Fabio Franciolini

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi NPPB block of the intermediate-conductance Ca2+-activated K+ channel
    Bernard Fioretti
    Dipartimento Biologia Cellulare e Molecolare, Universita di Perugia Via Pascoli 1, I 06123 Perugia, Italy
    Eur J Pharmacol 497:1-6. 2004
  2. ncbi A model of intracellular Ca2+ oscillations based on the activity of the intermediate-conductance Ca2+-activated K+ channels
    Bernard Fioretti
    Dipartimento di Biologia Cellulare e Molecolare Universita di Perugia via Pascoli 1, I 06123 Perugia, Italy
    Biophys Chem 113:17-23. 2005
  3. ncbi Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis
    Bernard Fioretti
    Dipartimento Biologia Cellulare e Molecolare, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    Am J Physiol Cell Physiol 289:C89-96. 2005
  4. pmc Extracellular guanosine-5'-triphosphate modulates myogenesis via intermediate Ca(2+)-activated K+ currents in C2C12 mouse cells
    Tiziana Pietrangelo
    Dipartimento Scienze del Farmaco, Istituto Interuniversitario di Miologia, Ce S I Centro di Scienze dell Invecchiamento University G d Annunzio Foundation, Via dei Vestini, I 66013 Chieti, Italy
    J Physiol 572:721-33. 2006
  5. doi Histamine hyperpolarizes human glioblastoma cells by activating the intermediate-conductance Ca2+-activated K+ channel
    Bernard Fioretti
    Dip Biologia Cellulare e Ambientale, Universita di Perugia, 1 I 06123 Perugia, Italy
    Am J Physiol Cell Physiol 297:C102-10. 2009
  6. doi Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    J Cell Physiol 226:1926-33. 2011
  7. ncbi Expression and modulation of the intermediate- conductance Ca2+-activated K+ channel in glioblastoma GL-15 cells
    Bernard Fioretti
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, CEMIN, Centro di Eccellenza Materiali Innovativi Nanostrutturati, Universita di Perugia, Italy
    Cell Physiol Biochem 18:47-56. 2006
  8. pmc Spontaneous low-frequency voltage oscillations in frog saccular hair cells
    Luigi Catacuzzeno
    Dipartimento Biologia Cellulare e Molecolare, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    J Physiol 561:685-701. 2004
  9. ncbi Voltage-gated outward K currents in frog saccular hair cells
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, I 06123 Perugia, Italy
    J Neurophysiol 90:3688-701. 2003
  10. ncbi Frog saccular hair cells dissociated with protease VIII exhibit inactivating BK currents, K(V) currents, and low-frequency electrical resonance
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, Via Pascoli 1, I 06100 Perugia, Italy
    Hear Res 175:36-44. 2003

Collaborators

Detail Information

Publications20

  1. ncbi NPPB block of the intermediate-conductance Ca2+-activated K+ channel
    Bernard Fioretti
    Dipartimento Biologia Cellulare e Molecolare, Universita di Perugia Via Pascoli 1, I 06123 Perugia, Italy
    Eur J Pharmacol 497:1-6. 2004
    ..As expected, NPPB also blocked the volume-activated Cl(-) current expressed by GL-15 cells, with an IC(50) of 44 microM. The functional implications of IK(Ca) current block by NPPB are discussed...
  2. ncbi A model of intracellular Ca2+ oscillations based on the activity of the intermediate-conductance Ca2+-activated K+ channels
    Bernard Fioretti
    Dipartimento di Biologia Cellulare e Molecolare Universita di Perugia via Pascoli 1, I 06123 Perugia, Italy
    Biophys Chem 113:17-23. 2005
    ..We found that this simple model gives rise to intracellular Ca2+ oscillations when using physiologically reasonable parameters, suggesting that IKCa channels could participate in the generation of intracellular Ca2+ oscillations...
  3. ncbi Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis
    Bernard Fioretti
    Dipartimento Biologia Cellulare e Molecolare, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    Am J Physiol Cell Physiol 289:C89-96. 2005
    ..These observations show that in C2C12 myoblasts the IK(Ca) channel expression correlates inversely with differentiation, yet it does not appear to have a role in myoblast proliferation...
  4. pmc Extracellular guanosine-5'-triphosphate modulates myogenesis via intermediate Ca(2+)-activated K+ currents in C2C12 mouse cells
    Tiziana Pietrangelo
    Dipartimento Scienze del Farmaco, Istituto Interuniversitario di Miologia, Ce S I Centro di Scienze dell Invecchiamento University G d Annunzio Foundation, Via dei Vestini, I 66013 Chieti, Italy
    J Physiol 572:721-33. 2006
    ..These data give new insights into nucleotide purinergic signalling pathways, and address the role of the GTP-dependent IK(Ca) channel activation and hyperpolarization in myogenesis...
  5. doi Histamine hyperpolarizes human glioblastoma cells by activating the intermediate-conductance Ca2+-activated K+ channel
    Bernard Fioretti
    Dip Biologia Cellulare e Ambientale, Universita di Perugia, 1 I 06123 Perugia, Italy
    Am J Physiol Cell Physiol 297:C102-10. 2009
    ..3 microM, at -40 mV. Notably in no instance was the BK(Ca) channel activated by histamine under physiological conditions. The most parsimonious explanation based on the different K(D(Ca)) for the two K(Ca) channels is provided...
  6. doi Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    J Cell Physiol 226:1926-33. 2011
    ..It is concluded that the modulation of K and Cl ion fluxes is essential for the FCS-induced glioblastoma cell migration...
  7. ncbi Expression and modulation of the intermediate- conductance Ca2+-activated K+ channel in glioblastoma GL-15 cells
    Bernard Fioretti
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, CEMIN, Centro di Eccellenza Materiali Innovativi Nanostrutturati, Universita di Perugia, Italy
    Cell Physiol Biochem 18:47-56. 2006
    ..Semiquantitative RT-PCR analysis demonstrated a ~35% reduction of the IK(Ca) channel mRNA resulting from ERK inhibition and a approximately 50% reduction with time in culture...
  8. pmc Spontaneous low-frequency voltage oscillations in frog saccular hair cells
    Luigi Catacuzzeno
    Dipartimento Biologia Cellulare e Molecolare, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    J Physiol 561:685-701. 2004
    ..In addition, the model indicates that the high densities of depolarization-activated currents expressed by non-oscillatory cells help to stabilize the resting membrane potential, thus preventing the spontaneous oscillations...
  9. ncbi Voltage-gated outward K currents in frog saccular hair cells
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, I 06123 Perugia, Italy
    J Neurophysiol 90:3688-701. 2003
    ..This thorough description of the IDRK and IA will contribute toward understanding the role of these currents in the electrical response on this preparation...
  10. ncbi Frog saccular hair cells dissociated with protease VIII exhibit inactivating BK currents, K(V) currents, and low-frequency electrical resonance
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, Via Pascoli 1, I 06100 Perugia, Italy
    Hear Res 175:36-44. 2003
    ....
  11. doi Identification of key signaling molecules involved in the activation of the swelling-activated chloride current in human glioblastoma cells
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Via Pascoli 1, 06123, Perugia, Italy
    J Membr Biol 247:45-55. 2014
    ....
  12. pmc Modeling study of the effects of membrane surface charge on calcium microdomains and neurotransmitter release
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    Biophys J 95:2160-71. 2008
    ..Our data suggest that membrane surface charges exert a significant influence on the profile of Ca(2+) microdomains, and should be taken into account in models of neurotransmitter release...
  13. doi Cromakalim activates the K(ATP) and enhances spontaneous transient outward potassium currents in rat saphenous arterial myocytes
    Bernard Fioretti
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    Pharmacol Res 57:398-402. 2008
    ....
  14. pmc Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia
    Luigi Sforna
    Dipartimento di Chimica, Biologia e Biotecnologie, Universita di Perugia, Perugia, Italy and
    J Neurophysiol 113:2653-65. 2015
    ....
  15. doi A theoretical study on the role of Ca(2+)-activated K+ channels in the regulation of hormone-induced Ca2+ oscillations and their synchronization in adjacent cells
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    J Theor Biol 309:103-12. 2012
    ....
  16. pmc The differential expression of low-threshold K+ currents generates distinct firing patterns in different subtypes of adult mouse trigeminal ganglion neurones
    Luigi Catacuzzeno
    Dipartimento Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    J Physiol 586:5101-18. 2008
    ..A minimal theoretical model of TG neuronal excitability confirmed that I(A) and I(DTX) have properties congruent with their suggested role...
  17. pmc A Calsequestrin-1 Mutation Associated with a Skeletal Muscle Disease Alters Sarcoplasmic Ca2+ Release
    Maria Cristina D'Adamo
    Section of Physiology and Biochemistry, Department of Experimental Medicine, University of Perugia School of Medicine, Perugia, Italy
    PLoS ONE 11:e0155516. 2016
    ..D244G variant and point out defects in sarcoplasmic Ca2+ homeostasis as a mechanism underlying this human disease, which could be distinctly classified as "CASQ1-couplonopathy". ..
  18. pmc Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Via Pascoli 1, I 06123 Perugia, Italy
    J Signal Transduct 2012:421564. 2012
    ..Altogether, these data suggest KCa3.1 channels as potential candidates for a targeted therapy against this tumor...
  19. doi Synthetic aromatic compounds interfering with melanogenesis are responsible of the rising trend of malignant melanoma incidence
    Giorgio Morpurgo
    Dipartimento di Biologia Cellulare e Ambientale, Universita di Perugia, Perugia, Italy
    Med Hypotheses 76:374-7. 2011
    ..AC that may interfere with tyrosinase are also present in a large variety of medicines used orally or as creams, and in many industrial products with which man is frequently in contact...
  20. doi A method to identify tissue cell subpopulations with distinct multi-molecular profiles from data on co-localization of two markers at a time: the case of sensory ganglia
    Lugi Catacuzzeno
    Dipartimento di Chimica, Biologia e Biotecnologie, Universita di Perugia, Via Pascoli 1, Perugia, Italy Electronic address
    J Neurosci Methods 224:88-95. 2014
    ....