F Fusi

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena
    Fabio Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, Via A Moro 2, Italy
    Eur J Nutr 42:10-7. 2003
  2. ncbi request reprint Mechanism of myricetin stimulation of vascular L-type Ca2+ current
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Italy
    J Pharmacol Exp Ther 313:790-7. 2005
  3. ncbi request reprint 3,5-di-t-butylcatechol (DTCAT) as an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC)
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Biochem Pharmacol 69:485-91. 2005
  4. pmc Ca(2+) entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes
    Fabio Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Pharmacol 137:323-8. 2002
  5. ncbi request reprint Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Cancer Chemother Pharmacol 61:443-51. 2008
  6. pmc 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca(2+) channel via superoxide anion generation
    F Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, via Piccolomini 170, 53100 Siena, Italy
    Br J Pharmacol 133:988-96. 2001
  7. pmc Effects of some sterically hindered phenols on whole-cell Ca(2+) current of guinea-pig gastric fundus smooth muscle cells
    F Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, via Piccolomini 170, 53100 Siena, Italy
    Br J Pharmacol 132:1326-32. 2001
  8. doi request reprint Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase in rat aortic ring preparations
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    J Pharm Pharmacol 60:489-97. 2008
  9. doi request reprint Cardamonin is a bifunctional vasodilator that inhibits Ca(v)1.2 current and stimulates K(Ca)1.1 current in rat tail artery myocytes
    Fabio Fusi
    Dipartimento di Neuroscienze, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    J Pharmacol Exp Ther 332:531-40. 2010
  10. ncbi request reprint Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle
    F Fusi
    Istituto di Scienze Farmacologiche, Universita di Siena, Italy
    Eur J Pharmacol 346:237-43. 1998

Detail Information

Publications32

  1. ncbi request reprint Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena
    Fabio Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, Via A Moro 2, Italy
    Eur J Nutr 42:10-7. 2003
    ..However, Saponara et al. [(2002) Br J Pharmacol 135: 1819-1827] have demonstrated that quercetin is an activator of vascular L-type Ca(2+) channels...
  2. ncbi request reprint Mechanism of myricetin stimulation of vascular L-type Ca2+ current
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Italy
    J Pharmacol Exp Ther 313:790-7. 2005
    ..8 muM. Myricetin induced a frequency- and V(h)-dependent block of I(Ca(L)). In conclusion, myricetin behaves as an L-type Ca(2+) channel agonist that stabilizes the channel in its inactivated state...
  3. ncbi request reprint 3,5-di-t-butylcatechol (DTCAT) as an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC)
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Biochem Pharmacol 69:485-91. 2005
    ....
  4. pmc Ca(2+) entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes
    Fabio Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Pharmacol 137:323-8. 2002
    ..In rat caudal artery smooth muscle, however, this mechanism does not result in a vasodilating effect since it is overwhelmed by the mechanism underlying norbormide-induced vasoconstriction...
  5. ncbi request reprint Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Cancer Chemother Pharmacol 61:443-51. 2008
    ....
  6. pmc 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca(2+) channel via superoxide anion generation
    F Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, via Piccolomini 170, 53100 Siena, Italy
    Br J Pharmacol 133:988-96. 2001
    ..These results indicate that, at micromolar concentrations, BHQ inhibits vascular I(Ca(L)) by giving rise to the formation of superoxide anion which in turn impairs the channel function...
  7. pmc Effects of some sterically hindered phenols on whole-cell Ca(2+) current of guinea-pig gastric fundus smooth muscle cells
    F Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, via Piccolomini 170, 53100 Siena, Italy
    Br J Pharmacol 132:1326-32. 2001
    ..5. We conclude that the inhibition of I(Ca(L)) by BHA and DTBHA is qualitatively similar to that of a Ca(2+) channel blocker and is characterized by the stabilizing effect of the inactivated state of the channel...
  8. doi request reprint Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase in rat aortic ring preparations
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    J Pharm Pharmacol 60:489-97. 2008
    ..To our knowledge, this has been the first account describing the vasodilating activity of homoisoflavonoids: compound 3 proved an effective vasorelaxing agent, partly acting via the activation of soluble guanylyl cyclase...
  9. doi request reprint Cardamonin is a bifunctional vasodilator that inhibits Ca(v)1.2 current and stimulates K(Ca)1.1 current in rat tail artery myocytes
    Fabio Fusi
    Dipartimento di Neuroscienze, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    J Pharmacol Exp Ther 332:531-40. 2010
    ..1 current, may represent a scaffold for the design of novel drugs of potential interest for treatment of systemic hypertension...
  10. ncbi request reprint Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle
    F Fusi
    Istituto di Scienze Farmacologiche, Universita di Siena, Italy
    Eur J Pharmacol 346:237-43. 1998
    ....
  11. ncbi request reprint L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles
    Fabio Fusi
    Dipartimento di Scienze Anatomiche e Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Naunyn Schmiedebergs Arch Pharmacol 368:470-8. 2003
    ..These results suggest that myricetin induces vasoconstriction by activating L-type Ca(2+) channel with similar efficacy but a site of action different to that of (S)-(-)-Bay K 8644...
  12. pmc (+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells
    S Saponara
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Siena, Italy
    Br J Pharmacol 149:1013-21. 2006
    ..BACKGROUND AND PURPOSE. The aim of this study was to investigate, in vascular smooth muscle cells, the mechanical and electrophysiological effects of (+/-)-naringenin...
  13. pmc Calcium antagonist and antiperoxidant properties of some hindered phenols
    G P Sgaragli
    Istituto di Scienze Farmacologiche, Siena, Italy
    Br J Pharmacol 110:369-77. 1993
    ..8. Di-t-BHA is proposed as a lead reference compound for future synthesis of new antioxidants combining two potentially useful properties in the prevention of tissue damage after ischaemia reperfusion injury...
  14. ncbi request reprint 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase
    F Fusi
    Istituto di Scienze Farmacologiche, , Via E.S. Piccolomini 170, 53100, Siena, Italy
    Biochem Pharmacol 62:1613-9. 2001
    ....
  15. ncbi request reprint Potentiation of mitochondrial Ca2+ sequestration by taurine
    M Palmi
    Istituto di Scienze Farmacologiche, Universita di Siena, Italy
    Biochem Pharmacol 58:1123-31. 1999
    ..The unique role of taurine in modulating mitochondrial Ca2+ homeostasis might be of particular importance under pathological conditions that are characterised by cell Ca2+ overload, such as ischaemia and oxidative stress...
  16. doi request reprint Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels
    D Iozzi
    Dipartimento di Scienze della Vita, Universita degli Studi di Siena, Siena, Italy
    Acta Physiol (Oxf) 208:329-39. 2013
    ..1) channels. Thus, the aim of the present investigation was to address the hypothesis that quercetin-induced vasorelaxation is caused by a PKG-mediated stimulation of KCa 1.1 currents...
  17. ncbi request reprint Neuroprotection afforded by some hindered phenols and alpha-tocopherol in guinea-pig detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions
    F Pessina
    Istituto di Scienze Farmacologiche, , Via E.S. Piccolomini 170, 53100 Siena, Italy
    Naunyn Schmiedebergs Arch Pharmacol 364:462-71. 2001
    ..The neuroprotection afforded by the phenol derivatives as well as by alpha-TOC was positively correlated to their antioxidant activity, but not to their Ca2+ antagonist activity...
  18. ncbi request reprint Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives
    F Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Curr Drug Targets 7:949-59. 2006
    ..DP7 is considered a lead compound for the development of novel dihydropyridines which do not affect CYP enzyme system but still retain the activity towards ABC-efflux transporters...
  19. ncbi request reprint Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl
    M Valoti
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, via Piccolomini 170, 53100, Siena, Italy
    Eur J Pharmacol 391:199-206. 2000
    ..They also suggest that, by reducing CYP content, L-deprenyl treatment may impair the metabolic disposition of other drugs given in combination regimens...
  20. pmc The flavonoid scaffold as a template for the design of modulators of the vascular Ca(v) 1.2 channels
    S Saponara
    Dipartimento di Neuroscienze, Universita degli Studi di Siena, Siena, Italy
    Br J Pharmacol 164:1684-97. 2011
    ..2 channel current (I(Ca1.2) ). Here we have tested the proposition that the flavonoid structure confers the ability to modulate Ca(v) 1.2 channels...
  21. pmc Quercetin as a novel activator of L-type Ca(2+) channels in rat tail artery smooth muscle cells
    Simona Saponara
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Pharmacol 135:1819-27. 2002
    ..Moreover quercetin slowed the rate of recovery from inactivation. 4. These results prove quercetin to be a naturally-occurring L-type Ca(2+) channel activator...
  22. doi request reprint In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents
    F Fusi
    Dipartimento di Scienze della Vita, Universita degli Studi di Siena, Via A Moro 2, 53100, Siena, Italy
    Naunyn Schmiedebergs Arch Pharmacol 389:1033-43. 2016
    ..Though an unambiguous divergence between MDR reverting and vascular activity is of overwhelming importance, these findings consistently contribute to the design and synthesis of novel and potent chemosensitizers. ..
  23. doi request reprint Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A
    S Saponara
    Dipartimento di Scienze della Vita, Universita degli Studi di Siena, Siena, Italy
    Br J Pharmacol 173:292-304. 2016
    ..2 channels [ICa1.2 ] of rat cardiomyocytes. As only few drugs stimulate ICa1.2 , this study was designed to analyse the effects of MuA on vascular Cav 1.2 channels...
  24. ncbi request reprint Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles
    Fabio Fusi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Eur J Pharmacol 561:112-20. 2007
    ..Ryanodine receptor Ca(2+) channels activation or the impairment of the contractile apparatus by DTCAT seem to play a secondary role in its vascular activity...
  25. doi request reprint Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels
    Simona Saponara
    Dipartimento di Neuroscienze, Sezione di Farmacologia, Fisiologia e Tossicologia, Universita degli Studi di Siena, Via A Moro 2, Siena, Italy
    Eur J Pharmacol 598:75-80. 2008
    ..These data contribute to a better understanding of quercetin effects on experimental in vivo cardioprotection...
  26. doi request reprint L-type Ca(2+) channel current characteristics are preserved in rat tail artery myocytes after one-day storage
    P Mugnai
    Dipartimento di Scienze della Vita, Universita di Siena, Siena, Italy
    Acta Physiol (Oxf) 211:334-45. 2014
    ..To develop a cheap and simple method of storing for 24-h vascular tissue and single myocytes while preserving therein the biophysical and pharmacological characteristics of L-type Ca(2+) channels and contractile activity...
  27. ncbi request reprint Pharmacokinetics of diphenhydramine in healthy volunteers with a dimenhydrinate 25 mg chewing gum formulation
    M Valoti
    Centro Interdisciplinare di Ricerca sul Metabolismo dei Farmaci Neuropsicotropi, Istituto di Scienze Farmacologiche, Universita di Siena, Siena, Italy
    Methods Find Exp Clin Pharmacol 25:377-81. 2003
    ..Moreover, the maximal concentrations of diphenhydramine attained in plasma were much lower than the concentration threshold needed to produce drowsiness...
  28. pmc 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility
    Simona Saponara
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Pharmacol 141:415-22. 2004
    ..In conclusion, DP7 may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of vascular effects. British Journal of Pharmacology (2004) 141, 415-422. doi:10.1038/sj.bjp.0705635..
  29. ncbi request reprint 3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart
    Simona Saponara
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Eur J Pharmacol 563:160-3. 2007
    ..DP7, up to 30 microM, failed to alter ECG parameters. In conclusion, DP7, may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of cardiac effects...
  30. ncbi request reprint Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles
    Sergio Bova
    Dipartimento di Farmacologia ed Anestesiologia, Universita degli Studi di Padova, L go E Meneghetti 2, 35131, Padova, Italy
    Eur J Pharmacol 470:185-91. 2003
    ..Our results indicate that rat non-vascular smooth muscles are relaxed by norbormide with a mechanism likely involving a reduction of Ca(2+) entry through L-type Ca(2+) channels...
  31. ncbi request reprint Calcium channel antagonists discovered by a multidisciplinary approach
    Emanuele Carosati
    Dipartimento di Chimica, Universita degli Studi di Perugia, Via Elce di Sotto 10, 06123 Perugia, Italy
    J Med Chem 49:5206-16. 2006
    ..As a result, 20 compounds were tested in vitro, and functional and binding assays revealed several hits with promising behavior as CEBs...
  32. doi request reprint Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening
    Emanuele Carosati
    Dipartimento di Chimica, Universita degli Studi di Perugia, Via Elce di Sotto 10, 06123 Perugia, Italia
    J Med Chem 51:5552-65. 2008
    ....