N Principi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc Infectious Discitis and Spondylodiscitis in Children
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Int J Mol Sci 17:539. 2016
  2. pmc Prevention of Community-Acquired Pneumonia with Available Pneumococcal Vaccines
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Int J Mol Sci 18:. 2016
  3. doi request reprint Influenza vaccination in patients with end-stage renal disease
    Nicola Principi
    Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Via Commenda 9 20122, Milano, Italy 39 02 55032203 39 02 50320206
    Expert Opin Drug Saf 14:1249-58. 2015
  4. pmc Kingella kingae infections in children
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    BMC Infect Dis 15:260. 2015
  5. pmc Nasal saline irrigation in preschool children: a survey of attitudes and prescribing habits of primary care pediatricians working in northern Italy
    Paola Marchisio
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Ital J Pediatr 40:47. 2014
  6. pmc Performance of lung ultrasonography in children with community-acquired pneumonia
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Ital J Pediatr 40:37. 2014
  7. pmc A case of meningitis due to varicella zoster virus reactivation in an immunocompetent child
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Ital J Pediatr 39:72. 2013
  8. pmc Intestinal tuberculosis in a child living in a country with a low incidence of tuberculosis: a case report
    Piera Dones
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    BMC Res Notes 7:762. 2014
  9. pmc Genetic polymorphisms and risk of recurrent wheezing in pediatric age
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    BMC Pulm Med 14:162. 2014
  10. pmc Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    BMC Pulm Med 14:130. 2014

Detail Information

Publications160 found, 100 shown here

  1. pmc Infectious Discitis and Spondylodiscitis in Children
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Int J Mol Sci 17:539. 2016
    ..the appropriate choice of drug is critical to achieve cure. ..
  2. pmc Prevention of Community-Acquired Pneumonia with Available Pneumococcal Vaccines
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Int J Mol Sci 18:. 2016
    ..Protein-based pneumococcal vaccines might be a possible solution to this problem...
  3. doi request reprint Influenza vaccination in patients with end-stage renal disease
    Nicola Principi
    Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Via Commenda 9 20122, Milano, Italy 39 02 55032203 39 02 50320206
    Expert Opin Drug Saf 14:1249-58. 2015
    ..However, influenza vaccination coverage of patients with ESRD is significantly lower than desired...
  4. pmc Kingella kingae infections in children
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    BMC Infect Dis 15:260. 2015
    ..The aim of this review is therefore to summarise current knowledge of the epidemiology, transmission, clinical presentation, diagnosis and treatment of K. kingae infections in children...
  5. pmc Nasal saline irrigation in preschool children: a survey of attitudes and prescribing habits of primary care pediatricians working in northern Italy
    Paola Marchisio
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Ital J Pediatr 40:47. 2014
    ..The main aim of this study was to evaluate the use of NSI in pre-school children by primary care pediatricians working in northern Italy...
  6. pmc Performance of lung ultrasonography in children with community-acquired pneumonia
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Ital J Pediatr 40:37. 2014
    ..The aim of this study was to bridge this gap in order to increase our knowledge of the performance of US in diagnosing CAP in childhood...
  7. pmc A case of meningitis due to varicella zoster virus reactivation in an immunocompetent child
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Ital J Pediatr 39:72. 2013
    ..Only a few cases have been described in the literature, most of which involved adult or elderly patients...
  8. pmc Intestinal tuberculosis in a child living in a country with a low incidence of tuberculosis: a case report
    Piera Dones
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    BMC Res Notes 7:762. 2014
    ..The main diagnostic dilemma is to differentiate intestinal tuberculosis and Crohn's disease because a misdiagnosis can have dramatic consequences...
  9. pmc Genetic polymorphisms and risk of recurrent wheezing in pediatric age
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    BMC Pulm Med 14:162. 2014
    ....
  10. pmc Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma
    Susanna Esposito
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    BMC Pulm Med 14:130. 2014
    ....
  11. pmc Clinical profile of recurrent community-acquired pneumonia in children
    Francesca Patria
    Department of Pathophysiology and Transplantation, Pediatric Highly Intensive Care Unit, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, Milan 20122, Italy
    BMC Pulm Med 13:60. 2013
    ....
  12. pmc Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a child
    Susanna Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    BMC Infect Dis 13:461. 2013
    ..Unfortunately, it is not easy to diagnose TB in the first years of life because of the diversity of its clinical presentation and the non-specific nature of most of its symptoms...
  13. doi request reprint Vaccine use in primary immunodeficiency disorders
    Nicola Principi
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy Electronic address
    Vaccine 32:3725-31. 2014
    ..The main aim of this paper is to discuss what is currently known about how and when vaccines can be used in patients with PIDs in order to facilitate physician choices and assure the best possible patient protection. ..
  14. pmc Effects of coronavirus infections in children
    Nicola Principi
    University of Milan, Milan, Italy
    Emerg Infect Dis 16:183-8. 2010
    ..Thus, circulating HCoVs should be closely monitored to detect the spread of particularly virulent strains in the community at an early stage and to facilitate the development of adequate preventive and therapeutic measures...
  15. pmc Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children: implications for the use of heptavalent pneumococcal conjugate vaccine
    Paola Marchisio
    University of Milan, Via Commenda 9, 20122 Milan, Italy
    Emerg Infect Dis 8:479-84. 2002
    ..pneumoniae. Most isolated strains are covered by the heptavalent conjugate vaccine, especially in the first years of life, suggesting that its use could reduce the incidence of pneumococcal disease...
  16. doi request reprint Adolescents and vaccines in the western world
    Nicola Principi
    Pediatric High Intensity Care Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy Electronic address
    Vaccine 31:5366-74. 2013
    ..Every effort should be made to overcome the barriers to adolescent immunisation, including those arising from the adolescents themselves. ..
  17. pmc Burden of paediatric influenza in Western Europe: a systematic review
    Evgeniya N Antonova
    MedImmune, LLC, 1 MedImmune Way, Gaithersburg, Maryland 20878, USA
    BMC Public Health 12:968. 2012
    ..Our aim was to summarise influenza burden (in terms of health outcomes and economic burden) in children in Western Europe via a systematic literature review...
  18. pmc Severe vitamin B12 deficiency in an exclusively breastfed 5-month-old Italian infant born to a mother receiving multivitamin supplementation during pregnancy
    Sophie Guez
    Pediatric Clinic 1, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    BMC Pediatr 12:85. 2012
    ..In infants, vitamin B12 deficiency may be due to an inborn error of absorption and metabolism, or nutritional problems...
  19. pmc Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children
    Susanna Esposito
    Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, Milano, 20122, Italy
    Virol J 9:270. 2012
    ..The aim of this study was to evaluate whether selected polymorphisms of TLR2, TLR3 and TLR4 influence the incidence and clinical picture of pandemic A/H1N1/2009 influenza...
  20. doi request reprint Diagnosis and therapy of tuberculous meningitis in children
    Nicola Principi
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    Tuberculosis (Edinb) 92:377-83. 2012
    ..In the meantime, when treating a child with suspected TBM, the most aggressive attitude to diagnosis and therapy is necessary, because TBM is a devastating disease...
  21. pmc Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
    Susanna Esposito
    Pediatric Clinic 1, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy
    Malar J 11:196. 2012
    ....
  22. doi request reprint Adjuvanted influenza vaccines
    Nicola Principi
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Hum Vaccin Immunother 8:59-66. 2012
    ..The aim of this review is to discuss the characteristics and advantages of the adjuvants that have so far been used and to describe some of the new adjuvants that are still in the development phase...
  23. doi request reprint Prevention of acute otitis media using currently available vaccines
    Nicola Principi
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Future Microbiol 7:457-65. 2012
    ..The aim of this review is to examine the clinical impact of vaccinations on AOM...
  24. doi request reprint Use of the 13-valent pneumococcal conjugate vaccine in infants and young children
    Nicola Principi
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    Expert Opin Biol Ther 12:641-8. 2012
    ....
  25. pmc Antibody response of healthy children to pandemic A/H1N1/2009 influenza virus
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    Virol J 8:563. 2011
    ....
  26. pmc Viral shedding in children infected by pandemic A/H1N1/2009 influenza virus
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Virol J 8:349. 2011
    ....
  27. pmc Clinical importance and impact on the households of oseltamivir-resistant seasonal A/H1N1 influenza virus in healthy children in Italy
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Virol J 7:202. 2010
    ....
  28. pmc Collection by trained pediatricians or parents of mid-turbinate nasal flocked swabs for the detection of influenza viruses in childhood
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Virol J 7:85. 2010
    ..Moreover, the direct involvement of parents significantly increases patient acceptance, thus simplifying collection and suggesting that this novel swab design should be considered for epidemiological surveys and vaccine efficacy studies...
  29. pmc Impact on respiratory tract infections of heptavalent pneumococcal conjugate vaccine administered at 3, 5 and 11 months of age
    Susanna Esposito
    Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Respir Res 8:12. 2007
    ..This study was designed to evaluate the impact of PCV-7 administered at 3, 5 and 11 months of age on respiratory tract infections in very young children...
  30. pmc Influenza vaccination among healthcare workers in a multidisciplinary University hospital in Italy
    Susanna Esposito
    Institute of Pediatrics, University of Milan, IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    BMC Public Health 8:422. 2008
    ..The aim of this study was to evaluate the current vaccination status of the HCWs in one of Italy's largest multidisciplinary University Hospitals...
  31. pmc Self-reported pediatricians' management of the well-appearing young child with fever without a source: first survey in an European country in the anti-pneumococcal vaccine era
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Public Health 9:300. 2009
    ..To investigate whether the introduction of PCV might affect clinical decision making, we conducted a cross-sectional survey aimed at Italian Pediatric physicians...
  32. pmc Knowledge of human papillomavirus infection and its prevention among adolescents and parents in the greater Milan area, Northern Italy
    Claudio Pelucchi
    Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    BMC Public Health 10:378. 2010
    ..The aim of this study was to provide data on the knowledge of Italian adolescents and parents concerning human papillomavirus (HPV) infection and its prevention in order to allow the development of adequate training programmes...
  33. pmc Clinical and socioeconomic impact of different types and subtypes of seasonal influenza viruses in children during influenza seasons 2007/2008 and 2008/2009
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    BMC Infect Dis 11:271. 2011
    ..This study evaluates the clinical presentation and socio-economic impact of laboratory-confirmed influenza A/H1N1, A/H3N2 or B infection in children attending an Emergency Room because of influenza-like illness...
  34. pmc Altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    BMC Infect Dis 10:305. 2010
    ..The aim of this study was to verify the real frequency of heart involvement in patients with bronchiolitis associated with RSV infection, and whether infants with mild or moderate disease also risk heart malfunction...
  35. ncbi request reprint Epidemiology of Streptococcus pneumoniae in Italian children
    N Principi
    Paediatric Department, University of Milan, Ospedale L Sacco, Italy
    Acta Paediatr Suppl 89:40-3. 2000
    ..2%, while for macrolides it reaches 25.5%. More data on the distribution of serotypes in Italian children are urgently needed in order to obtain a better understanding of the impact of the new pneumococcal vaccines...
  36. ncbi request reprint Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections
    N Principi
    Pediatric Department I, University of Milan, Milan, Italy
    Clin Infect Dis 32:1281-9. 2001
    ..pneumoniae and/or C. pneumoniae plays a significant role in community-acquired LRTIs in children of all ages and that such infections have a more complicated course when not treated with adequate antimicrobial agents...
  37. ncbi request reprint Emerging role of Mycoplasma pneumoniae and Chlamydia pneumoniae in paediatric respiratory-tract infections
    N Principi
    Department of Paediatrics, Azienda Ospedaliera Istituti Clinici di Perfezionamento, Milan, Italy
    Lancet Infect Dis 1:334-44. 2001
    ..However, a number of therapeutic issues remain unsolved...
  38. ncbi request reprint Mycoplasma pneumoniae and Chlamydia pneumoniae cause lower respiratory tract disease in paediatric patients
    Nicola Principi
    Paediatric Department I, University of Milan, Milan, Italy
    Curr Opin Infect Dis 15:295-300. 2002
    ..Carefully randomized and controlled trials are clearly needed to examine the effectiveness of different antibiotics against M. pneumoniae or C. pneumoniae and the optimal duration of therapy in various patient populations...
  39. ncbi request reprint [Anti-varicella vaccine: immunogenicity, efficacy, and safety]
    N Principi
    Clinica Pediatrica I, Universita degli Studi di Milano
    Ann Ig 14:51-4. 2002
  40. ncbi request reprint [Efficacy of the heptavalent pneumococcal vaccine against meningitis, pneumonia and acute otitis media in pediatric age. Theoretical coverage offered by the heptavalent conjugate vaccine in Italy]
    N Principi
    Clinica Pediatrica I, Universita degli Studi di Milano
    Ann Ig 14:21-30. 2002
    ..We hope that this vaccine can be systematically prescribed also in Italy: this could permit to reduce the number of both common and severe pneumococcal diseases at the moment largely present among italian children...
  41. ncbi request reprint Recurrent respiratory tract infections in pediatric age: a population-based survey of the therapeutic role of macrolides
    N Principi
    Pediatric Department I, University of Milan, Italy
    J Chemother 15:53-9. 2003
    ....
  42. ncbi request reprint Paediatric community-acquired pneumonia: current concept in pharmacological control
    Nicola Principi
    Paediatric Department I, University of Milan, Via Commenda 9, 20122 Milano, Italy
    Expert Opin Pharmacother 4:761-77. 2003
    ..In order to avoid unnecessary antibiotic use and limit the spread of antibiotic resistance, consensus guidelines for the management of CAP in childhood should be developed and used by practitioners in their offices and hospitals...
  43. ncbi request reprint Socioeconomic impact of influenza on healthy children and their families
    Nicola Principi
    Peditric Department I, Univeristy of Milan, Milan, Italy
    Pediatr Infect Dis J 22:S207-10. 2003
    ..Therefore it is difficult to conclude whether the socioeconomic impact of influenza justifies vaccinating all children regardless of age or underlying chronic disorders...
  44. ncbi request reprint Are we ready for universal influenza vaccination in paediatrics?
    Nicola Principi
    Institute of Paediatrics of the University of Milan, Italy
    Lancet Infect Dis 4:75-83. 2004
    ....
  45. ncbi request reprint Evaluation of rapid assay for detection of Streptococcus pneumoniae urinary antigen among infants and young children with possible invasive pneumococcal disease
    Susanna Esposito
    Institute of Pediatrics, University of Milan, Via Commenda 9, 20122 Milan, Italy
    Pediatr Infect Dis J 23:365-7. 2004
    ....
  46. pmc Pediatric influenza prevention and control
    Nicola Principi
    Institute of Pediatrics, University of Milan, Milan, Italy
    Emerg Infect Dis 10:574-80. 2004
    ....
  47. pmc Burden of influenza in healthy children and their households
    N Principi
    Institute of Paediatrics, University of Milan, Milan, Italy
    Arch Dis Child 89:1002-7. 2004
    ..A prospective, multicentre study was conducted to evaluate the burden of laboratory confirmed influenza in healthy children and their household contacts...
  48. ncbi request reprint Human metapneumovirus in paediatric patients
    N Principi
    Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Clin Microbiol Infect 12:301-8. 2006
    ..Further studies are also required to properly define hMPV diagnosis, treatment and prevention strategies...
  49. doi request reprint New insights into pediatric rhinosinusitis
    N Principi
    Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Pediatr Allergy Immunol 18:7-9. 2007
    ....
  50. doi request reprint Antigen-based assays for the identification of influenza virus and respiratory syncytial virus: why and how to use them in pediatric practice
    Nicola Principi
    Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milano, Italy
    Clin Lab Med 29:649-60. 2009
    ..The most recently marketed tests are similarly effective in identifying viruses, and so pediatricians should choose those that are less expensive, less time consuming, and easier to perform and to interpret...
  51. doi request reprint Management of severe community-acquired pneumonia of children in developing and developed countries
    Nicola Principi
    Department of Maternal and Paediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Thorax 66:815-22. 2011
    ....
  52. doi request reprint Present and future of influenza prevention in pediatrics
    Nicola Principi
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Expert Opin Biol Ther 11:641-53. 2011
    ..This makes adequate prevention desirable, and the best means of reducing the incidence and risks of infection in children is influenza vaccination...
  53. doi request reprint Universal protein vaccines against Neisseria meningitidis serogroup B, Streptococcus pneumoniae and influenza
    Nicola Principi
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Hum Vaccin 7:905-12. 2011
    ..This review provides a detailed description of the most important new information concerning protein vaccines against influenza and meningococcal and pneumococcal diseases...
  54. ncbi request reprint Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with pneumonia. Mowgli Study Group
    S Esposito
    Paediatric Dept I, Istituto di Ricerca e di Cura a Carattere Scientifico, Maggiore Hospital, Milan, Italy
    Eur Respir J 17:241-5. 2001
    ..The priorities for future research include the development of rapid, easily accessible and cost-effective diagnostic tests useful for each episode of pneumonia in children...
  55. ncbi request reprint Zidovudine therapy and HIV type 1 mutations in children with symptomatic HIV type 1 infection: effect of switching to didanosine or zidovudine plus didanosine therapy. Italian Multicenter Study Group on HIV Mutations in Children
    N Principi
    Pediatric Department 4, University of Milan, Italy
    AIDS Res Hum Retroviruses 14:1653-9. 1998
    ..These results suggest that genotypic resistance assays, together with viral load, may prove useful for rational treatment decisions both at the start of therapy and with failure...
  56. ncbi request reprint Use of antimicrobial agents for community-acquired lower respiratory tract infections in hospitalised children
    S Esposito
    Pediatric Department 1, University of Milan, Italy
    Eur J Clin Microbiol Infect Dis 20:647-50. 2001
    ..In order to contain costs and limit the risk of resistant bacteria emerging, it is urgent that pediatricians and parents be educated in the proper use of antibiotics...
  57. ncbi request reprint Clinical and socio-economic impact of influenza and respiratory syncytial virus infection on healthy children and their households
    S Esposito
    Institute of Pediatrics, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Clin Microbiol Infect 11:933-6. 2005
    ..The fact that influenza has a similar global clinical impact on the community to that of RSV infection, but represents a greater socio-economic burden, may contribute to broadening the acceptance of influenza vaccination...
  58. doi request reprint A retrospective evaluation of microbiology of acute otitis media complicated by spontaneous otorrhea in children living in Milan, Italy
    P Marchisio
    Department of Pathophysiology and Transplantation, Pediatric Clinic 1, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy
    Infection 41:629-35. 2013
    ..To evaluate the microbiology of acute otitis media (AOM) with otorrhea due to spontaneous tympanic membrane perforation (STMP) in children living in Milan, Italy...
  59. doi request reprint Role of respiratory pathogens in infants hospitalized for a first episode of wheezing and their impact on recurrences
    S Bosis
    Institute of Paediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Clin Microbiol Infect 14:677-84. 2008
    ..A high viral load seems to be strictly related to the likelihood of recurrence...
  60. pmc Efficacy of increasing dosages of clarithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia
    C Tagliabue
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    J Antimicrob Chemother 66:2323-9. 2011
    ..We evaluated the efficacy of increasing dosages of clarithromycin for the optimized therapy of M. pneumoniae respiratory infection in a mouse model...
  61. ncbi request reprint Plasma viremia and virus phenotype are correlates of disease progression in vertically human immunodeficiency virus type 1-infected children
    C Balotta
    Clinica delle Malattie Infettive, University of Milan, Italy
    Pediatr Infect Dis J 16:205-11. 1997
    ..To analyze the relationships among HIV-1 plasma viremia, phenotype and CD4 T cell counts in vertically infected children...
  62. doi request reprint Role of atypical bacteria in children undergoing tonsillectomy because of severely recurrent acute tonsillopharyngitis
    S Esposito
    Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Institute of Pediatrics, University of Milan, Via Commenda 9, 20122, Milano, Italy
    Eur J Clin Microbiol Infect Dis 27:1233-7. 2008
    ..pneumoniae, and that tonsillectomy seems to be effective in reducing the recurrence of both AT and acute respiratory disease during 12 months follow-up postsurgery...
  63. ncbi request reprint Effectiveness of a propolis and zinc solution in preventing acute otitis media in children with a history of recurrent acute otitis media
    P Marchisio
    Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Int J Immunopathol Pharmacol 23:567-75. 2010
    ..No effect can be expected on respiratory infections other than AOM...
  64. ncbi request reprint Use of complementary and alternative medicine in children with recurrent acute otitis media in Italy
    P Marchisio
    Department of Maternal and Paediatric Sciences, Università degli Studi di Milano and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Int J Immunopathol Pharmacol 24:441-9. 2011
    ..Together with the fact that paediatricians are the main prescribers, this is worrying because of the current lack of evidence regarding the efficacy, safety and cost-effectiveness of CAM in the prevention of RAOM...
  65. ncbi request reprint Seasonal variations in nasopharyngeal carriage of respiratory pathogens in healthy Italian children attending day-care centres or schools
    P Marchisio
    Pediatric Department 1, University of Milan, Italy
    J Med Microbiol 50:1095-9. 2001
    ..However, although statistically significant, the difference was slight and had limited clinical relevance. Therefore, seasonal influence on the nasopharyngeal carriage of respiratory pathogens in healthy children was negligible...
  66. ncbi request reprint Asthma in children: are chlamydia or mycoplasma involved?
    S Esposito
    Paediatric Department I, University of Milan, Italy
    Paediatr Drugs 3:159-68. 2001
    ..Carefully controlled randomised trials are clearly warranted to determine whether infection with atypical bacteria is really associated with asthma and to define the appropriate role of antimicrobial treatment...
  67. ncbi request reprint Differences in nasopharyngeal bacterial flora in children with nonsevere recurrent acute otitis media and chronic otitis media with effusion: implications for management
    Paola Marchisio
    Department of Pediatrics, University of Milan, Italy
    Pediatr Infect Dis J 22:262-8. 2003
    ....
  68. ncbi request reprint Effect of highly active antiretroviral therapy on cardiovascular involvement in children with human immunodeficiency virus infection
    Anna Plebani
    Institute of Pediatrics, University of Milan, Milan, Italy
    Pediatr Infect Dis J 23:559-63. 2004
    ....
  69. ncbi request reprint Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections
    Susanna Esposito
    Institute of Pediatrics, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Pediatr Infect Dis J 24:438-44. 2005
    ....
  70. ncbi request reprint [Epidemiology of meningitis, pneumonia and acute otitis due to Streptococcus pneumoniae in pediatric in Italy]
    S Esposito
    Clinica Pediatrica I, Universita degli Studi di Milano
    Ann Ig 14:7-16. 2002
    ..pneumoniae seems to play a significant role in the determination of several pediatric diseases and that quite similar are the group of serotypes mainly involved in the determination of both invasive and not invasive diseases...
  71. doi request reprint Comparison of posterior pharyngeal wall and nasopharyngeal swabbing as a means of detecting the carriage of Neisseria meningitidis in adolescents
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy
    Eur J Clin Microbiol Infect Dis 32:1129-33. 2013
    ..meningitidis carriage in large-scale epidemiological studies because they identify a significantly larger number of pathogen carriers and recover a significantly larger amount of bacterial DNA...
  72. ncbi request reprint Guidelines for the diagnosis and treatment of acute and subacute rhinosinusitis in children
    S Esposito
    Institute of Pediatrics, University of Milan, Milan, Italy
    J Chemother 20:147-57. 2008
    ..These guidelines are based on the 125 that were considered truly relevant and reflect the most widely shared positions concerning the diagnosis and treatment of acute, subacute and recurrent rhinosinusitis in children...
  73. doi request reprint Circulation of different rhinovirus groups among children with lower respiratory tract infection in Kiremba, Burundi
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy
    Eur J Clin Microbiol Infect Dis 31:3251-6. 2012
    ..01) and RV-C with wheezing (p < 0.05). In Burundi, RVs are frequently detected in children with LRTIs. RV-A seems to be the most important species and is identified mainly in patients with bronchitis and CAP...
  74. ncbi request reprint Hypertonic saline is more effective than normal saline in seasonal allergic rhinitis in children
    P Marchisio
    Department of Pathophysiology and Transplantation, University of Milan, Italy
    Int J Immunopathol Pharmacol 25:721-30. 2012
    ..Our data suggest that nasal irrigation with hypertonic saline might be included in the wide spectrum of therapies recommended for grass-pollen AR...
  75. ncbi request reprint Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume
    A Vigano
    Pediatric Department IV, University of Milan, Ospedale Luigi Sacco, Italy
    AIDS 14:251-61. 2000
    ..In children more than in adults, thymic function may be at least partly restored when disease-induced immunosuppression is attenuated by pharmacological means...
  76. ncbi request reprint Emerging role of Mycoplasma pneumoniae in children with acute pharyngitis
    S Esposito
    Pediatric Department I, University of Milan, Via Commenda 9, 20122 Milan, Italy
    Eur J Clin Microbiol Infect Dis 21:607-10. 2002
    ..05 in multivariate analysis). These data, which highlight the emerging role of Mycoplasma pneumoniae in acute pharyngitis, must be taken into account in the diagnosis and treatment of this clinical manifestation in children...
  77. ncbi request reprint Incidence of severe streptococcal-related diseases in Italian children in an era of high group A streptococcal resistance to macrolides. Italian Group A Streptococcal Resistance to Macrolides Study Group
    N Principi
    Pediatric Department 4, University of Milan, Italy
    J Chemother 11:379-84. 1999
    ..Further studies are needed to investigate the biological characteristics of resistant group A streptococcal strains and their relationships to short- and long-term clinical outcomes...
  78. ncbi request reprint Insights into infectious otitis media
    P Marchisio
    Departments of Mother and Child, University of Milan, Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Int J Immunopathol Pharmacol 23:20-3. 2010
    ..In recent years new data have been gathered regarding different microbiological aspects of otitis media. This new knowledge may contribute toward the development and implementation of therapeutic and preventive strategies...
  79. ncbi request reprint Theoretic coverage of heptavalent pneumococcal conjugate vaccine in the prevention of community-acquired pneumonia in children in Italy
    Susanna Esposito
    Pediatric Department I, Via Commenda 9, 20122 Milan, Italy
    Vaccine 21:2704-7. 2003
    ..This study confirms the significant role of S. pneumoniae in pediatric CAP, and highlights the importance of pneumococcal conjugate vaccines in preventing it during the first years of life...
  80. ncbi request reprint [Acute, subacute and recurrent bacterial rhinosinusitis in pediatrics: guidelines of the Study Group of the Italian Society for Pediatric Infectious Diseases (SITIP)]
    S Esposito
    Istituto di Pediatria, Universita di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milano, Italy
    Minerva Pediatr 59:474-5. 2007
  81. doi request reprint Can infants be protected by means of maternal vaccination?
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Clin Microbiol Infect 18:85-92. 2012
    ..This review analyses the advantages and limitations of maternal immunization as revealed by experience and the main publications...
  82. doi request reprint Impact of rhinovirus nasopharyngeal viral load and viremia on severity of respiratory infections in children
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milano, Italy
    Eur J Clin Microbiol Infect Dis 33:41-8. 2014
    ....
  83. doi request reprint DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    Eur J Clin Microbiol Infect Dis 32:877-81. 2013
    ..Although further studies are required, it seems that serotypes not included in PCV13 can play a major role in causing a higher bacterial load and PPE...
  84. doi request reprint No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis, community-acquired pneumonia and acute otitis media
    N Principi
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Commenda 9, 20122 Milano, Italy
    Eur J Clin Microbiol Infect Dis 32:151-60. 2013
    ....
  85. ncbi request reprint Clinical presentation of meningococcal disease in childhood
    C Sabatini
    Pediatric Clinic 1, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    J Prev Med Hyg 53:116-9. 2012
    ....
  86. ncbi request reprint Upper GI bleeding in healthy full-term infants: a case-control study
    M Lazzaroni
    Department of Gastroenterology, L Sacco University Hospital, Milano, Italy
    Am J Gastroenterol 97:89-94. 2002
    ....
  87. doi request reprint Preventing influenza in younger children
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Clin Microbiol Infect 18:42-9. 2012
    ..However, further studies are needed to establish whether universal influenza vaccination in the first years of life should be recommended, and with which vaccine...
  88. ncbi request reprint Fatty acid composition of plasma lipids in HIV-infected children. Comparison with seroreverters
    C Agostoni
    Pediatric Department V, University of Milan, Italy
    Acta Paediatr 89:172-6. 2000
    ..Compared to age-matched seroreverter subjects, HIV-seropositive children show a lipid fatty acid status suggestive of relative LA deficiency and increased turnover of the PUFA series...
  89. ncbi request reprint Meningitis complicated by subdural empyema and deafness caused by pneumoccoccal serotype 7F in a 17-month-old child: a case report
    S Bosis
    Pediatric Clinic 1, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    J Prev Med Hyg 53:98-100. 2012
    ..The 7F strain is not contained in PCV7 (the only vaccine on the market at the time of the onset of meningitis) but is included in the new pediatric 13-valent PCV, which may therefore prevent cases such as this in the future...
  90. ncbi request reprint A randomised comparison of isepamicin and amikacin in the treatment of bacterial infections in paediatric patients
    A Vigano
    Department of Paediatrics, University of Milan, L Sacco Hospital, Italy
    J Chemother 7:95-101. 1995
    ..Thus isepamicin was as effective and as well tolerated as amikacin in the treatment of various infections in paediatric patients...
  91. doi request reprint From clinical practice to guidelines: how to recognize rhinosinusitis in children
    S Esposito
    Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Pediatr Allergy Immunol 18:53-5. 2007
    ..Under these circumstances, computed tomography is the preferred evaluation. Together with their clinical judgment, these suggestions may be useful for pediatricians in diagnosing this common condition...
  92. pmc The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection
    C Tagliabue
    Institute of Pediatrics, University of Milan Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Milan, Italy
    J Infect Dis 198:1180-8. 2008
    ..We evaluated the efficacy of clarithromycin, dexamethasone, and combination therapy for M. pneumoniae respiratory infection...
  93. ncbi request reprint Comparison of manual methods of extracting genomic DNA from dried blood spots collected on different cards: implications for clinical practice
    C G Molteni
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Int J Immunopathol Pharmacol 26:779-83. 2013
    ..These conclusions support the use of Masterpure in studies that evaluate the associations between genetic variants and the severity or prevalence of infectious diseases...
  94. ncbi request reprint Role of vitamin D in children with respiratory tract infection
    S Esposito
    Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Int J Immunopathol Pharmacol 26:1-13. 2013
    ....
  95. ncbi request reprint Streptococcal pharyngitis in Italian children: epidemiology and treatment with miocamycin
    N Principi
    Paediatric Department IV, University of Milan, Italy
    Drugs Exp Clin Res 16:639-47. 1990
    ..The drug exhibited good clinical efficacy (resolution or improvement of acute signs and symptoms) in 96.3% of the children and a microbiological efficacy (eradication of the causative bacteria) in 85.3%...
  96. pmc Long-term pertussis-specific immunity after primary vaccination with a combined diphtheria, tetanus, tricomponent acellular pertussis, and hepatitis B vaccine in comparison with that after natural infection
    S Esposito
    Pediatric Department I, University of Milan, Milan, University of Palermo, Palermo, Italy
    Infect Immun 69:4516-20. 2001
    ..pertussis...
  97. pmc Effect of a rapid influenza diagnosis
    S Esposito
    Paediatric Department I, University of Milan, Italy
    Arch Dis Child 88:525-6. 2003
  98. ncbi request reprint Rhinosinusitis management in pediatrics: an overview
    S Esposito
    Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Int J Immunopathol Pharmacol 23:53-5. 2010
    ....
  99. ncbi request reprint Body composition in HIV-infected children: relations with disease progression and survival
    M Fontana
    Fourth Pediatric Department, University of Milan Medical School, Italy
    Am J Clin Nutr 69:1282-6. 1999
    ..Malnutrition is common in HIV-infected children, but the body compartment that is most affected has been ill defined...
  100. ncbi request reprint Risk factors for carriage of respiratory pathogens in the nasopharynx of healthy children. Ascanius Project Collaborative Group
    N Principi
    Pediatric Department 4, University of Milan Medical School, Italy
    Pediatr Infect Dis J 18:517-23. 1999
    ..To assess risk factors for nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in a large sample of healthy children...
  101. ncbi request reprint Emerging resistance to antibiotics against respiratory bacteria: impact on therapy of community-acquired pneumonia in children
    Susanna Esposito
    Pediatric Department I, University of Milan, Via Commenda 9, 20122 Milan, Italy
    Drug Resist Updat 5:73-87. 2002
    ..We here discuss the prevalence of different etiologic agents in CAP of children, the diagnostic criteria, problems related to antibiotic resistance, therapeutic strategies, and future implications...