A Galli

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Firenze, Italy
    PPAR Res 2009:748174. 2009
  2. ncbi request reprint Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Hepatology 41:1074-84. 2005
  3. ncbi request reprint The potential of antidiabetic thiazolidinediones for anticancer therapy
    Andrea Galli
    University of Florence, Gastroenterology Unit, Department of Clinical Pathophysiology, Viale Morgani 85, 50134 Firenze, Florence, Italy
    Expert Opin Investig Drugs 15:1039-49. 2006
  4. pmc Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms
    A Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgani 85, 50134 Florence, Italy
    Gut 53:1688-97. 2004
  5. doi request reprint Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor gamma-independent regulation of nucleophosmin
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Hepatology 52:493-505. 2010
  6. pmc In vivo effects of rosiglitazone in a human neuroblastoma xenograft
    I Cellai
    Department of Clinical Physiopathology, Center for Research, University of Florence, Italy
    Br J Cancer 102:685-92. 2010
  7. ncbi request reprint Human gastric epithelium produces IL-4 and IL-4delta2 isoform only upon Helicobacter pylori infection
    B Orsini
    Department of Clinical Pathophysiology, Gastroenterology Unit, University of Florence, Italy
    Int J Immunopathol Pharmacol 20:809-18. 2007
  8. pmc Antineoplastic effects of rosiglitazone and PPARgamma transactivation in neuroblastoma cells
    I Cellai
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence, Italy
    Br J Cancer 95:879-88. 2006
  9. ncbi request reprint Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis
    A Casini
    Alcohol Research Center and Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Pathol 192:81-9. 2000
  10. ncbi request reprint Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173
    D Catarzi
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via G Capponi, 9, 50121 Firenze, Italy
    J Med Chem 44:3157-65. 2001

Collaborators

Detail Information

Publications23

  1. pmc Peroxisome proliferator-activated receptor and retinoic x receptor in alcoholic liver disease
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Firenze, Italy
    PPAR Res 2009:748174. 2009
    ..In conclusion, RXR and PPAR play a central role in the onset and perpetuation of the mechanisms underling all steps of the clinical progression in ALD...
  2. ncbi request reprint Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Hepatology 41:1074-84. 2005
    ..In conclusion, our findings suggest that MMP-2 is required for the mitogenic and proinvasive effects of ROS on HSC and demonstrate that ERK1/2 and PI3K are the main signals involved in ROS-mediated MMP-2 expression...
  3. ncbi request reprint The potential of antidiabetic thiazolidinediones for anticancer therapy
    Andrea Galli
    University of Florence, Gastroenterology Unit, Department of Clinical Pathophysiology, Viale Morgani 85, 50134 Firenze, Florence, Italy
    Expert Opin Investig Drugs 15:1039-49. 2006
    ..This review summarises the molecular mechanisms of the antineoplastic actions of TZDs and the relevance of these findings in human pathology and therapy...
  4. pmc Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanisms
    A Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgani 85, 50134 Florence, Italy
    Gut 53:1688-97. 2004
    ..The authors analysed the effects of two TZD, rosiglitazone and pioglitazone, on invasiveness of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma...
  5. doi request reprint Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor gamma-independent regulation of nucleophosmin
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Hepatology 52:493-505. 2010
    ..TZD inhibited NPM expression at protein and messenger RNA levels and decreased NPM promoter activity. TZD inhibition of NPM was associated with the induction of p53 phosphorylation and p21 expression...
  6. pmc In vivo effects of rosiglitazone in a human neuroblastoma xenograft
    I Cellai
    Department of Clinical Physiopathology, Center for Research, University of Florence, Italy
    Br J Cancer 102:685-92. 2010
    ..The aim of this study was to evaluate whether RGZ maintains its anti-tumoural effects against SK-N-AS NB cells in vivo...
  7. ncbi request reprint Human gastric epithelium produces IL-4 and IL-4delta2 isoform only upon Helicobacter pylori infection
    B Orsini
    Department of Clinical Pathophysiology, Gastroenterology Unit, University of Florence, Italy
    Int J Immunopathol Pharmacol 20:809-18. 2007
    ..pylori-infected patients. Data suggest that gastric epithelial cells might regulate the balance between tolerance and immune response by the fine tuning of IL-4 and IL-4delta2 expression...
  8. pmc Antineoplastic effects of rosiglitazone and PPARgamma transactivation in neuroblastoma cells
    I Cellai
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence, Italy
    Br J Cancer 95:879-88. 2006
    ..This finding indicates that PPARgamma activity may be useful to select those patients, for whom PPARgamma agonists may have a beneficial therapeutic effect...
  9. ncbi request reprint Collagen type I synthesized by pancreatic periacinar stellate cells (PSC) co-localizes with lipid peroxidation-derived aldehydes in chronic alcoholic pancreatitis
    A Casini
    Alcohol Research Center and Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Pathol 192:81-9. 2000
    ..These results indicate that significant lipid peroxidation phenomena occur in CAP and that they are associated with active synthesis of collagen by PSC...
  10. ncbi request reprint Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173
    D Catarzi
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via G Capponi, 9, 50121 Firenze, Italy
    J Med Chem 44:3157-65. 2001
    ....
  11. pmc Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells
    Elisabetta Ceni
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgani 85, 50134 Firenze, Italy
    World J Gastroenterol 11:1122-30. 2005
    ..In this study, we analyzed the mechanism by which TZD inhibit growth of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma...
  12. ncbi request reprint Thiazolidinediones inhibit growth and invasiveness of the human adrenocortical cancer cell line H295R
    Pietro Ferruzzi
    Department of Clinical Pathophysiology, Endocrine Unit, Viale Pieraccini, 6, 50139 Florence, Italy
    J Clin Endocrinol Metab 90:1332-9. 2005
    ..These data suggest that TZDs reduce the malignant potential of the H295R ACC cell line and, therefore, might potentially constitute a novel tool in the medical treatment of human ACCs...
  13. doi request reprint Alcohol induced hepatic fibrosis: role of acetaldehyde
    Tommaso Mello
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Mol Aspects Med 29:17-21. 2008
    ..S., 1997. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 257, 59-84]. This review will focus on the molecular mechanisms by which acetaldehyde promote liver fibrosis...
  14. pmc The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices
    A M Pugliese
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Br J Pharmacol 157:818-30. 2009
    ..Activation of adenosine A(2A) receptors in the CA1 region of rat hippocampal slices during oxygen-glucose deprivation (OGD), a model of cerebral ischaemia, was investigated...
  15. ncbi request reprint Ethanol-induced alterations of matrix network in the duodenal mucosa of chronic alcohol abusers
    A Casini
    Alcohol Research Centre, Department of Clinical Pathophysiology, University of Florence, Italy
    Virchows Arch 434:127-35. 1999
    ..Chronic alcohol abuse may induce fibrosis of duodenal villi which is associated with a transformation of villus juxta-parenchymal cells into active subepithelial myofibroblast-like cells able to produce different ECM components...
  16. ncbi request reprint Pleiotropic effects of thiazolidinediones: taking a look beyond antidiabetic activity
    S Giannini
    Endocrinology Unit, Department of Clinical Pathophysiology, University of Florence, Italy
    J Endocrinol Invest 27:982-91. 2004
    ....
  17. ncbi request reprint Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells
    Elisabetta Ceni
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Gastroenterology 131:1235-52. 2006
    ..AcCHO stimulates synthesis of fibrillar collagens in hepatic stellate cells, but the molecular events directly involved in the activation of collagen genes are debatable...
  18. ncbi request reprint Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Gastroenterology 122:1924-40. 2002
    ..The aim of our study was to evaluate whether oral administration of synthetic PPARgamma ligands, thiazolidinediones (TZD), might affect collagen deposition in animal models of liver fibrosis...
  19. doi request reprint A new mechanism involving ERK contributes to rosiglitazone inhibition of tumor necrosis factor-alpha and interferon-gamma inflammatory effects in human endothelial cells
    Adriana Lombardi
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Arterioscler Thromb Vasc Biol 28:718-24. 2008
    ....
  20. doi request reprint Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1
    E Luchinat
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Florence, Italy
    Chem Commun (Camb) 51:584-7. 2015
    ..Microscopy data show a correlation between the intracellular levels of SOD1 and the content of zinc, corresponding to zinc binding to SOD1 observed by in-cell NMR. ..
  21. doi request reprint Cell fusion promotes chemoresistance in metastatic colon carcinoma
    V Carloni
    Department of Internal Medicine, Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    Oncogene 32:2649-60. 2013
    ..These findings highlight the importance of cell fusion in cancer progression and raise significant implications for overcoming chemoresistance in metastatic colon cancer...
  22. ncbi request reprint Presynaptic kynurenate-sensitive receptors inhibit glutamate release
    R Carpenedo
    Department of Preclinical and Clinical Pharmacology, Viale Pieraccini 6, University of Florence, 50139 Florence, Italy
    Eur J Neurosci 13:2141-7. 2001
    ..Nicotinic acetylcholine receptors, however, may contribute to the inhibitory effects of kynurenate found in microdialysis studies, but not in those found in isolated synaptosomes...
  23. doi request reprint Peroxisome-proliferator-activated receptor gamma (PPARgamma) is required for modulating endothelial inflammatory response through a nongenomic mechanism
    Giulia Cantini
    DENOthe Center of Excellence for Research, Transfer and High Education, University of Florence, Florence, Italy
    Eur J Cell Biol 89:645-53. 2010
    ....