Kazuyuki Matsushita

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. doi Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression
    Kazuyuki Matsushita
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Mol Cancer Res 11:689-98. 2013
  2. doi SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression
    Kazuyuki Matsushita
    Department of Molecular Diagnosis F8, Chiba University Graduate School of Medicine, Chiba City, Chiba 260 8670, Japan
    Mol Cancer Res 10:787-99. 2012
  3. pmc Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age
    Shawn A Ritchie
    Phenomenome Discoveries Inc, Saskatoon, Saskatchewan, Canada
    BMC Gastroenterol 10:140. 2010
  4. ncbi Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ
    Kazuyuki Matsushita
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8677, Japan
    Cancer Sci 97:57-63. 2006
  5. ncbi c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy
    Kazuyuki Matsushita
    Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670
    Front Biosci (Landmark Ed) 14:3401-8. 2009
  6. ncbi [Clinical application of alternative splicing form of c-myc suppressor FUSE-binding protein-interacting repressor for cancer detection and treatment]
    Kazuyuki Matsushita
    Department of Molecular Diagnosis and Division of Clinical Genetics and Proteomics, Graduate School of Medicine, Chiba University, Japan
    Rinsho Byori 57:1151-8. 2009
  7. doi SAP155-mediated c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants are activated in colon cancer tissues
    Toshiko Kajiwara
    Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Sci 104:149-56. 2013
  8. ncbi Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer
    Isamu Hoshino
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260 8670, Japan
    Anticancer Res 28:665-71. 2008
  9. doi Combined effects of p53 gene therapy and leptomycin B in human esophageal squamous cell carcinoma
    Isamu Hoshino
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
    Oncology 75:113-9. 2008
  10. ncbi Gene expression profiling induced by histone deacetylase inhibitor, FK228, in human esophageal squamous cancer cells
    Isamu Hoshino
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260 8670, Japan
    Oncol Rep 18:585-92. 2007

Detail Information

Publications66

  1. doi Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression
    Kazuyuki Matsushita
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Mol Cancer Res 11:689-98. 2013
    ....
  2. doi SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression
    Kazuyuki Matsushita
    Department of Molecular Diagnosis F8, Chiba University Graduate School of Medicine, Chiba City, Chiba 260 8670, Japan
    Mol Cancer Res 10:787-99. 2012
    ..In conclusion, altered FIR and c-myc pre-mRNA splicing, in addition to c-Myc expression by augmented FIR/FIRΔexon2-SAP155 complex, potentially contribute to colorectal cancer development...
  3. pmc Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age
    Shawn A Ritchie
    Phenomenome Discoveries Inc, Saskatoon, Saskatchewan, Canada
    BMC Gastroenterol 10:140. 2010
    ..The following studies were carried out to assess whether conventional therapy would result in restoration of systemic hPULCFAs in CRC patients, and to investigate the relationship between hPULCFA levels and age...
  4. ncbi Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of c-myc suppression by interferon-gamma in situ
    Kazuyuki Matsushita
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoh ku, Chiba 260 8677, Japan
    Cancer Sci 97:57-63. 2006
    ....
  5. ncbi c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy
    Kazuyuki Matsushita
    Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670
    Front Biosci (Landmark Ed) 14:3401-8. 2009
    ..Together, one clue to the development of cancer diagnosis and therapies directed against c-Myc may go through FIR and its splicing variant...
  6. ncbi [Clinical application of alternative splicing form of c-myc suppressor FUSE-binding protein-interacting repressor for cancer detection and treatment]
    Kazuyuki Matsushita
    Department of Molecular Diagnosis and Division of Clinical Genetics and Proteomics, Graduate School of Medicine, Chiba University, Japan
    Rinsho Byori 57:1151-8. 2009
    ..Together, FIR splicing variant, FIRDelta(exon)2 mRNA or proteins and its interacting proteins are applicable for novel screening tumor markers in colorectal cancer detection...
  7. doi SAP155-mediated c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants are activated in colon cancer tissues
    Toshiko Kajiwara
    Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer Sci 104:149-56. 2013
    ..Clinical implications for colorectal cancers of novel FIR splicing variants are also discussed in the present paper...
  8. ncbi Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer
    Isamu Hoshino
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260 8670, Japan
    Anticancer Res 28:665-71. 2008
    ..The effectiveness of one of the novel HDACIs, FK228, was examined in adenovirus-mediated p53 gene therapy of esophageal squamous cell carcinoma (ESCC)...
  9. doi Combined effects of p53 gene therapy and leptomycin B in human esophageal squamous cell carcinoma
    Isamu Hoshino
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan
    Oncology 75:113-9. 2008
    ..Currently, it has been shown that p53 protein has a nuclear export signal. In this study, we assessed whether LMB augments the transduced p53 gene effect...
  10. ncbi Gene expression profiling induced by histone deacetylase inhibitor, FK228, in human esophageal squamous cancer cells
    Isamu Hoshino
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba 260 8670, Japan
    Oncol Rep 18:585-92. 2007
    ..These observations of the expression patterns of functionally classified genes provided insights into the mechanism of the antitumor effect of FK228 in esophageal squamous carcinoma...
  11. ncbi Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients
    Isamu Hoshino
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 18:867-71. 2007
    ..Our results provide strong evidence that the reduced Prdx1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker...
  12. ncbi An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis
    Kazuyuki Matsushita
    Departments of Frontier Surgery, Molecular Diagnosis, and Molecular Pathology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan 160 8670
    Cancer Res 66:1409-17. 2006
    ..These results strongly suggest the expression of this splicing variant promotes tumor development by disabling FIR repression and sustaining high levels of c-Myc and opposing apoptosis in colorectal cancer...
  13. doi CHAP31 induces apoptosis only via the intrinsic pathway in human esophageal cancer cells
    Kentaro Murakami
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan matsuhm faculty chiba u jp
    Oncology 78:62-74. 2010
    ..This study describes the antiproliferative activity of CHAP31, a novel HDAC inhibitor. Furthermore, the molecular mechanism of CHAP31-induced apoptosis was investigated in ESCC...
  14. ncbi Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin
    Takanori Nishimori
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Proteomics 6:1011-8. 2006
    ..These results suggest that periplakin could be a useful marker for detection of early esophageal cancer and evaluation of tumor progression...
  15. doi Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease
    Sachio Tsuchida
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan
    Proteomics 13:2339-50. 2013
    ..Thus, LC-MS/MS analyses of GCF using TMT labeling led to the identification of LCN2, which may be a promising GCF biomarker for the detection of periodontal disease. ..
  16. doi Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis
    Hiroshi Umemura
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba 260 8670, Japan
    J Gastroenterol 46:577-85. 2011
    ..Serum biomarkers currently available for gastric cancers are not sufficiently sensitive and specific...
  17. doi Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer
    Hiroshi Kawahira
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuoh ku, Chiba, Japan
    Cancer Sci 101:289-91. 2010
    ..Although adenoviral DNA fragments may be pathogen-free, patients' feces and gargling saliva contain adenoviral DNA fragments for 12 days after injection...
  18. pmc Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway
    Bahityar Rahmutulla
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Oncotarget 5:2404-17. 2014
    ..This novel function of FIR splicing will contribute to clinical studies of cancer management through elucidating the mechanical interaction of FIR/FIRΔexon2/SAP155 as a potential target for cancer treatment. ..
  19. ncbi Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells
    Isamu Hoshino
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:7945-52. 2005
    ..The purpose of this study is to reveal the effect of FK228 on gene expression in the cell and to determine the mechanism of the antitumor activity of FK228 for further clinical applications...
  20. ncbi Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy
    Takeshi Tomonaga
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Cancer Res 65:4683-9. 2005
    ..These results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers...
  21. doi Serum cytokine and chemokine profiles in patients with juvenile muscular atrophy of distal upper extremity (Hirayama disease)
    Minako Beppu
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba 260 8670, Japan
    J Neuroimmunol . 2016
    ..These chemokines are associated with inflammatory cell recruitment. Allergic inflammation may involve in the pathogenesis of Hirayama disease...
  22. ncbi Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer
    Takeshi Tomonaga
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Cancer Res 63:3511-6. 2003
    ..These results suggest that overexpression of CENP-A could play an important role for aneuploidy in colorectal cancers...
  23. pmc Identification of a Novel Biomarker for Biliary Tract Cancer Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
    Shintaro Kikkawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba City 260 8670, Japan
    Int J Proteomics 2012:108609. 2012
    ..These results suggest that this protein fragment may be a promising biomarker for biliary tract cancer...
  24. doi Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma
    Koji Katada
    Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Proteomics 75:1803-15. 2012
    ..Our findings suggest that plectin promotes the migration and invasion of HNSCC cells through activation of Erk 1/2 kinase and is a potential prognostic biomarker of HNSCC...
  25. doi Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma
    Atsushi Kitamura
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer Sci 102:1366-73. 2011
    ..Combination therapy with SeV/ΔF/FIR plus cisplatin has therapeutic potential against HMPM. SeV/ΔF/FIR plus cisplatin will be an attractive modality against HMPM in the future...
  26. doi An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer
    Di Wu
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Int J Cancer 128:1018-30. 2011
    ..These results suggest that eIF4H isoform 1 plays an important role in carcinogenesis through the activation of oncogenic signaling and could be a promising molecular target for cancer therapy...
  27. ncbi Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis
    Takeshi Tomonaga
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 10:2007-14. 2004
    ..The aim of this study is to identify novel proteins as potential tumor markers in primary colorectal cancer tissues using a high-resolution two-dimensional gel electrophoresis (2-DE)...
  28. pmc Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation
    Takayuki Ishige
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan
    Sci Rep 6:21681. 2016
    ..In conclusion, this study revealed that GDF15 may be a novel functional secreted molecule for DGC progression, possibly having important roles for cancer progression via the affecting fibroblast function, as well as TGF-β. ..
  29. pmc Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1
    Kazuyuki Matsushita
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Oncotarget 6:5102-17. 2015
    ..In conclusion, the alternative splicing of FIR, which generates FIRΔexon2, may contribute to both colorectal carcinogenesis and leukemogenesis...
  30. pmc Human apolipoprotein e resequencing by proteomic analysis and its application to serotyping
    Motoi Nishimura
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan Division of Laboratory Medicine and Clinical Genetics, Chiba University Hospital, Chiba, Japan Clinical Proteomics Research Center, Chiba University Hospital, Chiba, Japan
    PLoS ONE 9:e85356. 2014
    ..ApoE levels in plasma and serum are clinically determined by immunoassay...
  31. ncbi Long-term results after dissection of positive thoracic lymph nodes in patients with esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    World J Surg 32:255-61. 2008
    ..The purpose of this study was to evaluate surgical outcome after the clearance of metastatic thoracic lymph nodes...
  32. doi Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31
    Takayuki Ishige
    Department of Molecular Diagnosis and Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hum Genet 57:807-8. 2012
    ..No peaks were observed in a normal control and two non-SCA31 patients, in whom the TGGAA repeat was absent. This method is valuable for genetic diagnosis of SCA31 in clinical practice...
  33. doi Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers
    Sachio Tsuchida
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan
    Proteomics 12:2190-202. 2012
    ..A total of 327 proteins including ApoA-I, SOD1, and DCD were identified in GCF. These results may serve as reference for future proteomic studies searching for GCF biomarkers of periodontal diseases...
  34. pmc Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells
    Yurie Tonoike
    Department of Otorhinolaryngology, Chiba University Hospital, Chiba City, Japan
    BMC Cell Biol 12:41. 2011
    ....
  35. doi Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma
    Fumio Nomura
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University and Divisions of Laboratory Medicine, Clinical Genetics and Proteomics, Chiba University Hospital, Chiba, Japan
    Biochem Biophys Res Commun 421:837-43. 2012
    ..Further studies in a larger number of HCC patients with various etiologies are needed to further evaluate the diagnostic and pathophysiological roles of elevation of serum anti-Ku86 in early HCC...
  36. pmc Decreases in the serum VLDL-TG/non-VLDL-TG ratio from early stages of chronic hepatitis C: alterations in TG-rich lipoprotein levels
    Motoi Nishimura
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba City, Japan
    PLoS ONE 6:e17309. 2011
    ..However, the results of these studies are variable. A homogenous assay protocol was recently proposed to directly measure the TG content in VLDL (VLDL-TG) and VLDL remnants...
  37. ncbi [HLA-DR antigen expression of colorectal cancer cells and its significance in long-term survival]
    Kazuyuki Matsushita
    Department of Academic Surgery M9, Graduate School of Medicine, Chiba University
    Nihon Rinsho 61:237-41. 2003
  38. ncbi [Two cases treated with trastuzumab as primary chemotherapy]
    Kentaro Murakami
    Dept of Frontier Surgery, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 34:1683-7. 2007
    ..Later, because of mild tumor regrowth, we used 2 courses of vinorelbine in combination with trastuzumab. The tumor grew more, so Bp + Ax was done. The woman is alive at this writing with no recurrence...
  39. doi Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients
    Sohei Kobayashi
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba City, Chiba 260 8670, Japan
    Oncotarget . 2016
    ..85) than that for anti-p53 antibodies or CA19-9. In conclusions, the combination of anti-FIRs antibodies with other clinically available tumor markers further improved the specificity and accuracy of cancer diagnosis...
  40. ncbi [Usefulness of the standardized serum cystatin C reagent in evaluation of renal function]
    Yoshitake Suzuki
    Division of Laboratory Medicine, Chiba University Hospital, Chiba 260 8677, Japan
    Rinsho Byori 61:665-70. 2013
    ..Further studies are required to evaluate the validity of standardization of sCysC measurement and find the dissociation among eGFR, sCysC and sCr depending in the renal disease or pathogenesis...
  41. pmc The FLS (fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis
    Toshihisa Semba
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    BMC Gastroenterol 13:120. 2013
    ..This study aims to reveal the differences between simple steatosis and NASH...
  42. doi High-resolution melting analyses for gene scanning of APC, MLH1, MSH2, and MSH6 associated with hereditary colorectal cancer
    Jurat Obul
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan
    Genet Test Mol Biomarkers 16:406-11. 2012
    ..For this purpose, we developed a novel gene scanning method by high-resolution melting (HRM) analysis...
  43. ncbi Low peritoneal and systemic inflammatory response after laparoscopy-assisted gastrectomy compared to open gastrectomy
    Toshiyuki Natsume
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Hepatogastroenterology 58:659-62. 2011
    ..Peritoneal immune response as well as systemic response was objectively evaluated in laparoscopy-assisted distal gastrectomy (LADG) compared to open distal gastrectomy (ODG)...
  44. pmc The application of a three-step proteome analysis for identification of new biomarkers of pancreatic cancer
    Mayinuer Abulaizi
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int J Proteomics 2011:628787. 2011
    ....
  45. doi Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma; clathrin heavy chain and formiminotransferase cyclodeaminase
    Masanori Seimiya
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatology 48:519-30. 2008
    ..2% for CHC+FTCD, and 61.1% for CHC+glypican-3 and FTCD+glypican-3, as 44.4% of glypican-3 negative early HCC were able to be detected by either CHC or FTCD staining...
  46. doi Paradoxical effects of thyroid function on glomerular filtration rate estimated from serum creatinine or standardized cystatin C in patients with Japanese Graves' disease
    Yoshitake Suzuki
    Department of Laboratory Medicine, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan Electronic address
    Clin Chim Acta 451:316-22. 2015
    ..This study examined the effects of thyroid hormones on eGFR by sCr (eGFRCr), and standardized sCysC (eGFRCysC) in patients with Japanese Graves' disease (GD)...
  47. doi High-throughput screening of extended RAS mutations based on high-resolution melting analysis for prediction of anti-EGFR treatment efficacy in colorectal carcinoma
    Takayuki Ishige
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan Division of Laboratory Medicine and Clinical Genetics, Chiba University Hospital, Chiba, Japan Electronic address
    Clin Biochem 47:340-3. 2014
    ..Thus, high-throughput and cost-effective methods for identification of the mutation status are required...
  48. doi The abnormal reaction data-detecting function of the automated biochemical analyzer was useful to prevent erroneous total-bilirubin measurement and to identify monoclonal proteins
    Masanori Seimiya
    Division of Laboratory Medicine, Chiba University Hospital, Chiba, Japan Clinical Proteomics Research Center, Chiba University Hospital, Chiba, Japan Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan Electronic address
    Clin Chim Acta 441:44-6. 2015
    ..We investigated the usefulness of this function for total-bilirubin (T-Bil) measurement in routine testing...
  49. doi Moesin is a possible target molecule for cytomegalovirus-related Guillain-Barré syndrome
    Setsu Sawai
    From the Departments of Molecular Diagnosis S S, M S, K Sogawa, T K, M I, M B, T I, K N, K Sato, K M, F N and Neurology M M, S M, M B, K Shibuya, Y S, S K, Graduate School of Medicine, Chiba University and Department of Physics Y K, School of Science, Kitasato University, Kanagawa, Japan
    Neurology 83:113-7. 2014
    ....
  50. ncbi The effects of carbon ion irradiation revealed by excised perforated intestines as a late morbidity for uterine cancer treatment
    Kazuyuki Matsushita
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Surg Today 36:692-700. 2006
    ..Perforated intestines as a late morbidity after carbon ion radiotherapy for uterine cancers were examined to reveal the biological characteristics of carbon ion for future applications for the treatment of gastrointestinal cancers...
  51. doi Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis
    Kiyoko Takane
    Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncotarget . 2016
    ..These results indicate that there are at least two distinct molecular subtypes of FAP tumors, resembling sporadic CRC and independent from the APC germline mutation status...
  52. ncbi Development and validation of the simultaneous measurement of four vitamin D metabolites in serum by LC-MS/MS for clinical laboratory applications
    Mamoru Satoh
    Division of Clinical Mass Spectrometry, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba, 260 8670, Japan
    Anal Bioanal Chem 408:7617-7627. 2016
    ..This method will aid further understanding of low-abundance vitamin D metabolites, as well as the accurate determination of 25(OH)D3 and 25(OH)D2...
  53. pmc Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy
    Kazuyuki Matsushita
    Kazuyuki Matsushita, Fumio Nomura, Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    World J Gastroenterol 20:4316-28. 2014
    ..To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR)...
  54. doi Transbronchial biopsy needle rinse solution used for comprehensive biomarker testing in patients with lung cancer
    Yuichi Sakairi
    Departments of General Thoracic Surgery, Medical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan and Division of Laboratory Medicine and Clinical Genetics and Department of Endoscopic Diagnostics and Therapeutics, Chiba University Hospital, Chiba, Japan
    J Thorac Oncol 9:26-32. 2014
    ..We investigated the utility of bronchoscopic sampling in non-small-cell lung cancer (NSCLC) patients compared with conventional histological materials for multiple genetic analyses...
  55. doi Reducing the incidence of pseudohyperkalemia by avoiding making a fist during phlebotomy: a quality improvement report
    Masanori Seimiya
    Division of Laboratory Medicine, Chiba University Hospital, Chiba City, Chiba, Japan
    Am J Kidney Dis 56:686-92. 2010
    ..We investigated the use of a standard protocol to avoid fist clenching during phlebotomy...
  56. doi YKL-40 identified by proteomic analysis as a biomarker of sepsis
    Noriyuki Hattori
    Department of Emergency and Critical Care Medicine, Chiba University, Graduate School of Medicine, Chiba, Japan
    Shock 32:393-400. 2009
    ..465, P < 0.01). YKL-40 identified by proteomic analysis is considered as a biomarker of sepsis. However, further investigation is needed to clarify its roles and clinical usefulness as a biomarker...
  57. ncbi [Clinical validity of renal function markers including serum cystatin C on chronic kidney disease classification]
    Yoshitake Suzuki
    Division of Laboratory Medicine, Chiba University Hospital, Chiba 260 8677, Japan
    Rinsho Byori 59:345-51. 2011
    ..Since eGFR and Ccr showed different results in early and severe CKD groups, it was suggested that Ccr and eGFR need to be evaluated as different renal function markers...
  58. doi A panel of autoantibodies against multiple tumor-associated antigens for detecting gastric cancer
    Isamu Hoshino
    Division of Gastroenterological Surgery, Chiba Cancer Center, 666 2 Nitonacho, Chuo Ku, Chiba, 260 8717, Japan
    Cancer Sci . 2017
    ..This article is protected by copyright. All rights reserved...
  59. doi How proteomic ApoE serotyping could impact Alzheimer's disease risk assessment: genetic testing by proteomics
    Motoi Nishimura
    Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan
    Expert Rev Proteomics 11:405-7. 2014
    ..Not limited to ApoE, proteomic analysis of human samples could be used to intentionally determine - and perhaps unintentionally reveal - personal genetic information. ..
  60. doi Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells
    Shingo Kagawa
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Surg Res 178:758-67. 2012
    ..The aims of this study were to elucidate the signaling mechanism by which Annexin II induces gemcitabine resistance and to develop a new therapy that overcomes the resistance against gemcitabine...
  61. ncbi The diagnostic value of endoscopic ultrasonography and magnetic resonance imaging for anorectal malignant melanoma: report of a case
    Hiroshi Sashiyama
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Japan
    Surg Today 33:209-13. 2003
    ..Thus, EUS and MRI are useful preoperative diagnostic tools for the tumor staging of primary anorectal malignant melanomas, as for other rectal tumors...
  62. pmc Alternative splicing of DNA damage response genes and gastrointestinal cancers
    Bahityar Rahmutulla
    Bahityar Rahmutulla, Kazuyuki Matsushita, Fumio Nomura, Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    World J Gastroenterol 20:17305-13. 2014
    ..Better understanding of the role and mechanism of alternative splicing in tumorigenesis may provide new directions for future cancer studies. ..
  63. doi Serous tubal intraepithelial carcinoma in a Japanese woman with a deleterious BRCA1 mutation
    Hiroshi Ishikawa
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba
    Jpn J Clin Oncol 44:597-601. 2014
    ....
  64. ncbi Recent advances in esophageal cancer gene therapy
    Hideaki Shimada
    Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Thorac Cardiovasc Surg 14:3-8. 2008
    ..Lastly we review the available experimental therapeutic models from the literature and our experimental work over the past few years are reviewed...
  65. ncbi Leupeptin-sensitive proteases involved in cell survival after X-ray irradiation in human RSa cells
    Hong chang Zhang
    Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Chuoku, Japan
    Cell Biol Int 29:662-8. 2005
    ..These results suggest that leupeptin-sensitive proteases are involved in the resistance of human RSa cells to X-ray cell-killing...
  66. ncbi [Treatment of colorectal cancer--hepatic metastases]
    Harufumi Makino
    Dept of Academic Surgery, Graduate School of Medicine, Chiba University
    Gan To Kagaku Ryoho 29:2447-9. 2002
    ..Patients who have metachronous liver metastases from colorectal cancer should therefore be considered for postoperative arterial infusion chemotherapy. It is necessary to improve the outcome for cases that have extra hepatic metastases...