Manabu Murakami

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. ncbi Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1160:102-12. 2007
  2. ncbi Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1024:122-9. 2004
  3. ncbi Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Mol Cell Cardiol 41:115-25. 2006
  4. ncbi [Functional analysis of murine DNA]
    Manabu Murakami
    Nihon Yakurigaku Zasshi 125:209-12. 2005
  5. ncbi Genomic organization and functional analysis of murine PKD2L1
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Biol Chem 280:5626-35. 2005
  6. ncbi Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Neurosci Lett 367:118-22. 2004
  7. ncbi Genetic characterization of a new splice variant of the beta2 subunit of the voltage-dependent calcium channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, Japan
    Mol Cell Biochem 254:217-25. 2003
  8. ncbi Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
    J Mol Neurosci 21:13-21. 2003
  9. ncbi Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Biol Chem 278:43261-7. 2003
  10. ncbi Identification and characterization of the murine TRPM4 channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
    Biochem Biophys Res Commun 307:522-8. 2003

Collaborators

Detail Information

Publications44

  1. ncbi Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1160:102-12. 2007
    ..These results suggest the importance of voltage-dependent calcium channels and the key role of the beta3 subunit in memory formation, nociceptive sensory transduction, and various neurological signal transduction pathways...
  2. ncbi Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1024:122-9. 2004
    ..The results of this study revealed the localization and functions of several calcium channels that are involved in nociceptive neurotransmission within the dorsal horn of the mouse spinal cord...
  3. ncbi Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Mol Cell Cardiol 41:115-25. 2006
    ..In vitro overlay and immunoprecipitation analyses revealed preferential binding between alpha1C-a and beta2, which is also expressed at a high level in the heart...
  4. ncbi [Functional analysis of murine DNA]
    Manabu Murakami
    Nihon Yakurigaku Zasshi 125:209-12. 2005
  5. ncbi Genomic organization and functional analysis of murine PKD2L1
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Biol Chem 280:5626-35. 2005
    ..We conclude that PKD2L1 forms functional cation channels on the plasma membrane by interacting with PKD1. These findings raise the possibility that PKD2L1 represents the third genetic locus that is responsible for PKD...
  6. ncbi Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Neurosci Lett 367:118-22. 2004
    ....
  7. ncbi Genetic characterization of a new splice variant of the beta2 subunit of the voltage-dependent calcium channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, Japan
    Mol Cell Biochem 254:217-25. 2003
    ..Other beta3 subunits, such as beta3 and beta4, significantly increased the peak current and accelerated current inactivation...
  8. ncbi Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
    J Mol Neurosci 21:13-21. 2003
    ..Furthermore, mRNA of these beta-subunits is strongly expressed in dorsal root ganglion neurons, which have many voltage-dependent calcium channels...
  9. ncbi Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Biol Chem 278:43261-7. 2003
    ....
  10. ncbi Identification and characterization of the murine TRPM4 channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
    Biochem Biophys Res Commun 307:522-8. 2003
    ..Both TRPM4 variants integrated into the plasma membrane. Furthermore, FRET analysis revealed that TRPM4a and TRPM4b localized close together, suggesting a multimerization of the two molecules...
  11. pmc Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita 010 8543, Japan
    J Biol Chem 283:24554-60. 2008
    ..These results identify a determining role for the beta3 subunit in the N-type channel population in SCG and a major role in sympathetic nerve regulation...
  12. ncbi Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry
    Yoichiro Takahashi
    Second Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 356:45-52. 2007
    ..These results reveal the essential role of Orai1 and its N-terminal sequence in SOCE...
  13. doi Endothelin-1-induced down-regulation of NaV1.7 expression in adrenal chromaffin cells: attenuation of catecholamine secretion and tau dephosphorylation
    Takayuki Nemoto
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    FEBS Lett 587:898-905. 2013
    ..These findings suggest that the endothelin-1-induced down-regulation of NaV1.7 diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau...
  14. ncbi Modified sympathetic regulation in N-type calcium channel null-mouse
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 354:1016-20. 2007
    ..Combined, our biochemical and physiological analyses strongly suggest that the remaining sympathetic tonus in NKO mice is dependent on R-type calcium channels...
  15. ncbi Molecular and electrical remodeling of L- and T-type Ca(2+) channels in rat right atrium with monocrotaline-induced pulmonary hypertension
    Takashi Koyama
    Department of Cardiology, Akita University School of Medicine, Akita, Japan
    Circ J 73:256-63. 2009
    ..Atrial arrhythmia is often encountered in chronic pulmonary disease with pulmonary hypertension (PH), but few studies have investigated the electrical remodeling of atrial Ca(2+) channels under PH...
  16. ncbi Upregulation of TRPC1 in the development of cardiac hypertrophy
    Takayoshi Ohba
    Second Department of Internal Medicine, Akita University School of Medicine, Hondoh, Akita, Japan
    J Mol Cell Cardiol 42:498-507. 2007
    ..These findings establish TRPC1 as a functionally important regulator of cardiac hypertrophy...
  17. doi Amlodipine inhibits cell proliferation via PKD1-related pathway
    Takayoshi Ohba
    Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondoh, Akita 010 8543, Japan
    Biochem Biophys Res Commun 369:376-81. 2008
    ..These data suggest that PKD1 contributes to the antiproliferative effect of amlodipine on hCASMCs via JAK/STAT signaling and p21((Waf1/Cip1)) up-regulation...
  18. ncbi Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha1B or beta3 subunits of voltage-dependent Ca2+-channels
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Japan
    Biol Pharm Bull 29:437-42. 2006
    ..These data suggest the importance of the alpha1B and beta3 subunits of the N-type voltage-dependent Ca2+ channel for the pheromone signal transduction system...
  19. doi Essential role of STIM1 in the development of cardiomyocyte hypertrophy
    Takayoshi Ohba
    Department of Physiology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Biochem Biophys Res Commun 389:172-6. 2009
    ..However, the knockdown of STIM1 suppressed these effects, thereby preventing a hypertrophic response. These results suggest that STIM1 plays an essential role in the development of cardiomyocyte hypertrophy...
  20. doi Behavioral and neurochemical characterization of mice deficient in the N-type Ca2+ channel alpha1B subunit
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 208:224-30. 2010
    ....
  21. ncbi Regulatory role of neuron-restrictive silencing factor in expression of TRPC1
    Takayoshi Ohba
    Second Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 351:764-70. 2006
    ..Our findings strongly suggest that NRSF regulates TRP1 gene expression and causes changes in the levels of calcium entry through SOCCs...
  22. ncbi Functional role of stromal interaction molecule 1 (STIM1) in vascular smooth muscle cells
    Yoichiro Takahashi
    Second Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 361:934-40. 2007
    ..These results suggest that STIM1 is an essential component of SOCE and that it is involved in VSMC proliferation...
  23. doi Modified autonomic regulation in mice with a P/Q-type calcium channel mutation
    Takayoshi Ohba
    Department of Physiology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Biochem Biophys Res Commun 381:27-32. 2009
    ..Atrium contraction analyses revealed a minor but significant role for P/Q-type channels in sympathetic and parasympathetic nerve regulation...
  24. doi Involvement of the orexin system in adrenal sympathetic regulation
    Takayuki Nemoto
    Department of Pharmacology, Graduate School of Medicine, University of Miyazaki, Miyazaki, Japan
    Pharmacology 91:250-8. 2013
    ..Our results indicate involvement of the orexin system in the sympathetic regulation of the adrenal medulla...
  25. ncbi The pathological role of transient receptor potential channels in heart disease
    Hiroyuki Watanabe
    Second Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Circ J 73:419-27. 2009
    ..Ultimately, TRP channels might become novel pharmacological targets in the treatment of human heart disease...
  26. ncbi Involvement of transient receptor potential canonical 1 (TRPC1) in angiotensin II-induced vascular smooth muscle cell hypertrophy
    Yoichiro Takahashi
    Second Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Atherosclerosis 195:287-96. 2007
    ..In conclusion, our data suggest that Ang II and subsequent NF-kappaB activation induces hCASMC hypertrophy through an enhancement of TRPC1 expression...
  27. doi Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway
    Takayuki Nemoto
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Neurochem Int 59:880-8. 2011
    ..Taken together, these results suggest that insulin-induced activation of PI3K∼mTOR pathway up-regulated tau protein via acceleration of protein synthesis, on which insulin promoted neurite-like process outgrowth...
  28. doi TRP channel and cardiovascular disease
    Hiroyuki Watanabe
    Second Department of Internal Medicine, Akita University School of Medicine 1 1 1, Hondoh, Akita 010 8543, Japan
    Pharmacol Ther 118:337-51. 2008
    ..Ultimately, TRP channels will become important novel pharmacological targets for the treatment of human cardiovascular diseases...
  29. ncbi Involvement of voltage-dependent Ca(2+) channel beta(3) subunit in the autonomic control of heart rate variability
    Tsai Wen Wu
    Department of Pharmacology, Akita University School of Medicine, Akita, Japan
    Pharmacology 76:170-9. 2006
    ..These results indicate the functional roles of Ca(V)beta(3) in regulating sympathetic nerve signaling...
  30. doi Transcriptional up-regulation of cell surface Na V 1.7 sodium channels by insulin-like growth factor-1 via inhibition of glycogen synthase kinase-3β in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion
    Toshihiko Yanagita
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Neuropharmacology 61:1265-74. 2011
    ..Thus, inhibition of GSK-3β caused by IGF-1 up-regulates cell surface expression of functional Na(+) channels via acceleration of α-subunit gene transcription...
  31. doi Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway
    Shin Makabe
    Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Atherosclerosis 213:377-84. 2010
    ..Transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important regulator of cellular oxidative stress. This study examined the role of Nrf2 in statin-mediated antioxidant effects in vascular smooth muscle cells...
  32. doi Modified sympathetic nerve regulation in AKAP5-null mice
    Chong Han
    Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Biochem Biophys Res Commun 469:897-902. 2016
    ..Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities...
  33. doi Store-operated Ca2+ entry suppresses distention-induced ATP release from the urothelium
    Kazumasa Matsumoto-Miyai
    Department of Neurophysiology, Akita University Graduate School of Medicine, Akita, Japan
    Am J Physiol Renal Physiol 300:F716-20. 2011
    ..Thus Ca(2+) release from the ER causes urothelial ATP release and depletion of Ca(2+) stores in the ER, which in turn causes the depletion-inducing SOCE to suppress the amount of urothelial ATP released...
  34. ncbi [Involvement of calcium channels in the pathogenesis of hypertension]
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine
    Nihon Rinsho 62:152-5. 2004
  35. doi Effects of propofol on electrocardiogram measures in mice
    Tomohiro Shintaku
    Department of Pharmacology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
    J Pharmacol Sci 126:351-8. 2014
    ..Propofol also reduced the response to atropine, indicative of suppression of mouse parasympathetic nerve activity. Our data suggest that propofol anesthesia should not be the first choice for cardiovascular analysis in mice. ..
  36. ncbi Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels
    Manabu Murakami
    Pharmakologie und Toxikologie, Universitat des Saarlandes, D 66421 Homburg, Germany
    J Biol Chem 277:40342-51. 2002
    ..The molecular mechanism responsible for the phenotype was traced to low expression of N-type calcium channels (alpha1B) and functional alterations of calcium channel currents in neurones projecting to the spinal cord...
  37. pmc Slow deactivation and U-shaped inactivation properties in cloned Cav1.2b channels in Chinese hamster ovary cells
    Masahiro Aoyama
    Department of Cell Physiology, Nagoya University Graduate School of Medicine, Japan
    Biophys J 84:709-24. 2003
    ..Computer calculation reconstructed slow deactivation and U-shaped inactivation properties. A similar kinetic scheme with Ca(2+)-agonist-binding states accounted for the results in the presence of Ca(2+) agonists...
  38. ncbi The effect of taurine on the salt-dependent blood pressure increase in the voltage-dependent calcium channel beta 3-subunit-deficient mouse
    Kunie Hagiwara
    Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Cardiovasc Pharmacol 41:S127-31. 2003
    ..It is suggested, therefore, that chronic supplementation of taurine has an anti-hypertensive action in salt-dependent blood pressure elevation...
  39. ncbi Involvement of the calcium channel beta3 subunit in olfactory signal transduction
    Takeshi Shiraiwa
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 355:1019-24. 2007
    ..Our data indicate the involvement of voltage-dependent Ca2+ channels and importance of the beta3 subunit in olfactory signal transduction...
  40. ncbi Activation of Rac1 by Rho-guanine nucleotide dissociation inhibitor-beta with defective isoprenyl-binding pocket
    Takahide Ota
    Division of Molecular Oncology and Virology, Medical Research Institute, Kanazawa Medical University, Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cell Biol Int 31:92-6. 2007
    ..Thus, impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis...
  41. ncbi Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis
    Per Olof Berggren
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, S 17176 Stockholm, Sweden
    Cell 119:273-84. 2004
    ..Since the increase in insulin release was manifested only at high glucose concentrations, blocking the beta3 subunit in the beta cell may constitute the basis for a novel diabetes therapy...
  42. ncbi Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels
    Kunie Hagiwara
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2 1 Seiryomachi Aobaku, Sendai 980 8575, Japan
    Neurosci Res 46:493-7. 2003
    ....
  43. ncbi Inhibitory effect of RNAi on Japanese encephalitis virus replication in vitro and in vivo
    Manabu Murakami
    Division of Molecular Oncology and Virology, Medical Research Institute, Kanazawa Medical University, Ishikawa 920 0293, Japan
    Microbiol Immunol 49:1047-56. 2005
    ..The results in vivo and in vitro provide evidence that JEV replication was efficiently inhibited by RNAi and RNAis could be used as an antiviral drug against JEV infection...
  44. doi Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol
    Masayo Maeda
    Department of Chemistry, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Toxicol Appl Pharmacol 229:232-8. 2008
    ..On the other hand, serial oral administration of low non-toxic doses of lapachol (5-20 mg/kg) weakly but significantly suppressed metastasis by an unknown mechanism, suggesting the possible use of lapachol as an anti-metastatic agent...