Lorenzo Lughetti

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. pmc Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature
    Francesco Di Dio
    Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy
    BMC Pediatr 16:62. 2016
  2. ncbi request reprint Childhood obesity and environmental pollutants: a dual relationship
    Lorenzo Iughetti
    Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia
    Acta Biomed 86:5-16. 2015
  3. pmc Final height and body mass index in adult survivors of childhood acute lymphoblastic leukemia treated without cranial radiotherapy: a retrospective longitudinal multicenter Italian study
    Patrizia Bruzzi
    Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124 Modena, Italy
    BMC Pediatr 14:236. 2014
  4. pmc Pharmacological treatment of obesity in children and adolescents: present and future
    Lorenzo Iughetti
    Obesity Research Center, Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    J Obes 2011:928165. 2011
  5. ncbi request reprint Dancing eye syndrome as first symptom of neuroblastoma
    Cristina Venturelli
    Post Graduate School of Pediatrics Pediatric Unit University of Modena and Reggio Emilia
    Acta Biomed 84:162-6. 2013
  6. pmc Unusual osseous presentation of blastomycosis in an immigrant child: a challenge for European pediatricians
    Margherita Codifava
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Ital J Pediatr 38:69. 2012
  7. pmc "Mi voglio bene": a pediatrician-based randomized controlled trial for the prevention of obesity in Italian preschool children
    Paolo Brambilla
    Department of Continuing Medical Education, Federazione italiana medici pediatri, Milano, Italy
    Ital J Pediatr 36:55. 2010
  8. doi request reprint Impaired GH secretion in patients with SHOX deficiency and efficacy of recombinant human GH therapy
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Horm Res Paediatr 78:279-87. 2012
  9. ncbi request reprint Growth hormone therapy in patients with short stature homeobox-gene (SHOX) deficiency
    L Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    J Endocrinol Invest 33:34-8. 2010
  10. pmc Obesity in patients with acute lymphoblastic leukemia in childhood
    Lorenzo Iughetti
    Department of Paediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Ital J Pediatr 38:4. 2012

Detail Information

Publications41

  1. pmc Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature
    Francesco Di Dio
    Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy
    BMC Pediatr 16:62. 2016
    ..Here we report an unusual presentation of RDD in an Italian toddler. Moreover, we reviewed the pediatric case reports published between 2004 and 2014, focusing in particular on medical therapy...
  2. ncbi request reprint Childhood obesity and environmental pollutants: a dual relationship
    Lorenzo Iughetti
    Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia
    Acta Biomed 86:5-16. 2015
    ..www.actabiomedica.it). ..
  3. pmc Final height and body mass index in adult survivors of childhood acute lymphoblastic leukemia treated without cranial radiotherapy: a retrospective longitudinal multicenter Italian study
    Patrizia Bruzzi
    Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124 Modena, Italy
    BMC Pediatr 14:236. 2014
    ..Our study investigated the effect of chemotherapy alone on body mass index (BMI) and on growth at the achievement of final height in a homogeneous cohort of Italian childhood ALL survivors...
  4. pmc Pharmacological treatment of obesity in children and adolescents: present and future
    Lorenzo Iughetti
    Obesity Research Center, Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    J Obes 2011:928165. 2011
    ..In this paper, we analyze the data on the currently approved obesity pharmacological treatment suggesting the new potential drugs...
  5. ncbi request reprint Dancing eye syndrome as first symptom of neuroblastoma
    Cristina Venturelli
    Post Graduate School of Pediatrics Pediatric Unit University of Modena and Reggio Emilia
    Acta Biomed 84:162-6. 2013
    ..OMS may also be triggered by infections and it is often associated to developmental impairment and disability...
  6. pmc Unusual osseous presentation of blastomycosis in an immigrant child: a challenge for European pediatricians
    Margherita Codifava
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Ital J Pediatr 38:69. 2012
    ..Direct visualization of single broadbased budding yeast with specific stains in sputum or tissue samples at microscopy is the primary method for diagnosis, while culture is timeconsuming and other methods are unreliable...
  7. pmc "Mi voglio bene": a pediatrician-based randomized controlled trial for the prevention of obesity in Italian preschool children
    Paolo Brambilla
    Department of Continuing Medical Education, Federazione italiana medici pediatri, Milano, Italy
    Ital J Pediatr 36:55. 2010
    ..We report the rationale and protocol of such trial, named the "Mi voglio bene" ("I love myself") study...
  8. doi request reprint Impaired GH secretion in patients with SHOX deficiency and efficacy of recombinant human GH therapy
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Horm Res Paediatr 78:279-87. 2012
    ..The aim of this study was to evaluate GH secretion and analyze growth and safety of recombinant human GH (rhGH) therapy in short children and adolescents with SHOX deficiency...
  9. ncbi request reprint Growth hormone therapy in patients with short stature homeobox-gene (SHOX) deficiency
    L Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    J Endocrinol Invest 33:34-8. 2010
    ..The conclusion is that GH therapy, at the same dosage used in patients with TS, induces a sustained catch-up growth and a height velocity and adult height gain in short patients with SHOX haploinsufficiency...
  10. pmc Obesity in patients with acute lymphoblastic leukemia in childhood
    Lorenzo Iughetti
    Department of Paediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Ital J Pediatr 38:4. 2012
    ..The present review has the aim of summarizing the published data and examining the most accepted mechanisms and main predisposing factors related to weight gain in this particular population...
  11. ncbi request reprint Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome
    L Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo, 71 41 100 Modena, Italy
    Eur J Pediatr 167:701-2. 2008
    ..Altogether, neuroradiological alterations were present in 61 of the 91 (67%) patients. Our results indicate that neuroradiological alterations are more frequent in PWS patients than has been reported to date...
  12. ncbi request reprint Rational approach to the treatment for heterozygous familial hypercholesterolemia in childhood and adolescence: a review
    L Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    J Endocrinol Invest 30:700-19. 2007
    ..This review provides an update on recent advances in the diagnosis, therapy, and follow-up of familial hypercholesterolemia during pediatric age and adolescence...
  13. doi request reprint Thirty-year persistence of obesity after presentation to a pediatric obesity clinic
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, Modena 41100, Italy
    Ann Hum Biol 35:439-48. 2008
    ..Few large, long-term studies are available on the relationship between childhood and adult obesity...
  14. ncbi request reprint Unexpected phenotype in a boy with trisomy of the SHOX gene
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    J Pediatr Endocrinol Metab 23:159-69. 2010
    ....
  15. doi request reprint Evaluation and management of hyperlipidemia in children and adolescents
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Curr Opin Pediatr 22:485-93. 2010
    ..To review the recent findings on evaluation and management of dyslipidemia in childhood and adolescence, giving a critical view on new therapeutic approaches...
  16. doi request reprint Plasma brain-derived neurotrophic factor concentrations in children and adolescents
    L Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Neuropeptides 45:205-11. 2011
    ..Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal plasticity influencing learning, memory and cognitive behavior. The aim of this study is to assess plasma BDNF variations according to pubertal status...
  17. pmc Obesity and craniopharyngioma
    Lorenzo Iughetti
    Department of Paediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Ital J Pediatr 37:38. 2011
    ..The present review has the aim of summarizing the published data and examining the most accepted mechanisms and main predisposing factors related to weight gain in this particular population...
  18. ncbi request reprint Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association?
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41 100, Modena, Italy
    Eur J Pediatr 165:897-903. 2006
    ..Seven CD children, without catch-up growth after at least 12-months GFD, were tested for GH secretion and, in five out of seven patients, the diagnosis of GHD was made in the absence of metabolic and systemic diseases...
  19. ncbi request reprint Low serum allopregnanolone levels in girls with precocious pubarche
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy
    Steroids 70:725-31. 2005
    ..These data suggest that this neurosteroid may be considered a new marker of pubertal development...
  20. ncbi request reprint High basal serum allopregnanolone levels in overweight girls
    B Predieri
    Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Int J Obes (Lond) 31:543-9. 2007
    ..The aim of our study was to evaluate basal serum AP levels in obese children...
  21. doi request reprint Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty
    B Predieri
    Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    J Endocrinol Invest 34:38-44. 2011
    ..Allopregnanolone concentrations significantly increase after GnRH and ACTH stimulation test suggesting both its ovarian and adrenal production...
  22. ncbi request reprint High serum allopregnanolone levels in girls with precocious puberty
    L Iughetti
    Department of Gynecological, Obstetrics, University of Modena and Reggio Emilia, 41 100 Modena, Italy
    J Clin Endocrinol Metab 87:2262-5. 2002
    ..The increase in serum allopregnanolone after GnRH and ACTH stimulation tests demonstrates that both adrenal cortex and gonads are sources of this neuroactive steroid...
  23. ncbi request reprint Relationship between body mass index and insulin measured during oral glucose tolerance testing in severely obese children and adolescents
    L Iughetti
    Paediatrics Clinic, University of Modena and Reggio Emilia, Italy
    Ann Hum Biol 31:196-201. 2004
    ..The study evaluated the accuracy of body mass index (BMI) in detecting hyperinsulinaemia during oral glucose tolerance testing (OGTT) in severely obese children...
  24. pmc SHOX point mutations and deletions in Leri-Weill dyschondrosteosis
    C Falcinelli
    Cattedra di Genetica Medica, Universita di Modena, Via del Pozzo 71, 41100 Modena, Italy
    J Med Genet 39:E33. 2002
  25. ncbi request reprint Sensitivity and specificity of body mass index and skinfold thicknesses in detecting excess adiposity in children aged 8-12 years
    G Bedogni
    University of Modena and Reggio Emilia, Italy
    Ann Hum Biol 30:132-9. 2003
    ..The study aimed to evaluate the sensitivity (SN) and specificity (SP) of body mass index (BMI) and skinfold thicknesses in detecting excess adiposity in children...
  26. ncbi request reprint Response to long-term growth hormone therapy in short children with reduced GH bioactivity
    Paola Travaglino
    Department of Pediatrics, University of Pavia, Pavia, Italy
    Horm Res 66:189-94. 2006
    ..The aim of the present study was to investigate whether short children with normal growth hormone (GH) immunoreactivity, but reduced bioactivity (bioinactive GH) could benefit from rhGH treatment as GH deficient (GHD) patients...
  27. ncbi request reprint SHOX gene in Leri-Weill syndrome and in idiopathic short stature
    S Bernasconi
    Department of Pediatrics, University of Parma, OORR, Italy
    J Endocrinol Invest 24:737-41. 2001
  28. ncbi request reprint Interactions among pro-inflammatory cytokines, IGF system and thyroid function in pre-pubertal obese subjects
    M E Street
    Department of Paediatrics, University Hospital of Parma, Parma, Italy
    J Biol Regul Homeost Agents 27:259-66. 2013
    ..Chronic inflammation in obese children was confirmed. Some of the changes in the IGF system could be a consequence of insulin resistance and could account also for later complications in obese subjects...
  29. ncbi request reprint Bone mass evaluated by calcaneous ultrasound and radial peripheral computed tomography in 726 youngsters
    C Volta
    Department of Paediatrics, University of Parma, Italy
    Acta Paediatr 93:747-51. 2004
    ..To compare the results of ultrasound and computed peripheral tomography in evaluating bone mass in a population of normal children...
  30. ncbi request reprint Endocrine aspects of coeliac disease
    Lorenzo Iughetti
    Department of Pediatrics, University of Modena and Reggio Emilia, Italy
    J Pediatr Endocrinol Metab 16:805-18. 2003
    ..We review the literature on endocrine aspects of CD, because patients with CD are at great risk of developing endocrine disorders...
  31. ncbi request reprint Adult height in children with short stature and idiopathic delayed puberty after different management
    Stefano Zucchini
    Department of Pediatrics, Azienda Ospedaliero Universitaria di Bologna S Orsola Malpighi, Via Massarenti 11, 40138, Bologna, Italy
    Eur J Pediatr 167:677-81. 2008
    ..Our data do not support the usefulness of growth-hormone therapy in improving adult height in subjects with short stature and delayed puberty, particularly in the female sex...
  32. pmc Impact of nutrition since early life on cardiovascular prevention
    Ornella Guardamagna
    Department of Paediatrics, University of Torino, Piazza Polonia 94, Torino, Italy
    Ital J Pediatr 38:73. 2012
    ..The purpose of this review is to examine the impact of nutrition since early life on disease...
  33. pmc Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births
    D Iafusco
    Department of Pediatrics, Second University of Naples, Italy
    Acta Diabetol 49:405-8. 2012
    ..Incidence of NDM was calculated at 1:90,000 (CI: 1:63,000-1:132,000) live births. Thus, with the definition currently in use, about 6 new cases with NDM are expected to be born in Italy each year...
  34. ncbi request reprint Diagnostic approach and therapy of overgrowth and tall stature in childhood
    L Iughetti
    Department of Paediatrics, University of Modena and Reggio Emilia, Modena, Italy
    Minerva Pediatr 55:563-82. 2003
    ..The novel advances in the understanding of constitutional and secondary tall stature are presented and discussed, together with the hormonal treatment of constitutional tall stature and other related outstanding questions...
  35. ncbi request reprint Menstrual cycle pattern during the first gynaecological years in girls with precocious puberty following gonadotropin-releasing hormone analogue treatment
    Teresa Arrigo
    Department of Pediatrics, University of Messina, Messina Gazzi, Italy
    Eur J Pediatr 166:73-4. 2007
  36. ncbi request reprint Genotype/phenotype correlations of males affected by Simpson-Golabi-Behmel syndrome with GPC3 gene mutations: patient report and review of the literature
    Sabrina Mariani
    Neonatal Intensive Care Unit, A S M N Reggio Emilia, Modena, Italy
    J Pediatr Endocrinol Metab 16:225-32. 2003
    ..We reviewed the clinical findings of all published patients with SGBS1 with GPC3 mutations to confirm the clinical specificity for the SGBS1 phenotype. Moreover, we report on a new patient with a GPC3 deletion and IGF-II evaluation...
  37. doi request reprint The Italian National Survey for Prader-Willi syndrome: an epidemiologic study
    Graziano Grugni
    Italian Auxological Institute Foundation, Research Institute, Verbania, Italy
    Am J Med Genet A 146:861-72. 2008
    ..Overall, there was no increase in number of deaths during GH treatment, suggesting that GH administration in patients with PWS, as a group, does not increase the risk of death...
  38. ncbi request reprint Childhood obesity
    Phyllis W Speiser
    Division of Pediatric Endocrinology, Schneider Children s Hospital, 269 01 76th Avenue, New Hyde Park, New York 11040, USA
    J Clin Endocrinol Metab 90:1871-87. 2005
    ..In developing a consensus statement, this international group has presented the evidence, developed recommendations, and provided a platform aimed toward future corrective action and ongoing debate in the international community...
  39. ncbi request reprint Early activation of vascular endothelial cells and platelets in obese children
    Giovambattista Desideri
    University of L Aquila, Department of Internal Medicine and Public Health, Piazzale Salvatore Tommasi n 1, 67100 Coppito, L Aquila, Italy
    J Clin Endocrinol Metab 90:3145-52. 2005
    ..Increased lipid peroxidation was also present in these children and likely contributed to the observed proinflammatory phenotype...
  40. ncbi request reprint Inaccuracy of insulin-like growth factor (IGF) binding protein (IGFBP)-3 assessment in the diagnosis of growth hormone (GH) deficiency from childhood to young adulthood: association to low GH dependency of IGF-II and presence of circulating IGFBP-3 18-kil
    Stefano Cianfarani
    Rina Balducci Center of Pediatric Endocrinology, Department of Public Health and Cell Biology, Room E 178, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy
    J Clin Endocrinol Metab 90:6028-34. 2005
    ..Poor sensitivity of IGF binding protein (IGFBP)-3 assessment in the work-up of GH deficiency (GHD) has been ascribed to the equal affinity of IGFBP-3 for IGF-I and IGF-II and to IGFBP-3 proteolysis...
  41. ncbi request reprint Isolated premature pubarche: ultrasonographic and color Doppler analysis--a longitudinal study
    Cesare Battaglia
    Reproductive Medicine Unit, University of Bologna, Via Massarenti 13, 40138 Bologna, Italy
    J Clin Endocrinol Metab 87:3148-54. 2002
    ..048). In conclusion, we affirm that PCO are greatly represented among girls with premature pubarche and progressively evolve...