Donato Gemmati

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi request reprint Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics
    Donato Gemmati
    Centre Hemostasis and Thrombosis Unit of Haematology, Department Medical Sciences, University of Ferrara, I 44100, Ferrara Italy
    Curr Pharm Des 22:1449-59. 2016
  2. doi request reprint Factor XIII-A dynamics in acute myocardial infarction: a novel prognostic biomarker?
    Donato Gemmati
    Gemmati Donato, Ctr Hemostasis and Thrombosis, Hematology Section, Dpt of Medical Sciences, University of Ferrara, Ferrara, Italy, Tel 39 0532 237291, Fax 39 0532 209010, E mail
    Thromb Haemost 114:123-32. 2015
  3. pmc Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Hematology Unit Center Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    BMC Med Genet 13:70. 2012
  4. ncbi request reprint Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Center Study for Hemostasis and Thrombosis, University of Ferrara, C so Giovecca 203, I 44100 Ferrara, Italy
    Cancer Epidemiol Biomarkers Prev 13:787-94. 2004
  5. doi request reprint DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators
    Donato Gemmati
    Haemostasis and Thrombosis Center, University of Ferrara, Ferrara, Italy
    J Vasc Surg 50:1444-51. 2009
  6. ncbi request reprint Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Center Study Haemostasis and Thrombosis, University of Ferrara, Corso Giovecca 203, I 14400 Ferrara, Italy
    Wound Repair Regen 12:512-7. 2004
  7. ncbi request reprint Influence of gene polymorphisms in ulcer healing process after superficial venous surgery
    Donato Gemmati
    Center Study Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    J Vasc Surg 44:554-62. 2006
  8. pmc Factor XIIIA-V34L and factor XIIIB-H95R gene variants: effects on survival in myocardial infarction patients
    Donato Gemmati
    Center Study Haemostasis and Thrombosis, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
    Mol Med 13:112-20. 2007
  9. ncbi request reprint Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Section of Haematology, Center Study Haemostasis and Thrombosis, University of Ferrara, Italy
    Haematologica 92:478-85. 2007
  10. doi request reprint Coagulation gene predictors of photodynamic therapy for occult choroidal neovascularization in age-related macular degeneration
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Invest Ophthalmol Vis Sci 49:3100-6. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics
    Donato Gemmati
    Centre Hemostasis and Thrombosis Unit of Haematology, Department Medical Sciences, University of Ferrara, I 44100, Ferrara Italy
    Curr Pharm Des 22:1449-59. 2016
    ..The present review accounts for the recognized role of FXIII in the healing process and gives some examples on how to use it as prognostic biological/ molecular marker or as potential tailored therapeutic molecule in complex diseases...
  2. doi request reprint Factor XIII-A dynamics in acute myocardial infarction: a novel prognostic biomarker?
    Donato Gemmati
    Gemmati Donato, Ctr Hemostasis and Thrombosis, Hematology Section, Dpt of Medical Sciences, University of Ferrara, Ferrara, Italy, Tel 39 0532 237291, Fax 39 0532 209010, E mail
    Thromb Haemost 114:123-32. 2015
    ..Different FXIII-A dynamics and levels could be utilised as early prognostic indicators during acute MI, revealing the individual potential to heal and suggesting tailored treatments to avoid heart failure or its extreme consequence...
  3. pmc Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Hematology Unit Center Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    BMC Med Genet 13:70. 2012
    ..Conversely, systemic iron overload is not always observed. We explored the role of common single nucleotide polymorphisms (SNPs) in the main iron homeostasis genes in MS patients...
  4. ncbi request reprint Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Center Study for Hemostasis and Thrombosis, University of Ferrara, C so Giovecca 203, I 44100 Ferrara, Italy
    Cancer Epidemiol Biomarkers Prev 13:787-94. 2004
    ..These data are in accordance with the hypothesis that polymorphisms in the genes for folate and methionine metabolism might play a greater role in the occurrence of ALL than NHL by influencing DNA synthesis and/or DNA methylation...
  5. doi request reprint DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators
    Donato Gemmati
    Haemostasis and Thrombosis Center, University of Ferrara, Ferrara, Italy
    J Vasc Surg 50:1444-51. 2009
    ..We selected a number of single nucleotide polymorphisms (SNPs) in candidate genes (HFE, FPN1, MMP12, and FXIII) involved in VLU to identify potentially prognostic markers by means of DNA-array technology...
  6. ncbi request reprint Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Center Study Haemostasis and Thrombosis, University of Ferrara, Corso Giovecca 203, I 14400 Ferrara, Italy
    Wound Repair Regen 12:512-7. 2004
    ....
  7. ncbi request reprint Influence of gene polymorphisms in ulcer healing process after superficial venous surgery
    Donato Gemmati
    Center Study Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    J Vasc Surg 44:554-62. 2006
    ..This study was conducted to investigate the role of HFE-C282Y and FXIII (V34L and P564L) gene variants in ulcer healing time after superficial venous surgery, by assessing the outcome of a cohort of homogeneous CVU patients...
  8. pmc Factor XIIIA-V34L and factor XIIIB-H95R gene variants: effects on survival in myocardial infarction patients
    Donato Gemmati
    Center Study Haemostasis and Thrombosis, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
    Mol Med 13:112-20. 2007
    ..Genetically determined higher FXIII activity might influence post-MI outcome. This paves the way for using FXIII molecules to improve myocardial healing, recovery of functions, and survival after infarction...
  9. ncbi request reprint Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Section of Haematology, Center Study Haemostasis and Thrombosis, University of Ferrara, Italy
    Haematologica 92:478-85. 2007
    ..We analyzed 110 patients with high-grade non-Hodgkin's lymphoma (NHL), 68 of whom were eligible for a chemotherapy combination containing methotrexate (MACOP-B) and 42 for chemotherapy without methotrexate (CHOP)...
  10. doi request reprint Coagulation gene predictors of photodynamic therapy for occult choroidal neovascularization in age-related macular degeneration
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Invest Ophthalmol Vis Sci 49:3100-6. 2008
    ....
  11. ncbi request reprint Predictive role of coagulation-balance gene polymorphisms in the efficacy of photodynamic therapy with verteporfin for classic choroidal neovascularization secondary to age-related macular degeneration
    Francesco Parmeggiani
    Department of Ophthalmology, Center Study for Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    Pharmacogenet Genomics 17:1039-46. 2007
    ..As PDT-V benefit is determined by CNV photothrombosis, we have retrospectively studied several coagulation-balance gene polymorphisms as predictors of PDT-V efficacy...
  12. doi request reprint Impact of coagulation-balance gene predictors on efficacy of photodynamic therapy for choroidal neovascularization in pathologic myopia
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Ophthalmology 117:517-23. 2010
    ....
  13. ncbi request reprint Prognostic role of factor XIII gene variants in nonhealing venous leg ulcers
    Silvia Tognazzo
    Center Study Haemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    J Vasc Surg 44:815-9. 2006
    ..Because FXIII properties depend upon its genetic variants, we investigated whether intragene polymorphisms may have modulating effects on the CVU area...
  14. ncbi request reprint Prevalence of factor XIII Val34Leu polymorphism in patients affected by spontaneous subconjunctival hemorrhage
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy
    Am J Ophthalmol 138:481-4. 2004
    ..To verify the prevalence of Val34Leu polymorphism in factor XIII A-chain gene (FXIII Val34Leu) in patients with spontaneous subconjunctival hemorrhage (SCH)...
  15. doi request reprint Genetic predictors of response to photodynamictherapy
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Mol Diagn Ther 15:195-210. 2011
    ....
  16. ncbi request reprint Pharmacogenetic aspects in therapeutic management of subfoveal choroidal neovascularisation: role of factor XIII-A 185 T-allele
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Curr Drug Targets 12:138-48. 2011
    ..optimize the eligibility criteria of PDT-V and, ii. customize the interventional strategy against CNV, for finally minimizing the socio-economic burden of neovascular macular degenerations...
  17. doi request reprint Time- and dose-dependent effects of chronic wound fluid on human adult dermal fibroblasts
    Monica De Mattei
    Department of Morphology and Embryology, Ferrara, Italy
    Dermatol Surg 34:347-56. 2008
    ..Wound healing is a biologic process that is altered in patients affected by chronic venous ulcers. The wound microenvironment is reflected in the chronic wound fluid (CWF), an exudate containing serum components and tissue-derived proteins...
  18. doi request reprint Predictive role of C677T MTHFR polymorphism in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration
    Francesco Parmeggiani
    Sezione di Clinica Oculistica, Dipartimento di Discipline Medico Chirurgiche della Comunicazione e del Comportamento, Universita degli Studi di Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy
    Pharmacogenomics 10:81-95. 2009
    ....
  19. ncbi request reprint Predictive role of gene polymorphisms affecting thrombin-generation pathway in variable efficacy of photodynamic therapy for neovascular age-related macular degeneration
    Francesco Parmeggiani
    Department of Ophthalmology, University of Ferrara, Italy
    Recent Pat DNA Gene Seq 3:114-22. 2009
    ..This review summarizes some of the recent published patents on treatment of neovascular AMD, with a particular attention to PDT-V application in combined therapeutic modalities...
  20. ncbi request reprint Poor responsiveness to clopidogrel: drug-specific or class-effect mechanism? Evidence from a clopidogrel-to-ticlopidine crossover study
    Gianluca Campo
    Cardiovascular Institute, Azienda Ospedaliera Universitaria S Anna, Ferrara, Italy
    J Am Coll Cardiol 50:1132-7. 2007
    ....
  21. ncbi request reprint Effects of physical stimulation with electromagnetic field and insulin growth factor-I treatment on proteoglycan synthesis of bovine articular cartilage
    Monica De Mattei
    Department of Morphology and Embryology, University of Ferrara, 44100 Ferrara, Italy
    Osteoarthritis Cartilage 12:793-800. 2004
    ..To investigate the single and combined effects of electromagnetic field (EMF) exposure and the insulin growth factor-I (IGF-I) on proteoglycan (PG) synthesis of bovine articular cartilage explants and chondrocytes cultured in monolayers...
  22. ncbi request reprint Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration
    Paolo Zamboni
    Inter Departmental Vascular Disease Center, University of Ferrara, Italy
    J Vasc Surg 42:309-14. 2005
    ..Because CVD leads to local iron overload in the affected legs, we investigated whether two common HFE mutations could increase the risk of chronic venous leg ulceration...
  23. ncbi request reprint Value of platelet reactivity in predicting response to treatment and clinical outcome in patients undergoing primary coronary intervention: insights into the STRATEGY Study
    Gianluca Campo
    Department of Cardiology, University of Ferrara, Ferrara, Italy
    J Am Coll Cardiol 48:2178-85. 2006
    ....
  24. ncbi request reprint Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events
    Gianluca Campo
    Department of Cardiology, University of Ferrara, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 26:2800-6. 2006
    ....
  25. ncbi request reprint Factor XIII contrasts the effects of metalloproteinases in human dermal fibroblast cultured cells
    Paolo Zamboni
    Department of Surgery and Vascular Laboratory, University of Ferrara, Italy
    Vasc Endovascular Surg 38:431-8. 2004
    ..These results support several in vivo reports about the effectiveness of its topical application in order to enhance the venous ulcer healing processes...
  26. pmc Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis
    Alessandra Ferlini
    Section of Medical Genetics, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    BMC Med Genet 11:64. 2010
    ....
  27. ncbi request reprint Clinical implications of gene polymorphisms in venous leg ulcer: a model in tissue injury and reparative process
    Paolo Zamboni
    Director of the Vascular Diseases Center, University of Ferrara, 44100 Ferrara, Italy
    Thromb Haemost 98:131-7. 2007
    ....
  28. pmc Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration
    Francesco Parmeggiani
    Eye Clinic, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, via Aldo Moro 8, 44124 Cona Ferrara, Italy
    Int J Mol Sci 16:19796-811. 2015
    ..Further investigations are warranted to outline the appropriate paradigm for guiding PDT-V utilization in the course of the combined therapeutic protocol for neovascular macular degeneration. ..
  29. pmc Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival
    Alessia Ongaro
    Department of Morphology and Embryology, Section of Histology, University of Ferrara, Via Fossato di Mortara 64 b, 44100 Ferrara, Italy
    Haematologica 94:1391-8. 2009
    ..Prediction of toxicity is difficult because of inter-individual variability susceptibility to antileukemic agents. Methotrexate interferes with folate metabolism leading to depletion of reduced folates...
  30. pmc The Active Metabolite of Warfarin (3'-Hydroxywarfarin) and Correlation with INR, Warfarin and Drug Weekly Dosage in Patients under Oral Anticoagulant Therapy: A Pharmacogenetics Study
    Donato Gemmati
    Centre Haemostasis and Thrombosis, Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy
    PLoS ONE 11:e0162084. 2016
    ..VKORC1/CYP2C9 pharmacogenetics investigation was performed to account for the known influence on warfarin homeostasis...
  31. ncbi request reprint Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers
    Paolo Zamboni
    Inter Departmental Vascular Disease Center, University of Ferrara, Ferrara, Italy
    Dermatol Surg 31:644-9; discussion 649. 2005
    ..Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway is one of the recognized mechanisms of MMP hyperactivation...
  32. ncbi request reprint Recurrent episodes of spontaneous subconjunctival hemorrhage in patients with factor XIII Val34Leu mutation
    Carlo Incorvaia
    Department of Ophthalmology, University of Ferrara, Ferrara, Italy
    Am J Ophthalmol 134:927-9. 2002
    ..To report on the occurrence of frequent episodes of spontaneous subconjunctival hemorrhage (SCH) in patients with the Leu 34 allele of the coagulation factor XIII (FXIII), known to be associated with high hemorrhagic risk...
  33. ncbi request reprint Effects of electromagnetic fields on proteoglycan metabolism of bovine articular cartilage explants
    Monica De Mattei
    Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy
    Connect Tissue Res 44:154-9. 2003
    ..This effect also is maintained in the presence of IL-1beta, thus counteracting the catabolic activity of the cytokine. Altogether, these data suggest that EMF exposure exerts a chondroprotective effect on articular cartilage in vitro...
  34. ncbi request reprint Vision loss after PDT
    Francesco Parmeggiani
    Ophthalmology 113:157. 2006
  35. ncbi request reprint Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation
    Christoph L Klein
    Institute for Reference Materials and Measurements, European Commission, Joint Research Centre, Geel, Belgium
    Clin Chem Lab Med 43:862-8. 2005
    ..This series of plasmid RMs are, to the best of our knowledge, the first plasmid-type clinical genetic RMs introduced worldwide...
  36. ncbi request reprint Asymptomatic carriership of factor V Leiden and genotypes of the fibrinogen gene cluster
    Giovanna Marchetti
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna, Italia
    Br J Haematol 121:632-8. 2003
    ..35 vs 2.69 +/- 0.41 g/l, P = 0.028) among the asymptomatic subjects. Our data suggest that, in the presence of inherited thrombophilia, frequent fibrinogen polymorphisms may interact to modulate the risk of venous thromboembolism...