Yoshiyuki Tatsumi

Summary

Affiliation: Central Research Laboratories
Country: Japan

Publications

  1. ncbi request reprint In vivo fungicidal effect of KP-103 in a guinea pig model of interdigital tinea pedis determined by using a new method for removing the antimycotic carryover effect
    Yoshiyuki Tatsumi
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Microbiol Immunol 46:433-9. 2002
  2. ncbi request reprint KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs
    Yoshiyuki Tatsum
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Microbiol Immunol 46:425-32. 2002
  3. ncbi request reprint F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp
    Yoshinori Kanai
    Research Laboratory Agrochemical and Animal Health Products Department, Kaken Pharmaceutical Co, Ltd, 301 Gensuke, Fujieda, Shizuoka 426 8646, Japan
    J Antibiot (Tokyo) 58:507-13. 2005
  4. pmc Mechanism of action of efinaconazole, a novel triazole antifungal agent
    Yoshiyuki Tatsumi
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Antimicrob Agents Chemother 57:2405-9. 2013
  5. pmc Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine
    Yoshiyuki Tatsumi
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Shinomiya, Yamashina ku, Kyoto City, Kyoto 607 8042, Japan
    Antimicrob Agents Chemother 46:3797-801. 2002
  6. pmc In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal
    Atsushi Iwata
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Antimicrob Agents Chemother 58:4920-2. 2014
  7. pmc Efficacy Coefficients Determined Using Nail Permeability and Antifungal Activity in Keratin-Containing Media Are Useful for Predicting Clinical Efficacies of Topical Drugs for Onychomycosis
    Yoshiki Matsuda
    Drug Research Center, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    PLoS ONE 11:e0159661. 2016
  8. pmc The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment
    Keita Sugiura
    Kaken Pharmaceutical Co Ltd, Kyoto, Japan
    Antimicrob Agents Chemother 58:3837-42. 2014

Collaborators

  • Takashi Hashimoto
  • Yayoi Nishiyama
  • Yoshinori Kanai
  • Keita Sugiura
  • Yoshiki Matsuda
  • Radhakrishnan Pillai
  • Atsushi Iwata
  • Maria Katafuchi-Nagashima
  • Yoshihiro Konno
  • Akane Ueda
  • Shinya Hosaka
  • Noriaki Sugimoto
  • Yoko Watanabe
  • Naomichi Kumagai
  • Yoshio Arakawa
  • William Jo Siu
  • Yoshiyuki Tatsum
  • Tadashi Arika
  • Mamoru Yokoo
  • Hideyo Yamaguchi

Detail Information

Publications8

  1. ncbi request reprint In vivo fungicidal effect of KP-103 in a guinea pig model of interdigital tinea pedis determined by using a new method for removing the antimycotic carryover effect
    Yoshiyuki Tatsumi
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Microbiol Immunol 46:433-9. 2002
    ....
  2. ncbi request reprint KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs
    Yoshiyuki Tatsum
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Microbiol Immunol 46:425-32. 2002
    ..The effectiveness of KP-103 against dermatophytoses may be due to the favorable pharmacokinetic properties in the skin tissues, together with its potent antifungal activity...
  3. ncbi request reprint F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp
    Yoshinori Kanai
    Research Laboratory Agrochemical and Animal Health Products Department, Kaken Pharmaceutical Co, Ltd, 301 Gensuke, Fujieda, Shizuoka 426 8646, Japan
    J Antibiot (Tokyo) 58:507-13. 2005
    ..The structures of these compounds were assigned as a decalin compound on the basis of various spectral analyses. These compounds showed antimicrobial activity against fungi including clinically important fungus, Aspergillus fumigatus...
  4. pmc Mechanism of action of efinaconazole, a novel triazole antifungal agent
    Yoshiyuki Tatsumi
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Antimicrob Agents Chemother 57:2405-9. 2013
    ..In conclusion, the primary mechanism of action of efinaconazole is blockage of ergosterol biosynthesis, presumably through sterol 14α-demethylase inhibition, leading to secondary degenerative changes...
  5. pmc Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine
    Yoshiyuki Tatsumi
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Shinomiya, Yamashina ku, Kyoto City, Kyoto 607 8042, Japan
    Antimicrob Agents Chemother 46:3797-801. 2002
    ..The effectiveness of KP-103 against tinea unguium is probably due to its favorable pharmacokinetic properties in the nails together with its potent antifungal activity...
  6. pmc In vitro and in vivo assessment of dermatophyte acquired resistance to efinaconazole, a novel triazole antifungal
    Atsushi Iwata
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    Antimicrob Agents Chemother 58:4920-2. 2014
    ..There was no evidence of efinaconazole resistance development in the tested strains under the experimental conditions used. ..
  7. pmc Efficacy Coefficients Determined Using Nail Permeability and Antifungal Activity in Keratin-Containing Media Are Useful for Predicting Clinical Efficacies of Topical Drugs for Onychomycosis
    Yoshiki Matsuda
    Drug Research Center, Kaken Pharmaceutical Co, Ltd, Kyoto, Japan
    PLoS ONE 11:e0159661. 2016
    ..In order to be more effective, topical drugs have to possess higher efficacy coefficients. ..
  8. pmc The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment
    Keita Sugiura
    Kaken Pharmaceutical Co Ltd, Kyoto, Japan
    Antimicrob Agents Chemother 58:3837-42. 2014
    ..01). These results suggest that the high nail permeability of efinaconazole and its potent fungicidal activity in the presence of keratin are related to its low keratin affinity, which may contribute to its efficacy in onychomycosis. ..