Claudio Muscari

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. doi Molecular mechanisms of ischemic preconditioning and postconditioning as putative therapeutic targets to reduce tumor survival and malignancy
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Bologna, Italy National Institute for Cardiovascular Research, Bologna, Italy BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, Ozzano Emilia BO, Italy Electronic address
    Med Hypotheses 81:1141-5. 2013
  2. pmc Priming adult stem cells by hypoxic pretreatments for applications in regenerative medicine
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    J Biomed Sci 20:63. 2013
  3. pmc Restored perfusion and reduced inflammation in the infarcted heart after grafting stem cells with a hyaluronan-based scaffold
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna 40126, Italy
    J Cell Mol Med 17:518-30. 2013
  4. doi Comparison between stem cells harvested from wet and dry lipoaspirates
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Connect Tissue Res 54:34-40. 2013
  5. doi Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Surg Res 164:e27-35. 2010
  6. doi Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Biochem 103:1046-52. 2008
  7. ncbi Different expression of NOS isoforms in early endothelial progenitor cells derived from peripheral and cord blood
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    J Cell Biochem 102:992-1001. 2007
  8. ncbi Long-term treatment with N-acetylcysteine, but not caloric restriction, protects mesenchymal stem cells of aged rats against tumor necrosis factor-induced death
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Exp Gerontol 41:800-4. 2006
  9. pmc Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage
    Claudio Muscari
    Department of Biochemistry, University of Bologna and National Institute for Cardiovascular Research, Bologna, Italy
    Biol Proced Online 12:9023. 2010
  10. ncbi Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Cell Biochem Funct 24:511-8. 2006

Collaborators

Detail Information

Publications31

  1. doi Molecular mechanisms of ischemic preconditioning and postconditioning as putative therapeutic targets to reduce tumor survival and malignancy
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Bologna, Italy National Institute for Cardiovascular Research, Bologna, Italy BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, Ozzano Emilia BO, Italy Electronic address
    Med Hypotheses 81:1141-5. 2013
    ..As a consequence, this strategy should be effective in blunting tumor capacity to progress toward malignancy and survive in ischemic conditions. ..
  2. pmc Priming adult stem cells by hypoxic pretreatments for applications in regenerative medicine
    Claudio Muscari
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    J Biomed Sci 20:63. 2013
    ..Stem cell adaptation to their natural hypoxic microenvironments (niche) in healthy and neoplastic tissues will be also considered. ..
  3. pmc Restored perfusion and reduced inflammation in the infarcted heart after grafting stem cells with a hyaluronan-based scaffold
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna 40126, Italy
    J Cell Mol Med 17:518-30. 2013
    ..These beneficial effects are superior to those obtained after grafting only the scaffold or MSCs, suggesting that a synergic action was achieved using the cell-integrated polymer construct...
  4. doi Comparison between stem cells harvested from wet and dry lipoaspirates
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Connect Tissue Res 54:34-40. 2013
    ..In conclusion, WL yields about 40% fewer ASC than DL due to the combined effect of tissue dilution and the reduced frequency of ASC in the SVF. The main biological features of ASC are suitable for cell-based therapies...
  5. doi Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Surg Res 164:e27-35. 2010
    ..The observed decrease in GSH/GSSG ratio and activation of JNK in the reperfused heart suggested that proteolysis could be triggered by reactive oxygen species...
  6. doi Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Biochem 103:1046-52. 2008
    ..These results suggest that polyamine depletion can represent a useful strategy to improve MSC differentiation into the cardiac lineage, especially in the presence of cardiomyocytes damaged by an ischemic environment...
  7. ncbi Different expression of NOS isoforms in early endothelial progenitor cells derived from peripheral and cord blood
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    J Cell Biochem 102:992-1001. 2007
    ....
  8. ncbi Long-term treatment with N-acetylcysteine, but not caloric restriction, protects mesenchymal stem cells of aged rats against tumor necrosis factor-induced death
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Exp Gerontol 41:800-4. 2006
    ..In conclusion, a prolonged supplementation with N-acetylcysteine in rats can increase resistance to necrotic death of MSCs and may also counteract an excessive rate of MSC proliferation...
  9. pmc Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage
    Claudio Muscari
    Department of Biochemistry, University of Bologna and National Institute for Cardiovascular Research, Bologna, Italy
    Biol Proced Online 12:9023. 2010
    ..BMMCs could better specialize for capillary formation in the presence of fibronectin and an elevated concentration of VEGF, whilst pig MSCs anyway showed a limited capability to differentiate into the endothelial cell lineage...
  10. ncbi Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Cell Biochem Funct 24:511-8. 2006
    ..Mitochondria can contribute to cell survival by the attenuation of proton leak from inner membrane...
  11. ncbi Evaluation of nitric oxide release in the coronary effluent by a novel EPR technique: a study on isolated rat hearts subjected to cold cardioplegia and reperfusion
    Claudio Muscari
    Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Life Sci 74:109-23. 2003
    ..Therefore, we suggest that the coronary spasm following a cold cardioplegic arrest is not due to an impaired production of basal NO and that NO-donors can be effective in relaxing vascular smooth muscle cells...
  12. ncbi Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Stem Cells 23:983-91. 2005
    ..Thus, polyamine depletion can be considered a useful tool for counteracting programmed cell death in BMSCs without involving the p53 proapoptotic protein...
  13. ncbi Early preconditioning prevents the loss of endothelial nitric oxide synthase and enhances its activity in the ischemic/reperfused rat heart
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    Life Sci 74:1127-37. 2004
    ..This suggest that early ischemic preconditioning may be useful to accelerate the complete recovery of endothelial function by preserving the level of cardiac eNOS and stimulating the basal production of nitric oxide...
  14. ncbi Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia
    Benedetta Tantini
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Cell Cardiol 40:775-82. 2006
    ..In conclusion, this finding may suggest novel pharmacological approaches for the protection of cardiomyocytes injury caused by ischemia...
  15. doi Localization of mesenchymal stem cells grafted with a hyaluronan-based scaffold in the infarcted heart
    Emanuela Fiumana
    Department of Biochemistry, University of Bologna, Bologna, Italy National Institute for Cardiovascular Research INRC, Bologna, Italy
    J Surg Res 179:e21-9. 2013
    ..The aim of this work was to investigate the localization of mesenchymal stem cells (MSCs) grafted with a well cell-adhesive polymer in the scar region of the infarcted heart...
  16. ncbi Evaluation of cellular energetics by the pasteur effect in intact cardiomyoblasts and isolated perfused hearts
    Claudio Muscari
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Mol Cell Biochem 258:91-7. 2004
    ..9%), it was 25% lower than control (p < 0.05). Therefore, we proposed this test as a tool for quantifying both physiological and pathological energetic modifications in living intact cardiomyocytes and in isolated and perfused hearts...
  17. doi Epigenetic signature of early cardiac regulatory genes in native human adipose-derived stem cells
    Alice Pasini
    Laboratory of Cellular and Molecular Engineering S Cavalcanti, University of Bologna, Campus of Cesena, Via Venezia, 52, 47521, Cesena, FC, Italy
    Cell Biochem Biophys 67:255-62. 2013
    ..These results suggest that the chromatin arrangement of these early cardiac regulatory genes could be explored as a level of intervention to address the differentiation of human ADSCs toward the cardiac lineage. ..
  18. pmc Mechanostimulation protocols for cardiac tissue engineering
    Marco Govoni
    BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, I 40064 Ozzano Emilia, Italy
    Biomed Res Int 2013:918640. 2013
    ..In the last fifteen years a large number of dynamic culture devices have been developed and many results have been collected. The aim of this brief review is to resume in a single streamlined paper the state of the art in this field. ..
  19. doi Architectural organization and functional features of early endothelial progenitor cells cultured in a hyaluronan-based polymer scaffold
    Gianandrea Pasquinelli
    Division of Clinical Pathology, Department of Radiological and Histocytopathological Sciences, University of Bologna, Bologna, Italy
    Tissue Eng Part A 15:2751-62. 2009
    ..These results indicate that non-woven HYAFF-11 could be a promising candidate as a vehicle for eEPCs for regenerative medicine applications...
  20. ncbi Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms
    Giulio Agnetti
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Life Sci 78:264-70. 2005
    ....
  21. doi An innovative stand-alone bioreactor for the highly reproducible transfer of cyclic mechanical stretch to stem cells cultured in a 3D scaffold
    Marco Govoni
    Department of Biochemistry G Moruzzi, University of Bologna, Italy Laboratory of Cellular and Molecular Engineering, University of Bologna, Cesena, Italy Health Science and Technology Interdepartmental Centre for Industrial Research HST CIRI, University of Bologna, Ozzano Emilia, Italy
    J Tissue Eng Regen Med 8:787-93. 2014
    ..This device is thus proposed as a prototypal instrument to obtain pseudotissue constructs to test in cardiovascular regenerative medicine, using good manufacturing procedures...
  22. pmc Hyaluronan and cardiac regeneration
    Francesca Bonafe
    Department of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna, Via Irnerio, 48, Bologna, 40126, Italy
    J Biomed Sci 21:100. 2014
    ....
  23. ncbi Nitric oxide synthase activity in rat cardiac mitochondria
    Barbara Zanella
    Department of Biochemistry, G Moruzzi University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    Basic Res Cardiol 99:159-64. 2004
    ..8 +/- 5 pmol/mg protein/30 min. This dual mtNOS machinery is suggested to be involved in modulating cardiac O(2) consumption in different (patho)physiological conditions...
  24. doi Mechanical Actuation Systems for the Phenotype Commitment of Stem Cell-Based Tendon and Ligament Tissue Substitutes
    Marco Govoni
    BioEngLab, Health Science and Technology Interdepartmental Center for Industrial Research HST CIRI, University of Bologna, Ozzano Emilia, BO, Italy
    Stem Cell Rev 12:189-201. 2016
    ..However, due to the scarcity of in vivo research, standard protocols still need to be defined for clinical applications. ..
  25. doi Adipose-derived stem cell adhesion on laminin-coated microcarriers improves commitment toward the cardiomyogenic lineage
    Jean Pierre Karam
    LUNAM Université, UMR S 1066 F 49933, Angers, France NSERM U1066, MINT Micro et Nanomédecines Biomimétiques, F 49933, Angers, France INRC National Institute for Cardiovascular Research, 40126, Bologna, Italy Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126, Bologna, Italy
    J Biomed Mater Res A 103:1828-39. 2015
    ..These results suggest that PAMs offering a LM biomimetic surface may be efficiently used for applications combining adult stem cells in tissue-engineering strategies of the ischemic heart...
  26. doi Nitric oxide regulates multiple functions and fate of adult progenitor and stem cells
    Francesca Bonafe
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio, 48, 40126, Bologna, Italy
    J Physiol Biochem 71:141-53. 2015
    ....
  27. doi Cancer stem cells and mesenchymal stem cells in the hypoxic tumor niche: two different targets for one only drug
    Francesca Bonafe
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Electronic address
    Med Hypotheses 84:227-30. 2015
    ..Corresponding experimental approaches to perform pre-clinical studies and verify this hypothesis are also addressed. ..
  28. doi Pharmacologically active microcarriers associated with thermosensitive hydrogel as a growth factor releasing biomimetic 3D scaffold for cardiac tissue-engineering
    Jean Pierre Karam
    LUNAM Université, UMR S 1066, F 49933 Angers, France INSERM U1066, MINT Micro et Nanomédecines Biomimétiques, F 49933 Angers, France National Institute for Cardiovascular Research INRC, I 40126 Bologna, Italy Department of Biomedical and NeuroMotor Sciences DIBINEM, University of Bologna, 40126 Bologna, Italy
    J Control Release 192:82-94. 2014
    ....
  29. ncbi Myocardial protection in adult cardiac surgery: current options and future challenges
    Francesco Nicolini
    Department of Cardiac Surgery, University of Parma, Parma, Italy
    Eur J Cardiothorac Surg 24:986-93. 2003
    ....
  30. ncbi [Regeneration of infarcted cardiac tissue: the route of stem cells]
    Francesca Bonafe
    Centro Ricerche sul Metabolismo Cardiaco Dipartimento di Biochimica G Moruzzi, Università degli Studi Via Irnerio, 48 40126 Bologna
    Ital Heart J Suppl 4:299-305. 2003
    ..A deeper investigation of these findings in the clinical field could lead to the identification of new therapeutic strategies aimed at ameliorating the cardiac performance of the infarcted patients for short and long periods...