Paola Sgadò

Summary

Affiliation: University of Trento
Country: Italy

Publications

  1. pmc Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology CIBIO, University of Trento, Via delle Regole 101, 38123 Trento, Italy
    Mol Autism 4:51. 2013
  2. pmc The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Trento, Italy
    Neural Dev 7:24. 2012
  3. doi request reprint Behavioral, neurochemical, and electrophysiological changes in an early spontaneous mouse model of nigrostriatal degeneration
    Paola Sgadò
    Department of Neuroscience, Section of Pharmacology, University of Pisa, Pisa, Italy
    Neurotox Res 20:170-81. 2011
  4. pmc Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Italy
    Exp Neurol 247:496-505. 2013
  5. doi request reprint Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease
    Paola Sgadò
    Department of Neuroscience, University of Pisa School of Medicine, Via Roma 55, Pisa, Italy
    Parkinsonism Relat Disord 14:S103-6. 2008
  6. doi request reprint Hippocampal dysregulation of FMRP/mGluR5 signaling in engrailed-2 knockout mice: a model of autism spectrum disorders
    Giovanni Provenzano
    aLaboratory of Molecular Neuropathology bLaboratory of Developmental Neurobiology, Centre for Integrative Biology CIBIO, University of Trento, Trento cC N R Neuroscience Institute, Pisa, Italy
    Neuroreport 26:1101-5. 2015
  7. pmc Mutant mouse models of autism spectrum disorders
    Giovanni Provenzano
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Trento, Italy
    Dis Markers 33:225-39. 2012

Collaborators

Detail Information

Publications7

  1. pmc Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology CIBIO, University of Trento, Via delle Regole 101, 38123 Trento, Italy
    Mol Autism 4:51. 2013
    ..To unravel recurrent ASD-related neuropathological mechanisms, we took advantage of the En2-/- mouse model and performed transcriptome profiling on cerebellar and hippocampal adult tissues...
  2. pmc The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Trento, Italy
    Neural Dev 7:24. 2012
    ....
  3. doi request reprint Behavioral, neurochemical, and electrophysiological changes in an early spontaneous mouse model of nigrostriatal degeneration
    Paola Sgadò
    Department of Neuroscience, Section of Pharmacology, University of Pisa, Pisa, Italy
    Neurotox Res 20:170-81. 2011
    ..These data suggests that in En1+/-;En2-/- mice nigrostriatal degeneration in the substantia nigra is functionally compensated...
  4. pmc Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: implications for autism spectrum disorders
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Italy
    Exp Neurol 247:496-505. 2013
    ..Our results raise the possibility of a link between altered function of En2, anatomical deficits of GABAergic forebrain neurons and the pathogenesis of ASD. ..
  5. doi request reprint Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease
    Paola Sgadò
    Department of Neuroscience, University of Pisa School of Medicine, Via Roma 55, Pisa, Italy
    Parkinsonism Relat Disord 14:S103-6. 2008
    ..Furthermore, our data suggest a role for these transcription factors in the maintenance of synaptic dopaminergic neurotransmission in adult neurons...
  6. doi request reprint Hippocampal dysregulation of FMRP/mGluR5 signaling in engrailed-2 knockout mice: a model of autism spectrum disorders
    Giovanni Provenzano
    aLaboratory of Molecular Neuropathology bLaboratory of Developmental Neurobiology, Centre for Integrative Biology CIBIO, University of Trento, Trento cC N R Neuroscience Institute, Pisa, Italy
    Neuroreport 26:1101-5. 2015
    ....
  7. pmc Mutant mouse models of autism spectrum disorders
    Giovanni Provenzano
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Trento, Italy
    Dis Markers 33:225-39. 2012
    ..Here we will review the most relevant genetic mouse models developed by targeted inactivation of ASD-associated genes, and discuss their importance for the development of novel pharmacological therapies of these disorders...