Carlo Ventura

Summary

Country: Italy

Publications

  1. ncbi request reprint Butyric and retinoic mixed ester of hyaluronan. A novel differentiating glycoconjugate affording a high throughput of cardiogenesis in embryonic stem cells
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, I 40138 Bologna, Italy
    J Biol Chem 279:23574-9. 2004
  2. ncbi request reprint Stem cells and cardiovascular repair: a role for natural and synthetic molecules harboring differentiating and paracrine logics
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, Institute of Cardiology National Institute of Biostructures and Biosystems, University of Bologna, Italy
    Cardiovasc Hematol Agents Med Chem 6:60-8. 2008
  3. ncbi request reprint Autocrine and intracrine signaling for cardiogenesis in embryonic stem cells: a clue for the development of novel differentiating agents
    C Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, Bologna, Italy
    Handb Exp Pharmacol . 2006
  4. pmc CAM and cell fate targeting: molecular and energetic insights into cell growth and differentiation
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems and Institute of Cardiology, S Orsola Malpighi Hospital, University of Bologna 40138 Bologna, Italy
    Evid Based Complement Alternat Med 2:277-83. 2005
  5. ncbi request reprint Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells
    Carlo Ventura
    Department of Biomedical Sciences, Center for Biotechnology Development and Biodiversity Research, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Circ Res 92:623-9. 2003
  6. ncbi request reprint Turning on stem cell cardiogenesis with extremely low frequency magnetic fields
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, Bologna, Italy
    FASEB J 19:155-7. 2005
  7. ncbi request reprint Protein kinase C signaling transduces endorphin-primed cardiogenesis in GTR1 embryonic stem cells
    Carlo Ventura
    Department of Biomedical Sciences, Center for Biotechnology Development and Biodiversity Research, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Circ Res 92:617-22. 2003
  8. ncbi request reprint Hyaluronan mixed esters of butyric and retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, Institute of Cardiology, National Institute of Biostructures and Biosystems, University of Bologna, Bologna, Italy
    J Biol Chem 282:14243-52. 2007
  9. doi request reprint Radio electric conveyed fields directly reprogram human dermal skin fibroblasts toward cardiac, neuronal, and skeletal muscle-like lineages
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Cell Transplant 22:1227-35. 2013
  10. pmc Amniotic fluid stem cells morph into a cardiovascular lineage: analysis of a chemically induced cardiac and vascular commitment
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy
    Drug Des Devel Ther 7:1063-73. 2013

Collaborators

  • Fabio Recchia
  • Salvatore Rinaldi
  • Laura Foroni
  • Vincenzo Lionetti
  • Nazzareno Galie
  • Bruno Nardo
  • Francesco Alviano
  • Giovanna Cenacchi
  • Camillo Ricordi
  • Tullia Maraldi
  • Matvey Tsivian
  • Daniel Remondini
  • Gianfranco Pintus
  • Gaetano La Manna
  • M Samaja
  • Mario Arpinati
  • Marina Marini
  • Margherita Maioli
  • Sara Santaniello
  • Gianfranco Pigliaru
  • Vania Fontani
  • Francesca Bianchi
  • Silvia Cantoni
  • Alessandro Castagna
  • Sabrina Valente
  • Gianandrea Pasquinelli
  • Valentina Basoli
  • Margherita Galletti
  • Luigi Bagella
  • Elena Olivi
  • Claudia Cavallini
  • Gaetano La Manna
  • Alessandro Delitala
  • Filippo Zambelli
  • Carlo Tremolada
  • Sara Gualini
  • Riccardo Tassinari
  • Giuseppe Cavallari
  • Flavia Neri
  • Andrea Montella
  • Sergio Stefoni
  • Pasquale Bandiera
  • Egle Milia
  • Roberto Pinna
  • Sara Cruciani
  • Roberta Muggironi
  • Regina Grillari-Voglauer
  • Alessandro Palmerio Delitala
  • Gaia Rocchitta
  • Rossana Migheli
  • Pier Andrea Serra
  • Alessandra Manes
  • Bastiano Sanna
  • Matteo Lotti Margotti
  • Antonello Mai
  • Massimiliano Palazzini
  • Erika Leonardi
  • Mirco Raffaini
  • Giovanni Contini
  • Alessandro P Delitala
  • Francesca Ponti
  • Raimonda Sanna
  • Armando J Mendez
  • Francesca Bonavita
  • Valentina Vaccari
  • Irene Frascari
  • Lucia Tarantino
  • Cavallini Claudia
  • Maria Cappuccilli
  • Elena Della Bella
  • Flavio Rizzolio
  • Irene Marchesi
  • Antonella Pintus
  • Saverio Bettuzzi
  • Maurizio Scaltriti
  • Francesco Galimi
  • Yolande Asara
  • Stefania Ninniri
  • Anna M Posadino
  • Marcella Debidda
  • Federico Bennardini
  • Bruna Tadolini
  • Gianni Sava

Detail Information

Publications31

  1. ncbi request reprint Butyric and retinoic mixed ester of hyaluronan. A novel differentiating glycoconjugate affording a high throughput of cardiogenesis in embryonic stem cells
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, I 40138 Bologna, Italy
    J Biol Chem 279:23574-9. 2004
    ....
  2. ncbi request reprint Stem cells and cardiovascular repair: a role for natural and synthetic molecules harboring differentiating and paracrine logics
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, Institute of Cardiology National Institute of Biostructures and Biosystems, University of Bologna, Italy
    Cardiovasc Hematol Agents Med Chem 6:60-8. 2008
    ..These molecules may ultimately provide new insights in stem cell biology and pave the way to novel approaches in tissue engineering and cardiovascular repair...
  3. ncbi request reprint Autocrine and intracrine signaling for cardiogenesis in embryonic stem cells: a clue for the development of novel differentiating agents
    C Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, Bologna, Italy
    Handb Exp Pharmacol . 2006
    ....
  4. pmc CAM and cell fate targeting: molecular and energetic insights into cell growth and differentiation
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems and Institute of Cardiology, S Orsola Malpighi Hospital, University of Bologna 40138 Bologna, Italy
    Evid Based Complement Alternat Med 2:277-83. 2005
    ..To this end, functional genomics and proteomics and the comprehension of the cell signaling networks may substantially contribute to the development of a molecular evidence-based CAM...
  5. ncbi request reprint Dynorphin B is an agonist of nuclear opioid receptors coupling nuclear protein kinase C activation to the transcription of cardiogenic genes in GTR1 embryonic stem cells
    Carlo Ventura
    Department of Biomedical Sciences, Center for Biotechnology Development and Biodiversity Research, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Circ Res 92:623-9. 2003
    ..Nuclear treatment with PKC inhibitors abolished the capability of dynorphin B to prime the transcription of cardiogenic genes...
  6. ncbi request reprint Turning on stem cell cardiogenesis with extremely low frequency magnetic fields
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, University of Bologna, Bologna, Italy
    FASEB J 19:155-7. 2005
    ....
  7. ncbi request reprint Protein kinase C signaling transduces endorphin-primed cardiogenesis in GTR1 embryonic stem cells
    Carlo Ventura
    Department of Biomedical Sciences, Center for Biotechnology Development and Biodiversity Research, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Circ Res 92:617-22. 2003
    ..PKC inhibitors prevented the expression of cardiogenic genes and dynorphin B in ES cells and abolished their development into beating cardiomyocytes...
  8. ncbi request reprint Hyaluronan mixed esters of butyric and retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts
    Carlo Ventura
    Laboratory of Molecular Biology and Stem Cell Engineering, Institute of Cardiology, National Institute of Biostructures and Biosystems, University of Bologna, Bologna, Italy
    J Biol Chem 282:14243-52. 2007
    ..These findings may contribute to further development in cell therapy of heart failure...
  9. doi request reprint Radio electric conveyed fields directly reprogram human dermal skin fibroblasts toward cardiac, neuronal, and skeletal muscle-like lineages
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Cell Transplant 22:1227-35. 2013
    ..Our results show for the first time the feasibility of using a physical stimulus to afford the expression of pluripotentiality in human adult somatic cells up to the attainment of three major target lineages for regenerative medicine...
  10. pmc Amniotic fluid stem cells morph into a cardiovascular lineage: analysis of a chemically induced cardiac and vascular commitment
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence, Italy
    Drug Des Devel Ther 7:1063-73. 2013
    ..These results demonstrate that a mixture of HA + BU + RA significantly increased the yield of elements committed toward cardiac and vascular phenotypes, confirming what we have previously observed in other cellular types. ..
  11. pmc Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    PLoS ONE 5:e15151. 2010
    ..We have recently developed hyaluronan mixed esters of butyric and retinoic acids (HBR), turning cardiovascular stem cell fate into a high-yield process. The HBR mechanism(s) remain still largely undefined...
  12. doi request reprint Mesenchymal stem cells and islet cotransplantation in diabetic rats: improved islet graft revascularization and function by human adipose tissue-derived stem cells preconditioned with natural molecules
    Giuseppe Cavallari
    Department of General Surgery and Transplantation, University of Bologna, Bologna, Italy
    Cell Transplant 21:2771-81. 2012
    ..The observed increase in islet graft revascularization and function suggests that our method of stem cell preconditioning may represent a novel strategy to remarkably improve the efficacy of islets-hMSCs cotransplantation...
  13. ncbi request reprint Creating prodynorphin-expressing stem cells alerted for a high-throughput of cardiogenic commitment
    Margherita Maioli
    Department of Biomedical Sciences and National Institute of Biostructures and Biosystems, University of Sassari, Sassari, Italy
    Regen Med 2:193-202. 2007
    ....
  14. doi request reprint Radioelectric asymmetric conveyed fields and human adipose-derived stem cells obtained with a nonenzymatic method and device: a novel approach to multipotency
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Cell Transplant 23:1489-500. 2014
    ....
  15. doi request reprint A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates
    Francesca Bianchi
    Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems, Bologna, Italy
    Cell Transplant 22:2063-77. 2013
    ....
  16. doi request reprint Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle differentiation in mouse embryonic stem cells: a new tool for improving tissue regeneration
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Cell Transplant 21:1225-33. 2012
    ....
  17. pmc REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence
    Margherita Maioli
    Center for developmental biology and reprogramming CEDEBIOR, Department of Biomedical Sciences, University of Sassari Viale San Pietro 43 B, 07100 Sassari, Italy
    Sci Rep 6:28682. 2016
    ..This suggests that REAC technology is effective on an intracellular niche level of stem cell regulation. ..
  18. pmc Anti-senescence efficacy of radio-electric asymmetric conveyer technology
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Viale San Pietro, 43 B, 07100, Sassari, Italy
    Age (Dordr) 36:9-20. 2014
    ..In conclusion, our study highlights a positive effect of TO-RGN in counteracting degenerative senescence processes in vitro. ..
  19. doi request reprint Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition
    Silvia Cantoni
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy
    FEBS J 280:2042-55. 2013
    ..These findings may provide novel perspectives on the use of histone deacetylase inhibitors in PAH...
  20. doi request reprint Rosuvastatin elicits KDR-dependent vasculogenic response of human placental stem cells through PI3K/AKT pathway
    Silvia Cantoni
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy
    Pharmacol Res 65:275-84. 2012
    ..This observation may pave the way to the use of RSV as a pharmacological enhancer of stem cell potential for cardiovascular cell therapy...
  21. pmc Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson's disease
    Margherita Maioli
    1 Department of Biomedical Sciences, University of Sassari, 07100, Sassari, Italy 2 Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems, 40121, Bologna, Italy 3 Department of Regenerative Medicine, Rinaldi Fontani Institute, 50144, Florence, Italy
    Sci Rep 5:10439. 2015
    ..These results open new perspectives in neurodegenerative diseases treatment, particularly in PD. Further studies will be needed to better address the therapeutic potential of the REAC technology. ..
  22. doi request reprint Dissecting histone deacetylase role in pulmonary arterial smooth muscle cell proliferation and migration
    Margherita Galletti
    National Institute of Biostructures and Biosystems NIBB, University of Bologna, Bologna, Italy Department of Experimental, Diagnostic and Specialty Medicine DIMES, University of Bologna, Bologna, Italy
    Biochem Pharmacol 91:181-90. 2014
    ..The finding that HDAC1 is a major conductor of PDGF-induced patterning in PAH-PASMCs prompts the development of novel selective inhibitors of this member of class I HDACs as a potential tool to control lung vascular homeostasis in PAH. ..
  23. doi request reprint Mesenchymal stem cells in renal function recovery after acute kidney injury: use of a differentiating agent in a rat model
    Gaetano La Manna
    Department of Internal Medicine, Aging and Renal Disease Section of Nephrology, University of Bologna, Bologna, Italy
    Cell Transplant 20:1193-208. 2011
    ..These results suggest that FMhMSCs could be useful in the treatment of AKI and the utilization of synthetic compounds could enhance the recovery induction ability of cells...
  24. pmc Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids
    Margherita Maioli
    Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Via Massarenti, 40138 Bologna, Italy
    Stem Cells Int 2016:2056416. 2016
    ..These in vitro results suggest that in vivo osteogenesis might be improved and further studies are needed. ..
  25. pmc Term Amniotic membrane is a high throughput source for multipotent Mesenchymal Stem Cells with the ability to differentiate into endothelial cells in vitro
    Francesco Alviano
    Department of Histology, Embryology and Applied Biology, University of Bologna, Italy
    BMC Dev Biol 7:11. 2007
    ..In agreement with the recommendation of the International Society for Cellular Therapy, the mesenchymal cells herein investigated were named Amniotic Membrane-human Mesenchymal Stromal Cells (AM-hMSC)...
  26. ncbi request reprint Mild exercise training, cardioprotection and stress genes profile
    Marina Marini
    Department of Histology, Embryology, and Applied Biology, University of Bologna, Via Belmeloro, 8, 40126, Bologna, Italy
    Eur J Appl Physiol 99:503-10. 2007
    ..As a whole, these data indicate that mild exercise training activates a second window of myocardial protection against ischemia/reperfusion by upregulating a number of protective genes, thereby warranting further investigation in man...
  27. ncbi request reprint PKC/Raf/MEK/ERK signaling pathway modulates native-LDL-induced E2F-1 gene expression and endothelial cell proliferation
    Gianfranco Pintus
    Department of Biomedical Sciences, Division of Biochemistry, Laboratory of Cardiovascular Research, University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Cardiovasc Res 59:934-44. 2003
    ..Due to this reason, the molecular sequelae of events resulting from native LDL (N-LDL) interaction with human endothelial cells (HECs) are largely under investigation...
  28. ncbi request reprint The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway
    Bastiano Sanna
    Department of Biomedical Sciences, Division of Biochemistry, Laboratory of Cardiovascular Research, University of Sassari, Viale San Pietro 43 B, 07100, Sassari, Italy
    Arch Biochem Biophys 403:209-18. 2002
    ..These results suggest that inhibition of MEK/ERK signaling by NAMI-A may have an important role in modulating an apoptotic event in ECV304...
  29. ncbi request reprint Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation
    Gianfranco Pintus
    Department of Biomedical Sciences, Division of Biochemistry, Laboratory of Cardiovascular Research, University of Sassari, Italy
    Eur J Biochem 269:5861-70. 2002
    ..These results suggest that inhibition of MEK/ERK signaling by NAMI-A may have an important role in modulating c-myc gene expression and ECV304 proliferation...
  30. ncbi request reprint Forced myocardin expression primes cardiac and smooth muscle transcription patterning in human mesenchymal stem cells
    Carlo Ventura
    Cardiovasc Res 67:182-3. 2005