E Tramontano

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. ncbi request reprint The use of a new in vitro reaction substrate reproducing both U3 and U5 regions of the HIV-1 3'-ends increases the correlation between the in vitro and in vivo effects of the HIV-1 integrase inhibitors
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella Universitaria SS554, 09142 Monserrato, Cagliari, Italy
    Biochem Pharmacol 67:1751-61. 2004
  2. ncbi request reprint HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella di Monserrato, 09142 Monserrato Cagliari, Italy
    Mini Rev Med Chem 6:727-37. 2006
  3. pmc HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions
    Francesca Esposito
    Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, SS 554, 09042 Monserrato, Italy
    Mol Biol Int 2012:586401. 2012
  4. pmc Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport
    Yongzhen Sun
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    BMC Genomics 12:533. 2011
  5. ncbi request reprint The exploding field of the HCV polymerase non-nucleoside inhibitors: summary of a first generation compounds
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Monserrato Cagliari, Italy
    Mini Rev Med Chem 8:1298-310. 2008
  6. ncbi request reprint 6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella Universitaria SS554, 09142 Monserrato Cagliari, Italy
    Antiviral Res 65:117-24. 2005
  7. ncbi request reprint Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate
    E Tramontano
    Dipartimento di Biologia Sperimentale, Sezione di Microbiologia, Universita di Cagliari, Italy
    Biochem Pharmacol 56:1583-9. 1998
  8. ncbi request reprint Effects of new quinizarin derivatives on both HCV NS5B RNA polymerase and HIV-1 reverse transcriptase associated ribonuclease H activities
    E Tramontano
    Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy
    J Chemother 23:273-6. 2011
  9. doi request reprint Purification and functional characterization of the full length recombinant Ebola virus VP35 protein expressed in E. coli
    Luca Zinzula
    Department of Applied Sciences in Biosystems, University of Cagliari, Cittadella di Monserrato SS554, Monserrato, Cagliari, Italy
    Protein Expr Purif 66:113-9. 2009
  10. ncbi request reprint 6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays
    Roberta Costi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, P le A Moro 5, I 00185 Rome, Italy
    Bioorg Med Chem Lett 14:1745-9. 2004

Collaborators

  • Francesca Esposito
  • Roberto Di Santo
  • Rino Ragno
  • M Palumbo
  • Roberta Costi
  • Yongzhen Sun
  • Luca Zinzula
  • Silvio Massa
  • Paolo La Colla
  • Roberta Loddo
  • Alessandra Pani
  • Marino Artico
  • Massimiliano La Colla
  • Cristina Parolin
  • Hongmei Luo
  • Liang Dong
  • Aiping Lv
  • Ying Li
  • Shilin Chen
  • Yingjie Zhu
  • Chao Sun
  • Yunyun Niu
  • Jingyuan Song
  • Elke Mühlberger
  • Dario Piano
  • Martina Trunschke
  • Dominik Conrad
  • Roberto Di Santo
  • Alessandra Roux
  • M Elena Marongiu
  • Teresa Pecere
  • Violetta Cecchetti
  • Claudia Del Vecchio
  • Giorgio Palu
  • Arnaldo Fravolini
  • Barbara Gatto
  • Sara Masiero

Detail Information

Publications12

  1. ncbi request reprint The use of a new in vitro reaction substrate reproducing both U3 and U5 regions of the HIV-1 3'-ends increases the correlation between the in vitro and in vivo effects of the HIV-1 integrase inhibitors
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella Universitaria SS554, 09142 Monserrato, Cagliari, Italy
    Biochem Pharmacol 67:1751-61. 2004
    ....
  2. ncbi request reprint HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella di Monserrato, 09142 Monserrato Cagliari, Italy
    Mini Rev Med Chem 6:727-37. 2006
    ..All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site...
  3. pmc HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions
    Francesca Esposito
    Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, SS 554, 09042 Monserrato, Italy
    Mol Biol Int 2012:586401. 2012
    ..This paper describes the HIV-1 RT function and molecular structure, illustrates the currently approved RTIs, and focuses on the mechanisms of action of the newer classes of RTIs...
  4. pmc Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport
    Yongzhen Sun
    The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, PR China
    BMC Genomics 12:533. 2011
    ..Despite its importance, little is known about the transcriptome of C. acuminata and the mechanism of CPT biosynthesis, as only few nucleotide sequences are included in the GenBank database...
  5. ncbi request reprint The exploding field of the HCV polymerase non-nucleoside inhibitors: summary of a first generation compounds
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Monserrato Cagliari, Italy
    Mini Rev Med Chem 8:1298-310. 2008
    ..All small molecules which have been identified to be selective non-nucleoside inhibitors (NNI) of the HCV RdRp to date are reported...
  6. ncbi request reprint 6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro
    Enzo Tramontano
    Department of Sciences and Biomedical Technologies, University of Cagliari, Cittadella Universitaria SS554, 09142 Monserrato Cagliari, Italy
    Antiviral Res 65:117-24. 2005
    ..Similar results were obtained against the Y181C and Y181C/K103N HIV-1 NNRTI resistant mutant strains. RDS 1643 may be the first HIV-1 inhibitor selectively targeted to the viral RT-associated RNase-H function...
  7. ncbi request reprint Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate
    E Tramontano
    Dipartimento di Biologia Sperimentale, Sezione di Microbiologia, Universita di Cagliari, Italy
    Biochem Pharmacol 56:1583-9. 1998
    ..Overall, these results suggest that codons 161 and 208 of the HIV-1 RT gene are involved in substrate binding as well as in NRTI recognition, and provide more insights into the mechanism by which HIV-1 becomes resistant to PFA...
  8. ncbi request reprint Effects of new quinizarin derivatives on both HCV NS5B RNA polymerase and HIV-1 reverse transcriptase associated ribonuclease H activities
    E Tramontano
    Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy
    J Chemother 23:273-6. 2011
    ..Our results demonstrate that anthraquinone derivatives are promising anti-polymerase viral inhibitors...
  9. doi request reprint Purification and functional characterization of the full length recombinant Ebola virus VP35 protein expressed in E. coli
    Luca Zinzula
    Department of Applied Sciences in Biosystems, University of Cagliari, Cittadella di Monserrato SS554, Monserrato, Cagliari, Italy
    Protein Expr Purif 66:113-9. 2009
    ....
  10. ncbi request reprint 6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays
    Roberta Costi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, P le A Moro 5, I 00185 Rome, Italy
    Bioorg Med Chem Lett 14:1745-9. 2004
    ..9 microM; 3'-processing: IC(50)=7.0 microM). A preliminary molecular modeling study was carried out to compare the spatial conformation of 8a with those of L-731988 (4) and 5CITEP (7) in the IN core...
  11. ncbi request reprint 2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays
    Roberta Costi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, P le A Moro 5, I 00185, Rome, Italy
    Bioorg Med Chem 12:199-215. 2004
    ..A Q(2) of 0.73 was obtained with the final model, confirming the predictive ability of the model. By studying the PLS coefficients in informative 3-D contour plots, ideas for the synthesis of new compounds could be generated...
  12. pmc New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action
    Cristina Parolin
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Microbiology and Virology, University of Padua, Italy
    Antimicrob Agents Chemother 47:889-96. 2003
    ..6 nM). These data indicate that WM5 is a promising lead compound for the development of a new class of HIV-1 transcription inhibitors characterized by recognition of viral RNA target(s)...