Carlo Laudanna

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. pmc Chemokines and the signaling modules regulating integrin affinity
    Alessio Montresor
    Division of General Pathology, Department of Pathology, University of Verona Verona, Italy
    Front Immunol 3:127. 2012
  2. ncbi request reprint Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Thromb Haemost 95:5-11. 2006
  3. ncbi request reprint Rapid leukocyte integrin activation by chemokines
    Carlo Laudanna
    Section of General Pathology, Department of Pathology, Faculty of Medicine, University of Verona, 37138, Verona, Italy
    Immunol Rev 186:37-46. 2002
  4. doi request reprint Integrin activation in the immune system
    Carlo Laudanna
    Department of Pathology, The Center for Biomedical Computing, University of Verona, Verona, Italy
    Wiley Interdiscip Rev Syst Biol Med 1:116-27. 2009
  5. ncbi request reprint Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Lab Invest 83:1155-63. 2003
  6. doi request reprint Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module
    Matteo Bolomini-Vittori
    University of Verona, School of Medicine, Department of Pathology, Division of General Pathology, Verona 37134, Italy
    Nat Immunol 10:185-94. 2009
  7. ncbi request reprint The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained a
    Cinzia Giagulli
    Department of Pathology, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    J Immunol 177:604-11. 2006
  8. ncbi request reprint RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing
    Cinzia Giagulli
    Department of Pathology, Faculty of Medicine, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Immunity 20:25-35. 2004
  9. pmc RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones
    Marco Della Peruta
    Department of Pathology, University of Verona, Strada Le Grazie 8, Verona, Italy
    Mol Cancer 9:61. 2010
  10. pmc TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity
    Stefano Angiari
    Department of Pathology and Diagnostics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Immunity 40:542-53. 2014

Collaborators

Detail Information

Publications36

  1. pmc Chemokines and the signaling modules regulating integrin affinity
    Alessio Montresor
    Division of General Pathology, Department of Pathology, University of Verona Verona, Italy
    Front Immunol 3:127. 2012
    ..We also discuss data suggesting a functional integration between the rho- and rap-modules of integrin activation. Finally we examine the universality of signaling mechanisms regulating integrin triggering by arrest chemokines...
  2. ncbi request reprint Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Thromb Haemost 95:5-11. 2006
    ....
  3. ncbi request reprint Rapid leukocyte integrin activation by chemokines
    Carlo Laudanna
    Section of General Pathology, Department of Pathology, Faculty of Medicine, University of Verona, 37138, Verona, Italy
    Immunol Rev 186:37-46. 2002
    ....
  4. doi request reprint Integrin activation in the immune system
    Carlo Laudanna
    Department of Pathology, The Center for Biomedical Computing, University of Verona, Verona, Italy
    Wiley Interdiscip Rev Syst Biol Med 1:116-27. 2009
    ..The principles and technologies of systems biology, and more specifically of network theory, may help to address this complexity and unveil the inner logic governing leukocyte recruitment during the immune response...
  5. ncbi request reprint Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement
    Carlo Laudanna
    Department of Pathology, University of Verona, Italy
    Lab Invest 83:1155-63. 2003
    ..These data suggest that the disregulation of the function of atypical zeta PKC might be involved in the acquisition of an invasive and metastatic phenotype in pancreatic adenocarcinoma cells...
  6. doi request reprint Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module
    Matteo Bolomini-Vittori
    University of Verona, School of Medicine, Department of Pathology, Division of General Pathology, Verona 37134, Italy
    Nat Immunol 10:185-94. 2009
    ..Thus, chemokines control lymphocyte trafficking by triggering a Rho-dependent signaling cascade leading to conformer-specific modulation of LFA-1 affinity...
  7. ncbi request reprint The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained a
    Cinzia Giagulli
    Department of Pathology, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    J Immunol 177:604-11. 2006
    ..Thus, Hck and Fgr play no role in chemoattractant-induced inside-out beta(2) integrin activation but regulate outside-in signaling-dependent sustained adhesion...
  8. ncbi request reprint RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing
    Cinzia Giagulli
    Department of Pathology, Faculty of Medicine, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Immunity 20:25-35. 2004
    ..Thus, RhoA controls the induction of LFA-1 high-affinity state by chemokines independently of zeta PKC, and this is critical to support chemokine-regulated homing of circulating lymphocytes...
  9. pmc RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones
    Marco Della Peruta
    Department of Pathology, University of Verona, Strada Le Grazie 8, Verona, Italy
    Mol Cancer 9:61. 2010
    ....
  10. pmc TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity
    Stefano Angiari
    Department of Pathology and Diagnostics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Immunity 40:542-53. 2014
    ..Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease...
  11. pmc Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1
    Stefano Angiari
    Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy
    J Immunol 191:5489-500. 2013
    ..Our data show that PSGL-1 represents a previously unknown, phase-specific mechanism for Treg-mediated suppression of the persistence of immune responses and autoimmunity induction. ..
  12. pmc JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation
    Alessio Montresor
    Department of Pathology and Diagnostics, Division of General Pathology, School of Medicine, and 2 The Center for Biomedical Computing, University of Verona, Verona 37134, Italy
    J Cell Biol 203:1003-19. 2013
    ..Thus, JAK tyrosine kinases control integrin activation and dependent lymphocyte trafficking by bridging chemokine receptors to the concurrent and hierarchical activation of the Rho and Rap modules of integrin activation. ..
  13. ncbi request reprint Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII
    Laura Piccio
    Department of Pathology, University of Verona, Verona, Italy
    J Immunol 174:5805-13. 2005
    ..These observations allow us to conclude that efficient recruitment of activated lymphocytes to the brain in the contexts mimicking EAE is controlled by FucT-VII and its cognate cell surface Ag CLA...
  14. doi request reprint A deadly migration
    Gabriela Constantin
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Immunity 32:147-9. 2010
    ..CD95 has long been viewed as a death receptor regulating apoptosis. In this issue of Immunity, Letellier et al. (2010) tell us a different story, about the capability of CD95L to regulate leukocyte recruitment to sites of inflammation...
  15. pmc JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia
    Alessio Montresor
    Department of Pathology and Diagnostics, Division of General Pathology, Laboratory of Cell Trafficking and Signal Transduction, University of Verona, Verona 37134, Italy, EU
    Oncotarget 6:34245-57. 2015
    ..Our results reveal JAK2 as critical component of chemokine signaling in CLL B-lymphocytes and indicate JAK inhibition as a potentially useful new pharmacological approach to B-CLL treatment...
  16. doi request reprint Protein tyrosine phosphatase receptor type γ is a JAK phosphatase and negatively regulates leukocyte integrin activation
    Michela Mirenda
    Division of General Pathology, Department of Pathology and Diagnostics, School of Medicine, University of Verona, Verona 37134, Italy and
    J Immunol 194:2168-79. 2015
    ....
  17. doi request reprint HOMECAT: consensus homologs mapping for interspecific knowledge transfer and functional genomic data integration
    Simone Zorzan
    Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Section of Physiology, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Bioinformatics 29:1574-6. 2013
    ....
  18. doi request reprint Comparative analysis of normal versus CLL B-lymphocytes reveals patient-specific variability in signaling mechanisms controlling LFA-1 activation by chemokines
    Alessio Montresor
    Department of Pathology, University of Verona, Verona, Italy
    Cancer Res 69:9281-90. 2009
    ..Our findings could potentially affect the diagnosis, prognosis, and therapy of CLL disorders...
  19. doi request reprint Leukocyte trafficking mechanisms in epilepsy
    Paolo F Fabene
    Department of Neurological, Neuropsychological, Morphological and Movement Sciences, Section of Anatomy, University of Verona, Verona, Italy
    Mol Immunol 55:100-4. 2013
    ..The emerging role for leukocytes and leukocyte adhesion mechanisms in seizure generation provides insight into the mechanisms of brain damage and may contribute to the development of novel therapeutic strategies in epilepsy...
  20. ncbi request reprint New models of intravital microscopy for analysis of chemokine receptor-mediated leukocyte vascular recognition
    Carlo Laudanna
    Section of General Pathology, Department of Pathology, University of Verona, Strade le Grazie 8, Verona 37134, Italy
    J Immunol Methods 273:115-23. 2003
    ..The new approach presented here to study the brain microcirculation may provide an useful tool for further investigations of physiologic and pathologic events that occur in the CNS...
  21. ncbi request reprint SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines
    Lara Toffali
    Department of Medicine, University of Verona, Verona 37134, Italy
    J Immunol . 2016
    ....
  22. ncbi request reprint Beta2 integrin-dependent neutrophil adhesion induced by minimally modified low-density lipoproteins is mainly mediated by F2-isoprostanes
    Luigi Fontana
    Department of Medicine, University of Verona, Italy
    Circulation 106:2434-41. 2002
    ..Among them, isoprostanes, and in particular iPF(2alpha)-III, seem to be crucial in mediating some of the key cellular events seen in myocardial ischemia-reperfusion injury...
  23. ncbi request reprint Analysis of integrin-dependent rapid adhesion under laminar-flow conditions
    Carlo Laudanna
    Department of Pathology, Faculty of Medicine, University of Verona, Verona, Italy
    Methods Mol Biol 239:17-26. 2004
  24. ncbi request reprint Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors
    Laura Piccio
    Department of Pathology, University of Verona, Verona, Italy
    J Immunol 168:1940-9. 2002
    ..In conclusion, our data unveils the molecular mechanisms controlling the recruitment of autoreactive lymphocytes in inflamed cerebral vessels and suggest new insights into the pathogenesis of autoimmune inflammatory diseases of the CNS...
  25. pmc Finding the shortest path with PesCa: a tool for network reconstruction
    Giovanni Scardoni
    Center for Biomedical Computing, University of Verona, Verona, Italy
    F1000Res 4:484. 2015
    ..Overall, the plugin enhances the ability of discovering interesting and not obvious relations between high dimensional sets of interacting objects...
  26. pmc Node interference and robustness: performing virtual knock-out experiments on biological networks: the case of leukocyte integrin activation network
    Giovanni Scardoni
    Center for BioMedical Computing CBMC, University of Verona, Verona, Italy
    PLoS ONE 9:e88938. 2014
    ....
  27. pmc Rac1 selective activation improves retina ganglion cell survival and regeneration
    Erika Lorenzetto
    Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Section of Physiology, University of Verona, Verona, Italy
    PLoS ONE 8:e64350. 2013
    ..Our data suggest that the selective activation of distinct Rac1-dependent pathways could represent a therapeutic strategy to counteract neuronal degenerative processes in the retina...
  28. pmc PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Proteomics 8:4695-708. 2008
    ....
  29. pmc Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e31015. 2012
    ..The final analysis pointed to a novel, very restricted, signaling module of 14 highly interconnected kinases, whose alteration is possibly involved in generation of acanthocytes in MLS and ChAc...
  30. ncbi request reprint Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion
    Daniele D'Ambrosio
    BioXell, Milan, Italy
    J Immunol 169:2303-12. 2002
    ....
  31. ncbi request reprint Getting to the site of inflammation: the leukocyte adhesion cascade updated
    Klaus Ley
    Robert M Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 7:678-89. 2007
    ..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade...
  32. ncbi request reprint RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9
    Ronit Pasvolsky
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 180:2815-23. 2008
    ....
  33. ncbi request reprint Integrin activation under flow: a local affair
    Carlo Laudanna
    Nat Immunol 6:429-30. 2005
  34. ncbi request reprint CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
    Luca Battistini
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia, Rome, Italy
    Blood 101:4775-82. 2003
    ..In conclusion, our results show that CD8+, but not CD4+, T cells from patients with RRMS in the acute phase of the disease display increased ability to be recruited in inflamed brain venules...
  35. ncbi request reprint Concurrency in leukocyte vascular recognition: developing the tools for a predictive computer model
    Daniele D'Ambrosio
    BioXell S p a, Via Olgettina 58, 20132 Milan, Italy
    Trends Immunol 25:411-6. 2004
  36. ncbi request reprint The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion
    Federico Furlan
    Department of Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, Milan, 20132, Italy
    J Cell Sci 117:2909-16. 2004
    ....