72-82. 2005
    ..The aim of this review is to describe recent experimental evidence implicating PARP as a pathophysiological modulator of acute and chronic inflammation...
  64. ncbi request reprint Role of poly(ADP-ribose) glycohydrolase (PARG) in shock, ischemia and reperfusion
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, Via C Valeria, Gazzi, 98123 Messina, Italy
    Pharmacol Res 52:100-8. 2005
    ..These animal models and cells isolated from them will be useful for further validation of PARG as a potential pharmaceutical target to intervene the pathogenesis induced by acute tissue injury, ischemia and inflammation...
  65. ncbi request reprint Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis
    Salvatore Cuzzocrea
    University of Messina, Messina, Italy
    Arthritis Rheum 52:1929-40. 2005
    ..To investigate the effects of combination therapy with M40403, a superoxide dismutase mimetic (SODm), and dexamethasone (DEX) on collagen-induced arthritis (CIA) in rats...
  66. pmc Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice
    Rosanna Di Paola
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, Messina, Italy
    Respir Res 6:66. 2005
    ..Our results clearly demonstrate that treatment with green tea extract exerts a protective effect and offers a novel therapeutic approach for the management of lung injury...
  67. ncbi request reprint Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, Messina, Italy
    FASEB J 19:1253-65. 2005
    ..In conclusion, GITR plays a critical role in the immunological response against CII and in the development of CIA...
  68. ncbi request reprint Synergistic interaction between methotrexate and a superoxide dismutase mimetic: pharmacologic and potential clinical significance
    Salvatore Cuzzocrea
    University of Messina, Messina, Italy
    Arthritis Rheum 52:3755-60. 2005
    ..To investigate the effects of combination therapy with M40403 and methotrexate (MTX) on collagen-induced arthritis (CIA) in rats...
  69. ncbi request reprint The role of the peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in the regulation of acute inflammation
    Salvatore Cuzzocrea
    Dipartment Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, Italy
    J Leukoc Biol 79:999-1010. 2006
    ..In conclusion, the increased inflammatory response observed in PPAR-alphaKO mice strongly suggests that a PPAR-alpha pathway modulates the degree of acute inflammation in the mice...
  70. ncbi request reprint Peroxisome proliferator-activated receptors and acute lung injury
    Salvatore Cuzzocrea
    Dipartment Clinical and Experimental Medicine and Pharmacology, Centro per lo Studio ed il Trattamento dei Neurolesi Lungodegenti, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Curr Opin Pharmacol 6:263-70. 2006
    ..PPARs have recently been implicated as regulators of cellular proliferation and inflammatory responses. Furthermore, it has been demonstrated that PPAR-gamma and PPAR-alpha reduce lung injury associated with inflammation and shock...
  71. ncbi request reprint Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Via C Valeria Gazzi 98100 Messina, Italy
    Clin Immunol 120:57-67. 2006
    ..These data demonstrate that GSK-3beta inhibition exerts an anti-inflammatory effect during chronic inflammation and is able to ameliorate the tissue damage associated with CIA...
  72. ncbi request reprint Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    J Immunol 177:631-41. 2006
    ....
  73. ncbi request reprint Poly(ADP-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    J Pharmacol Exp Ther 319:127-38. 2006
    ..Taken together, our results indicate that PARG activity modulates the inflammatory response and tissue injury events associated with spinal cord trauma and participate in target organ damage under these conditions...
  74. pmc Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice
    S Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Br J Pharmacol 149:687-702. 2006
    ..Here, we have investigated the effects of TDZD-8, a potent and selective GSK-3beta inhibitor, in a mouse model of carrageenan-induced pleurisy...
  75. ncbi request reprint Role of nitric oxide and reactive oxygen species in arthritis
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Curr Pharm Des 12:3551-70. 2006
    ....
  76. ncbi request reprint Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine, School of Medicine, University of Messina, Messina, Italy
    Mol Pharmacol 71:132-44. 2007
    ..In conclusion, these results suggest that the in vivo anti-inflammatory property of DEX is also related to the ER-alpha...
  77. ncbi request reprint Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina Italy
    FASEB J 21:117-29. 2007
    ..Our results clearly demonstrate that GITR-GITRL interaction plays an important role in the chronic lung injury induced by bleomycin in the mice...
  78. ncbi request reprint Role of poly(ADP-ribose) glycohydrolase in the development of inflammatory bowel disease in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Free Radic Biol Med 42:90-105. 2007
    ....
  79. ncbi request reprint Glycogen synthase kinase 3beta inhibition reduces the development of nonseptic shock induced by zymosan in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 27:97-107. 2007
    ..This study provides the first evidence that TDZD-8 attenuates the degree of zymosan-induced, nonseptic shock in mice...
  80. ncbi request reprint Glycogen synthase kinase-3beta inhibition attenuates the development of ischaemia/reperfusion injury of the gut
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Intensive Care Med 33:880-93. 2007
    ..This study investigated the effects of TDZD-8, a potent and selective GSK-3beta inhibitor, on tissue injury caused by ischaemia/reperfusion (I/R) of the gut...
  81. ncbi request reprint Effect of 17beta-estradiol on signal transduction pathways and secondary damage in experimental spinal cord trauma
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Shock 29:362-71. 2008
    ..Taken together, our results clearly demonstrate that administration of E2 before SCI reduces the development of inflammation and tissue injury associated with spinal cord trauma...
  82. ncbi request reprint Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury
    S Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Int J Immunopathol Pharmacol 20:619-30. 2007
    ..Taken together, these results clearly demonstrate treatment with the GSK-3beta inhibitor TDZD-8 reduces the development of lung injury and inflammation induced by BLM in mice...
  83. ncbi request reprint Peroxisome proliferator-activated receptor-alpha contributes to the anti-inflammatory activity of glucocorticoids
    Salvatore Cuzzocrea
    Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Mol Pharmacol 73:323-37. 2008
    ..These results indicate that PPAR-alpha can contribute to the anti-inflammatory activity of GCs...
  84. ncbi request reprint Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion
    Salvatore Cuzzocrea
    University of Messina, School of Medicine, Department of Clinical, Experimental Medicine and Pharmacology, Torre Biologica Policlinico Universitario, Via Consolare Valeria Gazzi, 98100 Messina, Italy
    Expert Opin Investig Drugs 17:1151-60. 2008
    ..Amine oxidases are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper amine oxidases catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine and histamine...
  85. pmc Role of PPAR-delta in the development of zymosan-induced multiple organ failure: an experiment mice study
    Maria Galuppo
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    J Inflamm (Lond) 7:12. 2010
    ..p), a synthetic high affinity ligand, on the development of zymosan-induced multiple organ failure (MOF)...
  86. ncbi request reprint New therapeutic strategy for mood disorders
    R Crupi
    Dept of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Curr Med Chem 18:4284-98. 2011
    ..Here we review different strategies that may be adopted for impairing mood disorders and that may be further developed for innovative therapeutic approaches...
  87. doi request reprint Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    J Pharmacol Exp Ther 339:859-69. 2011
    ....
  88. ncbi request reprint Effects of Hypericum perforatum extract in a rat model of ischemia and reperfusion injury
    Rosanna De Paola
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Shock 24:255-63. 2005
    ..perforatum extract may be a candidate for consideration as a therapeutic intervention for ischemia-reperfusion injury...
  89. pmc Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy
    Br J Pharmacol 140:366-76. 2003
    ..8. These results demonstrate that the two PPAR-gamma agonists, rosiglitazone and 15d-PGJ2, significantly reduce I/R injury of the intestine...
  90. doi request reprint Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, 98100 Messina, Italy
    J Neurochem 112:611-24. 2010
    ..Moreover, T0901317 significantly ameliorated the loss of limb function (evaluated by motor recovery score). These data suggest that LXR ligand may be useful in the treatment of inflammation associated with SCI...
  91. ncbi request reprint Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, Torre Biologicala, Policlinico Universitario, University of Messina, Via C Valeria Gazzi, 98100, Messina, Italy
    Intensive Care Med 29:2016-25. 2003
    ..Dithiocarbamates are anti-oxidants which are potent inhibitors of NF-kappaB. We postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate multiple-organ failure (MOF)...
  92. ncbi request reprint Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan
    Rosanna Di Paola
    Dipartimento Clinico Sperimentale di Medicina e Farmacologia, Facolta di Medicina e Chirurgia, Universita di Messina, Via C Valeria, Gazzi, 98100 Messina, Italy
    Shock 26:477-84. 2006
    ..Taken together, the present study clearly demonstrates that PPAR-alpha pathway modulates the degree of MODS associated with zymosan-induced nonseptic shock...
  93. doi request reprint Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis
    Lorenza Cannarile
    Department of Clinical and Experimental Medicine, Section of Pharmacology and Polo Scientifico e Didattico di Terni, University of Perugia, Perugia, Italy
    Gastroenterology 136:530-41. 2009
    ..Previous studies indicate that increased expression in transgenic mice of glucocorticoid-induced leucine zipper (GILZ), a gene rapidly induced by glucocorticoids, inhibits NF-kappaB and Th1 activity...
  94. doi request reprint Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice
    Emanuela Mazzon
    IRCCS Centro Neurolesi Bonino Pulejo, S S 113 via Palermo, CTR Casazza, Messina, Italy
    Pharmacol Res 64:68-79. 2011
    ..This study provides evidence that olprinone attenuates the degree of zymosan-induced shock in mice...
  95. doi request reprint Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Neurochem 108:1360-72. 2009
    ..Taken together, our results clearly demonstrate that the presence of IL-10 reduces the development of inflammation and tissue injury events associated with spinal cord trauma...
  96. ncbi request reprint Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Italy
    Cytokine 18:274-85. 2002
    ....
  97. ncbi request reprint Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury
    Salvatore Cuzzocrea
    Department of Experimental and Clinical Medicine and Pharmacology, University of Messina, Italy
    Shock 18:169-76. 2002
    ..These results suggest that the induction of iNOS and NO production are essential for the upregulation of the inflammatory response in splanchnic ischemia/reperfusion and participate in end organ damage under these conditions...
  98. ncbi request reprint Methylguanidine reduces the development of non septic shock induced by zymosan in mice
    Stefania Marzocco
    Department of Pharmaceutical Sciences, University of Salerno, via Ponte Don Melillo 11 c, 84084, Fisciano Salerno, Italy
    Life Sci 75:1417-33. 2004
    ..Taken together, the present results demonstrate that MG exerts potent anti-inflammatory effects on zymosan-induced shock...
  99. ncbi request reprint Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome
    Giuseppe Malleo
    Department of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    Cytokine 41:136-43. 2008
    ..Therefore, this study demonstrates that the absence of endogenous IL-10 enhances the MODS induced by zymosan in mice...
  100. ncbi request reprint Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein
    Salvatore Cuzzocrea
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica, Gazzi, Italy
    Shock 17:416-22. 2002
    ..These findings support the view that iNOS plays an important, pro-inflammatory role in the acute pancreatitis caused by cerulein in mice...
  101. doi request reprint Adenosine A2A receptor-selective stimulation reduces signaling pathways involved in the development of intestine ischemia and reperfusion injury
    Rosanna Di Paola
    IRCCS Centro Neurolesi Bonino Pulejo, School of Medicine, University of Messina, Messina, Italy
    Shock 33:541-51. 2010
    ....