Giovanni Ponti

Summary

Affiliation: University of modena and Reggio Emilia
Location: Modena, Italy
Summary:
BACKGROUND: By dermoscopy, regression structures are substantially defined by the presence of white and blue areas in the lesion image. As fibrosis and melanosis are often seen in malignant melanoma (MM), the presence of dermoscopic signs of regression may represent a clue for the diagnosis of malignancy.

OBJECTIVES: To assess the frequency and extent of dermoscopic signs of regression in melanoma in situ (MIS) and to describe its dermoscopic features.

METHODS: Dermoscopic images of 85 MIS, 85 invasive MMs and 85 dermoscopically equivocal lesions with a histological diagnosis of naevus were evaluated by three dermatologists, who assessed the presence of 11 parameters of regression.

RESULTS: The number of regression parameters per lesion increased according to melanoma thickness. White areas, the grey-blue veil and widespread blue areas were more frequent in invasive MMs than in the other two lesion groups, whereas light brown areas and regression of dermoscopic structures were more frequent in MIS. Peppering was observable in the same percentage of MIS and invasive MMs. Blue areas were more frequently structureless in equivocal lesions and invasive MMs, whereas the reticular pattern prevailed in MIS.

CONCLUSIONS: Frequency, morphology, extent and distribution of regression vary according to melanoma thickness and diameter. Lesions with reticular blue regression and light brown areas should undergo surgical excision for the suspicion of MIS. Moreover, the identification of the reticular pattern of blue regression can be considered a significant discriminator and a reliable predictor of MIS.

Grants:
Reticular grey-blue areas of regression as a dermoscopic marker of melanoma in situ.

Seidenari S, Ferrari C, Borsari S, Benati E, Ponti G, Bassoli S, Giusti F, Schianchi S, Pellacani G.

Br J Dermatol. 2010 Aug;163(2):302-9. Epub 2010 Apr 23.
Publications:
Reticular grey-blue areas of regression as a dermoscopic marker of melanoma in situ.

Seidenari S, Ferrari C, Borsari S, Benati E, Ponti G, Bassoli S, Giusti F, Schianchi S, Pellacani G.

Br J Dermatol. 2010 Aug;163(2):302-9. Epub 2010 Apr 23.

Publications

  1. doi request reprint Reticular grey-blue areas of regression as a dermoscopic marker of melanoma in situ
    S Seidenari
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    Br J Dermatol 163:302-9. 2010
  2. pmc Complete pathological response in a patient with multiple liver metastases from colon cancer treated with Folfox-6 chemotherapy plus bevacizumab: a case report
    Norma Malavasi
    University of Modena and Reggio Emilia, Department of Oncology and Haematology, Via del Pozzo, 71 41100 Modena, Italy
    J Hematol Oncol 2:35. 2009
  3. ncbi request reprint The long road to the use of microscope in clinical medicine in vivo: from early pioneering proposals to the modern perspectives of optical biopsy
    Giovanni Ponti
    Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Acta Med Hist Adriat 13:385-92. 2015
  4. doi request reprint Wall paintings facies and their possible genetic correlates in the ancient Pompeii: A bio-anthropologic message from the past?
    Giovanni Ponti
    Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Clinical Pathology Unit, University of Modena and Reggio Emilia, Modena, Italy Electronic address
    Gene 589:151-6. 2016
  5. doi request reprint Skeletal stigmata as keys to access to the composite and ancient Gorlin-Goltz syndrome history: The Egypt, Pompeii and Herculaneum lessons
    Giovanni Ponti
    Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, Italy Electronic address
    Gene 589:104-11. 2016
  6. doi request reprint Muir-Torre Syndrome and founder mismatch repair gene mutations: A long gone historical genetic challenge
    G Ponti
    Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Italy Electronic address
    Gene 589:127-32. 2016
  7. doi request reprint Giuseppe Moscati (1880-1927): a holistic approach to medicine
    Giovanni Ponti
    Department of Clinical Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia via del Pozzo Modena, Italy
    J Med Biogr 22:80-2. 2014
  8. ncbi request reprint Giuseppe Moscati: a man, a physician and a scientist
    Giovanni Ponti
    Department of Clinical Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, Modena, Italy
    Acta Med Hist Adriat 13:171-80. 2015
  9. pmc Hypomelanosis of Ito with a trisomy 2 mosaicism: a case report
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124 Modena, Italy
    J Med Case Rep 8:333. 2014
  10. doi request reprint Muir-Torre syndrome or phenocopy? The value of the immunohistochemical expression of mismatch repair proteins in sebaceous tumors of immunocompromised patients
    G Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, Via del Pozzo, 41100, Modena, Italy
    Fam Cancer 13:553-61. 2014

Collaborators

  • S Seidenari
  • G Pellacani
  • Lorenza Pastorino
  • Norma Malavasi
  • Giovanna Bianchi-Scarra
  • Annamaria Pollio
  • Sara Bassoli
  • Aldo Tomasi
  • Carmelo Guarneri
  • Francesca Giusti
  • Paola Ghiorzo
  • Cristel Ruini
  • Caterina Longo
  • William Bruno
  • Gabriele Luppi
  • Pier Franco Conte
  • Roberta Depenni
  • Federica Bertolini
  • Sandra Zironi

Detail Information

Publications24

  1. doi request reprint Reticular grey-blue areas of regression as a dermoscopic marker of melanoma in situ
    S Seidenari
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    Br J Dermatol 163:302-9. 2010
    ..As fibrosis and melanosis are often seen in malignant melanoma (MM), the presence of dermoscopic signs of regression may represent a clue for the diagnosis of malignancy...
  2. pmc Complete pathological response in a patient with multiple liver metastases from colon cancer treated with Folfox-6 chemotherapy plus bevacizumab: a case report
    Norma Malavasi
    University of Modena and Reggio Emilia, Department of Oncology and Haematology, Via del Pozzo, 71 41100 Modena, Italy
    J Hematol Oncol 2:35. 2009
    ..Excellent responses to bevacizumab-containing regimens do occur and referral to surgical oncology is a crucial step for documentation of complete pathological response...
  3. ncbi request reprint The long road to the use of microscope in clinical medicine in vivo: from early pioneering proposals to the modern perspectives of optical biopsy
    Giovanni Ponti
    Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Acta Med Hist Adriat 13:385-92. 2015
    ....
  4. doi request reprint Wall paintings facies and their possible genetic correlates in the ancient Pompeii: A bio-anthropologic message from the past?
    Giovanni Ponti
    Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Clinical Pathology Unit, University of Modena and Reggio Emilia, Modena, Italy Electronic address
    Gene 589:151-6. 2016
    ....
  5. doi request reprint Skeletal stigmata as keys to access to the composite and ancient Gorlin-Goltz syndrome history: The Egypt, Pompeii and Herculaneum lessons
    Giovanni Ponti
    Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, Italy Electronic address
    Gene 589:104-11. 2016
    ....
  6. doi request reprint Muir-Torre Syndrome and founder mismatch repair gene mutations: A long gone historical genetic challenge
    G Ponti
    Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Italy Electronic address
    Gene 589:127-32. 2016
    ....
  7. doi request reprint Giuseppe Moscati (1880-1927): a holistic approach to medicine
    Giovanni Ponti
    Department of Clinical Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia via del Pozzo Modena, Italy
    J Med Biogr 22:80-2. 2014
    ..In order to respond better to both the physical and spiritual needs of his patients, he developed his own holistic approach to healthcare involving meticulous drug regimens, meditation and discipline. ..
  8. ncbi request reprint Giuseppe Moscati: a man, a physician and a scientist
    Giovanni Ponti
    Department of Clinical Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, Modena, Italy
    Acta Med Hist Adriat 13:171-80. 2015
    ..This extraordinary man put considerable emphasis on primary care and holistic health in Italy, pioneering a new patient-centred, and holistic approach to medicine. ..
  9. pmc Hypomelanosis of Ito with a trisomy 2 mosaicism: a case report
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124 Modena, Italy
    J Med Case Rep 8:333. 2014
    ..Despite the preponderance of reported sporadic hypomelanosis of Ito, few reports of familial hypomelanosis of Ito have been described...
  10. doi request reprint Muir-Torre syndrome or phenocopy? The value of the immunohistochemical expression of mismatch repair proteins in sebaceous tumors of immunocompromised patients
    G Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, Via del Pozzo, 41100, Modena, Italy
    Fam Cancer 13:553-61. 2014
    ..IHC false positives are probably due to epigenetic alterations. MSI and lack of expression of MMR proteins can be recognized also in immunocompromised patients without MMR germline mutations...
  11. pmc Multiphoton laser tomography and fluorescence lifetime imaging of melanoma: morphologic features and quantitative data for sensitive and specific non-invasive diagnostics
    Stefania Seidenari
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    PLoS ONE 8:e70682. 2013
    ..Data from prospective preoperative trials are needed to confirm if MPT/FLIM could increase diagnostic specificity and thus reduce unnecessary surgical excisions. ..
  12. ncbi request reprint NF1 truncating mutations associated to aggressive clinical phenotype with elephantiasis neuromatosa and solid malignancies
    Giovanni Ponti
    Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, Italy
    Anticancer Res 34:3021-30. 2014
    ..In the present study, the authors discuss the clinical and biomolecular characterization of a cohort of 20 families with a diagnosis of type 1 neurofibromatosis...
  13. pmc Molecular targeted approaches for advanced BRAF V600, N-RAS, c-KIT, and GNAQ melanomas
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Dis Markers 2014:671283. 2014
    ..In our report, a practical flow chart is described along with our experience in this field. ..
  14. pmc Proteomic analysis of PTCH1+/- fibroblast lysate and conditioned culture media isolated from the skin of healthy subjects and nevoid basal cell carcinoma syndrome patients
    Giovanni Ponti
    Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Via del Pozzo, 41100 Modena, Italy
    Biomed Res Int 2013:794028. 2013
    ..The aim of this study was to compare the proteomic profile of cultured fibroblast and fibroblast conditioned culture media of PTCH1+ and nonmutated fibroblasts...
  15. pmc Novel PTCH1 mutations in patients with keratocystic odontogenic tumors screened for nevoid basal cell carcinoma (NBCC) syndrome
    Lorenza Pastorino
    Department of Internal Medicine and Medical Specialties University of Genoa, Genoa, Italy
    PLoS ONE 7:e43827. 2012
    ..Keratocystic odontogenic lesions are uncommon, and their discovery deserves the search for associated cutaneous basal cell carcinomas and other benign and malignant tumors related to NBCCS...
  16. pmc Diagnostic and pathogenetic role of café-au-lait macules in nevoid basal cell carcinoma syndrome
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, University of Modena and Reggio Emilia, Via del Pozzo 71, Modena, Italy
    Hered Cancer Clin Pract 10:15. 2012
    ..In our experience, we have noted an association of CALS with NBCCS; this seems interesting because we already know clinical criteria are a dynamic entity and can be modified by epidemiologic evidences...
  17. pmc Overwhelming response to Dabrafenib in a patient with double BRAF mutation (V600E; V600M) metastatic malignant melanoma
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, via del Pozzo 7, 41100, Modena, Italy
    J Hematol Oncol 5:60. 2012
    ..CT scan of June 2012 documented the astonishing clinical response...
  18. doi request reprint The somatic affairs of BRAF: tailored therapies for advanced malignant melanoma and orphan non-V600E (V600R-M) mutations
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, Modena, Italy
    J Clin Pathol 66:441-5. 2013
    ..However, all of them are still under treatment and disease progression free. An objective response with few side effects was observed in all patients. in vitro studies with the aim of testing drug sensitivity...
  19. doi request reprint Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes
    Giovanni Ponti
    Department of Clinical and Diagnostic Medicine and Public Health, University Hospital of Modena and Reggio Emilia, Italy
    Crit Rev Oncol Hematol 85:239-56. 2013
    ....
  20. doi request reprint Ameloblastoma: a neglected criterion for nevoid basal cell carcinoma (Gorlin) syndrome
    Giovanni Ponti
    Department of Head and Neck Surgery, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy
    Fam Cancer 11:411-8. 2012
    ..Thus, we propose the inclusion of ameloblasoma as criterion for the identification of NBCCS...
  21. doi request reprint Value and prognostic significance of mitotic rate in a retrospective series of pT1 cutaneous malignant melanoma patients
    G Ponti
    Department of Internal Medicine, Division of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, Modena, Italy
    Cancer Epidemiol 36:303-5. 2012
    ..The seventh edition of the American Joint Committee on Cancer (AJCC) melanoma staging system, introduced mitotic rate (MR) as one of the primary criteria for staging thin melanoma...
  22. doi request reprint Unicystic ameloblastoma associated with the novel K729M PTCH1 mutation in a patient with nevoid basal cell carcinoma (Gorlin) syndrome
    Giovanni Ponti
    Department of Head and Neck Surgery, Division of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    Cancer Genet 205:177-81. 2012
    ....
  23. pmc Clinico-pathological and biomolecular findings in Italian patients with multiple cutaneous neurofibromas
    Giovanni Ponti
    Department of Internal Medicine, Division of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    Hered Cancer Clin Pract 9:6. 2011
    ..As a consequence, a high number of cases (up to 50%) are sporadic. Mutation detection is complex due to the large size of the NF1 gene, the presence of pseudogenes and the great variety of lesions...
  24. pmc Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers
    Giovanni Ponti
    Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy
    J Hematol Oncol 3:2. 2010
    ....